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Familial papillary or follicular thyroid carcinoma

MedGen UID:
1681657
•Concept ID:
C5191836
•
Neoplastic Process
Synonyms: Familial Non-medullary Thyroid Gland Carcinoma; Familial nonmedullary primary thyroid carcinoma; Familial Nonmedullary Thyroid Gland Carcinoma; familial nonmedullary thyroid gland carcinoma; familial papillary or follicular thyroid carcinoma; Familial pure nonmedullary thyroid carcinoma; familial pure nonmedullary thyroid carcinoma; FNMTC; FNMTC - familial nonmedullary thyroid carcinoma; Hereditary Nonmedullary Thyroid Gland Carcinoma; Non-Syndromic Familial Thyroid Cancer
SNOMED CT: FNMTC - familial nonmedullary thyroid carcinoma (786038001); Familial nonmedullary primary thyroid carcinoma (786038001)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0017895
Orphanet: ORPHA319487

Definition

A rare hereditary nonmedullary thyroid carcinoma characterized by the presence of differentiated thyroid cancer of follicular cell origin in two or more first-degree relatives, in the absence of other familial tumor syndromes or radiation exposure. Frequent capsular invasion is observed. Biopsy reveals multicentric tumors with multiple adenomatous nodules with or without oxyphilia and follicular or papillary carcinoma histology. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFamilial papillary or follicular thyroid carcinoma

Professional guidelines

PubMed

Thyroid Carcinoma, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology.
Haddad RI, Bischoff L, Ball D, Bernet V, Blomain E, Busaidy NL, Campbell M, Dickson P, Duh QY, Ehya H, Goldner WS, Guo T, Haymart M, Holt S, Hunt JP, Iagaru A, Kandeel F, Lamonica DM, Mandel S, Markovina S, McIver B, Raeburn CD, Rezaee R, Ridge JA, Roth MY, Scheri RP, Shah JP, Sipos JA, Sippel R, Sturgeon C, Wang TN, Wirth LJ, Wong RJ, Yeh M, Cassara CJ, Darlow S
J Natl Compr Canc Netw 2022 Aug;20(8):925-951. doi: 10.6004/jnccn.2022.0040. PMID: 35948029
Thyroid cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up†.
Filetti S, Durante C, Hartl D, Leboulleux S, Locati LD, Newbold K, Papotti MG, Berruti A; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2019 Dec 1;30(12):1856-1883. doi: 10.1093/annonc/mdz400. PMID: 31549998
Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer.
Francis GL, Waguespack SG, Bauer AJ, Angelos P, Benvenga S, Cerutti JM, Dinauer CA, Hamilton J, Hay ID, Luster M, Parisi MT, Rachmiel M, Thompson GB, Yamashita S; American Thyroid Association Guidelines Task Force
Thyroid 2015 Jul;25(7):716-59. doi: 10.1089/thy.2014.0460. PMID: 25900731Free PMC Article

Recent clinical studies

Etiology

The 5(th) edition of WHO classification of tumors of endocrine organs: changes in the diagnosis of follicular-derived thyroid carcinoma.
Basolo F, Macerola E, Poma AM, Torregrossa L
Endocrine 2023 Jun;80(3):470-476. Epub 2023 Mar 25 doi: 10.1007/s12020-023-03336-4. PMID: 36964880Free PMC Article
Differentiated thyroid carcinoma: An update.
Houten PV, Netea-Maier RT, Smit JW
Best Pract Res Clin Endocrinol Metab 2023 Jan;37(1):101687. Epub 2022 Aug 12 doi: 10.1016/j.beem.2022.101687. PMID: 36002346
Update from the 2022 World Health Organization Classification of Thyroid Tumors: A Standardized Diagnostic Approach.
Jung CK, Bychkov A, Kakudo K
Endocrinol Metab (Seoul) 2022 Oct;37(5):703-718. Epub 2022 Oct 4 doi: 10.3803/EnM.2022.1553. PMID: 36193717Free PMC Article
Molecular targets of tyrosine kinase inhibitors in thyroid cancer.
Fallahi P, Ferrari SM, Galdiero MR, Varricchi G, Elia G, Ragusa F, Paparo SR, Benvenga S, Antonelli A
Semin Cancer Biol 2022 Feb;79:180-196. Epub 2020 Nov 26 doi: 10.1016/j.semcancer.2020.11.013. PMID: 33249201
Thyroid cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up†.
Filetti S, Durante C, Hartl D, Leboulleux S, Locati LD, Newbold K, Papotti MG, Berruti A; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2019 Dec 1;30(12):1856-1883. doi: 10.1093/annonc/mdz400. PMID: 31549998

