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Mixed Neuroendocrine Non-Neuroendocrine Neoplasm

MedGen UID:
1678094
•Concept ID:
C5191660
•
Neoplastic Process
Synonyms: MiNEN - mixed neuroendocrine-non neuroendocrine neoplasm; Mixed neuroendocrine-non neuroendocrine neoplasm
SNOMED CT: Mixed neuroendocrine-non neuroendocrine neoplasm (785766008); MiNEN - mixed neuroendocrine-non neuroendocrine neoplasm (785766008)

Definition

A rare neoplasm that consists of neuroendocrine and non-neuroendocrine cellular components. At least 30% of either component should be present for the diagnosis to be made. [from NCI]

Professional guidelines

PubMed

Dilemmas in Diagnosis and Management of Gastroenteropancreatic Mixed Neuroendocrine Non-neuroendocrine Neoplasms: First Single-Centre Report from India.
Desai GS, Pande P, Shah RC, Jagannath P
J Gastrointest Cancer 2020 Mar;51(1):102-108. doi: 10.1007/s12029-019-00213-0. PMID: 30784017
Alterations in ERBB2 and BRCA and microsatellite instability as new personalized treatment options in small bowel carcinoma.
Quaas A, Heydt C, Waldschmidt D, Alakus H, Zander T, Goeser T, Kasper P, Bruns C, Brunn A, Roth W, Hartmann N, Bunck A, Schmidt M, Buettner R, Merkelbach-Bruse S
BMC Gastroenterol 2019 Feb 4;19(1):21. doi: 10.1186/s12876-019-0942-z. PMID: 30717682Free PMC Article
The clinicopathological spectrum of olfactory neuroblastoma and sinonasal neuroendocrine neoplasms: Refinements in diagnostic criteria and impact of multimodal treatments on survival.
Turri-Zanoni M, Maragliano R, Battaglia P, Giovannardi M, Antognoni P, Lombardi D, Morassi ML, Pasquini E, Tarchini P, Asioli S, Foschini MP, Sessa F, Nicolai P, Castelnuovo P, La Rosa S
Oral Oncol 2017 Nov;74:21-29. doi: 10.1016/j.oraloncology.2017.09.010. PMID: 29103747

Recent clinical studies

Etiology

Gene expression profiling of pancreatic neuroendocrine carcinoma and mixed neuroendocrine-non-neuroendocrine neoplasm.
Kinowaki Y, Fukumura Y, Kawade G, Sugita K, Kinowaki K, Akahoshi K, Kobayashi M, Ono H, Kudo A, Tanabe M, Akashi T, Ohashi K, Kurata M
Gene 2024 Jan 30;893:147916. Epub 2023 Oct 20 doi: 10.1016/j.gene.2023.147916. PMID: 37866661
Clinicopathological and genetic characteristics of gastric neuroendocrine tumour (NET) G3 and comparisons with neuroendocrine carcinoma and NET G2.
Chen S, Sun L, Chen H, Li J, Lu C, Yang Y, Sun Y
Histopathology 2023 Nov;83(5):700-711. Epub 2023 Jul 5 doi: 10.1111/his.15002. PMID: 37403531
Long-term surgical outcomes of gastric neuroendocrine carcinoma and mixed neuroendocrine-non-neuroendocrine neoplasms.
Iwasaki K, Barroga E, Enomoto M, Tsurui K, Shimoda Y, Matsumoto M, Miyoshi K, Ota Y, Matsubayashi J, Nagakawa Y
World J Surg Oncol 2022 May 24;20(1):165. doi: 10.1186/s12957-022-02625-y. PMID: 35610656Free PMC Article
A Mixed Neuroendocrine/Non-Neuroendocrine Neoplasm Arising in the Background of Ulcerative Colitis: A Case Report and Review of the Literature.
Al Buthi SA, Bin Gheshayan SF, Al Samaani I, Al Ahmadi B, Al Selaim NA
Am J Case Rep 2022 Mar 3;23:e934396. doi: 10.12659/AJCR.934396. PMID: 35236818Free PMC Article
Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres.
Frizziero M, Wang X, Chakrabarty B, Childs A, Luong TV, Walter T, Khan MS, Morgan M, Christian A, Elshafie M, Shah T, Minicozzi A, Mansoor W, Meyer T, Lamarca A, Hubner RA, Valle JW, McNamara MG
World J Gastroenterol 2019 Oct 21;25(39):5991-6005. doi: 10.3748/wjg.v25.i39.5991. PMID: 31660035Free PMC Article

