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Hydatidiform mole, recurrent, 3(HYDM3)

MedGen UID:
1677775
Concept ID:
C5193093
Disease or Syndrome
Synonyms: HYDATIDIFORM MOLE, RECURRENT, 3; HYDM3
 
Gene (location): MEI1 (22q13.2)
 
Monarch Initiative: MONDO:0032746
OMIM®: 618431

Definition

Hydatidiform mole is a human pregnancy with abnormal or no embryonic development and excessive trophoblastic proliferation. Partial hydatidiform moles have a triploid dispermic genome, with 2 sets of paternal chromosomes and 1 set of maternal chromosomes; complete hydatidiform moles have a diploid androgenetic genome with all chromosomes originating from 1 (monospermic) or 2 (dispermic) sperms, and no maternal chromosomes (summary by Nguyen et al., 2018). For a discussion of genetic heterogeneity of recurrent hydatidiform mole, see HYDM1 (231090). [from OMIM]

Clinical features

From HPO
Female infertility
MedGen UID:
5795
Concept ID:
C0021361
Pathologic Function
Infertility in a woman.
Hydatidiform mole
MedGen UID:
9329
Concept ID:
C0020217
Neoplastic Process
Hydatidiform mole (HM) is an aberrant human pregnancy with absence of, or abnormal embryonic development, hydropic degeneration of chorionic villi, and excessive proliferation of the trophoblast.

Professional guidelines

PubMed

Khawajkie Y, Mechtouf N, Nguyen NMP, Rahimi K, Breguet M, Arseneau J, Ronnett BM, Hoffner L, Lazure F, Arnaud M, Peers F, Tan L, Rafea BA, Aguinaga M, Horowitz NS, Ao A, Tan SL, Brown R, Buckett W, Surti U, Hovanes K, Sahoo T, Sauthier P, Slim R
Mod Pathol 2020 May;33(5):880-892. Epub 2019 Dec 19 doi: 10.1038/s41379-019-0432-4. PMID: 31857680
Niemann I, Vejerslev LO, Frøding L, Blaakær J, Maroun LL, Hansen ES, Grove A, Lund H, Havsteen H, Sunde L
Dan Med J 2015 Nov;62(11):A5082. PMID: 26522484
Berkowitz RS, Goldstein DP
Gynecol Oncol 2009 Mar;112(3):654-62. Epub 2008 Oct 12 doi: 10.1016/j.ygyno.2008.09.005. PMID: 18851873

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Gestational Trophoblastic Neoplasia, 2022

Recent clinical studies

Etiology

Moein-Vaziri N, Fallahi J, Namavar-Jahromi B, Fardaei M, Momtahan M, Anvar Z
Taiwan J Obstet Gynecol 2018 Feb;57(1):1-6. doi: 10.1016/j.tjog.2017.12.001. PMID: 29458875
Gadducci A, Lanfredini N, Cosio S
Gynecol Endocrinol 2015;31(9):673-8. Epub 2015 Aug 18 doi: 10.3109/09513590.2015.1054803. PMID: 26288335
Williams D, Hodgetts V, Gupta J
Eur J Obstet Gynecol Reprod Biol 2010 May;150(1):3-7. Epub 2010 Feb 19 doi: 10.1016/j.ejogrb.2010.01.003. PMID: 20171777
Pandiyan N, Jequier AM
Obstet Gynecol Surv 1988 May;43(5):258-62. PMID: 3287245
Rustin GJ, Bagshawe KD
Crit Rev Oncol Hematol 1985;3(2):103-42. doi: 10.1016/s1040-8428(85)80022-6. PMID: 2992827

Diagnosis

Korenaga TK, Tewari KS
Gynecol Oncol 2020 Jun;157(3):799-809. Epub 2020 Apr 5 doi: 10.1016/j.ygyno.2020.03.015. PMID: 32268951Free PMC Article
Williams D, Hodgetts V, Gupta J
Eur J Obstet Gynecol Reprod Biol 2010 May;150(1):3-7. Epub 2010 Feb 19 doi: 10.1016/j.ejogrb.2010.01.003. PMID: 20171777
Berkowitz RS, Goldstein DP
Gynecol Oncol 2009 Mar;112(3):654-62. Epub 2008 Oct 12 doi: 10.1016/j.ygyno.2008.09.005. PMID: 18851873
Fisher RA, Hodges MD
Placenta 2003 Apr;24 Suppl A:S111-8. doi: 10.1053/plac.2002.0939. PMID: 12842422
Pandiyan N, Jequier AM
Obstet Gynecol Surv 1988 May;43(5):258-62. PMID: 3287245

