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Refractory WHO Grade 2 Glioma

MedGen UID:
1682187
Concept ID:
C4764052
Neoplastic Process
Synonym: Refractory WHO Grade II Glioma

Definition

WHO grade 2 glioma that is resistant to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory WHO Grade 2 Glioma

Professional guidelines

PubMed

Petersdorf SH, Livingston RB
J Neurooncol 1994;20(2):155-63. doi: 10.1007/BF01052725. PMID: 7807192

Recent clinical studies

Etiology

Dixit KS, Sachdev S, Amidei C, Kumthekar P, Kruser TJ, Gondi V, Grimm S, Lukas RV, Nicholas MK, Chmura SJ, Fought AJ, Mehta M, Raizer JJ
J Neurooncol 2021 Dec;155(3):297-306. Epub 2021 Oct 24 doi: 10.1007/s11060-021-03875-8. PMID: 34689306
Fangusaro J, Onar-Thomas A, Young Poussaint T, Wu S, Ligon AH, Lindeman N, Banerjee A, Packer RJ, Kilburn LB, Goldman S, Pollack IF, Qaddoumi I, Jakacki RI, Fisher PG, Dhall G, Baxter P, Kreissman SG, Stewart CF, Jones DTW, Pfister SM, Vezina G, Stern JS, Panigrahy A, Patay Z, Tamrazi B, Jones JY, Haque SS, Enterline DS, Cha S, Fisher MJ, Doyle LA, Smith M, Dunkel IJ, Fouladi M
Lancet Oncol 2019 Jul;20(7):1011-1022. Epub 2019 May 28 doi: 10.1016/S1470-2045(19)30277-3. PMID: 31151904Free PMC Article
Kondyli M, Larouche V, Saint-Martin C, Ellezam B, Pouliot L, Sinnett D, Legault G, Crevier L, Weil A, Farmer JP, Jabado N, Perreault S
J Neurooncol 2018 Nov;140(2):435-444. Epub 2018 Aug 10 doi: 10.1007/s11060-018-2971-9. PMID: 30097824
Reiss SN, Yerram P, Modelevsky L, Grommes C
J Immunother Cancer 2017 Dec 19;5(1):99. doi: 10.1186/s40425-017-0302-x. PMID: 29254497Free PMC Article
Couec ML, André N, Thebaud E, Minckes O, Rialland X, Corradini N, Aerts I, Marec Bérard P, Bourdeaut F, Leblond P; Comité Pharmacologie of the SFCE
Pediatr Blood Cancer 2012 Jul 15;59(1):34-8. Epub 2012 Jan 27 doi: 10.1002/pbc.24066. PMID: 22287258

Diagnosis

Peyrl A, Chocholous M, Sabel M, Lassaletta A, Sterba J, Leblond P, Nysom K, Torsvik I, Chi SN, Perwein T, Jones N, Holm S, Nyman P, Mörse H, Öberg A, Weiler-Wichtl L, Leiss U, Haberler C, Schmook MT, Mayr L, Dieckmann K, Kool M, Gojo J, Azizi AA, André N, Kieran M, Slavc I
JAMA Oncol 2023 Dec 1;9(12):1688-1695. doi: 10.1001/jamaoncol.2023.4437. PMID: 37883081Free PMC Article
Keskin E, Aydin HA, Bahadir B, Simsek K, Kalayci M
J Coll Physicians Surg Pak 2022 Oct;32(10):1347-1349. doi: 10.29271/jcpsp.2022.10.1347. PMID: 36205285
Fangusaro J, Onar-Thomas A, Young Poussaint T, Wu S, Ligon AH, Lindeman N, Banerjee A, Packer RJ, Kilburn LB, Goldman S, Pollack IF, Qaddoumi I, Jakacki RI, Fisher PG, Dhall G, Baxter P, Kreissman SG, Stewart CF, Jones DTW, Pfister SM, Vezina G, Stern JS, Panigrahy A, Patay Z, Tamrazi B, Jones JY, Haque SS, Enterline DS, Cha S, Fisher MJ, Doyle LA, Smith M, Dunkel IJ, Fouladi M
Lancet Oncol 2019 Jul;20(7):1011-1022. Epub 2019 May 28 doi: 10.1016/S1470-2045(19)30277-3. PMID: 31151904Free PMC Article
Kondyli M, Larouche V, Saint-Martin C, Ellezam B, Pouliot L, Sinnett D, Legault G, Crevier L, Weil A, Farmer JP, Jabado N, Perreault S
J Neurooncol 2018 Nov;140(2):435-444. Epub 2018 Aug 10 doi: 10.1007/s11060-018-2971-9. PMID: 30097824
Gonzalez-Quarante LH, Ruiz-Juretschke F, Sola Vendrell E, Gil de Sagredo Del Corral OL, Agarwal V, Garcia-Leal R
Neurocirugia (Astur : Engl Ed) 2018 Jan-Feb;29(1):44-55. Epub 2017 Oct 28 doi: 10.1016/j.neucir.2017.08.003. PMID: 29111096

