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Recurrent Desmoplastic Small Round Cell Tumor

MedGen UID:
1678584
•Concept ID:
C4764225
•
Neoplastic Process

Definition

The reemergence of desmoplastic small round cell tumor after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Desmoplastic Small Round Cell Tumor

Professional guidelines

PubMed

Abdominal desmoplastic small round cell tumor: multimodal treatment combining chemotherapy, surgery, and radiotherapy is the best option.
Honoré C, Amroun K, Vilcot L, Mir O, Domont J, Terrier P, Le Cesne A, Le Péchoux C, Bonvalot S
Ann Surg Oncol 2015 Apr;22(4):1073-9. Epub 2014 Oct 10 doi: 10.1245/s10434-014-4123-6. PMID: 25300608
Updates on the multimodality management of desmoplastic small round cell tumor.
Kallianpur AA, Shukla NK, Deo SV, Yadav P, Mudaly D, Yadav R, Palaniappan RM
J Surg Oncol 2012 May;105(6):617-21. Epub 2012 Jan 3 doi: 10.1002/jso.22130. PMID: 22215508
Assessment of molecular genetic detection of chromosome translocations in the differential diagnosis of pediatric sarcomas.
Dockhorn-Dworniczak B, Schäfer KL, Blasius S, Christiansen H, Koscielniak E, Ritter J, Winkelmann W, Jürgens H, Böcker W
Klin Padiatr 1997 Jul-Aug;209(4):156-64. doi: 10.1055/s-2008-1043964. PMID: 9293447

Recent clinical studies

Etiology

Primary Pulmonary Round Cell Sarcomas: Multiple Potential Pitfalls for the Pathologist.
Richards R, Jour G, Tafe LJ, Pinto A, Brčić I, Linos K, Kerr DA
Int J Surg Pathol 2022 Dec;30(8):844-852. Epub 2022 Apr 11 doi: 10.1177/10668969221091586. PMID: 35404156
Desmoplastic Small Round Cell Tumors With EWS-WT1 Transcript Expression: Should We Consider Children and Adult Patients Differently?
Olivier-Gougenheim L, Orbach D, Atallah V, Marec-Berard P, Bertrand A
J Pediatr Hematol Oncol 2022 Apr 1;44(3):e637-e642. doi: 10.1097/MPH.0000000000002252. PMID: 34310472
Desmoplastic Small Round Cell Tumor of Pancreatic Origin in a Young Child: A Case Report and Review of Literature.
Saleh D, Al-Maghrabi S, Al-Maghrabi H, Al-Maghrabi J
Am J Case Rep 2020 Jul 13;21:e922762. doi: 10.12659/AJCR.922762. PMID: 32655125Free PMC Article
Desmoplastic Small Round Cell Tumor: Long-Term Complications After Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy.
Stiles ZE, Murphy AJ, Anghelescu DL, Brown CL, Davidoff AM, Dickson PV, Glazer ES, Bishop MW, Furman WL, Pappo AS, Lucas JT Jr, Deneve JL
Ann Surg Oncol 2020 Jan;27(1):171-178. Epub 2019 Apr 8 doi: 10.1245/s10434-019-07339-2. PMID: 30963398Free PMC Article
Complete cytoreduction and HIPEC improves survival in desmoplastic small round cell tumor.
Hayes-Jordan A, Green HL, Lin H, Owusu-Agyemang P, Fitzgerald N, Arunkumar R, Mejia R, Okhuysen-Cawley R, Mauricio R, Fournier K, Ludwig J, Anderson P
Ann Surg Oncol 2014 Jan;21(1):220-4. Epub 2013 Sep 18 doi: 10.1245/s10434-013-3269-y. PMID: 24046124

