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Recurrent Transformed Chronic Lymphocytic Leukemia

MedGen UID:
1677818
Concept ID:
C4764084
Neoplastic Process
Synonym: Recurrent Richter Syndrome

Definition

The reemergence of chronic lymphocytic leukemia transformed to aggressive diffuse large B-cell lymphoma (Richter''s transformation) after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Transformed Chronic Lymphocytic Leukemia

Professional guidelines

PubMed

Parikh SA
Blood Cancer J 2018 Oct 3;8(10):93. doi: 10.1038/s41408-018-0131-2. PMID: 30283014Free PMC Article
Motta M, Wierda WG, Ferrajoli A
Cancer 2009 Sep 1;115(17):3830-41. doi: 10.1002/cncr.24479. PMID: 19536902Free PMC Article
Kalil N, Cheson BD
Drugs Aging 2000 Jan;16(1):9-27. doi: 10.2165/00002512-200016010-00002. PMID: 10733261

Recent clinical studies

Etiology

Eyre TA
Hematology Am Soc Hematol Educ Program 2023 Dec 8;2023(1):427-432. doi: 10.1182/hematology.2023000442. PMID: 38066897Free PMC Article
Walker JS, Hing ZA, Harrington B, Baumhardt J, Ozer HG, Lehman A, Giacopelli B, Beaver L, Williams K, Skinner JN, Cempre CB, Sun Q, Shacham S, Stromberg BR, Summers MK, Abruzzo LV, Rassenti L, Kipps TJ, Parikh S, Kay NE, Rogers KA, Woyach JA, Coppola V, Chook YM, Oakes C, Byrd JC, Lapalombella R
J Hematol Oncol 2021 Jan 15;14(1):17. doi: 10.1186/s13045-021-01032-2. PMID: 33451349Free PMC Article
Byrd JC, Furman RR, Coutre SE, Flinn IW, Burger JA, Blum K, Sharman JP, Wierda W, Zhao W, Heerema NA, Luan Y, Liu EA, Dean JP, O'Brien S
Clin Cancer Res 2020 Aug 1;26(15):3918-3927. Epub 2020 Mar 24 doi: 10.1158/1078-0432.CCR-19-2856. PMID: 32209572Free PMC Article
Parikh SA
Blood Cancer J 2018 Oct 3;8(10):93. doi: 10.1038/s41408-018-0131-2. PMID: 30283014Free PMC Article
Motta M, Wierda WG, Ferrajoli A
Cancer 2009 Sep 1;115(17):3830-41. doi: 10.1002/cncr.24479. PMID: 19536902Free PMC Article

Diagnosis

Parry EM, Leshchiner I, Guièze R, Johnson C, Tausch E, Parikh SA, Lemvigh C, Broséus J, Hergalant S, Messer C, Utro F, Levovitz C, Rhrissorrakrai K, Li L, Rosebrock D, Yin S, Deng S, Slowik K, Jacobs R, Huang T, Li S, Fell G, Redd R, Lin Z, Knisbacher BA, Livitz D, Schneider C, Ruthen N, Elagina L, Taylor-Weiner A, Persaud B, Martinez A, Fernandes SM, Purroy N, Anandappa AJ, Ma J, Hess J, Rassenti LZ, Kipps TJ, Jain N, Wierda W, Cymbalista F, Feugier P, Kay NE, Livak KJ, Danysh BP, Stewart C, Neuberg D, Davids MS, Brown JR, Parida L, Stilgenbauer S, Getz G, Wu CJ
Nat Med 2023 Jan;29(1):158-169. Epub 2023 Jan 9 doi: 10.1038/s41591-022-02113-6. PMID: 36624313Free PMC Article
Parikh SA
Blood Cancer J 2018 Oct 3;8(10):93. doi: 10.1038/s41408-018-0131-2. PMID: 30283014Free PMC Article
Amin NA, Malek SN
Semin Oncol 2016 Apr;43(2):215-21. Epub 2016 Feb 6 doi: 10.1053/j.seminoncol.2016.02.002. PMID: 27040699
Landau DA, Tausch E, Taylor-Weiner AN, Stewart C, Reiter JG, Bahlo J, Kluth S, Bozic I, Lawrence M, Böttcher S, Carter SL, Cibulskis K, Mertens D, Sougnez CL, Rosenberg M, Hess JM, Edelmann J, Kless S, Kneba M, Ritgen M, Fink A, Fischer K, Gabriel S, Lander ES, Nowak MA, Döhner H, Hallek M, Neuberg D, Getz G, Stilgenbauer S, Wu CJ
Nature 2015 Oct 22;526(7574):525-30. Epub 2015 Oct 14 doi: 10.1038/nature15395. PMID: 26466571Free PMC Article
Martín-Subero JI, López-Otín C, Campo E
Curr Opin Hematol 2013 Jul;20(4):362-8. doi: 10.1097/MOH.0b013e32836235dc. PMID: 23719185

