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Corrected Prolonged QT Interval by ECG Finding

MedGen UID:
167789
•Concept ID:
C0855333
•
Finding
Synonyms: Corrected Prolonged QT Interval; Corrected Prolonged QT Interval by EKG Finding

Definition

An electrocardiographic finding in which the QTc interval corrected for heart rate is prolonged. Thresholds for different age, gender, and patient populations exist. (CDISC) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCorrected Prolonged QT Interval by ECG Finding

Professional guidelines

PubMed

Diagnosis, management and therapeutic strategies for congenital long QT syndrome.
Wilde AAM, Amin AS, Postema PG
Heart 2022 Mar;108(5):332-338. Epub 2021 May 26 doi: 10.1136/heartjnl-2020-318259. PMID: 34039680Free PMC Article
Measurement and Management of QT Interval Prolongation for General Physicians.
Indraratna P, Tardo D, Delves M, Szirt R, Ng B
J Gen Intern Med 2020 Mar;35(3):865-873. Epub 2019 Oct 25 doi: 10.1007/s11606-019-05477-7. PMID: 31654357Free PMC Article
Pharmacological treatment of acquired QT prolongation and torsades de pointes.
Thomas SH, Behr ER
Br J Clin Pharmacol 2016 Mar;81(3):420-7. Epub 2015 Oct 26 doi: 10.1111/bcp.12726. PMID: 26183037Free PMC Article

Recent clinical studies

Etiology

Diagnosis, management and therapeutic strategies for congenital long QT syndrome.
Wilde AAM, Amin AS, Postema PG
Heart 2022 Mar;108(5):332-338. Epub 2021 May 26 doi: 10.1136/heartjnl-2020-318259. PMID: 34039680Free PMC Article
Managing drug-induced QT prolongation in clinical practice.
Khatib R, Sabir FRN, Omari C, Pepper C, Tayebjee MH
Postgrad Med J 2021 Jul;97(1149):452-458. Epub 2020 Oct 29 doi: 10.1136/postgradmedj-2020-138661. PMID: 33122341Free PMC Article
Potassium Channel Block and Novel Autoimmune-Associated Long QT Syndrome.
Boutjdir M, Lazzerini PE, Capecchi PL, Laghi-Pasini F, El-Sherif N
Card Electrophysiol Clin 2016 Jun;8(2):373-84. Epub 2016 Mar 26 doi: 10.1016/j.ccep.2016.02.002. PMID: 27261828
Pharmacological treatment of acquired QT prolongation and torsades de pointes.
Thomas SH, Behr ER
Br J Clin Pharmacol 2016 Mar;81(3):420-7. Epub 2015 Oct 26 doi: 10.1111/bcp.12726. PMID: 26183037Free PMC Article
The measurement of the QT interval.
Postema PG, Wilde AA
Curr Cardiol Rev 2014 Aug;10(3):287-94. doi: 10.2174/1573403x10666140514103612. PMID: 24827793Free PMC Article

Diagnosis

Diagnosis, management and therapeutic strategies for congenital long QT syndrome.
Wilde AAM, Amin AS, Postema PG
Heart 2022 Mar;108(5):332-338. Epub 2021 May 26 doi: 10.1136/heartjnl-2020-318259. PMID: 34039680Free PMC Article
Long QT Syndrome Type 2: Emerging Strategies for Correcting Class 2 KCNH2 (hERG) Mutations and Identifying New Patients.
Ono M, Burgess DE, Schroder EA, Elayi CS, Anderson CL, January CT, Sun B, Immadisetty K, Kekenes-Huskey PM, Delisle BP
Biomolecules 2020 Aug 4;10(8) doi: 10.3390/biom10081144. PMID: 32759882Free PMC Article
Risk factors for QTc-prolongation: systematic review of the evidence.
Vandael E, Vandenberk B, Vandenberghe J, Willems R, Foulon V
Int J Clin Pharm 2017 Feb;39(1):16-25. Epub 2016 Dec 23 doi: 10.1007/s11096-016-0414-2. PMID: 28012118
Development and validation of a risk score to predict QT interval prolongation in hospitalized patients.
Tisdale JE, Jaynes HA, Kingery JR, Mourad NA, Trujillo TN, Overholser BR, Kovacs RJ
Circ Cardiovasc Qual Outcomes 2013 Jul;6(4):479-87. Epub 2013 May 28 doi: 10.1161/CIRCOUTCOMES.113.000152. PMID: 23716032Free PMC Article
Unconventional applications in pacemaker therapy.
Obias-Manno D
AACN Clin Issues 2001 Feb;12(1):127-39. doi: 10.1097/00044067-200102000-00013. PMID: 11288322

