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Islet Glucagon Cell Hyperplasia

MedGen UID:: 1682321
•Concept ID:: C4763633
•: Pathologic Function

Definition

Hyperplasia of the alpha cells of the pancreas. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVIslet Glucagon Cell Hyperplasia

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Non-Neoplastic Disorder
      - Non-Neoplastic Disorder by Special Category
        Hyperplasia
        Islet Glucagon Cell Hyperplasia

Professional guidelines

PubMed

Management of postgastric bypass noninsulinoma pancreatogenous hypoglycemia.

Mathavan VK, Arregui M, Davis C, Singh K, Patel A, Meacham J
Surg Endosc 2010 Oct;24(10):2547-55. Epub 2010 Mar 31 doi: 10.1007/s00464-010-1001-6. PMID: 20354884

Medical treatment of endogenous organic hyperinsulinism.

Scandellari C, Zaccaria M, Sicolo N, Casara D, Erle G, Federspil G
Horm Metab Res 1976;Suppl 6:46-54. PMID: 179929

See all (2)

Recent clinical studies

Etiology

Exposure to Glucocorticoids in the First Part of Fetal Life is Associated with Insulin Secretory Defect in Adult Humans.

Riveline JP, Baz B, Nguewa JL, Vidal-Trecan T, Ibrahim F, Boudou P, Vicaut E, Brac de la Perrière A, Fetita S, Bréant B, Blondeau B, Tardy-Guidollet V, Morel Y, Gautier JF
J Clin Endocrinol Metab 2020 Mar 1;105(3) doi: 10.1210/clinem/dgz145. PMID: 31665349

Inhibiting or antagonizing glucagon: making progress in diabetes care.

Lefèbvre PJ, Paquot N, Scheen AJ
Diabetes Obes Metab 2015 Aug;17(8):720-5. Epub 2015 May 28 doi: 10.1111/dom.12480. PMID: 25924114

Insulin resistance alters islet morphology in nondiabetic humans.

Mezza T, Muscogiuri G, Sorice GP, Clemente G, Hu J, Pontecorvi A, Holst JJ, Giaccari A, Kulkarni RN
Diabetes 2014 Mar;63(3):994-1007. Epub 2013 Nov 11 doi: 10.2337/db13-1013. PMID: 24215793 Free PMC Article

Management of postgastric bypass noninsulinoma pancreatogenous hypoglycemia.

Mathavan VK, Arregui M, Davis C, Singh K, Patel A, Meacham J
Surg Endosc 2010 Oct;24(10):2547-55. Epub 2010 Mar 31 doi: 10.1007/s00464-010-1001-6. PMID: 20354884

Islet cell damage associated with tacrolimus and cyclosporine: morphological features in pancreas allograft biopsies and clinical correlation.

Drachenberg CB, Klassen DK, Weir MR, Wiland A, Fink JC, Bartlett ST, Cangro CB, Blahut S, Papadimitriou JC
Transplantation 1999 Aug 15;68(3):396-402. doi: 10.1097/00007890-199908150-00012. PMID: 10459544

See all (13)

Diagnosis

The Role of the α Cell in the Pathogenesis of Diabetes: A World beyond the Mirror.

Martínez MS, Manzano A, Olivar LC, Nava M, Salazar J, D'Marco L, Ortiz R, Chacín M, Guerrero-Wyss M, Cabrera de Bravo M, Cano C, Bermúdez V, Angarita L
Int J Mol Sci 2021 Sep 1;22(17) doi: 10.3390/ijms22179504. PMID: 34502413 Free PMC Article

GLP-1 and glucagon secretion from a pancreatic neuroendocrine tumor causing diabetes and hyperinsulinemic hypoglycemia.

Roberts RE, Zhao M, Whitelaw BC, Ramage J, Diaz-Cano S, le Roux CW, Quaglia A, Huang GC, Aylwin SJ
J Clin Endocrinol Metab 2012 Sep;97(9):3039-45. Epub 2012 Jul 6 doi: 10.1210/jc.2011-2005. PMID: 22774207

Pathologic pancreatic endocrine cell hyperplasia.

Ouyang D, Dhall D, Yu R
World J Gastroenterol 2011 Jan 14;17(2):137-43. doi: 10.3748/wjg.v17.i2.137. PMID: 21245985 Free PMC Article

Nesidioblastosis and endocrine hyperplasia of the pancreas: a secondary phenomenon.

Goudswaard WB, Houthoff HJ, Koudstaal J, Zwierstra RP
Hum Pathol 1986 Jan;17(1):46-54. doi: 10.1016/s0046-8177(86)80154-x. PMID: 2867969

The relationship between the hyperplastic pancreatic islet and insulin insensitivity in obesity.