Diagnosis

Mixed neuroendocrine-non-neuroendocrine neoplasm arising from long-segment Barrett's esophagus showing exceptionally aggressive clinical behavior.
Miyaguchi K, Kawasaki T, Tashima T, Ryozawa S
Cancer Rep (Hoboken) 2022 Sep;5(9):e1644. Epub 2022 Jul 8 doi: 10.1002/cnr2.1644. PMID: 35801304Free PMC Article
Mixed neuroendocrine-non-neuroendocrine neoplasm of the gallbladder: case report and literature review.
Ren X, Jiang H, Sun K, Qin X, Qu Y, Xia T, Chen Y
Diagn Pathol 2022 Jun 17;17(1):51. doi: 10.1186/s13000-022-01231-6. PMID: 35715834Free PMC Article
Long-term surgical outcomes of gastric neuroendocrine carcinoma and mixed neuroendocrine-non-neuroendocrine neoplasms.
Iwasaki K, Barroga E, Enomoto M, Tsurui K, Shimoda Y, Matsumoto M, Miyoshi K, Ota Y, Matsubayashi J, Nagakawa Y
World J Surg Oncol 2022 May 24;20(1):165. doi: 10.1186/s12957-022-02625-y. PMID: 35610656Free PMC Article
Mixed neuroendocrine non-neuroendocrine neoplasm: a case report and review.
Hiroi S, Yamamoto R, Hamaoka M, Hoshino M, Sasaki T, Matsugu Y, Nishisaka T, Nakahara H, Itamoto T
Clin J Gastroenterol 2022 Feb;15(1):244-255. Epub 2021 Nov 18 doi: 10.1007/s12328-021-01552-x. PMID: 34796444
Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres.
Frizziero M, Wang X, Chakrabarty B, Childs A, Luong TV, Walter T, Khan MS, Morgan M, Christian A, Elshafie M, Shah T, Minicozzi A, Mansoor W, Meyer T, Lamarca A, Hubner RA, Valle JW, McNamara MG
World J Gastroenterol 2019 Oct 21;25(39):5991-6005. doi: 10.3748/wjg.v25.i39.5991. PMID: 31660035Free PMC Article

Therapy

Thymoquinone Plus Immunotherapy in Extra-Pulmonary Neuroendocrine Carcinoma: Case Series for a Novel Combination.
Mohamed A, Azmi AS, Asa SL, Tirumani SH, Mahipal A, Cjakrabarti S, Bajor D, Selfridge JE, Kaseb AO
Curr Oncol 2022 Nov 21;29(11):9018-9030. doi: 10.3390/curroncol29110707. PMID: 36421360Free PMC Article
Clinicopathological features and prognostic factors associated with gastroenteropancreatic mixed neuroendocrine non-neuroendocrine neoplasms in Chinese patients.
Huang YC, Yang NN, Chen HC, Huang YL, Yan WT, Yang RX, Li N, Zhang S, Yang PP, Feng ZZ
World J Gastroenterol 2021 Feb 21;27(7):624-640. doi: 10.3748/wjg.v27.i7.624. PMID: 33642833Free PMC Article
Primary MiNEN of the urinary bladder: an hitherto undescribed entity composed of large cell neuroendocrine carcinoma and adenocarcinoma with a distinct clinical behavior : Description of a case and review of the pertinent literature.
Pini GM, Uccella S, Corinti M, Colecchia M, Pelosi G, Patriarca C
Virchows Arch 2021 Jul;479(1):69-78. Epub 2021 Jan 17 doi: 10.1007/s00428-021-03023-7. PMID: 33454836Free PMC Article

