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Autoimmune pancreatitis type 2

MedGen UID:
1679984
•Concept ID:
C5197785
•
Disease or Syndrome
Synonyms: Duct-centric Pancreatitis, Idiopathic; Idiopathic Duct centric Pancreatitis; Idiopathic Duct-centric Pancreatitides; Idiopathic Duct-centric Pancreatitis; Pancreatitis, Idiopathic Duct-centric; Type 2 AIP; Type 2 Autoimmune Pancreatitis
SNOMED CT: Autoimmune pancreatitis type 2 (1197740007)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0017228
Orphanet: ORPHA280315

Definition

Type 2 autoimmune pancreatitis is a form of autoimmune pancreatitis (see this term) affecting both sexes and having a younger age of onset (<60 years) and presenting with abdominal pain, steatorrhea and obstructive jaundice. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAutoimmune pancreatitis type 2

Professional guidelines

PubMed

Autoimmune Pancreatitis: From Pathogenesis to Treatment.
Nista EC, De Lucia SS, Manilla V, Schepis T, Pellegrino A, Ojetti V, Pignataro G, Zileri Dal Verme L, Franceschi F, Gasbarrini A, Candelli M
Int J Mol Sci 2022 Oct 21;23(20) doi: 10.3390/ijms232012667. PMID: 36293522Free PMC Article
Risk factors and treatment of relapses in autoimmune pancreatitis: Rituximab is safe and effective.
Soliman H, Vullierme MP, Maire F, Hentic O, Ruszniewski P, Lévy P, Rebours V
United European Gastroenterol J 2019 Oct;7(8):1073-1083. Epub 2019 Jul 3 doi: 10.1177/2050640619862459. PMID: 31662864Free PMC Article
Current concepts in the diagnosis and treatment of type 1 and type 2 autoimmune pancreatitis.
Detlefsen S, Löhr JM, Drewes AM, Frøkjær JB, Klöppel G
Recent Pat Inflamm Allergy Drug Discov 2011 May;5(2):136-49. doi: 10.2174/187221311795399228. PMID: 21453268

Recent clinical studies

Etiology

Unraveling the relationship between autoimmune pancreatitis type 2 and inflammatory bowel disease: Results from two centers and systematic review of the literature.
Nikolic S, Lanzillotta M, Panic N, Brismar TB, Moro CF, Capurso G, Della Torre E, Löhr JM, Vujasinovic M
United European Gastroenterol J 2022 Jun;10(5):496-506. Epub 2022 May 8 doi: 10.1002/ueg2.12237. PMID: 35526270Free PMC Article
Autoimmune pancreatitis type 2.
de Pretis N, Frulloni L
Curr Opin Gastroenterol 2020 Sep;36(5):417-420. doi: 10.1097/MOG.0000000000000655. PMID: 32618613
Risk factors and treatment of relapses in autoimmune pancreatitis: Rituximab is safe and effective.
Soliman H, Vullierme MP, Maire F, Hentic O, Ruszniewski P, Lévy P, Rebours V
United European Gastroenterol J 2019 Oct;7(8):1073-1083. Epub 2019 Jul 3 doi: 10.1177/2050640619862459. PMID: 31662864Free PMC Article
Autoimmune Pancreatitis Type 2: Diagnostic Utility of PD-L1 Immunohistochemistry.
Gupta R, Neyaz A, Chougule A, Akita M, Zen Y, Forcione D, Castillo CF, Ferrone CR, Deshpande V
Am J Surg Pathol 2019 Jul;43(7):898-906. doi: 10.1097/PAS.0000000000001282. PMID: 31135488

Diagnosis

Autoimmune Pancreatitis: From Pathogenesis to Treatment.
Nista EC, De Lucia SS, Manilla V, Schepis T, Pellegrino A, Ojetti V, Pignataro G, Zileri Dal Verme L, Franceschi F, Gasbarrini A, Candelli M
Int J Mol Sci 2022 Oct 21;23(20) doi: 10.3390/ijms232012667. PMID: 36293522Free PMC Article
Autoimmune pancreatitis type 2.
de Pretis N, Frulloni L
Curr Opin Gastroenterol 2020 Sep;36(5):417-420. doi: 10.1097/MOG.0000000000000655. PMID: 32618613
Pancreatic and biliary tract involvement in IgG4-related disease.
Rebours V, Lévy P
Presse Med 2020 Apr;49(1):104015. Epub 2020 Mar 29 doi: 10.1016/j.lpm.2020.104015. PMID: 32234378
Risk factors and treatment of relapses in autoimmune pancreatitis: Rituximab is safe and effective.
Soliman H, Vullierme MP, Maire F, Hentic O, Ruszniewski P, Lévy P, Rebours V
United European Gastroenterol J 2019 Oct;7(8):1073-1083. Epub 2019 Jul 3 doi: 10.1177/2050640619862459. PMID: 31662864Free PMC Article
Autoimmune Pancreatitis Type 2: Diagnostic Utility of PD-L1 Immunohistochemistry.
Gupta R, Neyaz A, Chougule A, Akita M, Zen Y, Forcione D, Castillo CF, Ferrone CR, Deshpande V
Am J Surg Pathol 2019 Jul;43(7):898-906. doi: 10.1097/PAS.0000000000001282. PMID: 31135488

