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Metastatic Lung Neuroendocrine Neoplasm

MedGen UID:
1679441
•Concept ID:
C4763733
•
Neoplastic Process

Definition

A neuroendocrine neoplasm that arises from the lung and has spread to another anatomic site. [from NCI]

Professional guidelines

PubMed

Small Cell Lung Cancer, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology.
Ganti AKP, Loo BW, Bassetti M, Blakely C, Chiang A, D'Amico TA, D'Avella C, Dowlati A, Downey RJ, Edelman M, Florsheim C, Gold KA, Goldman JW, Grecula JC, Hann C, Iams W, Iyengar P, Kelly K, Khalil M, Koczywas M, Merritt RE, Mohindra N, Molina J, Moran C, Pokharel S, Puri S, Qin A, Rusthoven C, Sands J, Santana-Davila R, Shafique M, Waqar SN, Gregory KM, Hughes M
J Natl Compr Canc Netw 2021 Dec;19(12):1441-1464. doi: 10.6004/jnccn.2021.0058. PMID: 34902832Free PMC Article
Best Practices Recommendations for Diagnostic Immunohistochemistry in Lung Cancer.
Yatabe Y, Dacic S, Borczuk AC, Warth A, Russell PA, Lantuejoul S, Beasley MB, Thunnissen E, Pelosi G, Rekhtman N, Bubendorf L, Mino-Kenudson M, Yoshida A, Geisinger KR, Noguchi M, Chirieac LR, Bolting J, Chung JH, Chou TY, Chen G, Poleri C, Lopez-Rios F, Papotti M, Sholl LM, Roden AC, Travis WD, Hirsch FR, Kerr KM, Tsao MS, Nicholson AG, Wistuba I, Moreira AL
J Thorac Oncol 2019 Mar;14(3):377-407. Epub 2018 Dec 18 doi: 10.1016/j.jtho.2018.12.005. PMID: 30572031Free PMC Article
Management of toxicities of immune checkpoint inhibitors.
Spain L, Diem S, Larkin J
Cancer Treat Rev 2016 Mar;44:51-60. Epub 2016 Feb 6 doi: 10.1016/j.ctrv.2016.02.001. PMID: 26874776

Recent clinical studies

Etiology

Immunogenomic Landscape of Neuroendocrine Prostate Cancer.
Bhinder B, Ferguson A, Sigouros M, Uppal M, Elsaeed AG, Bareja R, Alnajar H, Eng KW, Conteduca V, Sboner A, Mosquera JM, Elemento O, Beltran H
Clin Cancer Res 2023 Aug 1;29(15):2933-2943. doi: 10.1158/1078-0432.CCR-22-3743. PMID: 37223924Free PMC Article
Overview of the 2022 WHO Classification of Paragangliomas and Pheochromocytomas.
Mete O, Asa SL, Gill AJ, Kimura N, de Krijger RR, Tischler A
Endocr Pathol 2022 Mar;33(1):90-114. Epub 2022 Mar 13 doi: 10.1007/s12022-022-09704-6. PMID: 35285002
Single-cell RNA sequencing reveals spatiotemporal heterogeneity and malignant progression in pancreatic neuroendocrine tumor.
Zhou Y, Liu S, Liu C, Yang J, Lin Q, Zheng S, Chen C, Zhou Q, Chen R
Int J Biol Sci 2021;17(14):3760-3775. Epub 2021 Aug 28 doi: 10.7150/ijbs.61717. PMID: 34671197Free PMC Article
Everolimus for the treatment of advanced, non-functional neuroendocrine tumours of the lung or gastrointestinal tract (RADIANT-4): a randomised, placebo-controlled, phase 3 study.
Yao JC, Fazio N, Singh S, Buzzoni R, Carnaghi C, Wolin E, Tomasek J, Raderer M, Lahner H, Voi M, Pacaud LB, Rouyrre N, Sachs C, Valle JW, Fave GD, Van Cutsem E, Tesselaar M, Shimada Y, Oh DY, Strosberg J, Kulke MH, Pavel ME; RAD001 in Advanced Neuroendocrine Tumours, Fourth Trial (RADIANT-4) Study Group
Lancet 2016 Mar 5;387(10022):968-977. Epub 2015 Dec 17 doi: 10.1016/S0140-6736(15)00817-X. PMID: 26703889Free PMC Article
Brain metastases.
Ewend MG, Carey LA, Morris DE, Harvey RD, Hensing TA
Curr Treat Options Oncol 2001 Dec;2(6):537-47. doi: 10.1007/s11864-001-0075-8. PMID: 12057099

