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Islet Glucagon Cell Hyperplasia

MedGen UID:
1682321
•Concept ID:
C4763633
•
Pathologic Function

Definition

Hyperplasia of the alpha cells of the pancreas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIslet Glucagon Cell Hyperplasia

Professional guidelines

PubMed

Management of postgastric bypass noninsulinoma pancreatogenous hypoglycemia.
Mathavan VK, Arregui M, Davis C, Singh K, Patel A, Meacham J
Surg Endosc 2010 Oct;24(10):2547-55. Epub 2010 Mar 31 doi: 10.1007/s00464-010-1001-6. PMID: 20354884
Medical treatment of endogenous organic hyperinsulinism.
Scandellari C, Zaccaria M, Sicolo N, Casara D, Erle G, Federspil G
Horm Metab Res 1976;Suppl 6:46-54. PMID: 179929

Recent clinical studies

Etiology

Inhibiting or antagonizing glucagon: making progress in diabetes care.
Lefèbvre PJ, Paquot N, Scheen AJ
Diabetes Obes Metab 2015 Aug;17(8):720-5. Epub 2015 May 28 doi: 10.1111/dom.12480. PMID: 25924114
Insulin resistance alters islet morphology in nondiabetic humans.
Mezza T, Muscogiuri G, Sorice GP, Clemente G, Hu J, Pontecorvi A, Holst JJ, Giaccari A, Kulkarni RN
Diabetes 2014 Mar;63(3):994-1007. Epub 2013 Nov 11 doi: 10.2337/db13-1013. PMID: 24215793Free PMC Article
Management of postgastric bypass noninsulinoma pancreatogenous hypoglycemia.
Mathavan VK, Arregui M, Davis C, Singh K, Patel A, Meacham J
Surg Endosc 2010 Oct;24(10):2547-55. Epub 2010 Mar 31 doi: 10.1007/s00464-010-1001-6. PMID: 20354884
Nesidioblastosis in sickle cell disease.
Culberson DE, Manci EA, Shah AK, Haynes J, Ballas SK, Pegelow C, Vichinsky E
Pediatr Pathol Mol Med 2001 Mar-Apr;20(2):155-65. doi: 10.1080/15513810109168608. PMID: 12673839
Islet cell damage associated with tacrolimus and cyclosporine: morphological features in pancreas allograft biopsies and clinical correlation.
Drachenberg CB, Klassen DK, Weir MR, Wiland A, Fink JC, Bartlett ST, Cangro CB, Blahut S, Papadimitriou JC
Transplantation 1999 Aug 15;68(3):396-402. doi: 10.1097/00007890-199908150-00012. PMID: 10459544

Diagnosis

The Role of the α Cell in the Pathogenesis of Diabetes: A World beyond the Mirror.
Martínez MS, Manzano A, Olivar LC, Nava M, Salazar J, D'Marco L, Ortiz R, Chacín M, Guerrero-Wyss M, Cabrera de Bravo M, Cano C, Bermúdez V, Angarita L
Int J Mol Sci 2021 Sep 1;22(17) doi: 10.3390/ijms22179504. PMID: 34502413Free PMC Article
Insulin resistance alters islet morphology in nondiabetic humans.
Mezza T, Muscogiuri G, Sorice GP, Clemente G, Hu J, Pontecorvi A, Holst JJ, Giaccari A, Kulkarni RN
Diabetes 2014 Mar;63(3):994-1007. Epub 2013 Nov 11 doi: 10.2337/db13-1013. PMID: 24215793Free PMC Article
Pathologic pancreatic endocrine cell hyperplasia.
Ouyang D, Dhall D, Yu R
World J Gastroenterol 2011 Jan 14;17(2):137-43. doi: 10.3748/wjg.v17.i2.137. PMID: 21245985Free PMC Article
Nesidioblastosis and hyperplasia of alpha cells, microglucagonoma, and nonfunctioning islet cell tumor of the pancreas: review of the literature.
Yu R, Nissen NN, Dhall D, Heaney AP
Pancreas 2008 May;36(4):428-31. doi: 10.1097/MPA.0b013e31815ceb23. PMID: 18437091
The relationship between the hyperplastic pancreatic islet and insulin insensitivity in obesity.
Mahler RJ
Acta Diabetol Lat 1981;18(1):1-17. doi: 10.1007/BF02056101. PMID: 6452013

