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Increased circulating trypsinogen

MedGen UID:
1677064
•Concept ID:
C4324557
•
Finding
Synonym: Increased immunoreactive trypsinogen
 
HPO: HP:0032493

Definition

An abnormally high concentration of trypsinogen in the blood circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased circulating trypsinogen

Recent clinical studies

Etiology

Dramatic increase in serum trypsinogens, SPINK1 and hCGβ in aortic surgery patients after hypothermic circulatory arrest.
Stewart JA, Koistinen R, Lempiäinen A, Hotakainen K, Salminen US, Vakkuri A, Wennervirta J, Stenman UH, Koistinen H
Scand J Clin Lab Invest 2020 Dec;80(8):640-643. Epub 2020 Sep 23 doi: 10.1080/00365513.2020.1824297. PMID: 32967482
A Mini-Review on the Effect of Docosahexaenoic Acid (DHA) on Cerulein-Induced and Hypertriglyceridemic Acute Pancreatitis.
Jeong YK, Kim H
Int J Mol Sci 2017 Oct 25;18(11) doi: 10.3390/ijms18112239. PMID: 29068376Free PMC Article
Trypsinogen and other pancreatic enzymes in patients with renal disease: a comparison of high-efficiency hemodialysis and continuous ambulatory peritoneal dialysis.
Kimmel PL, Tenner S, Habwe VQ, Henry J, Lakshminarayan S, Steinberg W
Pancreas 1995 May;10(4):325-30. doi: 10.1097/00006676-199505000-00001. PMID: 7540759
Serum levels of immunoreactive trypsin during development: comparison with levels of lipase and amylase.
Colombo C, Maiavacca R, Ronchi M, Bottani P, Stripparo L, Corbetta C, Sereni LP
J Pediatr Gastroenterol Nutr 1989 Aug;9(2):194-9. doi: 10.1097/00005176-198908000-00011. PMID: 2478689
Elevated serum immunoreactive pancreatic cationic trypsinogen in acute malnutrition: evidence of pancreatic damage.
Durie PR, Forstner GG, Gaskin KJ, Weizman Z, Kopelman HR, Ellis L, Largman C
J Pediatr 1985 Feb;106(2):233-8. doi: 10.1016/s0022-3476(85)80293-6. PMID: 3968610

Diagnosis

Interpretation of serum pancreatic enzymes in pancreatic and nonpancreatic conditions.
Bush N, Akshintala VS
Curr Opin Gastroenterol 2023 Sep 1;39(5):403-410. Epub 2023 Jun 22 doi: 10.1097/MOG.0000000000000961. PMID: 37389417
Dramatic increase in serum trypsinogens, SPINK1 and hCGβ in aortic surgery patients after hypothermic circulatory arrest.
Stewart JA, Koistinen R, Lempiäinen A, Hotakainen K, Salminen US, Vakkuri A, Wennervirta J, Stenman UH, Koistinen H
Scand J Clin Lab Invest 2020 Dec;80(8):640-643. Epub 2020 Sep 23 doi: 10.1080/00365513.2020.1824297. PMID: 32967482
Evidence for a causal relationship between early exocrine pancreatic disease and cystic fibrosis-related diabetes: a Mendelian randomization study.
Soave D, Miller MR, Keenan K, Li W, Gong J, Ip W, Accurso F, Sun L, Rommens JM, Sontag M, Durie PR, Strug LJ
Diabetes 2014 Jun;63(6):2114-9. Epub 2014 Feb 18 doi: 10.2337/db13-1464. PMID: 24550193Free PMC Article
Laboratory diagnosis of acute pancreatitis: in search of the Holy Grail.
Lippi G, Valentino M, Cervellin G
Crit Rev Clin Lab Sci 2012 Jan-Feb;49(1):18-31. doi: 10.3109/10408363.2012.658354. PMID: 22339380
Elevated serum immunoreactive pancreatic cationic trypsinogen in acute malnutrition: evidence of pancreatic damage.
Durie PR, Forstner GG, Gaskin KJ, Weizman Z, Kopelman HR, Ellis L, Largman C
J Pediatr 1985 Feb;106(2):233-8. doi: 10.1016/s0022-3476(85)80293-6. PMID: 3968610