Diagnosis

Radiotheranostics in oncology: Making precision medicine possible.
Aboagye EO, Barwick TD, Haberkorn U
CA Cancer J Clin 2023 May-Jun;73(3):255-274. Epub 2023 Jan 9 doi: 10.3322/caac.21768. PMID: 36622841
Overview of the 2022 WHO Classification of Paragangliomas and Pheochromocytomas.
Mete O, Asa SL, Gill AJ, Kimura N, de Krijger RR, Tischler A
Endocr Pathol 2022 Mar;33(1):90-114. Epub 2022 Mar 13 doi: 10.1007/s12022-022-09704-6. PMID: 35285002
Commonwealth Neuroendocrine Tumour Research Collaboration and the North American Neuroendocrine Tumor Society Guidelines for the Diagnosis and Management of Patients With Lung Neuroendocrine Tumors: An International Collaborative Endorsement and Update of the 2015 European Neuroendocrine Tumor Society Expert Consensus Guidelines.
Singh S, Bergsland EK, Card CM, Hope TA, Kunz PL, Laidley DT, Lawrence B, Leyden S, Metz DC, Michael M, Modahl LE, Myrehaug S, Padda SK, Pommier RF, Ramirez RA, Soulen M, Strosberg J, Sung A, Thawer A, Wei B, Xu B, Segelov E
J Thorac Oncol 2020 Oct;15(10):1577-1598. Epub 2020 Jul 11 doi: 10.1016/j.jtho.2020.06.021. PMID: 32663527
Metastatic melanoma.
Kudchadkar RR, Lowe MC, Khan MK, McBrien SM
CA Cancer J Clin 2020 Mar;70(2):78-85. Epub 2020 Feb 26 doi: 10.3322/caac.21599. PMID: 32101327
Pulmonary neuroendocrine (carcinoid) tumors: European Neuroendocrine Tumor Society expert consensus and recommendations for best practice for typical and atypical pulmonary carcinoids.
Caplin ME, Baudin E, Ferolla P, Filosso P, Garcia-Yuste M, Lim E, Oberg K, Pelosi G, Perren A, Rossi RE, Travis WD; ENETS consensus conference participants
Ann Oncol 2015 Aug;26(8):1604-20. Epub 2015 Feb 2 doi: 10.1093/annonc/mdv041. PMID: 25646366

