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Corrected Prolonged QT Interval by ECG Finding

MedGen UID:
167789
•Concept ID:
C0855333
•
Finding
Synonyms: Corrected Prolonged QT Interval; Corrected Prolonged QT Interval by EKG Finding

Definition

An electrocardiographic finding in which the QTc interval corrected for heart rate is prolonged. Thresholds for different age, gender, and patient populations exist. (CDISC) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCorrected Prolonged QT Interval by ECG Finding

Professional guidelines

PubMed

Diagnosis, management and therapeutic strategies for congenital long QT syndrome.
Wilde AAM, Amin AS, Postema PG
Heart 2022 Mar;108(5):332-338. Epub 2021 May 26 doi: 10.1136/heartjnl-2020-318259. PMID: 34039680Free PMC Article
Measurement and Management of QT Interval Prolongation for General Physicians.
Indraratna P, Tardo D, Delves M, Szirt R, Ng B
J Gen Intern Med 2020 Mar;35(3):865-873. Epub 2019 Oct 25 doi: 10.1007/s11606-019-05477-7. PMID: 31654357Free PMC Article
Pharmacological treatment of acquired QT prolongation and torsades de pointes.
Thomas SH, Behr ER
Br J Clin Pharmacol 2016 Mar;81(3):420-7. Epub 2015 Oct 26 doi: 10.1111/bcp.12726. PMID: 26183037Free PMC Article

Recent clinical studies

Therapy

Relationship between serum bepridil concentration and corrected QT interval.
Matsui K, Mukai Y, Sakakura K, Wada K, Nakamura T, Kawabata A, Terakawa N, Hayakawa N, Kusano K, Hosomi K, Yokoyama S, Takada M
Int J Clin Pharmacol Ther 2021 Jan;59(1):63-70. doi: 10.5414/CP203843. PMID: 33026317
Update on the ECG component of the CiPA initiative.
Vicente J
J Electrocardiol 2018 Nov-Dec;51(6S):S98-S102. Epub 2018 Aug 7 doi: 10.1016/j.jelectrocard.2018.08.003. PMID: 30121123
Risk factors for QTc-prolongation: systematic review of the evidence.
Vandael E, Vandenberk B, Vandenberghe J, Willems R, Foulon V
Int J Clin Pharm 2017 Feb;39(1):16-25. Epub 2016 Dec 23 doi: 10.1007/s11096-016-0414-2. PMID: 28012118
Pharmacological treatment of acquired QT prolongation and torsades de pointes.
Thomas SH, Behr ER
Br J Clin Pharmacol 2016 Mar;81(3):420-7. Epub 2015 Oct 26 doi: 10.1111/bcp.12726. PMID: 26183037Free PMC Article
QTc prolongation, torsades de pointes, and psychotropic medications.
Beach SR, Celano CM, Noseworthy PA, Januzzi JL, Huffman JC
Psychosomatics 2013 Jan-Feb;54(1):1-13. doi: 10.1016/j.psym.2012.11.001. PMID: 23295003

Prognosis

Provocation testing in congenital long QT syndrome: A practical guide.
Abrahams T, Davies B, Laksman Z, Sy RW, Postema PG, Wilde AAM, Krahn AD, Han HC
Heart Rhythm 2023 Nov;20(11):1570-1582. Epub 2023 Jul 20 doi: 10.1016/j.hrthm.2023.07.059. PMID: 37481219
Prolonged QT Interval in Cirrhosis: Twisting Time?
Lee W, Vandenberk B, Raj SR, Lee SS
Gut Liver 2022 Nov 15;16(6):849-860. Epub 2022 Jul 22 doi: 10.5009/gnl210537. PMID: 35864808Free PMC Article
Electromechanical reciprocity and arrhythmogenesis in long-QT syndrome and beyond.
Odening KE, van der Linde HJ, Ackerman MJ, Volders PGA, Ter Bekke RMA
Eur Heart J 2022 Aug 21;43(32):3018-3028. doi: 10.1093/eurheartj/ehac135. PMID: 35445703Free PMC Article
Prolonged corrected QT interval in predicting atrial fibrillation: A systematic review and meta-analysis.
Zhang N, Gong M, Tse G, Zhang Z, Meng L, Yan BP, Zhang L, Wu G, Xia Y, Xin-Yan G, Li G, Liu T
Pacing Clin Electrophysiol 2018 Mar;41(3):321-327. Epub 2018 Feb 16 doi: 10.1111/pace.13292. PMID: 29380395
Development and validation of a risk score to predict QT interval prolongation in hospitalized patients.
Tisdale JE, Jaynes HA, Kingery JR, Mourad NA, Trujillo TN, Overholser BR, Kovacs RJ
Circ Cardiovasc Qual Outcomes 2013 Jul;6(4):479-87. Epub 2013 May 28 doi: 10.1161/CIRCOUTCOMES.113.000152. PMID: 23716032Free PMC Article