Diagnosis

The 5(th) edition of WHO classification of tumors of endocrine organs: changes in the diagnosis of follicular-derived thyroid carcinoma.
Basolo F, Macerola E, Poma AM, Torregrossa L
Endocrine 2023 Jun;80(3):470-476. Epub 2023 Mar 25 doi: 10.1007/s12020-023-03336-4. PMID: 36964880Free PMC Article
Differentiated thyroid carcinoma: An update.
Houten PV, Netea-Maier RT, Smit JW
Best Pract Res Clin Endocrinol Metab 2023 Jan;37(1):101687. Epub 2022 Aug 12 doi: 10.1016/j.beem.2022.101687. PMID: 36002346
Update from the 2022 World Health Organization Classification of Thyroid Tumors: A Standardized Diagnostic Approach.
Jung CK, Bychkov A, Kakudo K
Endocrinol Metab (Seoul) 2022 Oct;37(5):703-718. Epub 2022 Oct 4 doi: 10.3803/EnM.2022.1553. PMID: 36193717Free PMC Article
Molecular targets of tyrosine kinase inhibitors in thyroid cancer.
Fallahi P, Ferrari SM, Galdiero MR, Varricchi G, Elia G, Ragusa F, Paparo SR, Benvenga S, Antonelli A
Semin Cancer Biol 2022 Feb;79:180-196. Epub 2020 Nov 26 doi: 10.1016/j.semcancer.2020.11.013. PMID: 33249201
Thyroid Nodules: Advances in Evaluation and Management.
Kant R, Davis A, Verma V
Am Fam Physician 2020 Sep 1;102(5):298-304. PMID: 32866364

Therapy

Molecular targets of tyrosine kinase inhibitors in thyroid cancer.
Fallahi P, Ferrari SM, Galdiero MR, Varricchi G, Elia G, Ragusa F, Paparo SR, Benvenga S, Antonelli A
Semin Cancer Biol 2022 Feb;79:180-196. Epub 2020 Nov 26 doi: 10.1016/j.semcancer.2020.11.013. PMID: 33249201
Thyroid Cancer: Risk-Stratified Management and Individualized Therapy.
Raue F, Frank-Raue K
Clin Cancer Res 2016 Oct 15;22(20):5012-5021. doi: 10.1158/1078-0432.CCR-16-0484. PMID: 27742787
Follicular cell-derived thyroid cancer.
Dralle H, Machens A, Basa J, Fatourechi V, Franceschi S, Hay ID, Nikiforov YE, Pacini F, Pasieka JL, Sherman SI
Nat Rev Dis Primers 2015 Dec 10;1:15077. doi: 10.1038/nrdp.2015.77. PMID: 27188261
Follicular thyroid carcinoma.
Haigh PI
Curr Treat Options Oncol 2002 Aug;3(4):349-54. doi: 10.1007/s11864-002-0034-z. PMID: 12074771
Thyroid cancer.
Gimm O
Cancer Lett 2001 Feb 26;163(2):143-56. doi: 10.1016/s0304-3835(00)00697-2. PMID: 11165748

