U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Localized Ewing Sarcoma

MedGen UID:
167841
•Concept ID:
C0863029
•
Neoplastic Process
Synonyms: Ewing's Sarcoma, Localized; Localized Ewing's Sarcoma; Localized Ewing's Tumor

Definition

Ewing sarcoma that is confined to a specific site without evidence of spread to other anatomic sites. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocalized Ewing Sarcoma

Professional guidelines

PubMed

The clinical prognostic factors and treatment outcomes of adult patients with Ewing sarcoma.
Jagodzińska-Mucha P, Ługowska I, Świtaj T, Koseła-Paterczyk H, Wągrodzki M, Kozak K, Falkowski S, Morysiński T, Goryń T, Dawidowska A, Rutkowski P
Int J Clin Oncol 2020 Nov;25(11):2006-2014. Epub 2020 Jul 25 doi: 10.1007/s10147-020-01741-7. PMID: 32712877
Challenges in the management of localized Ewing sarcoma in a developing country.
Totadri S, Bansal D, Rao KLN, Jain R, Saxena AK, Kapoor R, Samujh R, Trehan A
Pediatr Hematol Oncol 2020 Oct;37(7):610-619. Epub 2020 Jun 19 doi: 10.1080/08880018.2020.1772912. PMID: 32558608
Ewing's sarcoma: standard and experimental treatment options.
Subbiah V, Anderson P, Lazar AJ, Burdett E, Raymond K, Ludwig JA
Curr Treat Options Oncol 2009 Apr;10(1-2):126-40. Epub 2009 Jun 17 doi: 10.1007/s11864-009-0104-6. PMID: 19533369

Recent clinical studies

Etiology

Ewing sarcoma: investigational mono- and combination therapies in clinical trials.
Gartrell J, Rodriguez-Galindo C
Expert Opin Investig Drugs 2021 Jun;30(6):653-663. Epub 2021 Jun 3 doi: 10.1080/13543784.2021.1919623. PMID: 33870845
Challenges in the management of localized Ewing sarcoma in a developing country.
Totadri S, Bansal D, Rao KLN, Jain R, Saxena AK, Kapoor R, Samujh R, Trehan A
Pediatr Hematol Oncol 2020 Oct;37(7):610-619. Epub 2020 Jun 19 doi: 10.1080/08880018.2020.1772912. PMID: 32558608
Investigational therapies for Ewing sarcoma: a search without a clear finding.
Vornicova O, Bar-Sela G
Expert Opin Investig Drugs 2016 Jun;25(6):679-86. Epub 2016 Apr 7 doi: 10.1517/13543784.2016.1168398. PMID: 26988130
Randomized controlled trial of interval-compressed chemotherapy for the treatment of localized Ewing sarcoma: a report from the Children's Oncology Group.
Womer RB, West DC, Krailo MD, Dickman PS, Pawel BR, Grier HE, Marcus K, Sailer S, Healey JH, Dormans JP, Weiss AR
J Clin Oncol 2012 Nov 20;30(33):4148-54. Epub 2012 Oct 22 doi: 10.1200/JCO.2011.41.5703. PMID: 23091096Free PMC Article
Ewing sarcoma: radiation dose and target volume.
Donaldson SS
Pediatr Blood Cancer 2004 May;42(5):471-6. doi: 10.1002/pbc.10472. PMID: 15049023

Diagnosis

Histological response to neoadjuvant chemotherapy in localized Ewing sarcoma of the bone: A retrospective analysis of available scoring tools.
Righi A, Pacheco M, Palmerini E, Carretta E, Gambarotti M, Longhi A, Magagnoli G, Sbaraglia M, Manfrini M, Picci P, Dei Tos AP
Eur J Surg Oncol 2021 Jul;47(7):1778-1783. Epub 2021 Feb 16 doi: 10.1016/j.ejso.2021.02.009. PMID: 33622576
The clinical prognostic factors and treatment outcomes of adult patients with Ewing sarcoma.
Jagodzińska-Mucha P, Ługowska I, Świtaj T, Koseła-Paterczyk H, Wągrodzki M, Kozak K, Falkowski S, Morysiński T, Goryń T, Dawidowska A, Rutkowski P
Int J Clin Oncol 2020 Nov;25(11):2006-2014. Epub 2020 Jul 25 doi: 10.1007/s10147-020-01741-7. PMID: 32712877
Randomized controlled trial of interval-compressed chemotherapy for the treatment of localized Ewing sarcoma: a report from the Children's Oncology Group.
Womer RB, West DC, Krailo MD, Dickman PS, Pawel BR, Grier HE, Marcus K, Sailer S, Healey JH, Dormans JP, Weiss AR
J Clin Oncol 2012 Nov 20;30(33):4148-54. Epub 2012 Oct 22 doi: 10.1200/JCO.2011.41.5703. PMID: 23091096Free PMC Article
Flow cytometric detection of Ewing sarcoma cells in peripheral blood and bone marrow.
Dubois SG, Epling CL, Teague J, Matthay KK, Sinclair E
Pediatr Blood Cancer 2010 Jan;54(1):13-8. doi: 10.1002/pbc.22245. PMID: 19711435Free PMC Article
Ewing's sarcoma: standard and experimental treatment options.
Subbiah V, Anderson P, Lazar AJ, Burdett E, Raymond K, Ludwig JA
Curr Treat Options Oncol 2009 Apr;10(1-2):126-40. Epub 2009 Jun 17 doi: 10.1007/s11864-009-0104-6. PMID: 19533369

