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Familial papillary or follicular thyroid carcinoma

MedGen UID:
1681657
•Concept ID:
C5191836
•
Neoplastic Process
Synonyms: Familial non medullary thyroid carcinoma; Familial Non-medullary Thyroid Gland Carcinoma; Familial nonmedullary thyroid carcinoma; Familial Nonmedullary Thyroid Gland Carcinoma; familial nonmedullary thyroid gland carcinoma; familial papillary or follicular thyroid carcinoma; Familial pure nonmedullary thyroid carcinoma; familial pure nonmedullary thyroid carcinoma; FNMTC; FNMTC - familial nonmedullary thyroid carcinoma; Non-Syndromic Familial Thyroid Cancer
SNOMED CT: Familial nonmedullary thyroid carcinoma (786038001); FNMTC - familial nonmedullary thyroid carcinoma (786038001); Familial non medullary thyroid carcinoma (786038001)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0017895
Orphanet: ORPHA319487

Definition

A rare hereditary nonmedullary thyroid carcinoma characterized by the presence of differentiated thyroid cancer of follicular cell origin in two or more first-degree relatives, in the absence of other familial tumor syndromes or radiation exposure. Frequent capsular invasion is observed. Biopsy reveals multicentric tumors with multiple adenomatous nodules with or without oxyphilia and follicular or papillary carcinoma histology. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFamilial papillary or follicular thyroid carcinoma

Professional guidelines

PubMed

Thyroid Carcinoma, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology.
Haddad RI, Bischoff L, Ball D, Bernet V, Blomain E, Busaidy NL, Campbell M, Dickson P, Duh QY, Ehya H, Goldner WS, Guo T, Haymart M, Holt S, Hunt JP, Iagaru A, Kandeel F, Lamonica DM, Mandel S, Markovina S, McIver B, Raeburn CD, Rezaee R, Ridge JA, Roth MY, Scheri RP, Shah JP, Sipos JA, Sippel R, Sturgeon C, Wang TN, Wirth LJ, Wong RJ, Yeh M, Cassara CJ, Darlow S
J Natl Compr Canc Netw 2022 Aug;20(8):925-951. doi: 10.6004/jnccn.2022.0040. PMID: 35948029
Thyroid cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up†.
Filetti S, Durante C, Hartl D, Leboulleux S, Locati LD, Newbold K, Papotti MG, Berruti A; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2019 Dec 1;30(12):1856-1883. doi: 10.1093/annonc/mdz400. PMID: 31549998
Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer.
Francis GL, Waguespack SG, Bauer AJ, Angelos P, Benvenga S, Cerutti JM, Dinauer CA, Hamilton J, Hay ID, Luster M, Parisi MT, Rachmiel M, Thompson GB, Yamashita S; American Thyroid Association Guidelines Task Force
Thyroid 2015 Jul;25(7):716-59. doi: 10.1089/thy.2014.0460. PMID: 25900731Free PMC Article

Recent clinical studies

Etiology

Update from the 2022 World Health Organization Classification of Thyroid Tumors: A Standardized Diagnostic Approach.
Jung CK, Bychkov A, Kakudo K
Endocrinol Metab (Seoul) 2022 Oct;37(5):703-718. Epub 2022 Oct 4 doi: 10.3803/EnM.2022.1553. PMID: 36193717Free PMC Article
Molecular targets of tyrosine kinase inhibitors in thyroid cancer.
Fallahi P, Ferrari SM, Galdiero MR, Varricchi G, Elia G, Ragusa F, Paparo SR, Benvenga S, Antonelli A
Semin Cancer Biol 2022 Feb;79:180-196. Epub 2020 Nov 26 doi: 10.1016/j.semcancer.2020.11.013. PMID: 33249201
Poorly differentiated thyroid carcinoma.
Xu B, Ghossein R
Semin Diagn Pathol 2020 Sep;37(5):243-247. Epub 2020 Apr 17 doi: 10.1053/j.semdp.2020.03.003. PMID: 32360274
Thyroid cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up†.
Filetti S, Durante C, Hartl D, Leboulleux S, Locati LD, Newbold K, Papotti MG, Berruti A; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2019 Dec 1;30(12):1856-1883. doi: 10.1093/annonc/mdz400. PMID: 31549998
Thyroid Cancer: Risk-Stratified Management and Individualized Therapy.
Raue F, Frank-Raue K
Clin Cancer Res 2016 Oct 15;22(20):5012-5021. doi: 10.1158/1078-0432.CCR-16-0484. PMID: 27742787