Therapy

Radiotheranostics in oncology: Making precision medicine possible.
Aboagye EO, Barwick TD, Haberkorn U
CA Cancer J Clin 2023 May-Jun;73(3):255-274. Epub 2023 Jan 9 doi: 10.3322/caac.21768. PMID: 36622841
Serotonin Pathway in Cancer.
Balakrishna P, George S, Hatoum H, Mukherjee S
Int J Mol Sci 2021 Jan 28;22(3) doi: 10.3390/ijms22031268. PMID: 33525332Free PMC Article
Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy.
Lv M, Chen M, Zhang R, Zhang W, Wang C, Zhang Y, Wei X, Guan Y, Liu J, Feng K, Jing M, Wang X, Liu YC, Mei Q, Han W, Jiang Z
Cell Res 2020 Nov;30(11):966-979. Epub 2020 Aug 24 doi: 10.1038/s41422-020-00395-4. PMID: 32839553Free PMC Article
Commonwealth Neuroendocrine Tumour Research Collaboration and the North American Neuroendocrine Tumor Society Guidelines for the Diagnosis and Management of Patients With Lung Neuroendocrine Tumors: An International Collaborative Endorsement and Update of the 2015 European Neuroendocrine Tumor Society Expert Consensus Guidelines.
Singh S, Bergsland EK, Card CM, Hope TA, Kunz PL, Laidley DT, Lawrence B, Leyden S, Metz DC, Michael M, Modahl LE, Myrehaug S, Padda SK, Pommier RF, Ramirez RA, Soulen M, Strosberg J, Sung A, Thawer A, Wei B, Xu B, Segelov E
J Thorac Oncol 2020 Oct;15(10):1577-1598. Epub 2020 Jul 11 doi: 10.1016/j.jtho.2020.06.021. PMID: 32663527
Selective RET kinase inhibition for patients with RET-altered cancers.
Subbiah V, Velcheti V, Tuch BB, Ebata K, Busaidy NL, Cabanillas ME, Wirth LJ, Stock S, Smith S, Lauriault V, Corsi-Travali S, Henry D, Burkard M, Hamor R, Bouhana K, Winski S, Wallace RD, Hartley D, Rhodes S, Reddy M, Brandhuber BJ, Andrews S, Rothenberg SM, Drilon A
Ann Oncol 2018 Aug 1;29(8):1869-1876. doi: 10.1093/annonc/mdy137. PMID: 29912274Free PMC Article

Prognosis

Organ-Specificity of Breast Cancer Metastasis.
Ibragimova MK, Tsyganov MM, Kravtsova EA, Tsydenova IA, Litviakov NV
Int J Mol Sci 2023 Oct 26;24(21) doi: 10.3390/ijms242115625. PMID: 37958607Free PMC Article
Overview of the 2022 WHO Classification of Paragangliomas and Pheochromocytomas.
Mete O, Asa SL, Gill AJ, Kimura N, de Krijger RR, Tischler A
Endocr Pathol 2022 Mar;33(1):90-114. Epub 2022 Mar 13 doi: 10.1007/s12022-022-09704-6. PMID: 35285002
The single-cell transcriptional landscape of lung carcinoid tumors.
Bischoff P, Trinks A, Wiederspahn J, Obermayer B, Pett JP, Jurmeister P, Elsner A, Dziodzio T, Rückert JC, Neudecker J, Falk C, Beule D, Sers C, Morkel M, Horst D, Klauschen F, Blüthgen N
Int J Cancer 2022 Jun 15;150(12):2058-2071. Epub 2022 Mar 16 doi: 10.1002/ijc.33995. PMID: 35262195
Single-cell RNA sequencing reveals spatiotemporal heterogeneity and malignant progression in pancreatic neuroendocrine tumor.
Zhou Y, Liu S, Liu C, Yang J, Lin Q, Zheng S, Chen C, Zhou Q, Chen R
Int J Biol Sci 2021;17(14):3760-3775. Epub 2021 Aug 28 doi: 10.7150/ijbs.61717. PMID: 34671197Free PMC Article
Pulmonary neuroendocrine (carcinoid) tumors: European Neuroendocrine Tumor Society expert consensus and recommendations for best practice for typical and atypical pulmonary carcinoids.
Caplin ME, Baudin E, Ferolla P, Filosso P, Garcia-Yuste M, Lim E, Oberg K, Pelosi G, Perren A, Rossi RE, Travis WD; ENETS consensus conference participants
Ann Oncol 2015 Aug;26(8):1604-20. Epub 2015 Feb 2 doi: 10.1093/annonc/mdv041. PMID: 25646366

