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Transformed Chronic Lymphocytic Leukemia to Diffuse Large B-Cell Lymphoma

MedGen UID:
1678720
Concept ID:
C4763751
Neoplastic Process

Definition

Histologic transformation of an indolent chronic lymphocytic leukemia to an aggressive diffuse large B-cell lymphoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTransformed Chronic Lymphocytic Leukemia to Diffuse Large B-Cell Lymphoma

Professional guidelines

PubMed

Thompson PA, Siddiqi T
Hematology Am Soc Hematol Educ Program 2022 Dec 9;2022(1):329-336. doi: 10.1182/hematology.2022000345. PMID: 36485138Free PMC Article
Condoluci A, Rossi D
Curr Treat Options Oncol 2017 Nov 21;18(12):75. doi: 10.1007/s11864-017-0512-y. PMID: 29159711
Rossi D, Gaidano G
Semin Oncol 2016 Apr;43(2):311-9. Epub 2016 Feb 15 doi: 10.1053/j.seminoncol.2016.02.012. PMID: 27040710

Recent clinical studies

Etiology

Parry EM, Ten Hacken E, Wu CJ
Blood 2023 Jul 6;142(1):11-22. doi: 10.1182/blood.2022016502. PMID: 36758208Free PMC Article
Klintman J, Appleby N, Stamatopoulos B, Ridout K, Eyre TA, Robbe P, Pascua LL, Knight SJL, Dreau H, Cabes M, Popitsch N, Ehinger M, Martín-Subero JI, Campo E, Månsson R, Rossi D, Taylor JC, Vavoulis DV, Schuh A
Blood 2021 May 20;137(20):2800-2816. doi: 10.1182/blood.2020005650. PMID: 33206936Free PMC Article
Davids MS, Roberts AW, Seymour JF, Pagel JM, Kahl BS, Wierda WG, Puvvada S, Kipps TJ, Anderson MA, Salem AH, Dunbar M, Zhu M, Peale F, Ross JA, Gressick L, Desai M, Kim SY, Verdugo M, Humerickhouse RA, Gordon GB, Gerecitano JF
J Clin Oncol 2017 Mar 10;35(8):826-833. Epub 2017 Jan 17 doi: 10.1200/JCO.2016.70.4320. PMID: 28095146Free PMC Article
Jain N, Keating MJ
Expert Rev Hematol 2016 Aug;9(8):793-801. Epub 2016 Jun 28 doi: 10.1080/17474086.2016.1199948. PMID: 27351634
Rossi D, Gaidano G
Adv Exp Med Biol 2013;792:173-91. doi: 10.1007/978-1-4614-8051-8_8. PMID: 24014297

Diagnosis

Parry EM, Ten Hacken E, Wu CJ
Blood 2023 Jul 6;142(1):11-22. doi: 10.1182/blood.2022016502. PMID: 36758208Free PMC Article
Parry EM, Leshchiner I, Guièze R, Johnson C, Tausch E, Parikh SA, Lemvigh C, Broséus J, Hergalant S, Messer C, Utro F, Levovitz C, Rhrissorrakrai K, Li L, Rosebrock D, Yin S, Deng S, Slowik K, Jacobs R, Huang T, Li S, Fell G, Redd R, Lin Z, Knisbacher BA, Livitz D, Schneider C, Ruthen N, Elagina L, Taylor-Weiner A, Persaud B, Martinez A, Fernandes SM, Purroy N, Anandappa AJ, Ma J, Hess J, Rassenti LZ, Kipps TJ, Jain N, Wierda W, Cymbalista F, Feugier P, Kay NE, Livak KJ, Danysh BP, Stewart C, Neuberg D, Davids MS, Brown JR, Parida L, Stilgenbauer S, Getz G, Wu CJ
Nat Med 2023 Jan;29(1):158-169. Epub 2023 Jan 9 doi: 10.1038/s41591-022-02113-6. PMID: 36624313Free PMC Article
Nakhoda S, Vistarop A, Wang YL
Br J Haematol 2023 Jan;200(2):137-149. Epub 2022 Aug 27 doi: 10.1111/bjh.18418. PMID: 36029036Free PMC Article
Nadeu F, Royo R, Massoni-Badosa R, Playa-Albinyana H, Garcia-Torre B, Duran-Ferrer M, Dawson KJ, Kulis M, Diaz-Navarro A, Villamor N, Melero JL, Chapaprieta V, Dueso-Barroso A, Delgado J, Moia R, Ruiz-Gil S, Marchese D, Giró A, Verdaguer-Dot N, Romo M, Clot G, Rozman M, Frigola G, Rivas-Delgado A, Baumann T, Alcoceba M, González M, Climent F, Abrisqueta P, Castellví J, Bosch F, Aymerich M, Enjuanes A, Ruiz-Gaspà S, López-Guillermo A, Jares P, Beà S, Capella-Gutierrez S, Gelpí JL, López-Bigas N, Torrents D, Campbell PJ, Gut I, Rossi D, Gaidano G, Puente XS, Garcia-Roves PM, Colomer D, Heyn H, Maura F, Martín-Subero JI, Campo E
Nat Med 2022 Aug;28(8):1662-1671. Epub 2022 Aug 11 doi: 10.1038/s41591-022-01927-8. PMID: 35953718Free PMC Article
Elton TS, Selemon H, Elton SM, Parinandi NL
Gene 2013 Dec 10;532(1):1-12. Epub 2012 Dec 14 doi: 10.1016/j.gene.2012.12.009. PMID: 23246696

