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Nephrotic Syndrome with Lesion of Persistent Glomerulonephritis

MedGen UID:
167849
•Concept ID:
C0866113
•
Disease or Syndrome

Definition

A renal functional disorder characterized by proteinuria, edema, hyperlipidemia and hypoalbuminemia. It results from damage to the renal vascular filtration apparatus. It is further characterized by a chronic inflammatory reaction in the glomerular capillaries. Sequelae may include hypertension, atherosclerosis, infection, hypercoagulablity and renal failure. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNephrotic Syndrome with Lesion of Persistent Glomerulonephritis

Professional guidelines

PubMed

Primary Membranous Nephropathy.
Couser WG
Clin J Am Soc Nephrol 2017 Jun 7;12(6):983-997. Epub 2017 May 26 doi: 10.2215/CJN.11761116. PMID: 28550082Free PMC Article
Treatment of the idiopathic nephrotic syndrome: regimens and outcomes in children and adults.
Tune BM, Mendoza SA
J Am Soc Nephrol 1997 May;8(5):824-32. doi: 10.1681/ASN.V85824. PMID: 9176855
Focal glomerulosclerosis: natural history and treatment. A report of 70 cases.
Beaufils H, Alphonse JC, Guedon J, Legrain M
Nephron 1978;21(2):75-85. doi: 10.1159/000181374. PMID: 673092

Recent clinical studies

Etiology

Points of view in nephrology: personalized management of IgA nephropathy, beyond KDIGO.
Trimarchi H, Fervenza FC, Coppo R
J Nephrol 2024 Apr;37(3):739-745. Epub 2024 Jan 18 doi: 10.1007/s40620-023-01833-3. PMID: 38236471
Glomerulosclerosis is a prognostic risk factor in patients with membranous nephropathy and non-nephrotic proteinuria.
Sun J, Li M, Zhu Q, Jia Y, Tian J, Zhang C, Du X
Ren Fail 2023 Dec;45(1):2188088. doi: 10.1080/0886022X.2023.2188088. PMID: 36967636Free PMC Article
Renal Involvement in Antiphospholipid Syndrome.
Turrent-Carriles A, Herrera-Félix JP, Amigo MC
Front Immunol 2018;9:1008. Epub 2018 May 17 doi: 10.3389/fimmu.2018.01008. PMID: 29867982Free PMC Article
Primary Membranous Nephropathy.
Couser WG
Clin J Am Soc Nephrol 2017 Jun 7;12(6):983-997. Epub 2017 May 26 doi: 10.2215/CJN.11761116. PMID: 28550082Free PMC Article
IgA nephropathy with presentation of nephrotic syndrome at onset in children.
Shima Y, Nakanishi K, Sato M, Hama T, Mukaiyama H, Togawa H, Tanaka R, Nozu K, Sako M, Iijima K, Suzuki H, Yoshikawa N
Pediatr Nephrol 2017 Mar;32(3):457-465. Epub 2016 Oct 6 doi: 10.1007/s00467-016-3502-6. PMID: 27714465

Diagnosis

Points of view in nephrology: personalized management of IgA nephropathy, beyond KDIGO.
Trimarchi H, Fervenza FC, Coppo R
J Nephrol 2024 Apr;37(3):739-745. Epub 2024 Jan 18 doi: 10.1007/s40620-023-01833-3. PMID: 38236471
Excretion Patterns of Urinary Sediment and Supernatant Podocyte Biomarkers in Patients with CKD.
Fukuda A, Minakawa A, Sato Y, Shibata H, Hara M, Fujimoto S
Kidney360 2022 Jan 27;3(1):63-73. Epub 2021 Nov 5 doi: 10.34067/KID.0004772021. PMID: 35368571Free PMC Article
Hydroxychloroquine-induced podocytopathy mimicking Fabry disease.
Serre J, Buob D, Boffa JJ
BMJ Case Rep 2019 May 13;12(5) doi: 10.1136/bcr-2018-228876. PMID: 31088818Free PMC Article
Primary Membranous Nephropathy.
Couser WG
Clin J Am Soc Nephrol 2017 Jun 7;12(6):983-997. Epub 2017 May 26 doi: 10.2215/CJN.11761116. PMID: 28550082Free PMC Article
Glomerular diseases: membranous nephropathy--a modern view.
Ponticelli C, Glassock RJ
Clin J Am Soc Nephrol 2014 Mar;9(3):609-16. Epub 2013 Jun 27 doi: 10.2215/CJN.04160413. PMID: 23813556Free PMC Article

