U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Composite Paraganglioma

MedGen UID:
1677462
•Concept ID:
C4763506
•
Neoplastic Process
Synonyms: Composite paraganglioma; Composite Pheochromocytoma and Paraganglioma; Composite Pheochromocytoma/Paraganglioma
SNOMED CT: Composite paraganglioma (817953005)

Definition

A neoplasm that combines morphologic characteristics of paraganglioma and neuroectodermal tumors such as neuroblastoma, ganglioneuroma, ganglioneuroblastoma, or peripheral nerve sheath tumor. [from NCI]

Professional guidelines

PubMed

Utility of GATA3 in the differential diagnosis of pheochromocytoma.
Perrino CM, Ho A, Dall CP, Zynger DL
Histopathology 2017 Sep;71(3):475-479. Epub 2017 Jun 5 doi: 10.1111/his.13229. PMID: 28374498
Paragangliomas: update on differential diagnostic considerations, composite tumors, and recent genetic developments.
Papathomas TG, de Krijger RR, Tischler AS
Semin Diagn Pathol 2013 Aug;30(3):207-23. doi: 10.1053/j.semdp.2013.06.006. PMID: 24144290
Differential diagnosis of pheochromocytomas and paragangliomas.
McNichol AM
Endocr Pathol 2001 Winter;12(4):407-15. doi: 10.1385/ep:12:4:407. PMID: 11914474

Recent clinical studies

Etiology

Overview of the 2022 WHO Classification of Paragangliomas and Pheochromocytomas.
Mete O, Asa SL, Gill AJ, Kimura N, de Krijger RR, Tischler A
Endocr Pathol 2022 Mar;33(1):90-114. Epub 2022 Mar 13 doi: 10.1007/s12022-022-09704-6. PMID: 35285002
Update on Adrenal Tumours in 2017 World Health Organization (WHO) of Endocrine Tumours.
Lam AK
Endocr Pathol 2017 Sep;28(3):213-227. doi: 10.1007/s12022-017-9484-5. PMID: 28477311

Diagnosis

Composite paraganglioma-ganglioneuroma with atypical catecholamine profile and phenylethanolamine N-methyltransferase expression: a case report and literature review.
Sasaki Y, Kanzawa M, Yamamoto M, Kanie K, Bando H, Yoshino K, Hirota Y, Shigemura K, Fujisawa M, Ogawa W, Fukuoka H
Endocr J 2024 Jan 29;71(1):65-74. Epub 2023 Nov 11 doi: 10.1507/endocrj.EJ23-0271. PMID: 37952980
Overview of the 2022 WHO Classification of Paragangliomas and Pheochromocytomas.
Mete O, Asa SL, Gill AJ, Kimura N, de Krijger RR, Tischler A
Endocr Pathol 2022 Mar;33(1):90-114. Epub 2022 Mar 13 doi: 10.1007/s12022-022-09704-6. PMID: 35285002
Composite Paraganglioma: Pioneering in the Head and Neck.
Delgado S, Smith SM, Mehra S, Prasad ML
Int J Surg Pathol 2019 May;27(3):282-289. Epub 2018 Sep 16 doi: 10.1177/1066896918799940. PMID: 30222023
Composite paraganglioma and ganglioneuroma in the retroperitoneum: a case report.
Ohtsuki Y, Watanabe R, Okada Y, Matsuka Y, Lee GH, Furihata M
Med Mol Morphol 2012 Jun;45(3):168-72. Epub 2012 Sep 22 doi: 10.1007/s00795-011-0567-y. PMID: 23001299
Composite paraganglioma-ganglioneuroma in the retroperitoneum.
Hirasaki S, Kanzaki H, Okuda M, Suzuki S, Fukuhara T, Hanaoka T
World J Surg Oncol 2009 Nov 5;7:81. doi: 10.1186/1477-7819-7-81. PMID: 19889235Free PMC Article

Prognosis

Overview of the 2022 WHO Classification of Paragangliomas and Pheochromocytomas.
Mete O, Asa SL, Gill AJ, Kimura N, de Krijger RR, Tischler A
Endocr Pathol 2022 Mar;33(1):90-114. Epub 2022 Mar 13 doi: 10.1007/s12022-022-09704-6. PMID: 35285002
Update on Adrenal Tumours in 2017 World Health Organization (WHO) of Endocrine Tumours.
Lam AK
Endocr Pathol 2017 Sep;28(3):213-227. doi: 10.1007/s12022-017-9484-5. PMID: 28477311
Composite paraganglioma-ganglioneuroma of the urinary bladder.
Usuda H, Emura I
Pathol Int 2005 Sep;55(9):596-601. doi: 10.1111/j.1440-1827.2005.01875.x. PMID: 16143037

Clinical prediction guides

Overview of the 2022 WHO Classification of Paragangliomas and Pheochromocytomas.
Mete O, Asa SL, Gill AJ, Kimura N, de Krijger RR, Tischler A
Endocr Pathol 2022 Mar;33(1):90-114. Epub 2022 Mar 13 doi: 10.1007/s12022-022-09704-6. PMID: 35285002
Update on Adrenal Tumours in 2017 World Health Organization (WHO) of Endocrine Tumours.
Lam AK
Endocr Pathol 2017 Sep;28(3):213-227. doi: 10.1007/s12022-017-9484-5. PMID: 28477311
Pigmented composite paraganglioma-ganglioneuroma of the urinary bladder.
Dundr P, Dudorkinová D, Povýsil C, Pesl M, Babjuk M, Dvorácek J, Zelinka T
Pathol Res Pract 2003;199(11):765-9. doi: 10.1078/0344-0338-00495. PMID: 14708645

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...