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Unresectable Basal Cell Carcinoma

MedGen UID:
1677325
•Concept ID:
C4763546
•
Neoplastic Process

Definition

Basal cell carcinoma that is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnresectable Basal Cell Carcinoma

Professional guidelines

PubMed

Hedgehog inhibitors with and without adjunctive therapy in treatment of locally advanced basal cell carcinoma.
Patel AD, Ravichandran S, Kheterpal M
Int J Dermatol 2022 Jan;61(1):118-124. Epub 2021 Aug 22 doi: 10.1111/ijd.15836. PMID: 34423419
Vismodegib and the hedgehog pathway: a new treatment for basal cell carcinoma.
Cirrone F, Harris CS
Clin Ther 2012 Oct;34(10):2039-50. Epub 2012 Oct 1 doi: 10.1016/j.clinthera.2012.08.011. PMID: 23036338

Recent clinical studies

Etiology

Hedgehog inhibitors with and without adjunctive therapy in treatment of locally advanced basal cell carcinoma.
Patel AD, Ravichandran S, Kheterpal M
Int J Dermatol 2022 Jan;61(1):118-124. Epub 2021 Aug 22 doi: 10.1111/ijd.15836. PMID: 34423419
Safety and efficacy of vismodegib in patients aged ≥65 years with advanced basal cell carcinoma.
Chang AL, Lewis KD, Arron ST, Migden MR, Solomon JA, Yoo S, Day BM, McKenna EF, Sekulic A
Oncotarget 2016 Nov 15;7(46):76118-76124. doi: 10.18632/oncotarget.12660. PMID: 27764798Free PMC Article

Therapy

Hedgehog inhibitors with and without adjunctive therapy in treatment of locally advanced basal cell carcinoma.
Patel AD, Ravichandran S, Kheterpal M
Int J Dermatol 2022 Jan;61(1):118-124. Epub 2021 Aug 22 doi: 10.1111/ijd.15836. PMID: 34423419
Advanced basal cell cancer: concise review of molecular characteristics and novel targeted and immune therapeutics.
Nikanjam M, Cohen PR, Kato S, Sicklick JK, Kurzrock R
Ann Oncol 2018 Nov 1;29(11):2192-2199. doi: 10.1093/annonc/mdy412. PMID: 30219896Free PMC Article
Safety and efficacy of vismodegib in patients aged ≥65 years with advanced basal cell carcinoma.
Chang AL, Lewis KD, Arron ST, Migden MR, Solomon JA, Yoo S, Day BM, McKenna EF, Sekulic A
Oncotarget 2016 Nov 15;7(46):76118-76124. doi: 10.18632/oncotarget.12660. PMID: 27764798Free PMC Article
Vismodegib and the hedgehog pathway: a new treatment for basal cell carcinoma.
Cirrone F, Harris CS
Clin Ther 2012 Oct;34(10):2039-50. Epub 2012 Oct 1 doi: 10.1016/j.clinthera.2012.08.011. PMID: 23036338

Prognosis

Advanced basal cell cancer: concise review of molecular characteristics and novel targeted and immune therapeutics.
Nikanjam M, Cohen PR, Kato S, Sicklick JK, Kurzrock R
Ann Oncol 2018 Nov 1;29(11):2192-2199. doi: 10.1093/annonc/mdy412. PMID: 30219896Free PMC Article

Clinical prediction guides

Advanced basal cell cancer: concise review of molecular characteristics and novel targeted and immune therapeutics.
Nikanjam M, Cohen PR, Kato S, Sicklick JK, Kurzrock R
Ann Oncol 2018 Nov 1;29(11):2192-2199. doi: 10.1093/annonc/mdy412. PMID: 30219896Free PMC Article

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