Therapy

Effect of Intravenous Ondansetron on the QT Interval of Patients' Electrocardiograms.
Krammes SK, Jacobs T, Clark JM, Lutes RE
Pediatr Emerg Care 2018 Jan;34(1):38-41. doi: 10.1097/PEC.0000000000000757. PMID: 27261956
Risk factors for QTc-prolongation: systematic review of the evidence.
Vandael E, Vandenberk B, Vandenberghe J, Willems R, Foulon V
Int J Clin Pharm 2017 Feb;39(1):16-25. Epub 2016 Dec 23 doi: 10.1007/s11096-016-0414-2. PMID: 28012118
Pharmacological treatment of acquired QT prolongation and torsades de pointes.
Thomas SH, Behr ER
Br J Clin Pharmacol 2016 Mar;81(3):420-7. Epub 2015 Oct 26 doi: 10.1111/bcp.12726. PMID: 26183037Free PMC Article
QTc prolongation, torsades de pointes, and psychotropic medications.
Beach SR, Celano CM, Noseworthy PA, Januzzi JL, Huffman JC
Psychosomatics 2013 Jan-Feb;54(1):1-13. doi: 10.1016/j.psym.2012.11.001. PMID: 23295003
Validation testing in thorough QT/QTc clinical trials.
Tsong Y, Zhong J, Chen WJ
J Biopharm Stat 2008;18(3):529-41. doi: 10.1080/10543400801995486. PMID: 18470761

Prognosis

Prolonged QT Interval in Cirrhosis: Twisting Time?
Lee W, Vandenberk B, Raj SR, Lee SS
Gut Liver 2022 Nov 15;16(6):849-860. Epub 2022 Jul 22 doi: 10.5009/gnl210537. PMID: 35864808Free PMC Article
Drug-specific risk of severe QT prolongation following acute drug overdose.
Campleman SL, Brent J, Pizon AF, Shulman J, Wax P, Manini AF; Toxicology Investigators’ Consortium (ToxIC)
Clin Toxicol (Phila) 2020 Dec;58(12):1326-1334. Epub 2020 Apr 7 doi: 10.1080/15563650.2020.1746330. PMID: 32252558Free PMC Article
Thorough QT/QTc in a Dish: An In Vitro Human Model That Accurately Predicts Clinical Concentration-QTc Relationships.
Blanchette AD, Grimm FA, Dalaijamts C, Hsieh NH, Ferguson K, Luo YS, Rusyn I, Chiu WA
Clin Pharmacol Ther 2019 May;105(5):1175-1186. Epub 2018 Dec 2 doi: 10.1002/cpt.1259. PMID: 30346629Free PMC Article
Breath Holding Spells in Children with Long QT Syndrome.
Robinson JA, Bos JM, Etheridge SP, Ackerman MJ
Congenit Heart Dis 2015 Jul-Aug;10(4):354-61. Epub 2015 Apr 27 doi: 10.1111/chd.12262. PMID: 25916402
Development and validation of a risk score to predict QT interval prolongation in hospitalized patients.
Tisdale JE, Jaynes HA, Kingery JR, Mourad NA, Trujillo TN, Overholser BR, Kovacs RJ
Circ Cardiovasc Qual Outcomes 2013 Jul;6(4):479-87. Epub 2013 May 28 doi: 10.1161/CIRCOUTCOMES.113.000152. PMID: 23716032Free PMC Article