Clinical prediction guides

Provocation testing in congenital long QT syndrome: A practical guide.
Abrahams T, Davies B, Laksman Z, Sy RW, Postema PG, Wilde AAM, Krahn AD, Han HC
Heart Rhythm 2023 Nov;20(11):1570-1582. Epub 2023 Jul 20 doi: 10.1016/j.hrthm.2023.07.059. PMID: 37481219
Electromechanical reciprocity and arrhythmogenesis in long-QT syndrome and beyond.
Odening KE, van der Linde HJ, Ackerman MJ, Volders PGA, Ter Bekke RMA
Eur Heart J 2022 Aug 21;43(32):3018-3028. doi: 10.1093/eurheartj/ehac135. PMID: 35445703Free PMC Article
Prolonged corrected QT interval in predicting atrial fibrillation: A systematic review and meta-analysis.
Zhang N, Gong M, Tse G, Zhang Z, Meng L, Yan BP, Zhang L, Wu G, Xia Y, Xin-Yan G, Li G, Liu T
Pacing Clin Electrophysiol 2018 Mar;41(3):321-327. Epub 2018 Feb 16 doi: 10.1111/pace.13292. PMID: 29380395
Risk factors for QTc-prolongation: systematic review of the evidence.
Vandael E, Vandenberk B, Vandenberghe J, Willems R, Foulon V
Int J Clin Pharm 2017 Feb;39(1):16-25. Epub 2016 Dec 23 doi: 10.1007/s11096-016-0414-2. PMID: 28012118
Development and validation of a risk score to predict QT interval prolongation in hospitalized patients.
Tisdale JE, Jaynes HA, Kingery JR, Mourad NA, Trujillo TN, Overholser BR, Kovacs RJ
Circ Cardiovasc Qual Outcomes 2013 Jul;6(4):479-87. Epub 2013 May 28 doi: 10.1161/CIRCOUTCOMES.113.000152. PMID: 23716032Free PMC Article

Recent systematic reviews

Comparison of methods for correcting QT interval in athletes and young people: A systematic review.
Mahendran S, Gupta I, Davis J, Davis AJ, Orchard JW, Orchard JJ
Clin Cardiol 2023 Sep;46(9):1106-1115. Epub 2023 Jul 20 doi: 10.1002/clc.24093. PMID: 37470093Free PMC Article
Intravenous haloperidol: A systematic review of side effects and recommendations for clinical use.
Beach SR, Gross AF, Hartney KE, Taylor JB, Rundell JR
Gen Hosp Psychiatry 2020 Nov-Dec;67:42-50. Epub 2020 Aug 22 doi: 10.1016/j.genhosppsych.2020.08.008. PMID: 32979582
Prolonged corrected QT interval in predicting atrial fibrillation: A systematic review and meta-analysis.
Zhang N, Gong M, Tse G, Zhang Z, Meng L, Yan BP, Zhang L, Wu G, Xia Y, Xin-Yan G, Li G, Liu T
Pacing Clin Electrophysiol 2018 Mar;41(3):321-327. Epub 2018 Feb 16 doi: 10.1111/pace.13292. PMID: 29380395
Incidence, Diagnosis, and Management of QT Prolongation Induced by Cancer Therapies: A Systematic Review.
Porta-Sánchez A, Gilbert C, Spears D, Amir E, Chan J, Nanthakumar K, Thavendiranathan P
J Am Heart Assoc 2017 Dec 7;6(12) doi: 10.1161/JAHA.117.007724. PMID: 29217664Free PMC Article
Risk factors for QTc-prolongation: systematic review of the evidence.
Vandael E, Vandenberk B, Vandenberghe J, Willems R, Foulon V
Int J Clin Pharm 2017 Feb;39(1):16-25. Epub 2016 Dec 23 doi: 10.1007/s11096-016-0414-2. PMID: 28012118

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