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Familial papillary or follicular thyroid carcinoma

MedGen UID:
1681657
Concept ID:
C5191836
Neoplastic Process
Synonyms: Familial Non-medullary Thyroid Gland Carcinoma; Familial nonmedullary primary thyroid carcinoma; Familial Nonmedullary Thyroid Gland Carcinoma; familial nonmedullary thyroid gland carcinoma; familial papillary or follicular thyroid carcinoma; Familial pure nonmedullary thyroid carcinoma; familial pure nonmedullary thyroid carcinoma; FNMTC; FNMTC - familial nonmedullary thyroid carcinoma; Hereditary Nonmedullary Thyroid Gland Carcinoma; Non-Syndromic Familial Thyroid Cancer
SNOMED CT: FNMTC - familial nonmedullary thyroid carcinoma (786038001); Familial nonmedullary primary thyroid carcinoma (786038001)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0017895
Orphanet: ORPHA319487

Definition

A rare hereditary nonmedullary thyroid carcinoma characterized by the presence of differentiated thyroid cancer of follicular cell origin in two or more first-degree relatives, in the absence of other familial tumor syndromes or radiation exposure. Frequent capsular invasion is observed. Biopsy reveals multicentric tumors with multiple adenomatous nodules with or without oxyphilia and follicular or papillary carcinoma histology. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFamilial papillary or follicular thyroid carcinoma

Professional guidelines

PubMed

Haddad RI, Bischoff L, Ball D, Bernet V, Blomain E, Busaidy NL, Campbell M, Dickson P, Duh QY, Ehya H, Goldner WS, Guo T, Haymart M, Holt S, Hunt JP, Iagaru A, Kandeel F, Lamonica DM, Mandel S, Markovina S, McIver B, Raeburn CD, Rezaee R, Ridge JA, Roth MY, Scheri RP, Shah JP, Sipos JA, Sippel R, Sturgeon C, Wang TN, Wirth LJ, Wong RJ, Yeh M, Cassara CJ, Darlow S
J Natl Compr Canc Netw 2022 Aug;20(8):925-951. doi: 10.6004/jnccn.2022.0040. PMID: 35948029
Filetti S, Durante C, Hartl D, Leboulleux S, Locati LD, Newbold K, Papotti MG, Berruti A; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2019 Dec 1;30(12):1856-1883. doi: 10.1093/annonc/mdz400. PMID: 31549998
Francis GL, Waguespack SG, Bauer AJ, Angelos P, Benvenga S, Cerutti JM, Dinauer CA, Hamilton J, Hay ID, Luster M, Parisi MT, Rachmiel M, Thompson GB, Yamashita S; American Thyroid Association Guidelines Task Force
Thyroid 2015 Jul;25(7):716-59. doi: 10.1089/thy.2014.0460. PMID: 25900731Free PMC Article

Recent clinical studies

Etiology

Basolo F, Macerola E, Poma AM, Torregrossa L
Endocrine 2023 Jun;80(3):470-476. Epub 2023 Mar 25 doi: 10.1007/s12020-023-03336-4. PMID: 36964880Free PMC Article
Houten PV, Netea-Maier RT, Smit JW
Best Pract Res Clin Endocrinol Metab 2023 Jan;37(1):101687. Epub 2022 Aug 12 doi: 10.1016/j.beem.2022.101687. PMID: 36002346
Jung CK, Bychkov A, Kakudo K
Endocrinol Metab (Seoul) 2022 Oct;37(5):703-718. Epub 2022 Oct 4 doi: 10.3803/EnM.2022.1553. PMID: 36193717Free PMC Article
Fallahi P, Ferrari SM, Galdiero MR, Varricchi G, Elia G, Ragusa F, Paparo SR, Benvenga S, Antonelli A
Semin Cancer Biol 2022 Feb;79:180-196. Epub 2020 Nov 26 doi: 10.1016/j.semcancer.2020.11.013. PMID: 33249201
Filetti S, Durante C, Hartl D, Leboulleux S, Locati LD, Newbold K, Papotti MG, Berruti A; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2019 Dec 1;30(12):1856-1883. doi: 10.1093/annonc/mdz400. PMID: 31549998

Diagnosis

Basolo F, Macerola E, Poma AM, Torregrossa L
Endocrine 2023 Jun;80(3):470-476. Epub 2023 Mar 25 doi: 10.1007/s12020-023-03336-4. PMID: 36964880Free PMC Article
Houten PV, Netea-Maier RT, Smit JW
Best Pract Res Clin Endocrinol Metab 2023 Jan;37(1):101687. Epub 2022 Aug 12 doi: 10.1016/j.beem.2022.101687. PMID: 36002346
Jung CK, Bychkov A, Kakudo K
Endocrinol Metab (Seoul) 2022 Oct;37(5):703-718. Epub 2022 Oct 4 doi: 10.3803/EnM.2022.1553. PMID: 36193717Free PMC Article
Fallahi P, Ferrari SM, Galdiero MR, Varricchi G, Elia G, Ragusa F, Paparo SR, Benvenga S, Antonelli A
Semin Cancer Biol 2022 Feb;79:180-196. Epub 2020 Nov 26 doi: 10.1016/j.semcancer.2020.11.013. PMID: 33249201
Kant R, Davis A, Verma V
Am Fam Physician 2020 Sep 1;102(5):298-304. PMID: 32866364

