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Malignant Hepatobiliary Neoplasm

MedGen UID:
167699
Concept ID:
C0854176
Neoplastic Process
Synonyms: Malignant Hepato-Biliary Neoplasm; Malignant Liver and Biliary Neoplasm; Malignant Liver and Biliary System Neoplasm

Definition

A malignant neoplasm that affects the liver parenchyma, bile ducts, and gallbladder. Representative examples include hepatocellular carcinoma, intrahepatic and extrahepatic cholangiocarcinoma, and gallbladder carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant Hepatobiliary Neoplasm

Professional guidelines

PubMed

McGuigan A, Kelly P, Turkington RC, Jones C, Coleman HG, McCain RS
World J Gastroenterol 2018 Nov 21;24(43):4846-4861. doi: 10.3748/wjg.v24.i43.4846. PMID: 30487695Free PMC Article
Tanaka M, Fernández-Del Castillo C, Kamisawa T, Jang JY, Levy P, Ohtsuka T, Salvia R, Shimizu Y, Tada M, Wolfgang CL
Pancreatology 2017 Sep-Oct;17(5):738-753. Epub 2017 Jul 13 doi: 10.1016/j.pan.2017.07.007. PMID: 28735806
Rizvi S, Gores GJ
Gastroenterology 2013 Dec;145(6):1215-29. Epub 2013 Oct 15 doi: 10.1053/j.gastro.2013.10.013. PMID: 24140396Free PMC Article

Recent clinical studies

Etiology

Gunasekaran G, Bekki Y, Lourdusamy V, Schwartz M
Hepatology 2021 Jan;73 Suppl 1:128-136. Epub 2020 Nov 26 doi: 10.1002/hep.31325. PMID: 32438491
Norton JA, Foster DS, Blumgart LH, Poultsides GA, Visser BC, Fraker DL, Alexander HR, Jensen RT
JAMA Surg 2018 Mar 1;153(3):e175083. doi: 10.1001/jamasurg.2017.5083. PMID: 29365025Free PMC Article
Blechacz B
Gut Liver 2017 Jan 15;11(1):13-26. doi: 10.5009/gnl15568. PMID: 27928095Free PMC Article
Li X, Yao W, Yuan Y, Chen P, Li B, Li J, Chu R, Song H, Xie D, Jiang X, Wang H
Gut 2017 Jan;66(1):157-167. Epub 2015 Oct 9 doi: 10.1136/gutjnl-2015-310514. PMID: 26452628
Zhang H, Yang T, Wu M, Shen F
Cancer Lett 2016 Sep 1;379(2):198-205. Epub 2015 Sep 25 doi: 10.1016/j.canlet.2015.09.008. PMID: 26409434

Diagnosis

Gunasekaran G, Bekki Y, Lourdusamy V, Schwartz M
Hepatology 2021 Jan;73 Suppl 1:128-136. Epub 2020 Nov 26 doi: 10.1002/hep.31325. PMID: 32438491
Norton JA, Foster DS, Blumgart LH, Poultsides GA, Visser BC, Fraker DL, Alexander HR, Jensen RT
JAMA Surg 2018 Mar 1;153(3):e175083. doi: 10.1001/jamasurg.2017.5083. PMID: 29365025Free PMC Article
Blechacz B
Gut Liver 2017 Jan 15;11(1):13-26. doi: 10.5009/gnl15568. PMID: 27928095Free PMC Article
Zhang H, Yang T, Wu M, Shen F
Cancer Lett 2016 Sep 1;379(2):198-205. Epub 2015 Sep 25 doi: 10.1016/j.canlet.2015.09.008. PMID: 26409434
Pavai S, Yap SF
Med J Malaysia 2003 Dec;58(5):667-72. PMID: 15190651

Therapy

Roudko V, Cimen Bozkus C, Greenbaum B, Lucas A, Samstein R, Bhardwaj N
Front Immunol 2021;12:757804. Epub 2021 Sep 24 doi: 10.3389/fimmu.2021.757804. PMID: 34630437Free PMC Article
Hou J, Karin M, Sun B
Nat Rev Clin Oncol 2021 May;18(5):261-279. Epub 2021 Jan 19 doi: 10.1038/s41571-020-00459-9. PMID: 33469195Free PMC Article
Kelley RK, Bridgewater J, Gores GJ, Zhu AX
J Hepatol 2020 Feb;72(2):353-363. doi: 10.1016/j.jhep.2019.10.009. PMID: 31954497
Cillo U, Fondevila C, Donadon M, Gringeri E, Mocchegiani F, Schlitt HJ, Ijzermans JNM, Vivarelli M, Zieniewicz K, Olde Damink SWM, Groot Koerkamp B
Liver Int 2019 May;39 Suppl 1(Suppl Suppl 1):143-155. doi: 10.1111/liv.14089. PMID: 30843343Free PMC Article
Xu F, Jin T, Zhu Y, Dai C
J Exp Clin Cancer Res 2018 May 29;37(1):110. doi: 10.1186/s13046-018-0777-4. PMID: 29843754Free PMC Article