Mahler RJ
Acta Diabetol Lat 1981;18(1):1-17. doi: 10.1007/BF02056101. PMID: 6452013

See all (20)

Therapy

The Role of the α Cell in the Pathogenesis of Diabetes: A World beyond the Mirror.

Inhibiting or antagonizing glucagon: making progress in diabetes care.

Lefèbvre PJ, Paquot N, Scheen AJ
Diabetes Obes Metab 2015 Aug;17(8):720-5. Epub 2015 May 28 doi: 10.1111/dom.12480. PMID: 25924114

Glucagon-like peptide-1 receptor imaging for the localisation of insulinomas: a prospective multicentre imaging study.

Christ E, Wild D, Ederer S, Béhé M, Nicolas G, Caplin ME, Brändle M, Clerici T, Fischli S, Stettler C, Ell PJ, Seufert J, Gloor B, Perren A, Reubi JC, Forrer F
Lancet Diabetes Endocrinol 2013 Oct;1(2):115-22. Epub 2013 Jul 25 doi: 10.1016/S2213-8587(13)70049-4. PMID: 24622317

Management of postgastric bypass noninsulinoma pancreatogenous hypoglycemia.

Mathavan VK, Arregui M, Davis C, Singh K, Patel A, Meacham J
Surg Endosc 2010 Oct;24(10):2547-55. Epub 2010 Mar 31 doi: 10.1007/s00464-010-1001-6. PMID: 20354884

Islet cell damage associated with tacrolimus and cyclosporine: morphological features in pancreas allograft biopsies and clinical correlation.

See all (12)

Prognosis

Glucagon-like peptide-1 receptor imaging for the localisation of insulinomas: a prospective multicentre imaging study.

Islet cell damage associated with tacrolimus and cyclosporine: morphological features in pancreas allograft biopsies and clinical correlation.

Immunohistochemical study of 100 pancreatic tumors in 28 patients with multiple endocrine neoplasia, type I.

Le Bodic MF, Heymann MF, Lecomte M, Berger N, Berger F, Louvel A, De Micco C, Patey M, De Mascarel A, Burtin F, Saint-Andre JP
Am J Surg Pathol 1996 Nov;20(11):1378-84. doi: 10.1097/00000478-199611000-00009. PMID: 8898842

The endocrine pancreas in patients with insulinomas. An immunocytochemical and ultrastructural study of the nontumoral tissue with morphometrical evaluations.

Bani Sacchi T, Bani D, Biliotti G
Int J Pancreatol 1989 Jul;5(1):11-28. PMID: 2568382

Gastrointestinal/pancreatic hormone concentrations in the portal venous system of nine patients with organic hyperinsulinism.

Glaser B, Valtysson G, Fajans SS, Vinik AI, Cho K, Thompson N
Metabolism 1981 Oct;30(10):1001-10. doi: 10.1016/0026-0495(81)90101-3. PMID: 6116152

See all (7)

Clinical prediction guides

The glucagon receptor antagonist desHis(1)Pro(4)Glu(9)-glucagon(Lys(12)PAL) alters alpha-cell turnover and lineage in mice, but does not cause alpha-cell hyperplasia.

Lafferty R, Tanday N, Dubey V, Coulter-Parkhill A, Vishal K, Moffett C, O'Harte F, Flatt PR, Irwin N
Mol Cell Endocrinol 2023 Jun 15;570:111932. Epub 2023 Apr 18 doi: 10.1016/j.mce.2023.111932. PMID: 37080378

A Primary Role for α-Cells as Amino Acid Sensors.

Dean ED
Diabetes 2020 Apr;69(4):542-549. Epub 2019 Oct 25 doi: 10.2337/dbi19-0021. PMID: 31653720 Free PMC Article

Glucagon receptor antagonism increases mouse pancreatic δ-cell mass through cell proliferation and duct-derived neogenesis.

Gu L, Cui X, Lang S, Wang H, Hong T, Wei R
Biochem Biophys Res Commun 2019 May 14;512(4):864-870. Epub 2019 Mar 28 doi: 10.1016/j.bbrc.2019.03.148. PMID: 30929915

Evolving function and potential of pancreatic alpha cells.

Stanojevic V, Habener JF
Best Pract Res Clin Endocrinol Metab 2015 Dec;29(6):859-71. Epub 2015 Oct 8 doi: 10.1016/j.beem.2015.10.002. PMID: 26696515 Free PMC Article

Inhibiting or antagonizing glucagon: making progress in diabetes care.

Lefèbvre PJ, Paquot N, Scheen AJ
Diabetes Obes Metab 2015 Aug;17(8):720-5. Epub 2015 May 28 doi: 10.1111/dom.12480. PMID: 25924114

See all (19)

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Islet Glucagon Cell Hyperplasia

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Supplemental Content

Table of contents

Practice guidelines

Related information

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