Therapy

Fallahi P, Ferrari SM, Galdiero MR, Varricchi G, Elia G, Ragusa F, Paparo SR, Benvenga S, Antonelli A
Semin Cancer Biol 2022 Feb;79:180-196. Epub 2020 Nov 26 doi: 10.1016/j.semcancer.2020.11.013. PMID: 33249201
Raue F, Frank-Raue K
Clin Cancer Res 2016 Oct 15;22(20):5012-5021. doi: 10.1158/1078-0432.CCR-16-0484. PMID: 27742787
Dralle H, Machens A, Basa J, Fatourechi V, Franceschi S, Hay ID, Nikiforov YE, Pacini F, Pasieka JL, Sherman SI
Nat Rev Dis Primers 2015 Dec 10;1:15077. doi: 10.1038/nrdp.2015.77. PMID: 27188261
Gimm O
Cancer Lett 2001 Feb 26;163(2):143-56. doi: 10.1016/s0304-3835(00)00697-2. PMID: 11165748
Schlumberger MJ, Torlantano M
Baillieres Best Pract Res Clin Endocrinol Metab 2000 Dec;14(4):601-13. doi: 10.1053/beem.2000.0105. PMID: 11289737

Prognosis

Kant R, Davis A, Verma V
Am Fam Physician 2020 Sep 1;102(5):298-304. PMID: 32866364
Xu B, Ghossein R
Semin Diagn Pathol 2020 Sep;37(5):243-247. Epub 2020 Apr 17 doi: 10.1053/j.semdp.2020.03.003. PMID: 32360274
Filetti S, Durante C, Hartl D, Leboulleux S, Locati LD, Newbold K, Papotti MG, Berruti A; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2019 Dec 1;30(12):1856-1883. doi: 10.1093/annonc/mdz400. PMID: 31549998
Mazeh H, Sippel RS
Thyroid 2013 Sep;23(9):1049-56. Epub 2013 Aug 3 doi: 10.1089/thy.2013.0079. PMID: 23734600
Sobrinho-Simões M, Eloy C, Magalhães J, Lobo C, Amaro T
Mod Pathol 2011 Apr;24 Suppl 2:S10-8. doi: 10.1038/modpathol.2010.133. PMID: 21455197

Clinical prediction guides

Kant R, Davis A, Verma V
Am Fam Physician 2020 Sep 1;102(5):298-304. PMID: 32866364
Gillanders SL, O'Neill JP
Eur J Surg Oncol 2018 Mar;44(3):286-296. Epub 2017 Aug 3 doi: 10.1016/j.ejso.2017.07.013. PMID: 28801060
Ríos A, Rodríguez JM, Parrilla P
Cir Esp 2015 Dec;93(10):611-8. Epub 2015 Sep 26 doi: 10.1016/j.ciresp.2015.06.004. PMID: 26412746
Mazeh H, Sippel RS
Thyroid 2013 Sep;23(9):1049-56. Epub 2013 Aug 3 doi: 10.1089/thy.2013.0079. PMID: 23734600
Sobrinho-Simões M, Eloy C, Magalhães J, Lobo C, Amaro T
Mod Pathol 2011 Apr;24 Suppl 2:S10-8. doi: 10.1038/modpathol.2010.133. PMID: 21455197

Recent systematic reviews

Zhang T, He L, Wang Z, Dong W, Sun W, Zhang P, Zhang H
Endocrine 2023 Dec;82(3):457-466. Epub 2023 Oct 7 doi: 10.1007/s12020-023-03466-9. PMID: 37804444Free PMC Article
Moleti M, Aversa T, Crisafulli S, Trifirò G, Corica D, Pepe G, Cannavò L, Di Mauro M, Paola G, Fontana A, Calapai F, Cannavò S, Wasniewska M
Front Endocrinol (Lausanne) 2023;14:1270518. Epub 2023 Sep 19 doi: 10.3389/fendo.2023.1270518. PMID: 37795368Free PMC Article
de Oliveira Maia M, Batista BAM, Sousa MP, de Souza LM, Maia CSC
Nutr Cancer 2020;72(8):1255-1263. Epub 2019 Oct 22 doi: 10.1080/01635581.2019.1679194. PMID: 31635488
Bertagna F, Albano D, Giovanella L, Bonacina M, Durmo R, Giubbini R, Treglia G
Hormones (Athens) 2019 Jun;18(2):145-149. Epub 2019 Apr 15 doi: 10.1007/s42000-019-00106-8. PMID: 30989578
Schmidbauer B, Menhart K, Hellwig D, Grosse J
Int J Mol Sci 2017 Jun 17;18(6) doi: 10.3390/ijms18061292. PMID: 28629126Free PMC Article

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