Diagnosis

Desmoplastic Small Round Cell Tumor of the Head and Neck: A Clinicopathological, Immunohistochemical and Molecular Analysis of Three Cases with Literature Review.
Sun M, Shao M, Jiang X, Yin T, Wang Q, Zhao L, Liu J, Lao IW, Yu L, Wang J
Int J Surg Pathol 2023 Aug;31(5):742-750. Epub 2022 Sep 28 doi: 10.1177/10668969221117989. PMID: 36172631
Desmoplastic Small Round Cell Tumor in a Pregnant Woman: A Case Report and Literature Review.
Zhou H, Alhaskawi A, Sun Q, Dong Y, Kota VG, Hasan Abdulla MHA, Ezzi SHA, Wang Z, Lu H
Yale J Biol Med 2021 Dec;94(4):613-622. Epub 2021 Dec 29 PMID: 34970100Free PMC Article
Recurrent secondary genomic alterations in desmoplastic small round cell tumors.
Chow WA, Yee JK, Tsark W, Wu X, Qin H, Guan M, Ross JS, Ali SM, Millis SZ
BMC Med Genet 2020 May 11;21(1):101. doi: 10.1186/s12881-020-01034-w. PMID: 32393201Free PMC Article
Desmoplastic small round cell tumor of the parotid gland-report of a rare case and a review of the literature.
Hatanaka KC, Takakuwa E, Hatanaka Y, Suzuki A, IIzuka S, Tsushima N, Mitsuhashi T, Sugita S, Homma A, Morinaga S, Hashegawa T, Matsuno Y
Diagn Pathol 2019 May 18;14(1):43. doi: 10.1186/s13000-019-0825-1. PMID: 31103034Free PMC Article
Desmoplastic Small Round Cell Tumor: Pathology, Genetics, and Potential Therapeutic Strategies.
Thway K, Noujaim J, Zaidi S, Miah AB, Benson C, Messiou C, Jones RL, Fisher C
Int J Surg Pathol 2016 Dec;24(8):672-684. Epub 2016 Sep 12 doi: 10.1177/1066896916668637. PMID: 27621277

Therapy

Desmoplastic Small Round Cell Tumor: Long-Term Complications After Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy.
Stiles ZE, Murphy AJ, Anghelescu DL, Brown CL, Davidoff AM, Dickson PV, Glazer ES, Bishop MW, Furman WL, Pappo AS, Lucas JT Jr, Deneve JL
Ann Surg Oncol 2020 Jan;27(1):171-178. Epub 2019 Apr 8 doi: 10.1245/s10434-019-07339-2. PMID: 30963398Free PMC Article
Recurrent desmoplastic small round cell tumor responding to an mTOR inhibitor containing regimen.
Tarek N, Hayes-Jordan A, Salvador L, McAleer MF, Herzog CE, Huh WW
Pediatr Blood Cancer 2018 Jan;65(1) Epub 2017 Sep 22 doi: 10.1002/pbc.26768. PMID: 28941151
Human Epidermal Growth Factor Receptor 2 (HER2) -Specific Chimeric Antigen Receptor-Modified T Cells for the Immunotherapy of HER2-Positive Sarcoma.
Ahmed N, Brawley VS, Hegde M, Robertson C, Ghazi A, Gerken C, Liu E, Dakhova O, Ashoori A, Corder A, Gray T, Wu MF, Liu H, Hicks J, Rainusso N, Dotti G, Mei Z, Grilley B, Gee A, Rooney CM, Brenner MK, Heslop HE, Wels WS, Wang LL, Anderson P, Gottschalk S
J Clin Oncol 2015 May 20;33(15):1688-96. Epub 2015 Mar 23 doi: 10.1200/JCO.2014.58.0225. PMID: 25800760Free PMC Article
Complete cytoreduction and HIPEC improves survival in desmoplastic small round cell tumor.
Hayes-Jordan A, Green HL, Lin H, Owusu-Agyemang P, Fitzgerald N, Arunkumar R, Mejia R, Okhuysen-Cawley R, Mauricio R, Fournier K, Ludwig J, Anderson P
Ann Surg Oncol 2014 Jan;21(1):220-4. Epub 2013 Sep 18 doi: 10.1245/s10434-013-3269-y. PMID: 24046124
Updates on the multimodality management of desmoplastic small round cell tumor.
Kallianpur AA, Shukla NK, Deo SV, Yadav P, Mudaly D, Yadav R, Palaniappan RM
J Surg Oncol 2012 May;105(6):617-21. Epub 2012 Jan 3 doi: 10.1002/jso.22130. PMID: 22215508