Prognosis

Mao J, Wang D, Long J, Yang X, Lin J, Song Y, Xie F, Xun Z, Wang Y, Wang Y, Li Y, Sun H, Xue J, Song Y, Zuo B, Zhang J, Bian J, Zhang T, Yang X, Zhang L, Sang X, Zhao H
J Immunother Cancer 2021 Dec;9(12) doi: 10.1136/jitc-2021-003334. PMID: 34873013Free PMC Article
Mazzaferro V, Citterio D, Bhoori S, Bongini M, Miceli R, De Carlis L, Colledan M, Salizzoni M, Romagnoli R, Antonelli B, Vivarelli M, Tisone G, Rossi M, Gruttadauria S, Di Sandro S, De Carlis R, Lucà MG, De Giorgio M, Mirabella S, Belli L, Fagiuoli S, Martini S, Iavarone M, Svegliati Baroni G, Angelico M, Ginanni Corradini S, Volpes R, Mariani L, Regalia E, Flores M, Droz Dit Busset M, Sposito C
Lancet Oncol 2020 Jul;21(7):947-956. doi: 10.1016/S1470-2045(20)30224-2. PMID: 32615109
Kelley RK, Bridgewater J, Gores GJ, Zhu AX
J Hepatol 2020 Feb;72(2):353-363. doi: 10.1016/j.jhep.2019.10.009. PMID: 31954497
McGuigan A, Kelly P, Turkington RC, Jones C, Coleman HG, McCain RS
World J Gastroenterol 2018 Nov 21;24(43):4846-4861. doi: 10.3748/wjg.v24.i43.4846. PMID: 30487695Free PMC Article
Rizvi S, Gores GJ
Gastroenterology 2013 Dec;145(6):1215-29. Epub 2013 Oct 15 doi: 10.1053/j.gastro.2013.10.013. PMID: 24140396Free PMC Article

Clinical prediction guides

Wang J, Ding ZW, Chen K, Liu YZ, Li N, Hu MG
BMC Cancer 2021 Dec 16;21(1):1337. doi: 10.1186/s12885-021-09047-1. PMID: 34911488Free PMC Article
Lin WP, Xing KL, Fu JC, Ling YH, Li SH, Yu WS, Zhang YF, Zhong C, Wang JH, Chen ZY, Lu LH, Wei W, Guo RP
JAMA Netw Open 2021 Sep 1;4(9):e2125055. doi: 10.1001/jamanetworkopen.2021.25055. PMID: 34515782Free PMC Article
Okusaka T, Nakamura M, Yoshida M, Kitano M, Uesaka K, Ito Y, Furuse J, Hanada K, Okazaki K; Committee for Revision of Clinical Guidelines for Pancreatic Cancer of the Japan Pancreas Society
Pancreas 2020 Mar;49(3):326-335. doi: 10.1097/MPA.0000000000001513. PMID: 32132516Free PMC Article
Zhang H, Yang T, Wu M, Shen F
Cancer Lett 2016 Sep 1;379(2):198-205. Epub 2015 Sep 25 doi: 10.1016/j.canlet.2015.09.008. PMID: 26409434
Wang Y, Li J, Xia Y, Gong R, Wang K, Yan Z, Wan X, Liu G, Wu D, Shi L, Lau W, Wu M, Shen F
J Clin Oncol 2013 Mar 20;31(9):1188-95. Epub 2013 Jan 28 doi: 10.1200/JCO.2012.41.5984. PMID: 23358969

Recent systematic reviews

Zhu JQ, Wu H, Li ZL, Xu XF, Xing H, Wang MD, Jia HD, Liang L, Li C, Sun LY, Wang YG, Shen F, Huang DS, Yang T
Adv Mater 2022 Sep;34(38):e2201651. Epub 2022 Aug 19 doi: 10.1002/adma.202201651. PMID: 35583434
McGovern J, Dolan RD, Horgan PG, Laird BJ, McMillan DC
J Cachexia Sarcopenia Muscle 2021 Dec;12(6):1408-1417. Epub 2021 Oct 18 doi: 10.1002/jcsm.12831. PMID: 34664431Free PMC Article
Luvira V, Satitkarnmanee E, Pugkhem A, Kietpeerakool C, Lumbiganon P, Pattanittum P
Cochrane Database Syst Rev 2021 Sep 13;9(9):CD012814. doi: 10.1002/14651858.CD012814.pub2. PMID: 34515993Free PMC Article
Lambert JE, Hayes LD, Keegan TJ, Subar DA, Gaffney CJ
Ann Surg 2021 Jul 1;274(1):70-77. doi: 10.1097/SLA.0000000000004527. PMID: 33201129
Peeraphatdit TB, Wang J, Odenwald MA, Hu S, Hart J, Charlton MR
Hepatology 2020 Jul;72(1):315-329. doi: 10.1002/hep.31227. PMID: 32167613

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