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Metastatic Sarcomatoid Renal Cell Carcinoma

MedGen UID:
1678535
•Concept ID:
C4763834
•
Neoplastic Process

Definition

Sarcomatoid renal cell carcinoma that has spread to another anatomical site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Sarcomatoid Renal Cell Carcinoma

Professional guidelines

PubMed

Renal cell carcinoma: an overview of the epidemiology, diagnosis, and treatment.
Bahadoram S, Davoodi M, Hassanzadeh S, Bahadoram M, Barahman M, Mafakher L
G Ital Nefrol 2022 Jun 20;39(3) PMID: 35819037
Management of Metastatic Clear Cell Renal Cell Carcinoma: ASCO Guideline.
Rathmell WK, Rumble RB, Van Veldhuizen PJ, Al-Ahmadie H, Emamekhoo H, Hauke RJ, Louie AV, Milowsky MI, Molina AM, Rose TL, Siva S, Zaorsky NG, Zhang T, Qamar R, Kungel TM, Lewis B, Singer EA
J Clin Oncol 2022 Sep 1;40(25):2957-2995. Epub 2022 Jun 21 doi: 10.1200/JCO.22.00868. PMID: 35728020
Renal Cell Carcinoma: Diagnosis and Management.
Gray RE, Harris GT
Am Fam Physician 2019 Feb 1;99(3):179-184. PMID: 30702258

Recent clinical studies

Etiology

The Role of Cytoreductive Nephrectomy in Renal Cell Carcinoma with Sarcomatoid Histology: A Case Series and Review of the Literature.
Studentova H, Rusarova N, Ondruskova A, Zemankova A, Student V Jr, Skanderova D, Melichar B
Curr Oncol 2022 Aug 3;29(8):5475-5488. doi: 10.3390/curroncol29080433. PMID: 36005171Free PMC Article
Cabozantinib in Pretreated Patients with Metastatic Renal Cell Carcinoma with Sarcomatoid Differentiation: A Real-World Study.
Santoni M, Massari F, Grande E, Procopio G, Matrana MR, Rizzo M, De Giorgi U, Basso U, Milella M, Iacovelli R, Aurilio G, Incorvaia L, Buti S, Caffo O, Fornarini G, Carrozza F, Mollica V, Rizzo A, Farag F, Molina-Cerrillo J, Battelli N
Target Oncol 2021 Sep;16(5):625-632. Epub 2021 Aug 2 doi: 10.1007/s11523-021-00828-z. PMID: 34338966
Immunotherapy in metastatic sarcomatoid renal cell carcinoma: A single institution experience.
Park JJ, Kellezi O, Hamasha R, Ali A, Alva AS
Cancer Treat Res Commun 2020;25:100251. Epub 2020 Nov 23 doi: 10.1016/j.ctarc.2020.100251. PMID: 33310369
A Population Study to Identify Candidates for Cytoreductive Nephrectomy in Patients with Metastatic Sarcomatoid Renal Cell Carcinoma from the Surveillance, Epidemiology, and End Results (SEER) Database.
Ji B, Li D, Fu S, Zhang Z, Yang T, Wu Y, Zuo Y, Xu Z, Yu N
Med Sci Monit 2020 Jun 9;26:e921297. doi: 10.12659/MSM.921297. PMID: 32516796Free PMC Article
Metastatic sarcomatoid renal cell carcinoma treated with vascular endothelial growth factor-targeted therapy.
Golshayan AR, George S, Heng DY, Elson P, Wood LS, Mekhail TM, Garcia JA, Aydin H, Zhou M, Bukowski RM, Rini BI
J Clin Oncol 2009 Jan 10;27(2):235-41. Epub 2008 Dec 8 doi: 10.1200/JCO.2008.18.0000. PMID: 19064974