Therapy

Nakhoda S, Vistarop A, Wang YL
Br J Haematol 2023 Jan;200(2):137-149. Epub 2022 Aug 27 doi: 10.1111/bjh.18418. PMID: 36029036Free PMC Article
Thompson PA, Siddiqi T
Hematology Am Soc Hematol Educ Program 2022 Dec 9;2022(1):329-336. doi: 10.1182/hematology.2022000345. PMID: 36485138Free PMC Article
Sigmund AM, Kittai AS
Curr Oncol Rep 2022 Aug;24(8):1081-1090. Epub 2022 Apr 6 doi: 10.1007/s11912-022-01274-4. PMID: 35384590
Condoluci A, Rossi D
Curr Oncol Rep 2021 Feb 12;23(3):26. doi: 10.1007/s11912-020-01001-x. PMID: 33580422Free PMC Article
Xu-Monette ZY, Zhou J, Young KH
Blood 2018 Jan 4;131(1):68-83. Epub 2017 Nov 8 doi: 10.1182/blood-2017-07-740993. PMID: 29118007Free PMC Article

Prognosis

Nadeu F, Royo R, Massoni-Badosa R, Playa-Albinyana H, Garcia-Torre B, Duran-Ferrer M, Dawson KJ, Kulis M, Diaz-Navarro A, Villamor N, Melero JL, Chapaprieta V, Dueso-Barroso A, Delgado J, Moia R, Ruiz-Gil S, Marchese D, Giró A, Verdaguer-Dot N, Romo M, Clot G, Rozman M, Frigola G, Rivas-Delgado A, Baumann T, Alcoceba M, González M, Climent F, Abrisqueta P, Castellví J, Bosch F, Aymerich M, Enjuanes A, Ruiz-Gaspà S, López-Guillermo A, Jares P, Beà S, Capella-Gutierrez S, Gelpí JL, López-Bigas N, Torrents D, Campbell PJ, Gut I, Rossi D, Gaidano G, Puente XS, Garcia-Roves PM, Colomer D, Heyn H, Maura F, Martín-Subero JI, Campo E
Nat Med 2022 Aug;28(8):1662-1671. Epub 2022 Aug 11 doi: 10.1038/s41591-022-01927-8. PMID: 35953718Free PMC Article
Sigmund AM, Kittai AS
Curr Oncol Rep 2022 Aug;24(8):1081-1090. Epub 2022 Apr 6 doi: 10.1007/s11912-022-01274-4. PMID: 35384590
Condoluci A, Rossi D
Curr Oncol Rep 2021 Feb 12;23(3):26. doi: 10.1007/s11912-020-01001-x. PMID: 33580422Free PMC Article
Xu-Monette ZY, Zhou J, Young KH
Blood 2018 Jan 4;131(1):68-83. Epub 2017 Nov 8 doi: 10.1182/blood-2017-07-740993. PMID: 29118007Free PMC Article
Rossi D, Gaidano G
Adv Exp Med Biol 2013;792:173-91. doi: 10.1007/978-1-4614-8051-8_8. PMID: 24014297

Clinical prediction guides

Sigmund AM, Kittai AS
Curr Oncol Rep 2022 Aug;24(8):1081-1090. Epub 2022 Apr 6 doi: 10.1007/s11912-022-01274-4. PMID: 35384590
Rhodes JM, Mato AR
PET Clin 2019 Jul;14(3):405-410. Epub 2019 Apr 12 doi: 10.1016/j.cpet.2019.03.007. PMID: 31084779
Xu-Monette ZY, Zhou J, Young KH
Blood 2018 Jan 4;131(1):68-83. Epub 2017 Nov 8 doi: 10.1182/blood-2017-07-740993. PMID: 29118007Free PMC Article
Davids MS, Roberts AW, Seymour JF, Pagel JM, Kahl BS, Wierda WG, Puvvada S, Kipps TJ, Anderson MA, Salem AH, Dunbar M, Zhu M, Peale F, Ross JA, Gressick L, Desai M, Kim SY, Verdugo M, Humerickhouse RA, Gordon GB, Gerecitano JF
J Clin Oncol 2017 Mar 10;35(8):826-833. Epub 2017 Jan 17 doi: 10.1200/JCO.2016.70.4320. PMID: 28095146Free PMC Article
Rossi D, Gaidano G
Adv Exp Med Biol 2013;792:173-91. doi: 10.1007/978-1-4614-8051-8_8. PMID: 24014297

Recent systematic reviews

Sousa-Pimenta M, Martins Â, Mariz JM, Berraondo P
Front Immunol 2023;14:1295293. Epub 2023 Nov 23 doi: 10.3389/fimmu.2023.1295293. PMID: 38077330Free PMC Article
Delestre F, Blanche P, Bouayed E, Bouscary D, Mouthon L, Brezin A, Le Jeunne C, Chaigne B
Surv Ophthalmol 2021 Jan-Feb;66(1):124-131. Epub 2020 May 11 doi: 10.1016/j.survophthal.2020.05.001. PMID: 32407752
Wen KW, Fakhri B, Menke J, Ruiz-Cordero R, Gill RM, Ohgami RS
Ann Diagn Pathol 2020 Jun;46:151534. Epub 2020 May 15 doi: 10.1016/j.anndiagpath.2020.151534. PMID: 32473554

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