Therapy

Peyrl A, Chocholous M, Sabel M, Lassaletta A, Sterba J, Leblond P, Nysom K, Torsvik I, Chi SN, Perwein T, Jones N, Holm S, Nyman P, Mörse H, Öberg A, Weiler-Wichtl L, Leiss U, Haberler C, Schmook MT, Mayr L, Dieckmann K, Kool M, Gojo J, Azizi AA, André N, Kieran M, Slavc I
JAMA Oncol 2023 Dec 1;9(12):1688-1695. doi: 10.1001/jamaoncol.2023.4437. PMID: 37883081Free PMC Article
Dixit KS, Sachdev S, Amidei C, Kumthekar P, Kruser TJ, Gondi V, Grimm S, Lukas RV, Nicholas MK, Chmura SJ, Fought AJ, Mehta M, Raizer JJ
J Neurooncol 2021 Dec;155(3):297-306. Epub 2021 Oct 24 doi: 10.1007/s11060-021-03875-8. PMID: 34689306
McCrea HJ, Ivanidze J, O'Connor A, Hersh EH, Boockvar JA, Gobin YP, Knopman J, Greenfield JP
J Neurosurg Pediatr 2021 Aug 6;28(4):371-379. doi: 10.3171/2021.3.PEDS20738. PMID: 34359048
Fangusaro J, Onar-Thomas A, Young Poussaint T, Wu S, Ligon AH, Lindeman N, Banerjee A, Packer RJ, Kilburn LB, Goldman S, Pollack IF, Qaddoumi I, Jakacki RI, Fisher PG, Dhall G, Baxter P, Kreissman SG, Stewart CF, Jones DTW, Pfister SM, Vezina G, Stern JS, Panigrahy A, Patay Z, Tamrazi B, Jones JY, Haque SS, Enterline DS, Cha S, Fisher MJ, Doyle LA, Smith M, Dunkel IJ, Fouladi M
Lancet Oncol 2019 Jul;20(7):1011-1022. Epub 2019 May 28 doi: 10.1016/S1470-2045(19)30277-3. PMID: 31151904Free PMC Article
Grimm SA, Chamberlain MC
CNS Oncol 2015;4(5):333-9. Epub 2015 Oct 28 doi: 10.2217/cns.15.27. PMID: 26509217Free PMC Article

