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Classic Hodgkin Lymphoma Type Post-Transplant Lymphoproliferative Disorder

MedGen UID:
1682426
•Concept ID:
C5190713
•
Neoplastic Process
Synonyms: Classical Hodgkin Lymphoma Post-Transplant Lymphoproliferative Disorder; Classical Hodgkin Lymphoma Type Post-Transplant Lymphoproliferative Disorder; Classical Hodgkin lymphoma type post-transplant lymphoproliferative disorder; Classical Hodgkin lymphoma type posttransplant lymphoproliferative disorder; Classical Hodgkin Lymphoma Type PTLD; Hodgkin Lymphoma Post-Transplant Lymphoproliferative Disorder; Hodgkin Lymphoma PTLD; Hodgkin's Lymphoma Post-Transplant Lymphoproliferative Disorder; Hodgkin's Lymphoma PTLD
SNOMED CT: Classical Hodgkin lymphoma type posttransplant lymphoproliferative disorder (782919005); Classical Hodgkin lymphoma type post-transplant lymphoproliferative disorder (782919005)

Definition

An Epstein-Barr positive lymphoproliferation fulfilling the criteria for classic Hodgkin lymphoma and arising as a result of post-transplant immunosuppression therapy. It is most often seen in renal transplant patients. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVClassic Hodgkin Lymphoma Type Post-Transplant Lymphoproliferative Disorder

Professional guidelines

PubMed

Classical Hodgkin lymphoma-type PTLD after solid organ transplantation in children: a report on 17 patients treated according to subsequent GPOH-HD treatment schedules.
Kampers J, Orjuela-Grimm M, Schober T, Schulz TF, Stiefel M, Klein C, Körholz D, Mauz-Körholz C, Kreipe H, Beier R, Maecker-Kolhoff B
Leuk Lymphoma 2017 Mar;58(3):633-638. Epub 2016 Aug 11 doi: 10.1080/10428194.2016.1205742. PMID: 27685149

Recent clinical studies

Etiology

Post-transplant lymphoproliferative disorders.
Singavi AK, Harrington AM, Fenske TS
Cancer Treat Res 2015;165:305-27. doi: 10.1007/978-3-319-13150-4_13. PMID: 25655616
Successful treatment of a classic Hodgkin lymphoma-type post-transplant lymphoproliferative disorder with tailored chemotherapy and Epstein-Barr virus-specific cytotoxic T lymphocytes in a pediatric heart transplant recipient.
Basso S, Zecca M, Calafiore L, Rubert L, Fiocchi R, Paulli M, Quartuccio G, Guido I, Sebastiani R, Croci GA, Beschi C, Nardiello I, Ginevri F, Cugno C, Comoli P
Pediatr Transplant 2013 Nov;17(7):E168-73. Epub 2013 Sep 1 doi: 10.1111/petr.12146. PMID: 23992468
Post transplant lymphoproliferative disorders: risk, classification, and therapeutic recommendations.
Jagadeesh D, Woda BA, Draper J, Evens AM
Curr Treat Options Oncol 2012 Mar;13(1):122-36. doi: 10.1007/s11864-011-0177-x. PMID: 22241590
Cryptogenic organizing pneumonia after rituximab therapy for presumed post-kidney transplant lymphoproliferative disease.
Bitzan M, Ouahed JD, Carpineta L, Bernard C, Bell LE
Pediatr Nephrol 2010 Jun;25(6):1163-7. Epub 2010 Feb 6 doi: 10.1007/s00467-010-1447-8. PMID: 20140460

Diagnosis

Classical Hodgkin lymphoma type post-transplant lymphoproliferative disorder in a kidney transplant recipient: a diagnostic pitfall.
Mohri T, Ikura Y, Hirakoso A, Okamoto M, Hishizawa M, Takaori-Kondo A, Kato S, Nakamura S, Yoshimura K, Okabe H, Iwai Y
Int J Hematol 2018 Aug;108(2):218-227. Epub 2018 Jan 29 doi: 10.1007/s12185-018-2410-x. PMID: 29380181
Post-transplant lymphoproliferative disorders.
Singavi AK, Harrington AM, Fenske TS
Cancer Treat Res 2015;165:305-27. doi: 10.1007/978-3-319-13150-4_13. PMID: 25655616
Post transplant lymphoproliferative disorders: risk, classification, and therapeutic recommendations.
Jagadeesh D, Woda BA, Draper J, Evens AM
Curr Treat Options Oncol 2012 Mar;13(1):122-36. doi: 10.1007/s11864-011-0177-x. PMID: 22241590
Classical Hodgkin's lymphoma arising in different host's conditions: pathobiology parameters, therapeutic options, and outcome.
Carbone A, Spina M, Gloghini A, Tirelli U
Am J Hematol 2011 Feb;86(2):170-9. doi: 10.1002/ajh.21910. PMID: 21264899
EBV-associated lymphoproliferative disorders: classification and treatment.
Carbone A, Gloghini A, Dotti G
Oncologist 2008 May;13(5):577-85. doi: 10.1634/theoncologist.2008-0036. PMID: 18515742