Therapy

Autoimmune Pancreatitis: From Pathogenesis to Treatment.
Nista EC, De Lucia SS, Manilla V, Schepis T, Pellegrino A, Ojetti V, Pignataro G, Zileri Dal Verme L, Franceschi F, Gasbarrini A, Candelli M
Int J Mol Sci 2022 Oct 21;23(20) doi: 10.3390/ijms232012667. PMID: 36293522Free PMC Article
Antitumor Necrosis Factor Therapy Is Effective for Autoimmune Pancreatitis Type 2.
Lorenzo D, Vullierme MP, Rebours V
Am J Gastroenterol 2020 Jul;115(7):1133-1134. doi: 10.14309/ajg.0000000000000668. PMID: 32618666
Pancreatic and biliary tract involvement in IgG4-related disease.
Rebours V, Lévy P
Presse Med 2020 Apr;49(1):104015. Epub 2020 Mar 29 doi: 10.1016/j.lpm.2020.104015. PMID: 32234378
Risk factors and treatment of relapses in autoimmune pancreatitis: Rituximab is safe and effective.
Soliman H, Vullierme MP, Maire F, Hentic O, Ruszniewski P, Lévy P, Rebours V
United European Gastroenterol J 2019 Oct;7(8):1073-1083. Epub 2019 Jul 3 doi: 10.1177/2050640619862459. PMID: 31662864Free PMC Article

Prognosis

Unraveling the relationship between autoimmune pancreatitis type 2 and inflammatory bowel disease: Results from two centers and systematic review of the literature.
Nikolic S, Lanzillotta M, Panic N, Brismar TB, Moro CF, Capurso G, Della Torre E, Löhr JM, Vujasinovic M
United European Gastroenterol J 2022 Jun;10(5):496-506. Epub 2022 May 8 doi: 10.1002/ueg2.12237. PMID: 35526270Free PMC Article
Autoimmune Pancreatitis Type 2: Diagnostic Utility of PD-L1 Immunohistochemistry.
Gupta R, Neyaz A, Chougule A, Akita M, Zen Y, Forcione D, Castillo CF, Ferrone CR, Deshpande V
Am J Surg Pathol 2019 Jul;43(7):898-906. doi: 10.1097/PAS.0000000000001282. PMID: 31135488

Clinical prediction guides

Pancreatic and biliary tract involvement in IgG4-related disease.
Rebours V, Lévy P
Presse Med 2020 Apr;49(1):104015. Epub 2020 Mar 29 doi: 10.1016/j.lpm.2020.104015. PMID: 32234378
Autoimmune Pancreatitis Type 2: Diagnostic Utility of PD-L1 Immunohistochemistry.
Gupta R, Neyaz A, Chougule A, Akita M, Zen Y, Forcione D, Castillo CF, Ferrone CR, Deshpande V
Am J Surg Pathol 2019 Jul;43(7):898-906. doi: 10.1097/PAS.0000000000001282. PMID: 31135488
IL-8 Expression in Granulocytic Epithelial Lesions of Idiopathic Duct-centric Pancreatitis (Type 2 Autoimmune Pancreatitis).
Ku Y, Hong SM, Fujikura K, Kim SJ, Akita M, Abe-Suzuki S, Shiomi H, Masuda A, Itoh T, Azuma T, Kim MH, Zen Y
Am J Surg Pathol 2017 Aug;41(8):1129-1138. doi: 10.1097/PAS.0000000000000891. PMID: 28614208

Recent systematic reviews

Unraveling the relationship between autoimmune pancreatitis type 2 and inflammatory bowel disease: Results from two centers and systematic review of the literature.
Nikolic S, Lanzillotta M, Panic N, Brismar TB, Moro CF, Capurso G, Della Torre E, Löhr JM, Vujasinovic M
United European Gastroenterol J 2022 Jun;10(5):496-506. Epub 2022 May 8 doi: 10.1002/ueg2.12237. PMID: 35526270Free PMC Article

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