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Corrected Prolonged QT Interval by ECG Finding

MedGen UID:
167789
•Concept ID:
C0855333
•
Finding
Synonyms: Corrected Prolonged QT Interval; Corrected Prolonged QT Interval by EKG Finding

Definition

An electrocardiographic finding in which the QTc interval corrected for heart rate is prolonged. Thresholds for different age, gender, and patient populations exist. (CDISC) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCorrected Prolonged QT Interval by ECG Finding

Professional guidelines

PubMed

Diagnosis, management and therapeutic strategies for congenital long QT syndrome.
Wilde AAM, Amin AS, Postema PG
Heart 2022 Mar;108(5):332-338. Epub 2021 May 26 doi: 10.1136/heartjnl-2020-318259. PMID: 34039680Free PMC Article
Measurement and Management of QT Interval Prolongation for General Physicians.
Indraratna P, Tardo D, Delves M, Szirt R, Ng B
J Gen Intern Med 2020 Mar;35(3):865-873. Epub 2019 Oct 25 doi: 10.1007/s11606-019-05477-7. PMID: 31654357Free PMC Article
Pharmacological treatment of acquired QT prolongation and torsades de pointes.
Thomas SH, Behr ER
Br J Clin Pharmacol 2016 Mar;81(3):420-7. Epub 2015 Oct 26 doi: 10.1111/bcp.12726. PMID: 26183037Free PMC Article

Recent clinical studies

Etiology

Diagnosis, management and therapeutic strategies for congenital long QT syndrome.
Wilde AAM, Amin AS, Postema PG
Heart 2022 Mar;108(5):332-338. Epub 2021 May 26 doi: 10.1136/heartjnl-2020-318259. PMID: 34039680Free PMC Article
Managing drug-induced QT prolongation in clinical practice.
Khatib R, Sabir FRN, Omari C, Pepper C, Tayebjee MH
Postgrad Med J 2021 Jul;97(1149):452-458. Epub 2020 Oct 29 doi: 10.1136/postgradmedj-2020-138661. PMID: 33122341Free PMC Article
Pharmacological treatment of acquired QT prolongation and torsades de pointes.
Thomas SH, Behr ER
Br J Clin Pharmacol 2016 Mar;81(3):420-7. Epub 2015 Oct 26 doi: 10.1111/bcp.12726. PMID: 26183037Free PMC Article
The measurement of the QT interval.
Postema PG, Wilde AA
Curr Cardiol Rev 2014 Aug;10(3):287-94. doi: 10.2174/1573403x10666140514103612. PMID: 24827793Free PMC Article
QT interval prolongation and the risk of torsades de pointes: essentials for clinicians.
Trinkley KE, Page RL 2nd, Lien H, Yamanouye K, Tisdale JE
Curr Med Res Opin 2013 Dec;29(12):1719-26. Epub 2013 Sep 23 doi: 10.1185/03007995.2013.840568. PMID: 24020938

Diagnosis

Prolonged QT Interval in Athletes: Distinguishing between Pathology and Physiology.
Christou GA, Vlahos AP, Christou KA, Mantzoukas S, Drougias CA, Christodoulou DK
Cardiology 2022;147(5-6):578-586. Epub 2022 Aug 10 doi: 10.1159/000526385. PMID: 35947943
Diagnosis, management and therapeutic strategies for congenital long QT syndrome.
Wilde AAM, Amin AS, Postema PG
Heart 2022 Mar;108(5):332-338. Epub 2021 May 26 doi: 10.1136/heartjnl-2020-318259. PMID: 34039680Free PMC Article
Prolonged corrected QT interval in predicting atrial fibrillation: A systematic review and meta-analysis.
Zhang N, Gong M, Tse G, Zhang Z, Meng L, Yan BP, Zhang L, Wu G, Xia Y, Xin-Yan G, Li G, Liu T
Pacing Clin Electrophysiol 2018 Mar;41(3):321-327. Epub 2018 Feb 16 doi: 10.1111/pace.13292. PMID: 29380395
Risk factors for QTc-prolongation: systematic review of the evidence.
Vandael E, Vandenberk B, Vandenberghe J, Willems R, Foulon V
Int J Clin Pharm 2017 Feb;39(1):16-25. Epub 2016 Dec 23 doi: 10.1007/s11096-016-0414-2. PMID: 28012118
Development and validation of a risk score to predict QT interval prolongation in hospitalized patients.
Tisdale JE, Jaynes HA, Kingery JR, Mourad NA, Trujillo TN, Overholser BR, Kovacs RJ
Circ Cardiovasc Qual Outcomes 2013 Jul;6(4):479-87. Epub 2013 May 28 doi: 10.1161/CIRCOUTCOMES.113.000152. PMID: 23716032Free PMC Article