Therapy

The Role of the α Cell in the Pathogenesis of Diabetes: A World beyond the Mirror.
Martínez MS, Manzano A, Olivar LC, Nava M, Salazar J, D'Marco L, Ortiz R, Chacín M, Guerrero-Wyss M, Cabrera de Bravo M, Cano C, Bermúdez V, Angarita L
Int J Mol Sci 2021 Sep 1;22(17) doi: 10.3390/ijms22179504. PMID: 34502413Free PMC Article
Inhibiting or antagonizing glucagon: making progress in diabetes care.
Lefèbvre PJ, Paquot N, Scheen AJ
Diabetes Obes Metab 2015 Aug;17(8):720-5. Epub 2015 May 28 doi: 10.1111/dom.12480. PMID: 25924114
Glucagon-like peptide-1 receptor imaging for the localisation of insulinomas: a prospective multicentre imaging study.
Christ E, Wild D, Ederer S, Béhé M, Nicolas G, Caplin ME, Brändle M, Clerici T, Fischli S, Stettler C, Ell PJ, Seufert J, Gloor B, Perren A, Reubi JC, Forrer F
Lancet Diabetes Endocrinol 2013 Oct;1(2):115-22. Epub 2013 Jul 25 doi: 10.1016/S2213-8587(13)70049-4. PMID: 24622317
Management of postgastric bypass noninsulinoma pancreatogenous hypoglycemia.
Mathavan VK, Arregui M, Davis C, Singh K, Patel A, Meacham J
Surg Endosc 2010 Oct;24(10):2547-55. Epub 2010 Mar 31 doi: 10.1007/s00464-010-1001-6. PMID: 20354884
Islet cell damage associated with tacrolimus and cyclosporine: morphological features in pancreas allograft biopsies and clinical correlation.
Drachenberg CB, Klassen DK, Weir MR, Wiland A, Fink JC, Bartlett ST, Cangro CB, Blahut S, Papadimitriou JC
Transplantation 1999 Aug 15;68(3):396-402. doi: 10.1097/00007890-199908150-00012. PMID: 10459544

Prognosis

Glucagon-like peptide-1 receptor imaging for the localisation of insulinomas: a prospective multicentre imaging study.
Christ E, Wild D, Ederer S, Béhé M, Nicolas G, Caplin ME, Brändle M, Clerici T, Fischli S, Stettler C, Ell PJ, Seufert J, Gloor B, Perren A, Reubi JC, Forrer F
Lancet Diabetes Endocrinol 2013 Oct;1(2):115-22. Epub 2013 Jul 25 doi: 10.1016/S2213-8587(13)70049-4. PMID: 24622317
Islet cell damage associated with tacrolimus and cyclosporine: morphological features in pancreas allograft biopsies and clinical correlation.
Drachenberg CB, Klassen DK, Weir MR, Wiland A, Fink JC, Bartlett ST, Cangro CB, Blahut S, Papadimitriou JC
Transplantation 1999 Aug 15;68(3):396-402. doi: 10.1097/00007890-199908150-00012. PMID: 10459544
Immunohistochemical study of 100 pancreatic tumors in 28 patients with multiple endocrine neoplasia, type I.
Le Bodic MF, Heymann MF, Lecomte M, Berger N, Berger F, Louvel A, De Micco C, Patey M, De Mascarel A, Burtin F, Saint-Andre JP
Am J Surg Pathol 1996 Nov;20(11):1378-84. doi: 10.1097/00000478-199611000-00009. PMID: 8898842
Pancreatic mixed ductal-islet tumors. Is this an entity?
Permert J, Mogaki M, Andrén-Sandberg A, Kazakoff K, Pour PM
Int J Pancreatol 1992 Feb;11(1):23-9. doi: 10.1007/BF02925989. PMID: 1316418
Gastrointestinal/pancreatic hormone concentrations in the portal venous system of nine patients with organic hyperinsulinism.
Glaser B, Valtysson G, Fajans SS, Vinik AI, Cho K, Thompson N
Metabolism 1981 Oct;30(10):1001-10. doi: 10.1016/0026-0495(81)90101-3. PMID: 6116152

Clinical prediction guides

The glucagon receptor antagonist desHis(1)Pro(4)Glu(9)-glucagon(Lys(12)PAL) alters alpha-cell turnover and lineage in mice, but does not cause alpha-cell hyperplasia.
Lafferty R, Tanday N, Dubey V, Coulter-Parkhill A, Vishal K, Moffett C, O'Harte F, Flatt PR, Irwin N
Mol Cell Endocrinol 2023 Jun 15;570:111932. Epub 2023 Apr 18 doi: 10.1016/j.mce.2023.111932. PMID: 37080378
A Primary Role for α-Cells as Amino Acid Sensors.
Dean ED
Diabetes 2020 Apr;69(4):542-549. Epub 2019 Oct 25 doi: 10.2337/dbi19-0021. PMID: 31653720Free PMC Article
Glucagon receptor antagonism increases mouse pancreatic δ-cell mass through cell proliferation and duct-derived neogenesis.
Gu L, Cui X, Lang S, Wang H, Hong T, Wei R
Biochem Biophys Res Commun 2019 May 14;512(4):864-870. Epub 2019 Mar 28 doi: 10.1016/j.bbrc.2019.03.148. PMID: 30929915
Evolving function and potential of pancreatic alpha cells.
Stanojevic V, Habener JF
Best Pract Res Clin Endocrinol Metab 2015 Dec;29(6):859-71. Epub 2015 Oct 8 doi: 10.1016/j.beem.2015.10.002. PMID: 26696515Free PMC Article
Inhibiting or antagonizing glucagon: making progress in diabetes care.
Lefèbvre PJ, Paquot N, Scheen AJ
Diabetes Obes Metab 2015 Aug;17(8):720-5. Epub 2015 May 28 doi: 10.1111/dom.12480. PMID: 25924114

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