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Increased risk of squamous cell skin cancer on sun-exposed areas

MedGen UID:
1678310
•Concept ID:
C5194774
•
Finding

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased risk of squamous cell skin cancer on sun-exposed areas

Professional guidelines

PubMed

Lower lip basal cell and squamous cell carcinomas: a reappraisal of the similarities and differences in clinical presentation and management.
Hwang JR, Khachemoune A
Arch Dermatol Res 2023 Mar;315(2):117-125. Epub 2022 Mar 21 doi: 10.1007/s00403-022-02345-z. PMID: 35312855
Management of actinic keratosis at specific body sites in patients at high risk of carcinoma lesions: expert consensus from the AKTeam™ of expert clinicians.
Richard MA, Amici JM, Basset-Seguin N, Claudel JP, Cribier B, Dreno B
J Eur Acad Dermatol Venereol 2018 Mar;32(3):339-346. Epub 2018 Jan 15 doi: 10.1111/jdv.14753. PMID: 29235161

Recent clinical studies

Etiology

Lower lip basal cell and squamous cell carcinomas: a reappraisal of the similarities and differences in clinical presentation and management.
Hwang JR, Khachemoune A
Arch Dermatol Res 2023 Mar;315(2):117-125. Epub 2022 Mar 21 doi: 10.1007/s00403-022-02345-z. PMID: 35312855
Increased risk of skin cancer in Japanese heterozygotes of xeroderma pigmentosum group A.
Hirai Y, Noda A, Kodama Y, Cordova KA, Cullings HM, Yonehara S, Fujihara M, Moriwaki SI, Nishigori C, Mabuchi K, Kraemer KH, Nakamura N
J Hum Genet 2018 Nov;63(11):1181-1184. Epub 2018 Aug 8 doi: 10.1038/s10038-018-0495-y. PMID: 30089811Free PMC Article
Management of actinic keratosis at specific body sites in patients at high risk of carcinoma lesions: expert consensus from the AKTeam™ of expert clinicians.
Richard MA, Amici JM, Basset-Seguin N, Claudel JP, Cribier B, Dreno B
J Eur Acad Dermatol Venereol 2018 Mar;32(3):339-346. Epub 2018 Jan 15 doi: 10.1111/jdv.14753. PMID: 29235161
A qualitative systematic review of the efficacy of sun protection education in organ transplant recipients.
Wu SZ, Jiang P, DeCaro JE, Bordeaux JS
J Am Acad Dermatol 2016 Dec;75(6):1238-1244.e5. Epub 2016 Jul 27 doi: 10.1016/j.jaad.2016.06.031. PMID: 27476105
Arsenic carcinogenesis in the skin.
Yu HS, Liao WT, Chai CY
J Biomed Sci 2006 Sep;13(5):657-66. Epub 2006 Jun 29 doi: 10.1007/s11373-006-9092-8. PMID: 16807664

Diagnosis

Lower lip basal cell and squamous cell carcinomas: a reappraisal of the similarities and differences in clinical presentation and management.
Hwang JR, Khachemoune A
Arch Dermatol Res 2023 Mar;315(2):117-125. Epub 2022 Mar 21 doi: 10.1007/s00403-022-02345-z. PMID: 35312855
Effect of Pegylated Interferon and Mitomycin C on Ocular Surface Squamous Neoplasia in Xeroderma Pigmentosum: A Case Series.
Dirar QS, Musalem HM, Al-Hazzaa SAF, Al Zoba AA, Almalki AA
Am J Case Rep 2020 Apr 6;21:e921301. doi: 10.12659/AJCR.921301. PMID: 32251268Free PMC Article
Epidemiology and clinical evolution of non-melanoma skin cancer in renal transplant recipients: a single-center experience in São Paulo, Brazil.
Hayashida MZ, Fernandes VM, Fernandes DR, Ogawa MM, Tomimori J
Int J Dermatol 2015 Oct;54(10):e383-8. Epub 2015 May 13 doi: 10.1111/ijd.12632. PMID: 25969871
Spreading pigmented actinic keratosis: a review.
Uhlenhake EE, Sangueza OP, Lee AD, Jorizzo JL
J Am Acad Dermatol 2010 Sep;63(3):499-506. Epub 2010 Mar 23 doi: 10.1016/j.jaad.2009.07.026. PMID: 20334953
Localized cutaneous metastases from an atypical fibroxanthoma.
Giuffrida TJ, Kligora CJ, Goldstein GD
Dermatol Surg 2004 Dec;30(12 Pt 2):1561-4. doi: 10.1111/j.1524-4725.2004.30560.x. PMID: 15606841

