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Stage IV Ovarian Choriocarcinoma

MedGen UID:
167735
•Concept ID:
C0854944
•
Neoplastic Process
Synonyms: Ovarian Germ Cell Choriocarcinoma Stage IV; Ovarian Germ Cell Choriocarcinoma, Stage IV; Stage IV Ovarian Choriocarcinoma AJCC v6; Stage IV Ovarian Choriocarcinoma AJCC v7; Stage IV Ovarian Germ Cell Choriocarcinoma

Definition

Stage IV includes: Any T, Any N, M1. M1: Distant metastasis (excludes peritoneal metastasis). (AJCC 6th and 7th eds.) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVStage IV Ovarian Choriocarcinoma

Professional guidelines

PubMed

Malignant germ cell tumors: clinical characteristics, treatment, and outcome. A report from the study group for Pediatric Solid Malignant Tumors in the Kyushu Area, Japan.
Suita S, Shono K, Tajiri T, Takamatsu T, Mizote H, Nagasaki A, Inomata Y, Hara T, Okamura J, Miyazaki S, Kawakami K, Eguchi H, Tsuneyoshi M; Committee for Pediatric Solid Malignant Tumors in the Kyushu Area
J Pediatr Surg 2002 Dec;37(12):1703-6. doi: 10.1053/jpsu.2002.36700. PMID: 12483635
Treatment of malignant ovarian germ cell tumors with preservation of fertility: reproductive performance after persistent remission.
Kanazawa K, Suzuki T, Sakumoto K
Am J Clin Oncol 2000 Jun;23(3):244-8. doi: 10.1097/00000421-200006000-00007. PMID: 10857886

Recent clinical studies

Etiology

Ultra-High-Risk Gestational Choriocarcinoma of the Ovary Associated with Ectopic Pregnancy.
Malovrh EP, Lukinovič N, Bujas T, Sobočan M, Knez J
Curr Oncol 2023 Feb 11;30(2):2217-2226. doi: 10.3390/curroncol30020171. PMID: 36826132Free PMC Article
Residual tumor after the salvage surgery is the major risk factors for primary treatment failure in malignant ovarian germ cell tumors: a retrospective study of single institution.
Lee CW, Song MJ, Park ST, Ki EY, Lee SJ, Lee KH, Ryu KS, Park JS, Hur SY
World J Surg Oncol 2011 Oct 11;9:123. doi: 10.1186/1477-7819-9-123. PMID: 21988930Free PMC Article
Survival and reproductive outcomes in women treated for malignant ovarian germ cell tumors.
Weinberg LE, Lurain JR, Singh DK, Schink JC
Gynecol Oncol 2011 May 1;121(2):285-9. Epub 2011 Jan 21 doi: 10.1016/j.ygyno.2011.01.003. PMID: 21256579
Clinicopathologic characteristics of malignant germ cell tumors in the ovaries of Korean women: a Korean Gynecologic Oncology Group Study.
Lee KH, Lee IH, Kim BG, Nam JH, Kim WK, Kang SB, Ryu SY, Cho CH, Choi HS, Kim KT; Korean Gynecologic Oncology Group
Int J Gynecol Cancer 2009 Jan;19(1):84-7. doi: 10.1111/IGC.0b013e31819914c5. PMID: 19258947
Endometrial carcinoma in elderly women.
Hoffman K, Nekhlyudov L, Deligdisch L
Gynecol Oncol 1995 Aug;58(2):198-201. doi: 10.1006/gyno.1995.1210. PMID: 7622105

Diagnosis

Ultra-High-Risk Gestational Choriocarcinoma of the Ovary Associated with Ectopic Pregnancy.
Malovrh EP, Lukinovič N, Bujas T, Sobočan M, Knez J
Curr Oncol 2023 Feb 11;30(2):2217-2226. doi: 10.3390/curroncol30020171. PMID: 36826132Free PMC Article
Historical, morphological and clinical overview of placental site trophoblastic tumors: from bench to bedside.
Santoro G, Laganà AS, Micali A, Barresi V, Giacobbe V, Palmara V
Arch Gynecol Obstet 2017 Jan;295(1):173-187. Epub 2016 Aug 22 doi: 10.1007/s00404-016-4182-y. PMID: 27549089
Clinicopathologic characteristics of malignant germ cell tumors in the ovaries of Korean women: a Korean Gynecologic Oncology Group Study.
Lee KH, Lee IH, Kim BG, Nam JH, Kim WK, Kang SB, Ryu SY, Cho CH, Choi HS, Kim KT; Korean Gynecologic Oncology Group
Int J Gynecol Cancer 2009 Jan;19(1):84-7. doi: 10.1111/IGC.0b013e31819914c5. PMID: 19258947
Ovarian mixed germ cell tumor composed of dysgerminoma, endodermal sinus tumor, choriocarcinoma and mature teratoma in a 44-year-old woman: case report and literature review.
Akahira J, Ito K, Kosuge S, Konno R, Sato S, Yajima A, Sasano H
Pathol Int 1998 Jun;48(6):471-4. doi: 10.1111/j.1440-1827.1998.tb03935.x. PMID: 9702861
Endometrial carcinoma in elderly women.
Hoffman K, Nekhlyudov L, Deligdisch L
Gynecol Oncol 1995 Aug;58(2):198-201. doi: 10.1006/gyno.1995.1210. PMID: 7622105