Therapy

Points of view in nephrology: personalized management of IgA nephropathy, beyond KDIGO.
Trimarchi H, Fervenza FC, Coppo R
J Nephrol 2024 Apr;37(3):739-745. Epub 2024 Jan 18 doi: 10.1007/s40620-023-01833-3. PMID: 38236471
Primary Membranous Nephropathy.
Couser WG
Clin J Am Soc Nephrol 2017 Jun 7;12(6):983-997. Epub 2017 May 26 doi: 10.2215/CJN.11761116. PMID: 28550082Free PMC Article
IgA nephropathy with presentation of nephrotic syndrome at onset in children.
Shima Y, Nakanishi K, Sato M, Hama T, Mukaiyama H, Togawa H, Tanaka R, Nozu K, Sako M, Iijima K, Suzuki H, Yoshikawa N
Pediatr Nephrol 2017 Mar;32(3):457-465. Epub 2016 Oct 6 doi: 10.1007/s00467-016-3502-6. PMID: 27714465
Glomerular diseases: membranous nephropathy--a modern view.
Ponticelli C, Glassock RJ
Clin J Am Soc Nephrol 2014 Mar;9(3):609-16. Epub 2013 Jun 27 doi: 10.2215/CJN.04160413. PMID: 23813556Free PMC Article
Treatment of the idiopathic nephrotic syndrome: regimens and outcomes in children and adults.
Tune BM, Mendoza SA
J Am Soc Nephrol 1997 May;8(5):824-32. doi: 10.1681/ASN.V85824. PMID: 9176855

Prognosis

Glomerulosclerosis is a prognostic risk factor in patients with membranous nephropathy and non-nephrotic proteinuria.
Sun J, Li M, Zhu Q, Jia Y, Tian J, Zhang C, Du X
Ren Fail 2023 Dec;45(1):2188088. doi: 10.1080/0886022X.2023.2188088. PMID: 36967636Free PMC Article
Renal Involvement in Antiphospholipid Syndrome.
Turrent-Carriles A, Herrera-Félix JP, Amigo MC
Front Immunol 2018;9:1008. Epub 2018 May 17 doi: 10.3389/fimmu.2018.01008. PMID: 29867982Free PMC Article
IgA nephropathy with presentation of nephrotic syndrome at onset in children.
Shima Y, Nakanishi K, Sato M, Hama T, Mukaiyama H, Togawa H, Tanaka R, Nozu K, Sako M, Iijima K, Suzuki H, Yoshikawa N
Pediatr Nephrol 2017 Mar;32(3):457-465. Epub 2016 Oct 6 doi: 10.1007/s00467-016-3502-6. PMID: 27714465
Glomerular diseases: membranous nephropathy--a modern view.
Ponticelli C, Glassock RJ
Clin J Am Soc Nephrol 2014 Mar;9(3):609-16. Epub 2013 Jun 27 doi: 10.2215/CJN.04160413. PMID: 23813556Free PMC Article
Treatment of the idiopathic nephrotic syndrome: regimens and outcomes in children and adults.
Tune BM, Mendoza SA
J Am Soc Nephrol 1997 May;8(5):824-32. doi: 10.1681/ASN.V85824. PMID: 9176855

Clinical prediction guides

Glomerulosclerosis is a prognostic risk factor in patients with membranous nephropathy and non-nephrotic proteinuria.
Sun J, Li M, Zhu Q, Jia Y, Tian J, Zhang C, Du X
Ren Fail 2023 Dec;45(1):2188088. doi: 10.1080/0886022X.2023.2188088. PMID: 36967636Free PMC Article
Evaluation of renal lesions and clinicopathologic correlation in rheumatoid arthritis.
Muthukumar P, Dhanapriya J, Gopalakrishnan N, Dineshkumar T, Sakthirajan R, Balasubramaniyan T
Saudi J Kidney Dis Transpl 2017 Jan-Feb;28(1):44-50. doi: 10.4103/1319-2442.198118. PMID: 28098102
IgA nephropathy with presentation of nephrotic syndrome at onset in children.
Shima Y, Nakanishi K, Sato M, Hama T, Mukaiyama H, Togawa H, Tanaka R, Nozu K, Sako M, Iijima K, Suzuki H, Yoshikawa N
Pediatr Nephrol 2017 Mar;32(3):457-465. Epub 2016 Oct 6 doi: 10.1007/s00467-016-3502-6. PMID: 27714465
Glomerular diseases: membranous nephropathy--a modern view.
Ponticelli C, Glassock RJ
Clin J Am Soc Nephrol 2014 Mar;9(3):609-16. Epub 2013 Jun 27 doi: 10.2215/CJN.04160413. PMID: 23813556Free PMC Article
Mesangioproliferative glomerulonephritis.
Migone L, Olivetti G, Allegri L, Dall'Aglio P
Clin Nephrol 1980 May;13(5):219-30. PMID: 6994961

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