Prognosis

Colorectal neuroendocrine carcinoma and mixed neuroendocrine-non-neuroendocrine neoplasm: Prognostic factors and PD-L1 expression.
Ho YH, Hsu CY, Yau Li AF, Liang WY
Hum Pathol 2024 Mar;145:80-85. Epub 2024 Feb 27 doi: 10.1016/j.humpath.2024.02.012. PMID: 38423221
Long-term surgical outcomes of gastric neuroendocrine carcinoma and mixed neuroendocrine-non-neuroendocrine neoplasms.
Iwasaki K, Barroga E, Enomoto M, Tsurui K, Shimoda Y, Matsumoto M, Miyoshi K, Ota Y, Matsubayashi J, Nagakawa Y
World J Surg Oncol 2022 May 24;20(1):165. doi: 10.1186/s12957-022-02625-y. PMID: 35610656Free PMC Article
A Mixed Neuroendocrine/Non-Neuroendocrine Neoplasm Arising in the Background of Ulcerative Colitis: A Case Report and Review of the Literature.
Al Buthi SA, Bin Gheshayan SF, Al Samaani I, Al Ahmadi B, Al Selaim NA
Am J Case Rep 2022 Mar 3;23:e934396. doi: 10.12659/AJCR.934396. PMID: 35236818Free PMC Article
Clinicopathological characteristics and prognostic factors of patients with primary gallbladder neuroendocrine carcinomas.
Wang W, Yang CX, Yu XZ, Zhang SL, Wang J, Wang J
J Dig Dis 2022 Mar;23(3):166-173. Epub 2022 Mar 15 doi: 10.1111/1751-2980.13088. PMID: 35187836
Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres.
Frizziero M, Wang X, Chakrabarty B, Childs A, Luong TV, Walter T, Khan MS, Morgan M, Christian A, Elshafie M, Shah T, Minicozzi A, Mansoor W, Meyer T, Lamarca A, Hubner RA, Valle JW, McNamara MG
World J Gastroenterol 2019 Oct 21;25(39):5991-6005. doi: 10.3748/wjg.v25.i39.5991. PMID: 31660035Free PMC Article

Clinical prediction guides

Synchronous or metachronous presentation of pancreatic neuroendocrine tumor versus secondary lesion to pancreas in patients affected by renal cell carcinoma. Systematic review.
Persano I, Parlagreco E, La Salvia A, Audisio M, Volante M, Buttigliero C, Scagliotti GV, Brizzi MP
Semin Oncol 2022 Dec;49(6):476-481. Epub 2023 Feb 2 doi: 10.1053/j.seminoncol.2023.01.007. PMID: 36759234
Long-term surgical outcomes of gastric neuroendocrine carcinoma and mixed neuroendocrine-non-neuroendocrine neoplasms.
Iwasaki K, Barroga E, Enomoto M, Tsurui K, Shimoda Y, Matsumoto M, Miyoshi K, Ota Y, Matsubayashi J, Nagakawa Y
World J Surg Oncol 2022 May 24;20(1):165. doi: 10.1186/s12957-022-02625-y. PMID: 35610656Free PMC Article
Clinicopathological features and lymph node and distant metastasis patterns in patients with gastroenteropancreatic mixed neuroendocrine-non-neuroendocrine neoplasm.
Zhang P, Li Z, Li J, Li J, Zhang X, Lu Z, Sun Y, Li Y, Zhou J, Wang X, Peng Z, Shen L, Lu M
Cancer Med 2021 Jul;10(14):4855-4863. Epub 2021 Jun 10 doi: 10.1002/cam4.4031. PMID: 34109756Free PMC Article
Neuroendocrine carcinoma and mixed neuroendocrine‒non-neuroendocrine neoplasm of the stomach: a clinicopathological and exome sequencing study.
Ishida S, Akita M, Fujikura K, Komatsu M, Sawada R, Matsumoto H, Saegusa J, Itoh T, Kakeji Y, Zen Y
Hum Pathol 2021 Apr;110:1-10. Epub 2021 Jan 21 doi: 10.1016/j.humpath.2020.12.008. PMID: 33359239
Gallbladder Mixed Neuroendocrine-Non-neuroendocrine Neoplasm (MiNEN) Arising in Intracholecystic Papillary Neoplasm: Clinicopathologic and Molecular Analysis of a Case and Review of the Literature.
Sciarra A, Missiaglia E, Trimech M, Melloul E, Brouland JP, Sempoux C, La Rosa S
Endocr Pathol 2020 Mar;31(1):84-93. doi: 10.1007/s12022-020-09605-6. PMID: 31981075

Recent systematic reviews

Synchronous or metachronous presentation of pancreatic neuroendocrine tumor versus secondary lesion to pancreas in patients affected by renal cell carcinoma. Systematic review.
Persano I, Parlagreco E, La Salvia A, Audisio M, Volante M, Buttigliero C, Scagliotti GV, Brizzi MP
Semin Oncol 2022 Dec;49(6):476-481. Epub 2023 Feb 2 doi: 10.1053/j.seminoncol.2023.01.007. PMID: 36759234

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