Prognosis

Desmoplastic Small Round Cell Tumor in a Pregnant Woman: A Case Report and Literature Review.
Zhou H, Alhaskawi A, Sun Q, Dong Y, Kota VG, Hasan Abdulla MHA, Ezzi SHA, Wang Z, Lu H
Yale J Biol Med 2021 Dec;94(4):613-622. Epub 2021 Dec 29 PMID: 34970100Free PMC Article
Recurrent secondary genomic alterations in desmoplastic small round cell tumors.
Chow WA, Yee JK, Tsark W, Wu X, Qin H, Guan M, Ross JS, Ali SM, Millis SZ
BMC Med Genet 2020 May 11;21(1):101. doi: 10.1186/s12881-020-01034-w. PMID: 32393201Free PMC Article
Desmoplastic Small Round Cell Tumor: Long-Term Complications After Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy.
Stiles ZE, Murphy AJ, Anghelescu DL, Brown CL, Davidoff AM, Dickson PV, Glazer ES, Bishop MW, Furman WL, Pappo AS, Lucas JT Jr, Deneve JL
Ann Surg Oncol 2020 Jan;27(1):171-178. Epub 2019 Apr 8 doi: 10.1245/s10434-019-07339-2. PMID: 30963398Free PMC Article
Recurrent desmoplastic small round cell tumor responding to an mTOR inhibitor containing regimen.
Tarek N, Hayes-Jordan A, Salvador L, McAleer MF, Herzog CE, Huh WW
Pediatr Blood Cancer 2018 Jan;65(1) Epub 2017 Sep 22 doi: 10.1002/pbc.26768. PMID: 28941151
Desmoplastic Small Round Cell Tumor: Pathology, Genetics, and Potential Therapeutic Strategies.
Thway K, Noujaim J, Zaidi S, Miah AB, Benson C, Messiou C, Jones RL, Fisher C
Int J Surg Pathol 2016 Dec;24(8):672-684. Epub 2016 Sep 12 doi: 10.1177/1066896916668637. PMID: 27621277

Clinical prediction guides

Desmoplastic Small Round Cell Tumor With Ascending Intraspinal Metastasis at Recurrence: Case Report and Review of the Literature.
Cacciotti C, Samji N, Cox S, Yikilmaz A, Hann C, Marin JA, Fowler J, VanHouwelingen L, Athale U
J Pediatr Hematol Oncol 2022 Mar 1;44(2):e561-e566. doi: 10.1097/MPH.0000000000002138. PMID: 33710117
Recurrent secondary genomic alterations in desmoplastic small round cell tumors.
Chow WA, Yee JK, Tsark W, Wu X, Qin H, Guan M, Ross JS, Ali SM, Millis SZ
BMC Med Genet 2020 May 11;21(1):101. doi: 10.1186/s12881-020-01034-w. PMID: 32393201Free PMC Article
Recurrent desmoplastic small round cell tumor responding to an mTOR inhibitor containing regimen.
Tarek N, Hayes-Jordan A, Salvador L, McAleer MF, Herzog CE, Huh WW
Pediatr Blood Cancer 2018 Jan;65(1) Epub 2017 Sep 22 doi: 10.1002/pbc.26768. PMID: 28941151
Complete cytoreduction and HIPEC improves survival in desmoplastic small round cell tumor.
Hayes-Jordan A, Green HL, Lin H, Owusu-Agyemang P, Fitzgerald N, Arunkumar R, Mejia R, Okhuysen-Cawley R, Mauricio R, Fournier K, Ludwig J, Anderson P
Ann Surg Oncol 2014 Jan;21(1):220-4. Epub 2013 Sep 18 doi: 10.1245/s10434-013-3269-y. PMID: 24046124
FNA biopsy of small round cell tumors of childhood: cytomorphologic features and the role of ancillary studies.
Silverman JF, Joshi VV
Diagn Cytopathol 1994;10(3):245-55. doi: 10.1002/dc.2840100312. PMID: 8050333

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