Diagnosis

Nivolumab plus ipilimumab induced endocrinopathy and acute interstitial nephritis in metastatic sarcomatoid renal-cell carcinoma: A case report and review of literature.
Hino C, Nishino K, Pham B, Jeon WJ, Nguyen M, Cao H
Front Immunol 2022;13:993622. Epub 2022 Aug 16 doi: 10.3389/fimmu.2022.993622. PMID: 36052087Free PMC Article
A case of multiple metastatic sarcomatoid renal cell carcinoma with complete response to nivolumab.
Tomioka M, Nakane K, Ozawa K, Iinuma K, Suzui N, Miyazaki T, Koie T
Cancer Rep (Hoboken) 2021 Aug;4(4):e1356. Epub 2021 Mar 3 doi: 10.1002/cnr2.1356. PMID: 33656804Free PMC Article
Salvage ipilimumab associated with a significant response in sarcomatoid renal cell carcinoma.
George G, Schmidt L, Tolat P, Riese M, Kilari D
J Immunother Cancer 2020 Feb;8(1) doi: 10.1136/jitc-2020-000584. PMID: 32114501Free PMC Article
Metastatic sarcomatoid renal cell carcinoma manifesting as a subcutaneous soft tissue mass.
Logunova V, Sokumbi O, Iczkowski KA
J Cutan Pathol 2017 Oct;44(10):874-877. Epub 2017 Jul 24 doi: 10.1111/cup.12998. PMID: 28675457
Does postoperative radiation therapy impact survival in non-metastatic sarcomatoid renal cell carcinoma? A SEER-based study.
Eminaga O, Akbarov I, Wille S, Engelmann U
Int Urol Nephrol 2015 Oct;47(10):1653-63. Epub 2015 Sep 2 doi: 10.1007/s11255-015-1093-y. PMID: 26329746

Therapy

Nivolumab plus ipilimumab induced endocrinopathy and acute interstitial nephritis in metastatic sarcomatoid renal-cell carcinoma: A case report and review of literature.
Hino C, Nishino K, Pham B, Jeon WJ, Nguyen M, Cao H
Front Immunol 2022;13:993622. Epub 2022 Aug 16 doi: 10.3389/fimmu.2022.993622. PMID: 36052087Free PMC Article
The Role of Cytoreductive Nephrectomy in Renal Cell Carcinoma with Sarcomatoid Histology: A Case Series and Review of the Literature.
Studentova H, Rusarova N, Ondruskova A, Zemankova A, Student V Jr, Skanderova D, Melichar B
Curr Oncol 2022 Aug 3;29(8):5475-5488. doi: 10.3390/curroncol29080433. PMID: 36005171Free PMC Article
Immunotherapy in metastatic sarcomatoid renal cell carcinoma: A single institution experience.
Park JJ, Kellezi O, Hamasha R, Ali A, Alva AS
Cancer Treat Res Commun 2020;25:100251. Epub 2020 Nov 23 doi: 10.1016/j.ctarc.2020.100251. PMID: 33310369
A multicenter, prospective phase II trial of gemcitabine plus axitinib in patients with renal cell carcinoma with a predominant sarcomatoid component.
Park I, Lee HJ, Bae WK, Yoon S, Lee JL
Invest New Drugs 2019 Dec;37(6):1239-1246. Epub 2019 Jun 24 doi: 10.1007/s10637-019-00817-0. PMID: 31231787
Metastatic sarcomatoid renal cell carcinoma treated with vascular endothelial growth factor-targeted therapy.
Golshayan AR, George S, Heng DY, Elson P, Wood LS, Mekhail TM, Garcia JA, Aydin H, Zhou M, Bukowski RM, Rini BI
J Clin Oncol 2009 Jan 10;27(2):235-41. Epub 2008 Dec 8 doi: 10.1200/JCO.2008.18.0000. PMID: 19064974