Clinical prediction guides

Drug-specific risk of severe QT prolongation following acute drug overdose.
Campleman SL, Brent J, Pizon AF, Shulman J, Wax P, Manini AF; Toxicology Investigators’ Consortium (ToxIC)
Clin Toxicol (Phila) 2020 Dec;58(12):1326-1334. Epub 2020 Apr 7 doi: 10.1080/15563650.2020.1746330. PMID: 32252558Free PMC Article
Effect of Intravenous Ondansetron on the QT Interval of Patients' Electrocardiograms.
Krammes SK, Jacobs T, Clark JM, Lutes RE
Pediatr Emerg Care 2018 Jan;34(1):38-41. doi: 10.1097/PEC.0000000000000757. PMID: 27261956
Risk factors for QTc-prolongation: systematic review of the evidence.
Vandael E, Vandenberk B, Vandenberghe J, Willems R, Foulon V
Int J Clin Pharm 2017 Feb;39(1):16-25. Epub 2016 Dec 23 doi: 10.1007/s11096-016-0414-2. PMID: 28012118
Breath Holding Spells in Children with Long QT Syndrome.
Robinson JA, Bos JM, Etheridge SP, Ackerman MJ
Congenit Heart Dis 2015 Jul-Aug;10(4):354-61. Epub 2015 Apr 27 doi: 10.1111/chd.12262. PMID: 25916402
Development and validation of a risk score to predict QT interval prolongation in hospitalized patients.
Tisdale JE, Jaynes HA, Kingery JR, Mourad NA, Trujillo TN, Overholser BR, Kovacs RJ
Circ Cardiovasc Qual Outcomes 2013 Jul;6(4):479-87. Epub 2013 May 28 doi: 10.1161/CIRCOUTCOMES.113.000152. PMID: 23716032Free PMC Article

Recent systematic reviews

Comparison of methods for correcting QT interval in athletes and young people: A systematic review.
Mahendran S, Gupta I, Davis J, Davis AJ, Orchard JW, Orchard JJ
Clin Cardiol 2023 Sep;46(9):1106-1115. Epub 2023 Jul 20 doi: 10.1002/clc.24093. PMID: 37470093Free PMC Article
Intravenous haloperidol: A systematic review of side effects and recommendations for clinical use.
Beach SR, Gross AF, Hartney KE, Taylor JB, Rundell JR
Gen Hosp Psychiatry 2020 Nov-Dec;67:42-50. Epub 2020 Aug 22 doi: 10.1016/j.genhosppsych.2020.08.008. PMID: 32979582
Prolonged corrected QT interval in predicting atrial fibrillation: A systematic review and meta-analysis.
Zhang N, Gong M, Tse G, Zhang Z, Meng L, Yan BP, Zhang L, Wu G, Xia Y, Xin-Yan G, Li G, Liu T
Pacing Clin Electrophysiol 2018 Mar;41(3):321-327. Epub 2018 Feb 16 doi: 10.1111/pace.13292. PMID: 29380395
Incidence, Diagnosis, and Management of QT Prolongation Induced by Cancer Therapies: A Systematic Review.
Porta-Sánchez A, Gilbert C, Spears D, Amir E, Chan J, Nanthakumar K, Thavendiranathan P
J Am Heart Assoc 2017 Dec 7;6(12) doi: 10.1161/JAHA.117.007724. PMID: 29217664Free PMC Article
Risk factors for QTc-prolongation: systematic review of the evidence.
Vandael E, Vandenberk B, Vandenberghe J, Willems R, Foulon V
Int J Clin Pharm 2017 Feb;39(1):16-25. Epub 2016 Dec 23 doi: 10.1007/s11096-016-0414-2. PMID: 28012118

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