Therapy

Albright BB, Ellett T, Knochenhauer HE, Goins EC, Monuszko KA, Kaplan SJ, Previs RA, Moss HA, Havrilesky LJ, Davidson BA
BJOG 2023 Apr;130(5):443-453. Epub 2023 Jan 25 doi: 10.1111/1471-0528.17374. PMID: 36648416Free PMC Article
Gadducci A, Lanfredini N, Cosio S
Gynecol Endocrinol 2015;31(9):673-8. Epub 2015 Aug 18 doi: 10.3109/09513590.2015.1054803. PMID: 26288335
Tse KY, Ngan HY
Best Pract Res Clin Obstet Gynaecol 2012 Jun;26(3):357-70. Epub 2012 Jan 28 doi: 10.1016/j.bpobgyn.2011.11.009. PMID: 22285526
Palmer JR
J Reprod Med 1994 Mar;39(3):155-62. PMID: 8035370
Rustin GJ, Bagshawe KD
Crit Rev Oncol Hematol 1985;3(2):103-42. doi: 10.1016/s1040-8428(85)80022-6. PMID: 2992827

Prognosis

Korenaga TK, Tewari KS
Gynecol Oncol 2020 Jun;157(3):799-809. Epub 2020 Apr 5 doi: 10.1016/j.ygyno.2020.03.015. PMID: 32268951Free PMC Article
Gadducci A, Lanfredini N, Cosio S
Gynecol Endocrinol 2015;31(9):673-8. Epub 2015 Aug 18 doi: 10.3109/09513590.2015.1054803. PMID: 26288335
Tse KY, Ngan HY
Best Pract Res Clin Obstet Gynaecol 2012 Jun;26(3):357-70. Epub 2012 Jan 28 doi: 10.1016/j.bpobgyn.2011.11.009. PMID: 22285526
Pandiyan N, Jequier AM
Obstet Gynecol Surv 1988 May;43(5):258-62. PMID: 3287245
Rustin GJ, Bagshawe KD
Crit Rev Oncol Hematol 1985;3(2):103-42. doi: 10.1016/s1040-8428(85)80022-6. PMID: 2992827

Clinical prediction guides

Albright BB, Ellett T, Knochenhauer HE, Goins EC, Monuszko KA, Kaplan SJ, Previs RA, Moss HA, Havrilesky LJ, Davidson BA
BJOG 2023 Apr;130(5):443-453. Epub 2023 Jan 25 doi: 10.1111/1471-0528.17374. PMID: 36648416Free PMC Article
Fatemi N, Ray PF, Ramezanali F, Shahani T, Amiri-Yekta A, Kherraf ZE, Cazin C, Almadani N, Varkiani M, Sarmadi S, Sodeifi N, Gourabi H, Biglari A, Totonchi M
Eur J Obstet Gynecol Reprod Biol 2021 Apr;259:100-104. Epub 2021 Feb 10 doi: 10.1016/j.ejogrb.2021.02.006. PMID: 33639414
Capozzi VA, Butera D, Armano G, Monfardini L, Gaiano M, Gambino G, Sozzi G, Merisio C, Berretta R
Eur J Obstet Gynecol Reprod Biol 2021 Apr;259:18-25. Epub 2021 Jan 29 doi: 10.1016/j.ejogrb.2021.01.051. PMID: 33550107
Taylor F, Short D, Harvey R, Winter MC, Tidy J, Hancock BW, Savage PM, Sarwar N, Seckl MJ, Coleman RE
BJOG 2016 Jun;123(7):1175-81. Epub 2016 Jan 15 doi: 10.1111/1471-0528.13867. PMID: 26774079
Estrada H, Buentello B, Zenteno JC, Fiszman R, Aguinaga M
Prenat Diagn 2013 Mar;33(3):205-8. Epub 2013 Jan 28 doi: 10.1002/pd.4036. PMID: 23354651

Recent systematic reviews

Albright BB, Ellett T, Knochenhauer HE, Goins EC, Monuszko KA, Kaplan SJ, Previs RA, Moss HA, Havrilesky LJ, Davidson BA
BJOG 2023 Apr;130(5):443-453. Epub 2023 Jan 25 doi: 10.1111/1471-0528.17374. PMID: 36648416Free PMC Article
Gupta S, Agarwal A, Banerjee J, Alvarez JG
Obstet Gynecol Surv 2007 May;62(5):335-47; quiz 353-4. doi: 10.1097/01.ogx.0000261644.89300.df. PMID: 17425812

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2022
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Gestational Trophoblastic Neoplasia, 2022

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