Diagnosis

Molecular targets of tyrosine kinase inhibitors in thyroid cancer.
Fallahi P, Ferrari SM, Galdiero MR, Varricchi G, Elia G, Ragusa F, Paparo SR, Benvenga S, Antonelli A
Semin Cancer Biol 2022 Feb;79:180-196. Epub 2020 Nov 26 doi: 10.1016/j.semcancer.2020.11.013. PMID: 33249201
Thyroid Nodules: Advances in Evaluation and Management.
Kant R, Davis A, Verma V
Am Fam Physician 2020 Sep 1;102(5):298-304. PMID: 32866364
Poorly differentiated thyroid carcinoma.
Xu B, Ghossein R
Semin Diagn Pathol 2020 Sep;37(5):243-247. Epub 2020 Apr 17 doi: 10.1053/j.semdp.2020.03.003. PMID: 32360274
Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP): An Update.
Xu B, Ghossein RA
Head Neck Pathol 2020 Jun;14(2):303-310. Epub 2020 Mar 2 doi: 10.1007/s12105-019-01124-z. PMID: 32124418Free PMC Article
Follicular thyroid carcinoma.
Sobrinho-Simões M, Eloy C, Magalhães J, Lobo C, Amaro T
Mod Pathol 2011 Apr;24 Suppl 2:S10-8. doi: 10.1038/modpathol.2010.133. PMID: 21455197

Therapy

Efficacy and safety of pembrolizumab monotherapy in patients with advanced thyroid cancer in the phase 2 KEYNOTE-158 study.
Oh DY, Algazi A, Capdevila J, Longo F, Miller W Jr, Chun Bing JT, Bonilla CE, Chung HC, Guren TK, Lin CC, Motola-Kuba D, Shah M, Hadoux J, Yao L, Jin F, Norwood K, Lebellec L
Cancer 2023 Apr 15;129(8):1195-1204. Epub 2023 Feb 7 doi: 10.1002/cncr.34657. PMID: 36748723
Molecular targets of tyrosine kinase inhibitors in thyroid cancer.
Fallahi P, Ferrari SM, Galdiero MR, Varricchi G, Elia G, Ragusa F, Paparo SR, Benvenga S, Antonelli A
Semin Cancer Biol 2022 Feb;79:180-196. Epub 2020 Nov 26 doi: 10.1016/j.semcancer.2020.11.013. PMID: 33249201
Thyroid Cancer: Risk-Stratified Management and Individualized Therapy.
Raue F, Frank-Raue K
Clin Cancer Res 2016 Oct 15;22(20):5012-5021. doi: 10.1158/1078-0432.CCR-16-0484. PMID: 27742787
Follicular thyroid carcinoma.
Haigh PI
Curr Treat Options Oncol 2002 Aug;3(4):349-54. doi: 10.1007/s11864-002-0034-z. PMID: 12074771
Thyroid cancer.
Gimm O
Cancer Lett 2001 Feb 26;163(2):143-56. doi: 10.1016/s0304-3835(00)00697-2. PMID: 11165748