Therapy

Effect of Pegylated Interferon and Mitomycin C on Ocular Surface Squamous Neoplasia in Xeroderma Pigmentosum: A Case Series.
Dirar QS, Musalem HM, Al-Hazzaa SAF, Al Zoba AA, Almalki AA
Am J Case Rep 2020 Apr 6;21:e921301. doi: 10.12659/AJCR.921301. PMID: 32251268Free PMC Article
A qualitative systematic review of the efficacy of sun protection education in organ transplant recipients.
Wu SZ, Jiang P, DeCaro JE, Bordeaux JS
J Am Acad Dermatol 2016 Dec;75(6):1238-1244.e5. Epub 2016 Jul 27 doi: 10.1016/j.jaad.2016.06.031. PMID: 27476105
MAL Daylight Photodynamic Therapy for Actinic Keratosis: Clinical and Imaging Evaluation by 3D Camera.
Cantisani C, Paolino G, Pellacani G, Didona D, Scarno M, Faina V, Gobello T, Calvieri S
Int J Mol Sci 2016 Jul 11;17(7) doi: 10.3390/ijms17071108. PMID: 27409613Free PMC Article
Epidemiology and clinical evolution of non-melanoma skin cancer in renal transplant recipients: a single-center experience in São Paulo, Brazil.
Hayashida MZ, Fernandes VM, Fernandes DR, Ogawa MM, Tomimori J
Int J Dermatol 2015 Oct;54(10):e383-8. Epub 2015 May 13 doi: 10.1111/ijd.12632. PMID: 25969871
Clinical findings using ingenol mebutate gel to treat actinic keratoses.
Martin G, Swanson N
J Am Acad Dermatol 2013 Jan;68(1 Suppl 1):S39-48. doi: 10.1016/j.jaad.2012.09.050. PMID: 23228305

Prognosis

Epidemiology and clinical evolution of non-melanoma skin cancer in renal transplant recipients: a single-center experience in São Paulo, Brazil.
Hayashida MZ, Fernandes VM, Fernandes DR, Ogawa MM, Tomimori J
Int J Dermatol 2015 Oct;54(10):e383-8. Epub 2015 May 13 doi: 10.1111/ijd.12632. PMID: 25969871
UV dose determines key characteristics of nonmelanoma skin cancer.
Ramos J, Villa J, Ruiz A, Armstrong R, Matta J
Cancer Epidemiol Biomarkers Prev 2004 Dec;13(12):2006-11. PMID: 15598755
Ocular and cutaneous squamous cell carcinoma in an African American man with epidermodysplasia verruciformis resulting in blindness and death.
Partridge ME, Pariser RJ
J Am Acad Dermatol 2003 Nov;49(5 Suppl):S262-4. doi: 10.1016/s0190-9622(03)00465-1. PMID: 14576647
Incidence rates of skin cancer in Townsville, Australia.
Buettner PG, Raasch BA
Int J Cancer 1998 Nov 23;78(5):587-93. doi: 10.1002/(sici)1097-0215(19981123)78:5<587::aid-ijc10>3.0.co;2-e. PMID: 9808527
Skin cancers in organ transplant recipients.
Euvrard S, Kanitakis J, Pouteil-Noble C, Claudy A, Touraine JL
Ann Transplant 1997;2(4):28-32. PMID: 9869876

Clinical prediction guides

MAL Daylight Photodynamic Therapy for Actinic Keratosis: Clinical and Imaging Evaluation by 3D Camera.
Cantisani C, Paolino G, Pellacani G, Didona D, Scarno M, Faina V, Gobello T, Calvieri S
Int J Mol Sci 2016 Jul 11;17(7) doi: 10.3390/ijms17071108. PMID: 27409613Free PMC Article
Epidemiology and clinical evolution of non-melanoma skin cancer in renal transplant recipients: a single-center experience in São Paulo, Brazil.
Hayashida MZ, Fernandes VM, Fernandes DR, Ogawa MM, Tomimori J
Int J Dermatol 2015 Oct;54(10):e383-8. Epub 2015 May 13 doi: 10.1111/ijd.12632. PMID: 25969871
Clinical findings using ingenol mebutate gel to treat actinic keratoses.
Martin G, Swanson N
J Am Acad Dermatol 2013 Jan;68(1 Suppl 1):S39-48. doi: 10.1016/j.jaad.2012.09.050. PMID: 23228305
Loss of heterozygosity of nucleotide excision repair factors in sporadic oral squamous cell carcinoma using microdissected tissue.
Miyashita H, Mori S, Tanda N, Nakayama K, Kanzaki A, Sato A, Morikawa H, Motegi K, Takebayashi Y, Fukumoto M
Oncol Rep 2001 Sep-Oct;8(5):1133-8. doi: 10.3892/or.8.5.1133. PMID: 11496330

Recent systematic reviews

Management of actinic keratosis at specific body sites in patients at high risk of carcinoma lesions: expert consensus from the AKTeam™ of expert clinicians.
Richard MA, Amici JM, Basset-Seguin N, Claudel JP, Cribier B, Dreno B
J Eur Acad Dermatol Venereol 2018 Mar;32(3):339-346. Epub 2018 Jan 15 doi: 10.1111/jdv.14753. PMID: 29235161
A qualitative systematic review of the efficacy of sun protection education in organ transplant recipients.
Wu SZ, Jiang P, DeCaro JE, Bordeaux JS
J Am Acad Dermatol 2016 Dec;75(6):1238-1244.e5. Epub 2016 Jul 27 doi: 10.1016/j.jaad.2016.06.031. PMID: 27476105

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