Therapy

Comparative analysis of post-transplant lymphoproliferative disorders after solid organ and hematopoietic stem cell transplantation reveals differences in the tumor microenvironment.
Overkamp M, Granai M, Bonzheim I, Steinhilber J, Schittenhelm J, Bethge W, Quintanilla-Martinez L, Fend F, Federmann B
Virchows Arch 2021 Jun;478(6):1135-1148. Epub 2020 Dec 15 doi: 10.1007/s00428-020-02985-4. PMID: 33324999Free PMC Article
HLA class I associations with EBV+ post-transplant lymphoproliferative disorder.
Jones K, Wockner L, Thornton A, Gottlieb D, Ritchie DS, Seymour JF, Kumarasinghe G, Gandhi MK
Transpl Immunol 2015 Mar;32(2):126-30. Epub 2015 Feb 27 doi: 10.1016/j.trim.2015.02.005. PMID: 25731678
Post-transplant lymphoproliferative disorders.
Singavi AK, Harrington AM, Fenske TS
Cancer Treat Res 2015;165:305-27. doi: 10.1007/978-3-319-13150-4_13. PMID: 25655616
Post transplant lymphoproliferative disorders: risk, classification, and therapeutic recommendations.
Jagadeesh D, Woda BA, Draper J, Evens AM
Curr Treat Options Oncol 2012 Mar;13(1):122-36. doi: 10.1007/s11864-011-0177-x. PMID: 22241590
Classical Hodgkin's lymphoma arising in different host's conditions: pathobiology parameters, therapeutic options, and outcome.
Carbone A, Spina M, Gloghini A, Tirelli U
Am J Hematol 2011 Feb;86(2):170-9. doi: 10.1002/ajh.21910. PMID: 21264899

Prognosis

Comparative analysis of post-transplant lymphoproliferative disorders after solid organ and hematopoietic stem cell transplantation reveals differences in the tumor microenvironment.
Overkamp M, Granai M, Bonzheim I, Steinhilber J, Schittenhelm J, Bethge W, Quintanilla-Martinez L, Fend F, Federmann B
Virchows Arch 2021 Jun;478(6):1135-1148. Epub 2020 Dec 15 doi: 10.1007/s00428-020-02985-4. PMID: 33324999Free PMC Article
Clinicopathological evaluation of the programmed cell death 1 (PD1)/programmed cell death-ligand 1 (PD-L1) axis in post-transplant lymphoproliferative disorders: association with Epstein-Barr virus, PD-L1 copy number alterations, and outcome.
Veloza L, Teixido C, Castrejon N, Climent F, Carrió A, Marginet M, Soldini D, González-Farré B, Ribera-Cortada I, Lopez-Guillermo A, González-Barca E, Sierra A, Herrera M, Gómez C, Garcia A, Balagué O, Campo E, Martinez A
Histopathology 2019 Dec;75(6):799-812. Epub 2019 Oct 6 doi: 10.1111/his.13857. PMID: 30861172
Classical Hodgkin lymphoma type post-transplant lymphoproliferative disorder in a kidney transplant recipient: a diagnostic pitfall.
Mohri T, Ikura Y, Hirakoso A, Okamoto M, Hishizawa M, Takaori-Kondo A, Kato S, Nakamura S, Yoshimura K, Okabe H, Iwai Y
Int J Hematol 2018 Aug;108(2):218-227. Epub 2018 Jan 29 doi: 10.1007/s12185-018-2410-x. PMID: 29380181
Classical Hodgkin lymphoma-type PTLD after solid organ transplantation in children: a report on 17 patients treated according to subsequent GPOH-HD treatment schedules.
Kampers J, Orjuela-Grimm M, Schober T, Schulz TF, Stiefel M, Klein C, Körholz D, Mauz-Körholz C, Kreipe H, Beier R, Maecker-Kolhoff B
Leuk Lymphoma 2017 Mar;58(3):633-638. Epub 2016 Aug 11 doi: 10.1080/10428194.2016.1205742. PMID: 27685149
Post-transplant lymphoproliferative disorders.
Singavi AK, Harrington AM, Fenske TS
Cancer Treat Res 2015;165:305-27. doi: 10.1007/978-3-319-13150-4_13. PMID: 25655616

Clinical prediction guides

Comparative analysis of post-transplant lymphoproliferative disorders after solid organ and hematopoietic stem cell transplantation reveals differences in the tumor microenvironment.
Overkamp M, Granai M, Bonzheim I, Steinhilber J, Schittenhelm J, Bethge W, Quintanilla-Martinez L, Fend F, Federmann B
Virchows Arch 2021 Jun;478(6):1135-1148. Epub 2020 Dec 15 doi: 10.1007/s00428-020-02985-4. PMID: 33324999Free PMC Article
Classical Hodgkin lymphoma-like post-transplant lymphoproliferative disease after allogeneic stem cell transplantation for primary myelofibrosis is successfully treated with nivolumab: A case report.
Gunes AK, Demir I, Pehlivan M
J Oncol Pharm Pract 2021 Mar;27(2):509-512. Epub 2020 Aug 6 doi: 10.1177/1078155220946462. PMID: 32762294
Clinicopathological evaluation of the programmed cell death 1 (PD1)/programmed cell death-ligand 1 (PD-L1) axis in post-transplant lymphoproliferative disorders: association with Epstein-Barr virus, PD-L1 copy number alterations, and outcome.
Veloza L, Teixido C, Castrejon N, Climent F, Carrió A, Marginet M, Soldini D, González-Farré B, Ribera-Cortada I, Lopez-Guillermo A, González-Barca E, Sierra A, Herrera M, Gómez C, Garcia A, Balagué O, Campo E, Martinez A
Histopathology 2019 Dec;75(6):799-812. Epub 2019 Oct 6 doi: 10.1111/his.13857. PMID: 30861172
Classical Hodgkin's lymphoma arising in different host's conditions: pathobiology parameters, therapeutic options, and outcome.
Carbone A, Spina M, Gloghini A, Tirelli U
Am J Hematol 2011 Feb;86(2):170-9. doi: 10.1002/ajh.21910. PMID: 21264899
Somatic hypermutation and B cell receptor selection in normal and transformed human B cells.
Küppers R
Ann N Y Acad Sci 2003 Apr;987:173-9. doi: 10.1111/j.1749-6632.2003.tb06046.x. PMID: 12727637

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