Therapy

Eyre TA
Hematology Am Soc Hematol Educ Program 2023 Dec 8;2023(1):427-432. doi: 10.1182/hematology.2023000442. PMID: 38066897Free PMC Article
Byrd JC, Furman RR, Coutre SE, Flinn IW, Burger JA, Blum K, Sharman JP, Wierda W, Zhao W, Heerema NA, Luan Y, Liu EA, Dean JP, O'Brien S
Clin Cancer Res 2020 Aug 1;26(15):3918-3927. Epub 2020 Mar 24 doi: 10.1158/1078-0432.CCR-19-2856. PMID: 32209572Free PMC Article
Parikh SA
Blood Cancer J 2018 Oct 3;8(10):93. doi: 10.1038/s41408-018-0131-2. PMID: 30283014Free PMC Article
Byrd JC, Harrington B, O'Brien S, Jones JA, Schuh A, Devereux S, Chaves J, Wierda WG, Awan FT, Brown JR, Hillmen P, Stephens DM, Ghia P, Barrientos JC, Pagel JM, Woyach J, Johnson D, Huang J, Wang X, Kaptein A, Lannutti BJ, Covey T, Fardis M, McGreivy J, Hamdy A, Rothbaum W, Izumi R, Diacovo TG, Johnson AJ, Furman RR
N Engl J Med 2016 Jan 28;374(4):323-32. Epub 2015 Dec 7 doi: 10.1056/NEJMoa1509981. PMID: 26641137Free PMC Article
Landau DA, Tausch E, Taylor-Weiner AN, Stewart C, Reiter JG, Bahlo J, Kluth S, Bozic I, Lawrence M, Böttcher S, Carter SL, Cibulskis K, Mertens D, Sougnez CL, Rosenberg M, Hess JM, Edelmann J, Kless S, Kneba M, Ritgen M, Fink A, Fischer K, Gabriel S, Lander ES, Nowak MA, Döhner H, Hallek M, Neuberg D, Getz G, Stilgenbauer S, Wu CJ
Nature 2015 Oct 22;526(7574):525-30. Epub 2015 Oct 14 doi: 10.1038/nature15395. PMID: 26466571Free PMC Article

Prognosis

Eyre TA
Hematology Am Soc Hematol Educ Program 2023 Dec 8;2023(1):427-432. doi: 10.1182/hematology.2023000442. PMID: 38066897Free PMC Article
Byrd JC, Furman RR, Coutre SE, Flinn IW, Burger JA, Blum K, Sharman JP, Wierda W, Zhao W, Heerema NA, Luan Y, Liu EA, Dean JP, O'Brien S
Clin Cancer Res 2020 Aug 1;26(15):3918-3927. Epub 2020 Mar 24 doi: 10.1158/1078-0432.CCR-19-2856. PMID: 32209572Free PMC Article
Parikh SA
Blood Cancer J 2018 Oct 3;8(10):93. doi: 10.1038/s41408-018-0131-2. PMID: 30283014Free PMC Article
Amin NA, Malek SN
Semin Oncol 2016 Apr;43(2):215-21. Epub 2016 Feb 6 doi: 10.1053/j.seminoncol.2016.02.002. PMID: 27040699
Landau DA, Tausch E, Taylor-Weiner AN, Stewart C, Reiter JG, Bahlo J, Kluth S, Bozic I, Lawrence M, Böttcher S, Carter SL, Cibulskis K, Mertens D, Sougnez CL, Rosenberg M, Hess JM, Edelmann J, Kless S, Kneba M, Ritgen M, Fink A, Fischer K, Gabriel S, Lander ES, Nowak MA, Döhner H, Hallek M, Neuberg D, Getz G, Stilgenbauer S, Wu CJ
Nature 2015 Oct 22;526(7574):525-30. Epub 2015 Oct 14 doi: 10.1038/nature15395. PMID: 26466571Free PMC Article

Clinical prediction guides

Byrd JC, Furman RR, Coutre SE, Flinn IW, Burger JA, Blum K, Sharman JP, Wierda W, Zhao W, Heerema NA, Luan Y, Liu EA, Dean JP, O'Brien S
Clin Cancer Res 2020 Aug 1;26(15):3918-3927. Epub 2020 Mar 24 doi: 10.1158/1078-0432.CCR-19-2856. PMID: 32209572Free PMC Article
Parikh SA
Blood Cancer J 2018 Oct 3;8(10):93. doi: 10.1038/s41408-018-0131-2. PMID: 30283014Free PMC Article
Byrd JC, Harrington B, O'Brien S, Jones JA, Schuh A, Devereux S, Chaves J, Wierda WG, Awan FT, Brown JR, Hillmen P, Stephens DM, Ghia P, Barrientos JC, Pagel JM, Woyach J, Johnson D, Huang J, Wang X, Kaptein A, Lannutti BJ, Covey T, Fardis M, McGreivy J, Hamdy A, Rothbaum W, Izumi R, Diacovo TG, Johnson AJ, Furman RR
N Engl J Med 2016 Jan 28;374(4):323-32. Epub 2015 Dec 7 doi: 10.1056/NEJMoa1509981. PMID: 26641137Free PMC Article
Sutton LA, Rosenquist R
Semin Cancer Biol 2015 Oct;34:22-35. Epub 2015 May 9 doi: 10.1016/j.semcancer.2015.04.009. PMID: 25963298
Kalil N, Cheson BD
Drugs Aging 2000 Jan;16(1):9-27. doi: 10.2165/00002512-200016010-00002. PMID: 10733261

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