Prognosis

Thyroid Nodules: Advances in Evaluation and Management.
Kant R, Davis A, Verma V
Am Fam Physician 2020 Sep 1;102(5):298-304. PMID: 32866364
Poorly differentiated thyroid carcinoma.
Xu B, Ghossein R
Semin Diagn Pathol 2020 Sep;37(5):243-247. Epub 2020 Apr 17 doi: 10.1053/j.semdp.2020.03.003. PMID: 32360274
Thyroid cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up†.
Filetti S, Durante C, Hartl D, Leboulleux S, Locati LD, Newbold K, Papotti MG, Berruti A; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2019 Dec 1;30(12):1856-1883. doi: 10.1093/annonc/mdz400. PMID: 31549998
Follicular thyroid carcinoma.
Sobrinho-Simões M, Eloy C, Magalhães J, Lobo C, Amaro T
Mod Pathol 2011 Apr;24 Suppl 2:S10-8. doi: 10.1038/modpathol.2010.133. PMID: 21455197
Thyroid cancer.
Gimm O
Cancer Lett 2001 Feb 26;163(2):143-56. doi: 10.1016/s0304-3835(00)00697-2. PMID: 11165748

Clinical prediction guides

Thyroid Nodules: Advances in Evaluation and Management.
Kant R, Davis A, Verma V
Am Fam Physician 2020 Sep 1;102(5):298-304. PMID: 32866364
BRAF and TERT promoter mutations: clinical application in thyroid cancer.
Chung JH
Endocr J 2020 Jun 29;67(6):577-584. Epub 2020 Apr 21 doi: 10.1507/endocrj.EJ20-0063. PMID: 32321884
Prognostic markers in well differentiated papillary and follicular thyroid cancer (WDTC).
Gillanders SL, O'Neill JP
Eur J Surg Oncol 2018 Mar;44(3):286-296. Epub 2017 Aug 3 doi: 10.1016/j.ejso.2017.07.013. PMID: 28801060
Familial nonmedullary thyroid carcinoma.
Mazeh H, Sippel RS
Thyroid 2013 Sep;23(9):1049-56. Epub 2013 Aug 3 doi: 10.1089/thy.2013.0079. PMID: 23734600
Follicular thyroid carcinoma.
Sobrinho-Simões M, Eloy C, Magalhães J, Lobo C, Amaro T
Mod Pathol 2011 Apr;24 Suppl 2:S10-8. doi: 10.1038/modpathol.2010.133. PMID: 21455197

Recent systematic reviews

Risk factors for death of follicular thyroid carcinoma: a systematic review and meta-analysis.
Zhang T, He L, Wang Z, Dong W, Sun W, Zhang P, Zhang H
Endocrine 2023 Dec;82(3):457-466. Epub 2023 Oct 7 doi: 10.1007/s12020-023-03466-9. PMID: 37804444Free PMC Article
Global incidence and prevalence of differentiated thyroid cancer in childhood: systematic review and meta-analysis.
Moleti M, Aversa T, Crisafulli S, Trifirò G, Corica D, Pepe G, Cannavò L, Di Mauro M, Paola G, Fontana A, Calapai F, Cannavò S, Wasniewska M
Front Endocrinol (Lausanne) 2023;14:1270518. Epub 2023 Sep 19 doi: 10.3389/fendo.2023.1270518. PMID: 37795368Free PMC Article
Highly Differentiated Follicular Carcinoma of Ovarian Origin: A Systematic Review of the Literature.
Giovannopoulou E, Saliaris K, Kavoura E, Pavlakis K, Lathouras K
Curr Oncol 2022 Nov 23;29(12):9105-9116. doi: 10.3390/curroncol29120712. PMID: 36547126Free PMC Article
Differentiated Thyroid Cancer-Treatment: State of the Art.
Schmidbauer B, Menhart K, Hellwig D, Grosse J
Int J Mol Sci 2017 Jun 17;18(6) doi: 10.3390/ijms18061292. PMID: 28629126Free PMC Article
Cribriform-morular variant of papillary thyroid carcinoma: a distinctive type of thyroid cancer.
Lam AK, Saremi N
Endocr Relat Cancer 2017 Apr;24(4):R109-R121. doi: 10.1530/ERC-17-0014. PMID: 28314770

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