Prognosis

Peyrl A, Chocholous M, Sabel M, Lassaletta A, Sterba J, Leblond P, Nysom K, Torsvik I, Chi SN, Perwein T, Jones N, Holm S, Nyman P, Mörse H, Öberg A, Weiler-Wichtl L, Leiss U, Haberler C, Schmook MT, Mayr L, Dieckmann K, Kool M, Gojo J, Azizi AA, André N, Kieran M, Slavc I
JAMA Oncol 2023 Dec 1;9(12):1688-1695. doi: 10.1001/jamaoncol.2023.4437. PMID: 37883081Free PMC Article
Fangusaro J, Onar-Thomas A, Young Poussaint T, Wu S, Ligon AH, Lindeman N, Banerjee A, Packer RJ, Kilburn LB, Goldman S, Pollack IF, Qaddoumi I, Jakacki RI, Fisher PG, Dhall G, Baxter P, Kreissman SG, Stewart CF, Jones DTW, Pfister SM, Vezina G, Stern JS, Panigrahy A, Patay Z, Tamrazi B, Jones JY, Haque SS, Enterline DS, Cha S, Fisher MJ, Doyle LA, Smith M, Dunkel IJ, Fouladi M
Lancet Oncol 2019 Jul;20(7):1011-1022. Epub 2019 May 28 doi: 10.1016/S1470-2045(19)30277-3. PMID: 31151904Free PMC Article
Chastagner P, Devictor B, Geoerger B, Aerts I, Leblond P, Frappaz D, Gentet JC, Bracard S, André N
Cancer Chemother Pharmacol 2015 Aug;76(2):425-32. Epub 2015 Jun 27 doi: 10.1007/s00280-015-2781-0. PMID: 26115930
Kalra M, Heath JA, Kellie SJ, Dalla Pozza L, Stevens MM, Swamy S, McCowage GB
J Pediatr Hematol Oncol 2015 Aug;37(6):e341-6. doi: 10.1097/MPH.0000000000000371. PMID: 26056795
Bouffet E, Jakacki R, Goldman S, Hargrave D, Hawkins C, Shroff M, Hukin J, Bartels U, Foreman N, Kellie S, Hilden J, Etzl M, Wilson B, Stephens D, Tabori U, Baruchel S
J Clin Oncol 2012 Apr 20;30(12):1358-63. Epub 2012 Mar 5 doi: 10.1200/JCO.2011.34.5843. PMID: 22393086

Clinical prediction guides

Keskin E, Aydin HA, Bahadir B, Simsek K, Kalayci M
J Coll Physicians Surg Pak 2022 Oct;32(10):1347-1349. doi: 10.29271/jcpsp.2022.10.1347. PMID: 36205285
Dixit KS, Sachdev S, Amidei C, Kumthekar P, Kruser TJ, Gondi V, Grimm S, Lukas RV, Nicholas MK, Chmura SJ, Fought AJ, Mehta M, Raizer JJ
J Neurooncol 2021 Dec;155(3):297-306. Epub 2021 Oct 24 doi: 10.1007/s11060-021-03875-8. PMID: 34689306
Fangusaro J, Onar-Thomas A, Young Poussaint T, Wu S, Ligon AH, Lindeman N, Banerjee A, Packer RJ, Kilburn LB, Goldman S, Pollack IF, Qaddoumi I, Jakacki RI, Fisher PG, Dhall G, Baxter P, Kreissman SG, Stewart CF, Jones DTW, Pfister SM, Vezina G, Stern JS, Panigrahy A, Patay Z, Tamrazi B, Jones JY, Haque SS, Enterline DS, Cha S, Fisher MJ, Doyle LA, Smith M, Dunkel IJ, Fouladi M
Lancet Oncol 2019 Jul;20(7):1011-1022. Epub 2019 May 28 doi: 10.1016/S1470-2045(19)30277-3. PMID: 31151904Free PMC Article
Kondyli M, Larouche V, Saint-Martin C, Ellezam B, Pouliot L, Sinnett D, Legault G, Crevier L, Weil A, Farmer JP, Jabado N, Perreault S
J Neurooncol 2018 Nov;140(2):435-444. Epub 2018 Aug 10 doi: 10.1007/s11060-018-2971-9. PMID: 30097824
Couec ML, André N, Thebaud E, Minckes O, Rialland X, Corradini N, Aerts I, Marec Bérard P, Bourdeaut F, Leblond P; Comité Pharmacologie of the SFCE
Pediatr Blood Cancer 2012 Jul 15;59(1):34-8. Epub 2012 Jan 27 doi: 10.1002/pbc.24066. PMID: 22287258

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