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Resectable Pancreatic Carcinoma

MedGen UID:
167709
•Concept ID:
C0854778
•
Neoplastic Process
Synonyms: Pancreatic Carcinoma, Resectable; Resectable Carcinoma of Pancreas; Resectable Carcinoma of the Pancreas; Resectable Pancreas Carcinoma; Resectable Pancreatic Cancer

Definition

Carcinoma of the pancreas amenable to surgical removal. [from NCI]

Professional guidelines

PubMed

Current Clinical Strategies of Pancreatic Cancer Treatment and Open Molecular Questions.
Brunner M, Wu Z, Krautz C, Pilarsky C, Grützmann R, Weber GF
Int J Mol Sci 2019 Sep 13;20(18) doi: 10.3390/ijms20184543. PMID: 31540286Free PMC Article
Neoadjuvant strategy as initial treatment in resectable pancreatic cancer: concrete evidence of benefit.
DE Felice F, Musio D, Raffetto N, Tombolini V
Anticancer Res 2014 Sep;34(9):4673-6. PMID: 25202043
An evidence-based approach to the surgical management of resectable pancreatic adenocarcinoma.
Stojadinovic A, Brooks A, Hoos A, Jaques DP, Conlon KC, Brennan MF
J Am Coll Surg 2003 Jun;196(6):954-64. doi: 10.1016/S1072-7515(03)00010-3. PMID: 12788434

Recent clinical studies

Etiology

Comparison of neoadjuvant treatment and surgery first for resectable or borderline resectable pancreatic carcinoma: A systematic review and network meta-analysis of randomized controlled trials.
Huan L, Yu F, Cao D, Zhou H, Qin M, Cao Y
PLoS One 2024;19(3):e0295983. Epub 2024 Mar 7 doi: 10.1371/journal.pone.0295983. PMID: 38451955Free PMC Article
Long-Term Effect of Pancreaticoduodenectomy Combined with Revascularization for Resectable Pancreatic Carcinoma in Elderly Patients.
Yang J, Xu Z, Zhang J, Zheng Y, Gu J, Zhou Q, Wang X, Guo S, Zhang H, Chen S, Wang H
Med Sci Monit 2022 Nov 21;28:e938443. doi: 10.12659/MSM.938443. PMID: 36404606Free PMC Article
Encouraging long-term survival following autophagy inhibition using neoadjuvant hydroxychloroquine and gemcitabine for high-risk patients with resectable pancreatic carcinoma.
AlMasri SS, Zenati MS, Desilva A, Nassour I, Boone BA, Singhi AD, Bartlett DL, Liotta LA, Espina V, Loughran P, Lotze MT, Paniccia A, Zeh HJ 3rd, Zureikat AH, Bahary N
Cancer Med 2021 Oct;10(20):7233-7241. Epub 2021 Sep 24 doi: 10.1002/cam4.4211. PMID: 34559451Free PMC Article
Neoadjuvant strategy as initial treatment in resectable pancreatic cancer: concrete evidence of benefit.
DE Felice F, Musio D, Raffetto N, Tombolini V
Anticancer Res 2014 Sep;34(9):4673-6. PMID: 25202043
Adjuvant radiotherapy in resectable pancreatic carcinoma.
Morganti AG, Valentini V, Macchia G, Alfieri S, Trodella L, Brizi MG, Bossola M, Ziccarelli L, Doglietto GB, Cellini N
Eur J Surg Oncol 2002 Aug;28(5):523-30. doi: 10.1053/ejso.2002.1289. PMID: 12217306

Diagnosis

Current and emerging therapeutic strategies in pancreatic cancer: Challenges and opportunities.
Manrai M, Tilak TVSVGK, Dawra S, Srivastava S, Singh A
World J Gastroenterol 2021 Oct 21;27(39):6572-6589. doi: 10.3748/wjg.v27.i39.6572. PMID: 34754153Free PMC Article
Encouraging long-term survival following autophagy inhibition using neoadjuvant hydroxychloroquine and gemcitabine for high-risk patients with resectable pancreatic carcinoma.
AlMasri SS, Zenati MS, Desilva A, Nassour I, Boone BA, Singhi AD, Bartlett DL, Liotta LA, Espina V, Loughran P, Lotze MT, Paniccia A, Zeh HJ 3rd, Zureikat AH, Bahary N
Cancer Med 2021 Oct;10(20):7233-7241. Epub 2021 Sep 24 doi: 10.1002/cam4.4211. PMID: 34559451Free PMC Article
Prognostic impact of normalization of serum tumor markers following neoadjuvant chemotherapy in patients with borderline resectable pancreatic carcinoma with arterial contact.
Murakami Y, Uemura K, Sudo T, Hashimoto Y, Kondo N, Nakagawa N, Okada K, Takahashi S, Sueda T
Cancer Chemother Pharmacol 2017 Apr;79(4):801-811. Epub 2017 Mar 17 doi: 10.1007/s00280-017-3281-1. PMID: 28314992
Evaluation of serum D-dimer, fibrinogen, and CA19-9 for postoperative monitoring and survival prediction in resectable pancreatic carcinoma.
Cao J, Fu Z, Gao L, Wang X, Cheng S, Wang X, Ren H
World J Surg Oncol 2017 Feb 20;15(1):48. doi: 10.1186/s12957-017-1104-9. PMID: 28219450Free PMC Article
Adjuvant radiotherapy in resectable pancreatic carcinoma.
Morganti AG, Valentini V, Macchia G, Alfieri S, Trodella L, Brizi MG, Bossola M, Ziccarelli L, Doglietto GB, Cellini N
Eur J Surg Oncol 2002 Aug;28(5):523-30. doi: 10.1053/ejso.2002.1289. PMID: 12217306