Prognosis

Thyroid Nodules: Advances in Evaluation and Management.
Kant R, Davis A, Verma V
Am Fam Physician 2020 Sep 1;102(5):298-304. PMID: 32866364
Poorly differentiated thyroid carcinoma.
Xu B, Ghossein R
Semin Diagn Pathol 2020 Sep;37(5):243-247. Epub 2020 Apr 17 doi: 10.1053/j.semdp.2020.03.003. PMID: 32360274
Thyroid cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up†.
Filetti S, Durante C, Hartl D, Leboulleux S, Locati LD, Newbold K, Papotti MG, Berruti A; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2019 Dec 1;30(12):1856-1883. doi: 10.1093/annonc/mdz400. PMID: 31549998
Follicular thyroid carcinoma.
Sobrinho-Simões M, Eloy C, Magalhães J, Lobo C, Amaro T
Mod Pathol 2011 Apr;24 Suppl 2:S10-8. doi: 10.1038/modpathol.2010.133. PMID: 21455197
Follicular thyroid carcinoma.
Haigh PI
Curr Treat Options Oncol 2002 Aug;3(4):349-54. doi: 10.1007/s11864-002-0034-z. PMID: 12074771

Clinical prediction guides

Thyroid Nodules: Advances in Evaluation and Management.
Kant R, Davis A, Verma V
Am Fam Physician 2020 Sep 1;102(5):298-304. PMID: 32866364
BRAF and TERT promoter mutations: clinical application in thyroid cancer.
Chung JH
Endocr J 2020 Jun 29;67(6):577-584. Epub 2020 Apr 21 doi: 10.1507/endocrj.EJ20-0063. PMID: 32321884
Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features in Asian Practice: Perspectives for Surgical Pathology and Cytopathology.
Bychkov A, Jung CK, Liu Z, Kakudo K
Endocr Pathol 2018 Sep;29(3):276-288. doi: 10.1007/s12022-018-9519-6. PMID: 29476382Free PMC Article
Familial nonmedullary thyroid carcinoma.
Mazeh H, Sippel RS
Thyroid 2013 Sep;23(9):1049-56. Epub 2013 Aug 3 doi: 10.1089/thy.2013.0079. PMID: 23734600
Follicular thyroid carcinoma.
Sobrinho-Simões M, Eloy C, Magalhães J, Lobo C, Amaro T
Mod Pathol 2011 Apr;24 Suppl 2:S10-8. doi: 10.1038/modpathol.2010.133. PMID: 21455197

Recent systematic reviews

Risk Factors for Recurrence of Follicular Thyroid Cancer: A Systematic Review.
Grønlund MP, Jensen JS, Hahn CH, Grønhøj C, Buchwald CV
Thyroid 2021 Oct;31(10):1523-1530. Epub 2021 Jul 5 doi: 10.1089/thy.2020.0921. PMID: 34102860
Active surveillance of low-risk papillary thyroid cancer: A meta-analysis.
Saravana-Bawan B, Bajwa A, Paterson J, McMullen T
Surgery 2020 Jan;167(1):46-55. Epub 2019 Sep 13 doi: 10.1016/j.surg.2019.03.040. PMID: 31526581
Familial Kidney Cancer: Implications of New Syndromes and Molecular Insights.
Carlo MI, Hakimi AA, Stewart GD, Bratslavsky G, Brugarolas J, Chen YB, Linehan WM, Maher ER, Merino MJ, Offit K, Reuter VE, Shuch B, Coleman JA
Eur Urol 2019 Dec;76(6):754-764. Epub 2019 Jul 18 doi: 10.1016/j.eururo.2019.06.015. PMID: 31326218Free PMC Article
Differentiated Thyroid Cancer-Treatment: State of the Art.
Schmidbauer B, Menhart K, Hellwig D, Grosse J
Int J Mol Sci 2017 Jun 17;18(6) doi: 10.3390/ijms18061292. PMID: 28629126Free PMC Article
Cribriform-morular variant of papillary thyroid carcinoma: a distinctive type of thyroid cancer.
Lam AK, Saremi N
Endocr Relat Cancer 2017 Apr;24(4):R109-R121. doi: 10.1530/ERC-17-0014. PMID: 28314770

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