Therapy

Ewing sarcoma: investigational mono- and combination therapies in clinical trials.
Gartrell J, Rodriguez-Galindo C
Expert Opin Investig Drugs 2021 Jun;30(6):653-663. Epub 2021 Jun 3 doi: 10.1080/13543784.2021.1919623. PMID: 33870845
Challenges in the management of localized Ewing sarcoma in a developing country.
Totadri S, Bansal D, Rao KLN, Jain R, Saxena AK, Kapoor R, Samujh R, Trehan A
Pediatr Hematol Oncol 2020 Oct;37(7):610-619. Epub 2020 Jun 19 doi: 10.1080/08880018.2020.1772912. PMID: 32558608
Prospects and challenges for the development of new therapies for Ewing sarcoma.
Grohar PJ, Helman LJ
Pharmacol Ther 2013 Feb;137(2):216-24. Epub 2012 Oct 18 doi: 10.1016/j.pharmthera.2012.10.004. PMID: 23085431Free PMC Article
Randomized controlled trial of interval-compressed chemotherapy for the treatment of localized Ewing sarcoma: a report from the Children's Oncology Group.
Womer RB, West DC, Krailo MD, Dickman PS, Pawel BR, Grier HE, Marcus K, Sailer S, Healey JH, Dormans JP, Weiss AR
J Clin Oncol 2012 Nov 20;30(33):4148-54. Epub 2012 Oct 22 doi: 10.1200/JCO.2011.41.5703. PMID: 23091096Free PMC Article
Ewing's sarcoma: standard and experimental treatment options.
Subbiah V, Anderson P, Lazar AJ, Burdett E, Raymond K, Ludwig JA
Curr Treat Options Oncol 2009 Apr;10(1-2):126-40. Epub 2009 Jun 17 doi: 10.1007/s11864-009-0104-6. PMID: 19533369

Prognosis

Challenges in the management of localized Ewing sarcoma in a developing country.
Totadri S, Bansal D, Rao KLN, Jain R, Saxena AK, Kapoor R, Samujh R, Trehan A
Pediatr Hematol Oncol 2020 Oct;37(7):610-619. Epub 2020 Jun 19 doi: 10.1080/08880018.2020.1772912. PMID: 32558608
Investigational therapies for Ewing sarcoma: a search without a clear finding.
Vornicova O, Bar-Sela G
Expert Opin Investig Drugs 2016 Jun;25(6):679-86. Epub 2016 Apr 7 doi: 10.1517/13543784.2016.1168398. PMID: 26988130
Prospects and challenges for the development of new therapies for Ewing sarcoma.
Grohar PJ, Helman LJ
Pharmacol Ther 2013 Feb;137(2):216-24. Epub 2012 Oct 18 doi: 10.1016/j.pharmthera.2012.10.004. PMID: 23085431Free PMC Article
Ewing's sarcoma: standard and experimental treatment options.
Subbiah V, Anderson P, Lazar AJ, Burdett E, Raymond K, Ludwig JA
Curr Treat Options Oncol 2009 Apr;10(1-2):126-40. Epub 2009 Jun 17 doi: 10.1007/s11864-009-0104-6. PMID: 19533369
Ewing sarcoma: radiation dose and target volume.
Donaldson SS
Pediatr Blood Cancer 2004 May;42(5):471-6. doi: 10.1002/pbc.10472. PMID: 15049023

Clinical prediction guides

Histological response to neoadjuvant chemotherapy in localized Ewing sarcoma of the bone: A retrospective analysis of available scoring tools.
Righi A, Pacheco M, Palmerini E, Carretta E, Gambarotti M, Longhi A, Magagnoli G, Sbaraglia M, Manfrini M, Picci P, Dei Tos AP
Eur J Surg Oncol 2021 Jul;47(7):1778-1783. Epub 2021 Feb 16 doi: 10.1016/j.ejso.2021.02.009. PMID: 33622576
Challenges in the management of localized Ewing sarcoma in a developing country.
Totadri S, Bansal D, Rao KLN, Jain R, Saxena AK, Kapoor R, Samujh R, Trehan A
Pediatr Hematol Oncol 2020 Oct;37(7):610-619. Epub 2020 Jun 19 doi: 10.1080/08880018.2020.1772912. PMID: 32558608
Risk stratification by somatic mutation burden in Ewing sarcoma.
Liu KX, Lamba N, Hwang WL, Niemierko A, DuBois SG, Haas-Kogan DA
Cancer 2019 Apr 15;125(8):1357-1364. Epub 2019 Jan 2 doi: 10.1002/cncr.31919. PMID: 30602061
Localized Adult Ewing Sarcoma: Favorable Outcomes with Alternating Vincristine, Doxorubicin, Cyclophosphamide, and Ifosfamide, Etoposide (VDC/IE)-Based Multimodality Therapy.
Pretz JL, Barysauskas CM, George S, Hornick JL, Raut CP, Chen YE, Marcus KJ, Choy E, Hornicek F, Ready JE, DeLaney TF, Baldini EH
Oncologist 2017 Oct;22(10):1265-1270. Epub 2017 May 26 doi: 10.1634/theoncologist.2016-0463. PMID: 28550026Free PMC Article
Ewing's sarcoma: standard and experimental treatment options.
Subbiah V, Anderson P, Lazar AJ, Burdett E, Raymond K, Ludwig JA
Curr Treat Options Oncol 2009 Apr;10(1-2):126-40. Epub 2009 Jun 17 doi: 10.1007/s11864-009-0104-6. PMID: 19533369

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...