Prognosis

Nivolumab plus ipilimumab induced endocrinopathy and acute interstitial nephritis in metastatic sarcomatoid renal-cell carcinoma: A case report and review of literature.
Hino C, Nishino K, Pham B, Jeon WJ, Nguyen M, Cao H
Front Immunol 2022;13:993622. Epub 2022 Aug 16 doi: 10.3389/fimmu.2022.993622. PMID: 36052087Free PMC Article
The Role of Cytoreductive Nephrectomy in Renal Cell Carcinoma with Sarcomatoid Histology: A Case Series and Review of the Literature.
Studentova H, Rusarova N, Ondruskova A, Zemankova A, Student V Jr, Skanderova D, Melichar B
Curr Oncol 2022 Aug 3;29(8):5475-5488. doi: 10.3390/curroncol29080433. PMID: 36005171Free PMC Article
Cabozantinib in Pretreated Patients with Metastatic Renal Cell Carcinoma with Sarcomatoid Differentiation: A Real-World Study.
Santoni M, Massari F, Grande E, Procopio G, Matrana MR, Rizzo M, De Giorgi U, Basso U, Milella M, Iacovelli R, Aurilio G, Incorvaia L, Buti S, Caffo O, Fornarini G, Carrozza F, Mollica V, Rizzo A, Farag F, Molina-Cerrillo J, Battelli N
Target Oncol 2021 Sep;16(5):625-632. Epub 2021 Aug 2 doi: 10.1007/s11523-021-00828-z. PMID: 34338966
Immunotherapy in metastatic sarcomatoid renal cell carcinoma: A single institution experience.
Park JJ, Kellezi O, Hamasha R, Ali A, Alva AS
Cancer Treat Res Commun 2020;25:100251. Epub 2020 Nov 23 doi: 10.1016/j.ctarc.2020.100251. PMID: 33310369
Does postoperative radiation therapy impact survival in non-metastatic sarcomatoid renal cell carcinoma? A SEER-based study.
Eminaga O, Akbarov I, Wille S, Engelmann U
Int Urol Nephrol 2015 Oct;47(10):1653-63. Epub 2015 Sep 2 doi: 10.1007/s11255-015-1093-y. PMID: 26329746

Clinical prediction guides

The Role of Cytoreductive Nephrectomy in Renal Cell Carcinoma with Sarcomatoid Histology: A Case Series and Review of the Literature.
Studentova H, Rusarova N, Ondruskova A, Zemankova A, Student V Jr, Skanderova D, Melichar B
Curr Oncol 2022 Aug 3;29(8):5475-5488. doi: 10.3390/curroncol29080433. PMID: 36005171Free PMC Article
Cabozantinib in Pretreated Patients with Metastatic Renal Cell Carcinoma with Sarcomatoid Differentiation: A Real-World Study.
Santoni M, Massari F, Grande E, Procopio G, Matrana MR, Rizzo M, De Giorgi U, Basso U, Milella M, Iacovelli R, Aurilio G, Incorvaia L, Buti S, Caffo O, Fornarini G, Carrozza F, Mollica V, Rizzo A, Farag F, Molina-Cerrillo J, Battelli N
Target Oncol 2021 Sep;16(5):625-632. Epub 2021 Aug 2 doi: 10.1007/s11523-021-00828-z. PMID: 34338966
A Population Study to Identify Candidates for Cytoreductive Nephrectomy in Patients with Metastatic Sarcomatoid Renal Cell Carcinoma from the Surveillance, Epidemiology, and End Results (SEER) Database.
Ji B, Li D, Fu S, Zhang Z, Yang T, Wu Y, Zuo Y, Xu Z, Yu N
Med Sci Monit 2020 Jun 9;26:e921297. doi: 10.12659/MSM.921297. PMID: 32516796Free PMC Article
Does postoperative radiation therapy impact survival in non-metastatic sarcomatoid renal cell carcinoma? A SEER-based study.
Eminaga O, Akbarov I, Wille S, Engelmann U
Int Urol Nephrol 2015 Oct;47(10):1653-63. Epub 2015 Sep 2 doi: 10.1007/s11255-015-1093-y. PMID: 26329746
Metastatic sarcomatoid renal cell carcinoma treated with vascular endothelial growth factor-targeted therapy.
Golshayan AR, George S, Heng DY, Elson P, Wood LS, Mekhail TM, Garcia JA, Aydin H, Zhou M, Bukowski RM, Rini BI
J Clin Oncol 2009 Jan 10;27(2):235-41. Epub 2008 Dec 8 doi: 10.1200/JCO.2008.18.0000. PMID: 19064974

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