Therapy

Dramatic increase in serum trypsinogens, SPINK1 and hCGβ in aortic surgery patients after hypothermic circulatory arrest.
Stewart JA, Koistinen R, Lempiäinen A, Hotakainen K, Salminen US, Vakkuri A, Wennervirta J, Stenman UH, Koistinen H
Scand J Clin Lab Invest 2020 Dec;80(8):640-643. Epub 2020 Sep 23 doi: 10.1080/00365513.2020.1824297. PMID: 32967482
A Mini-Review on the Effect of Docosahexaenoic Acid (DHA) on Cerulein-Induced and Hypertriglyceridemic Acute Pancreatitis.
Jeong YK, Kim H
Int J Mol Sci 2017 Oct 25;18(11) doi: 10.3390/ijms18112239. PMID: 29068376Free PMC Article
Evidence for a causal relationship between early exocrine pancreatic disease and cystic fibrosis-related diabetes: a Mendelian randomization study.
Soave D, Miller MR, Keenan K, Li W, Gong J, Ip W, Accurso F, Sun L, Rommens JM, Sontag M, Durie PR, Strug LJ
Diabetes 2014 Jun;63(6):2114-9. Epub 2014 Feb 18 doi: 10.2337/db13-1464. PMID: 24550193Free PMC Article
Somatostatin infused during acute pancreatitis retains its biological activity.
Annibale B, Ribaldi S, Anania MC, Stagnitti F, Strom R, Corleto V, Delle Fave G
Pancreas 1989;4(6):674-9. doi: 10.1097/00006676-198912000-00004. PMID: 2573057

Prognosis

Evidence for a causal relationship between early exocrine pancreatic disease and cystic fibrosis-related diabetes: a Mendelian randomization study.
Soave D, Miller MR, Keenan K, Li W, Gong J, Ip W, Accurso F, Sun L, Rommens JM, Sontag M, Durie PR, Strug LJ
Diabetes 2014 Jun;63(6):2114-9. Epub 2014 Feb 18 doi: 10.2337/db13-1464. PMID: 24550193Free PMC Article
Acute pancreatitis in Soweto, South Africa: relationship between trypsinogen load, trypsinogen activation, and fibrinolysis.
Segal I, Chaloner C, Douglas J, John KD, Zaidi A, Cotter L, Appelros S, Borgström A, Braganza JM
Am J Gastroenterol 2002 Apr;97(4):883-92. doi: 10.1111/j.1572-0241.2002.05604.x. PMID: 12003423
Elevated serum immunoreactive pancreatic cationic trypsinogen in acute malnutrition: evidence of pancreatic damage.
Durie PR, Forstner GG, Gaskin KJ, Weizman Z, Kopelman HR, Ellis L, Largman C
J Pediatr 1985 Feb;106(2):233-8. doi: 10.1016/s0022-3476(85)80293-6. PMID: 3968610
Serial alterations in the forms of immunoreactive pancreatic cationic trypsin in plasma from patients with acute pancreatitis.
Durie PR, Gaskin KJ, Ogilvie JE, Smith CR, Forstner GG, Largman C
J Pediatr Gastroenterol Nutr 1985 Apr;4(2):199-207. doi: 10.1097/00005176-198504000-00008. PMID: 2580962

Clinical prediction guides

Dramatic increase in serum trypsinogens, SPINK1 and hCGβ in aortic surgery patients after hypothermic circulatory arrest.
Stewart JA, Koistinen R, Lempiäinen A, Hotakainen K, Salminen US, Vakkuri A, Wennervirta J, Stenman UH, Koistinen H
Scand J Clin Lab Invest 2020 Dec;80(8):640-643. Epub 2020 Sep 23 doi: 10.1080/00365513.2020.1824297. PMID: 32967482
Evidence for a causal relationship between early exocrine pancreatic disease and cystic fibrosis-related diabetes: a Mendelian randomization study.
Soave D, Miller MR, Keenan K, Li W, Gong J, Ip W, Accurso F, Sun L, Rommens JM, Sontag M, Durie PR, Strug LJ
Diabetes 2014 Jun;63(6):2114-9. Epub 2014 Feb 18 doi: 10.2337/db13-1464. PMID: 24550193Free PMC Article
Somatostatin infused during acute pancreatitis retains its biological activity.
Annibale B, Ribaldi S, Anania MC, Stagnitti F, Strom R, Corleto V, Delle Fave G
Pancreas 1989;4(6):674-9. doi: 10.1097/00006676-198912000-00004. PMID: 2573057
Raised serum concentrations of pancreatic enzymes in cigarette smokers.
Dubick MA, Conteas CN, Billy HT, Majumdar AP, Geokas MC
Gut 1987 Mar;28(3):330-5. doi: 10.1136/gut.28.3.330. PMID: 2436981Free PMC Article

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