Therapy

The Association of Serum Magnesium Levels and QT Interval with Neurological Outcomes After Targeted Temperature Management.
Kumar M, Perucki W, Hiendlmayr B, Mazigh S, O'Sullivan DM, Fernandez AB
Ther Hypothermia Temp Manag 2022 Nov;12(4):210-214. Epub 2022 Apr 22 doi: 10.1089/ther.2021.0038. PMID: 35467975
Update on the ECG component of the CiPA initiative.
Vicente J
J Electrocardiol 2018 Nov-Dec;51(6S):S98-S102. Epub 2018 Aug 7 doi: 10.1016/j.jelectrocard.2018.08.003. PMID: 30121123
Risk factors for QTc-prolongation: systematic review of the evidence.
Vandael E, Vandenberk B, Vandenberghe J, Willems R, Foulon V
Int J Clin Pharm 2017 Feb;39(1):16-25. Epub 2016 Dec 23 doi: 10.1007/s11096-016-0414-2. PMID: 28012118
Pharmacological treatment of acquired QT prolongation and torsades de pointes.
Thomas SH, Behr ER
Br J Clin Pharmacol 2016 Mar;81(3):420-7. Epub 2015 Oct 26 doi: 10.1111/bcp.12726. PMID: 26183037Free PMC Article
QTc prolongation, torsades de pointes, and psychotropic medications.
Beach SR, Celano CM, Noseworthy PA, Januzzi JL, Huffman JC
Psychosomatics 2013 Jan-Feb;54(1):1-13. doi: 10.1016/j.psym.2012.11.001. PMID: 23295003

Prognosis

Prolonged QT Interval in Cirrhosis: Twisting Time?
Lee W, Vandenberk B, Raj SR, Lee SS
Gut Liver 2022 Nov 15;16(6):849-860. Epub 2022 Jul 22 doi: 10.5009/gnl210537. PMID: 35864808Free PMC Article
Electromechanical reciprocity and arrhythmogenesis in long-QT syndrome and beyond.
Odening KE, van der Linde HJ, Ackerman MJ, Volders PGA, Ter Bekke RMA
Eur Heart J 2022 Aug 21;43(32):3018-3028. doi: 10.1093/eurheartj/ehac135. PMID: 35445703Free PMC Article
Prolonged corrected QT interval in predicting atrial fibrillation: A systematic review and meta-analysis.
Zhang N, Gong M, Tse G, Zhang Z, Meng L, Yan BP, Zhang L, Wu G, Xia Y, Xin-Yan G, Li G, Liu T
Pacing Clin Electrophysiol 2018 Mar;41(3):321-327. Epub 2018 Feb 16 doi: 10.1111/pace.13292. PMID: 29380395
Incidence, Diagnosis, and Management of QT Prolongation Induced by Cancer Therapies: A Systematic Review.
Porta-Sánchez A, Gilbert C, Spears D, Amir E, Chan J, Nanthakumar K, Thavendiranathan P
J Am Heart Assoc 2017 Dec 7;6(12) doi: 10.1161/JAHA.117.007724. PMID: 29217664Free PMC Article
Development and validation of a risk score to predict QT interval prolongation in hospitalized patients.
Tisdale JE, Jaynes HA, Kingery JR, Mourad NA, Trujillo TN, Overholser BR, Kovacs RJ
Circ Cardiovasc Qual Outcomes 2013 Jul;6(4):479-87. Epub 2013 May 28 doi: 10.1161/CIRCOUTCOMES.113.000152. PMID: 23716032Free PMC Article