Therapy

Residual tumor after the salvage surgery is the major risk factors for primary treatment failure in malignant ovarian germ cell tumors: a retrospective study of single institution.
Lee CW, Song MJ, Park ST, Ki EY, Lee SJ, Lee KH, Ryu KS, Park JS, Hur SY
World J Surg Oncol 2011 Oct 11;9:123. doi: 10.1186/1477-7819-9-123. PMID: 21988930Free PMC Article
Survival and reproductive outcomes in women treated for malignant ovarian germ cell tumors.
Weinberg LE, Lurain JR, Singh DK, Schink JC
Gynecol Oncol 2011 May 1;121(2):285-9. Epub 2011 Jan 21 doi: 10.1016/j.ygyno.2011.01.003. PMID: 21256579
Concurrent ovarian-type primary peritoneal adenocarcinoma and peritoneal choriocarcinoma. A case report and review of the literature.
Pentheroudakis G, White J, Davis J, Brown I, Vasey P
Gynecol Oncol 2004 Feb;92(2):697-700. doi: 10.1016/j.ygyno.2003.10.049. PMID: 14766269
Malignant germ cell tumors: clinical characteristics, treatment, and outcome. A report from the study group for Pediatric Solid Malignant Tumors in the Kyushu Area, Japan.
Suita S, Shono K, Tajiri T, Takamatsu T, Mizote H, Nagasaki A, Inomata Y, Hara T, Okamura J, Miyazaki S, Kawakami K, Eguchi H, Tsuneyoshi M; Committee for Pediatric Solid Malignant Tumors in the Kyushu Area
J Pediatr Surg 2002 Dec;37(12):1703-6. doi: 10.1053/jpsu.2002.36700. PMID: 12483635
Primary chemotherapy and the role of second-look laparotomy in non-dysgerminomatous germ cell malignancies of the ovary.
Pippitt CH Jr, Cain JM, Hakes TB, Pierce VK, Lewis JL Jr
Gynecol Oncol 1988 Oct;31(2):268-75. doi: 10.1016/s0090-8258(88)80004-0. PMID: 2458993

Prognosis

Historical, morphological and clinical overview of placental site trophoblastic tumors: from bench to bedside.
Santoro G, Laganà AS, Micali A, Barresi V, Giacobbe V, Palmara V
Arch Gynecol Obstet 2017 Jan;295(1):173-187. Epub 2016 Aug 22 doi: 10.1007/s00404-016-4182-y. PMID: 27549089
Residual tumor after the salvage surgery is the major risk factors for primary treatment failure in malignant ovarian germ cell tumors: a retrospective study of single institution.
Lee CW, Song MJ, Park ST, Ki EY, Lee SJ, Lee KH, Ryu KS, Park JS, Hur SY
World J Surg Oncol 2011 Oct 11;9:123. doi: 10.1186/1477-7819-9-123. PMID: 21988930Free PMC Article
Clinicopathologic characteristics of malignant germ cell tumors in the ovaries of Korean women: a Korean Gynecologic Oncology Group Study.
Lee KH, Lee IH, Kim BG, Nam JH, Kim WK, Kang SB, Ryu SY, Cho CH, Choi HS, Kim KT; Korean Gynecologic Oncology Group
Int J Gynecol Cancer 2009 Jan;19(1):84-7. doi: 10.1111/IGC.0b013e31819914c5. PMID: 19258947
Malignant germ cell tumors: clinical characteristics, treatment, and outcome. A report from the study group for Pediatric Solid Malignant Tumors in the Kyushu Area, Japan.
Suita S, Shono K, Tajiri T, Takamatsu T, Mizote H, Nagasaki A, Inomata Y, Hara T, Okamura J, Miyazaki S, Kawakami K, Eguchi H, Tsuneyoshi M; Committee for Pediatric Solid Malignant Tumors in the Kyushu Area
J Pediatr Surg 2002 Dec;37(12):1703-6. doi: 10.1053/jpsu.2002.36700. PMID: 12483635
Primary chemotherapy and the role of second-look laparotomy in non-dysgerminomatous germ cell malignancies of the ovary.
Pippitt CH Jr, Cain JM, Hakes TB, Pierce VK, Lewis JL Jr
Gynecol Oncol 1988 Oct;31(2):268-75. doi: 10.1016/s0090-8258(88)80004-0. PMID: 2458993

Clinical prediction guides

Clinicopathologic characteristics of malignant germ cell tumors in the ovaries of Korean women: a Korean Gynecologic Oncology Group Study.
Lee KH, Lee IH, Kim BG, Nam JH, Kim WK, Kang SB, Ryu SY, Cho CH, Choi HS, Kim KT; Korean Gynecologic Oncology Group
Int J Gynecol Cancer 2009 Jan;19(1):84-7. doi: 10.1111/IGC.0b013e31819914c5. PMID: 19258947
Detection of numerical and structural chromosome abnormalities in pediatric germ cell tumors by means of interphase cytogenetics.
Stock C, Ambros IM, Lion T, Haas OA, Zoubek A, Gadner H, Ambros PF
Genes Chromosomes Cancer 1994 Sep;11(1):40-50. doi: 10.1002/gcc.2870110107. PMID: 7529045
Primary chemotherapy and the role of second-look laparotomy in non-dysgerminomatous germ cell malignancies of the ovary.
Pippitt CH Jr, Cain JM, Hakes TB, Pierce VK, Lewis JL Jr
Gynecol Oncol 1988 Oct;31(2):268-75. doi: 10.1016/s0090-8258(88)80004-0. PMID: 2458993

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