Therapy

Encouraging long-term survival following autophagy inhibition using neoadjuvant hydroxychloroquine and gemcitabine for high-risk patients with resectable pancreatic carcinoma.
AlMasri SS, Zenati MS, Desilva A, Nassour I, Boone BA, Singhi AD, Bartlett DL, Liotta LA, Espina V, Loughran P, Lotze MT, Paniccia A, Zeh HJ 3rd, Zureikat AH, Bahary N
Cancer Med 2021 Oct;10(20):7233-7241. Epub 2021 Sep 24 doi: 10.1002/cam4.4211. PMID: 34559451Free PMC Article
Current Clinical Strategies of Pancreatic Cancer Treatment and Open Molecular Questions.
Brunner M, Wu Z, Krautz C, Pilarsky C, Grützmann R, Weber GF
Int J Mol Sci 2019 Sep 13;20(18) doi: 10.3390/ijms20184543. PMID: 31540286Free PMC Article
Chemotherapy in pancreatic adenocarcinoma.
Squadroni M, Fazio N
Eur Rev Med Pharmacol Sci 2010 Apr;14(4):386-94. PMID: 20496553
An evidence-based approach to the surgical management of resectable pancreatic adenocarcinoma.
Stojadinovic A, Brooks A, Hoos A, Jaques DP, Conlon KC, Brennan MF
J Am Coll Surg 2003 Jun;196(6):954-64. doi: 10.1016/S1072-7515(03)00010-3. PMID: 12788434
Adjuvant radiotherapy in resectable pancreatic carcinoma.
Morganti AG, Valentini V, Macchia G, Alfieri S, Trodella L, Brizi MG, Bossola M, Ziccarelli L, Doglietto GB, Cellini N
Eur J Surg Oncol 2002 Aug;28(5):523-30. doi: 10.1053/ejso.2002.1289. PMID: 12217306

Prognosis

Long-Term Effect of Pancreaticoduodenectomy Combined with Revascularization for Resectable Pancreatic Carcinoma in Elderly Patients.
Yang J, Xu Z, Zhang J, Zheng Y, Gu J, Zhou Q, Wang X, Guo S, Zhang H, Chen S, Wang H
Med Sci Monit 2022 Nov 21;28:e938443. doi: 10.12659/MSM.938443. PMID: 36404606Free PMC Article
Current and emerging therapeutic strategies in pancreatic cancer: Challenges and opportunities.
Manrai M, Tilak TVSVGK, Dawra S, Srivastava S, Singh A
World J Gastroenterol 2021 Oct 21;27(39):6572-6589. doi: 10.3748/wjg.v27.i39.6572. PMID: 34754153Free PMC Article
Current Clinical Strategies of Pancreatic Cancer Treatment and Open Molecular Questions.
Brunner M, Wu Z, Krautz C, Pilarsky C, Grützmann R, Weber GF
Int J Mol Sci 2019 Sep 13;20(18) doi: 10.3390/ijms20184543. PMID: 31540286Free PMC Article
Overexpression of Tbx3 predicts poor prognosis of patients with resectable pancreatic carcinoma.
Wang HC, Meng QC, Shan ZZ, Yuan Z, Huang XY
Asian Pac J Cancer Prev 2015;16(4):1397-401. doi: 10.7314/apjcp.2015.16.4.1397. PMID: 25743805
Adjuvant radiotherapy in resectable pancreatic carcinoma.
Morganti AG, Valentini V, Macchia G, Alfieri S, Trodella L, Brizi MG, Bossola M, Ziccarelli L, Doglietto GB, Cellini N
Eur J Surg Oncol 2002 Aug;28(5):523-30. doi: 10.1053/ejso.2002.1289. PMID: 12217306

Clinical prediction guides

Prognostic impact of normalization of serum tumor markers following neoadjuvant chemotherapy in patients with borderline resectable pancreatic carcinoma with arterial contact.
Murakami Y, Uemura K, Sudo T, Hashimoto Y, Kondo N, Nakagawa N, Okada K, Takahashi S, Sueda T
Cancer Chemother Pharmacol 2017 Apr;79(4):801-811. Epub 2017 Mar 17 doi: 10.1007/s00280-017-3281-1. PMID: 28314992
Evaluation of serum D-dimer, fibrinogen, and CA19-9 for postoperative monitoring and survival prediction in resectable pancreatic carcinoma.
Cao J, Fu Z, Gao L, Wang X, Cheng S, Wang X, Ren H
World J Surg Oncol 2017 Feb 20;15(1):48. doi: 10.1186/s12957-017-1104-9. PMID: 28219450Free PMC Article
Overexpression of Tbx3 predicts poor prognosis of patients with resectable pancreatic carcinoma.
Wang HC, Meng QC, Shan ZZ, Yuan Z, Huang XY
Asian Pac J Cancer Prev 2015;16(4):1397-401. doi: 10.7314/apjcp.2015.16.4.1397. PMID: 25743805
Chemotherapy in pancreatic adenocarcinoma.
Squadroni M, Fazio N
Eur Rev Med Pharmacol Sci 2010 Apr;14(4):386-94. PMID: 20496553
Adjuvant radiotherapy in resectable pancreatic carcinoma.
Morganti AG, Valentini V, Macchia G, Alfieri S, Trodella L, Brizi MG, Bossola M, Ziccarelli L, Doglietto GB, Cellini N
Eur J Surg Oncol 2002 Aug;28(5):523-30. doi: 10.1053/ejso.2002.1289. PMID: 12217306

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