Clinical prediction guides

Electromechanical reciprocity and arrhythmogenesis in long-QT syndrome and beyond.
Odening KE, van der Linde HJ, Ackerman MJ, Volders PGA, Ter Bekke RMA
Eur Heart J 2022 Aug 21;43(32):3018-3028. doi: 10.1093/eurheartj/ehac135. PMID: 35445703Free PMC Article
Prolonged corrected QT interval in predicting atrial fibrillation: A systematic review and meta-analysis.
Zhang N, Gong M, Tse G, Zhang Z, Meng L, Yan BP, Zhang L, Wu G, Xia Y, Xin-Yan G, Li G, Liu T
Pacing Clin Electrophysiol 2018 Mar;41(3):321-327. Epub 2018 Feb 16 doi: 10.1111/pace.13292. PMID: 29380395
Ciprofloxacin does not Prolong the QTc Interval: A Clinical Study in ICU Patients and Review of the Literature.
Heemskerk C, Woldman E, Pereboom M, Van der Hoeven R, Mantel-Teeuwisse A, Van Gemeren C, Becker ML
J Pharm Pharm Sci 2017;20(1):360-364. doi: 10.18433/J3ZD15. PMID: 29145929
Risk factors for QTc-prolongation: systematic review of the evidence.
Vandael E, Vandenberk B, Vandenberghe J, Willems R, Foulon V
Int J Clin Pharm 2017 Feb;39(1):16-25. Epub 2016 Dec 23 doi: 10.1007/s11096-016-0414-2. PMID: 28012118
Development and validation of a risk score to predict QT interval prolongation in hospitalized patients.
Tisdale JE, Jaynes HA, Kingery JR, Mourad NA, Trujillo TN, Overholser BR, Kovacs RJ
Circ Cardiovasc Qual Outcomes 2013 Jul;6(4):479-87. Epub 2013 May 28 doi: 10.1161/CIRCOUTCOMES.113.000152. PMID: 23716032Free PMC Article

Recent systematic reviews

Intravenous haloperidol: A systematic review of side effects and recommendations for clinical use.
Beach SR, Gross AF, Hartney KE, Taylor JB, Rundell JR
Gen Hosp Psychiatry 2020 Nov-Dec;67:42-50. Epub 2020 Aug 22 doi: 10.1016/j.genhosppsych.2020.08.008. PMID: 32979582
Prolonged corrected QT interval in predicting atrial fibrillation: A systematic review and meta-analysis.
Zhang N, Gong M, Tse G, Zhang Z, Meng L, Yan BP, Zhang L, Wu G, Xia Y, Xin-Yan G, Li G, Liu T
Pacing Clin Electrophysiol 2018 Mar;41(3):321-327. Epub 2018 Feb 16 doi: 10.1111/pace.13292. PMID: 29380395
Incidence, Diagnosis, and Management of QT Prolongation Induced by Cancer Therapies: A Systematic Review.
Porta-Sánchez A, Gilbert C, Spears D, Amir E, Chan J, Nanthakumar K, Thavendiranathan P
J Am Heart Assoc 2017 Dec 7;6(12) doi: 10.1161/JAHA.117.007724. PMID: 29217664Free PMC Article
Risk factors for QTc-prolongation: systematic review of the evidence.
Vandael E, Vandenberk B, Vandenberghe J, Willems R, Foulon V
Int J Clin Pharm 2017 Feb;39(1):16-25. Epub 2016 Dec 23 doi: 10.1007/s11096-016-0414-2. PMID: 28012118
Do Studies Evaluating QT/QTc Interval Prolongation with Dietary Supplements Meet FDA Standards: A Systematic Review.
Nguyen TA, Kurian A, Leong J, Patel UM, Shah SA
J Diet Suppl 2017 Jul 4;14(4):467-477. Epub 2016 Dec 12 doi: 10.1080/19390211.2016.1253633. PMID: 27937000

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