Clinical prediction guides

Understanding the increasing incidence of neuroendocrine tumors.
Pathak S, Starr JS, Halfdanarson T, Sonbol MB
Expert Rev Endocrinol Metab 2023 Sep-Nov;18(5):377-385. Epub 2023 Jul 19 doi: 10.1080/17446651.2023.2237593. PMID: 37466336
IL-18-secreting CAR T cells targeting DLL3 are highly effective in small cell lung cancer models.
Jaspers JE, Khan JF, Godfrey WD, Lopez AV, Ciampricotti M, Rudin CM, Brentjens RJ
J Clin Invest 2023 May 1;133(9) doi: 10.1172/JCI166028. PMID: 36951942Free PMC Article
Overview of the 2022 WHO Classification of Paragangliomas and Pheochromocytomas.
Mete O, Asa SL, Gill AJ, Kimura N, de Krijger RR, Tischler A
Endocr Pathol 2022 Mar;33(1):90-114. Epub 2022 Mar 13 doi: 10.1007/s12022-022-09704-6. PMID: 35285002
Predicting response to cancer immunotherapy using noninvasive radiomic biomarkers.
Trebeschi S, Drago SG, Birkbak NJ, Kurilova I, Cǎlin AM, Delli Pizzi A, Lalezari F, Lambregts DMJ, Rohaan MW, Parmar C, Rozeman EA, Hartemink KJ, Swanton C, Haanen JBAG, Blank CU, Smit EF, Beets-Tan RGH, Aerts HJWL
Ann Oncol 2019 Jun 1;30(6):998-1004. doi: 10.1093/annonc/mdz108. PMID: 30895304Free PMC Article
GATA3: a multispecific but potentially useful marker in surgical pathology: a systematic analysis of 2500 epithelial and nonepithelial tumors.
Miettinen M, McCue PA, Sarlomo-Rikala M, Rys J, Czapiewski P, Wazny K, Langfort R, Waloszczyk P, Biernat W, Lasota J, Wang Z
Am J Surg Pathol 2014 Jan;38(1):13-22. doi: 10.1097/PAS.0b013e3182a0218f. PMID: 24145643Free PMC Article

Recent systematic reviews

Endocrine and paracrine characteristics of neuroendocrine prostate cancer.
Arman T, Nelson PS
Front Endocrinol (Lausanne) 2022;13:1012005. Epub 2022 Nov 11 doi: 10.3389/fendo.2022.1012005. PMID: 36440195Free PMC Article
Systematic review of fetal and placental metastases among pregnant patients with cancer.
Khazzaka A, Rassy E, Sleiman Z, Boussios S, Pavlidis N
Cancer Treat Rev 2022 Mar;104:102356. Epub 2022 Feb 11 doi: 10.1016/j.ctrv.2022.102356. PMID: 35182890
Encephalitis Induced by Immune Checkpoint Inhibitors: A Systematic Review.
Velasco R, Villagrán M, Jové M, Simó M, Vilariño N, Alemany M, Palmero R, Martínez-Villacampa MM, Nadal E, Bruna J
JAMA Neurol 2021 Jul 1;78(7):864-873. doi: 10.1001/jamaneurol.2021.0249. PMID: 33720308
Commonwealth Neuroendocrine Tumour Research Collaboration and the North American Neuroendocrine Tumor Society Guidelines for the Diagnosis and Management of Patients With Lung Neuroendocrine Tumors: An International Collaborative Endorsement and Update of the 2015 European Neuroendocrine Tumor Society Expert Consensus Guidelines.
Singh S, Bergsland EK, Card CM, Hope TA, Kunz PL, Laidley DT, Lawrence B, Leyden S, Metz DC, Michael M, Modahl LE, Myrehaug S, Padda SK, Pommier RF, Ramirez RA, Soulen M, Strosberg J, Sung A, Thawer A, Wei B, Xu B, Segelov E
J Thorac Oncol 2020 Oct;15(10):1577-1598. Epub 2020 Jul 11 doi: 10.1016/j.jtho.2020.06.021. PMID: 32663527
Pulmonary neuroendocrine (carcinoid) tumors: European Neuroendocrine Tumor Society expert consensus and recommendations for best practice for typical and atypical pulmonary carcinoids.
Caplin ME, Baudin E, Ferolla P, Filosso P, Garcia-Yuste M, Lim E, Oberg K, Pelosi G, Perren A, Rossi RE, Travis WD; ENETS consensus conference participants
Ann Oncol 2015 Aug;26(8):1604-20. Epub 2015 Feb 2 doi: 10.1093/annonc/mdv041. PMID: 25646366

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