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Recurrent Primary Vitreoretinal Non-Hodgkin Lymphoma

MedGen UID:
1682469
•Concept ID:
C4763391
•
Neoplastic Process
Synonyms: Recurrent Primary Vitreoretinal Lymphoma; Recurrent PVRL

Definition

The reemergence of primary vitreoretinal non-Hodgkin lymphoma after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Primary Vitreoretinal Non-Hodgkin Lymphoma

Professional guidelines

PubMed

Evidence-based expert consensus on the management of primary central nervous system lymphoma in China.
Chen T, Liu Y, Wang Y, Chang Q, Wu J, Wang Z, Geng D, Yu JT, Li Y, Li XQ, Chen H, Zhuang D, Li J, Wang B, Jiang T, Lyu L, Song Y, Qiu X, Li W, Lin S, Zhang X, Lu D, Lei J, Chen Y, Mao Y
J Hematol Oncol 2022 Sep 29;15(1):136. doi: 10.1186/s13045-022-01356-7. PMID: 36176002Free PMC Article
Optical coherence tomography manifestations of primary vitreoretinal lymphoma.
Saito T, Ohguro N, Iwahashi C, Hashida N
Graefes Arch Clin Exp Ophthalmol 2016 Dec;254(12):2319-2326. Epub 2016 Jun 1 doi: 10.1007/s00417-016-3395-x. PMID: 27251192

Recent clinical studies

Etiology

Long-term outcomes of combined intravitreal methotrexate and systemic high-dose methotrexate therapy in vitreoretinal lymphoma.
Cheng CL, Yeh PT, Fang WQ, Ma WL, Hou HA, Tsai CH, Lin CP, Tien HF
Cancer Med 2023 Apr;12(7):8102-8111. Epub 2023 Jan 5 doi: 10.1002/cam4.5609. PMID: 36602288Free PMC Article
Comparative Molecular Analysis of Primary Central Nervous System Lymphomas and Matched Vitreoretinal Lymphomas by Vitreous Liquid Biopsy.
Balikov DA, Hu K, Liu CJ, Betz BL, Chinnaiyan AM, Devisetty LV, Venneti S, Tomlins SA, Cani AK, Rao RC
Int J Mol Sci 2021 Sep 16;22(18) doi: 10.3390/ijms22189992. PMID: 34576156Free PMC Article
CYSTOID MACULAR EDEMA IN THE SETTING OF PRIMARY VITREORETINAL LYMPHOMA.
Deák GG, Sneed SR, Jampol LM
Retin Cases Brief Rep 2021 Mar 1;15(2):104-106. doi: 10.1097/ICB.0000000000000797. PMID: 30015778
Lenalidomide in combination with intravenous rituximab (REVRI) in relapsed/refractory primary CNS lymphoma or primary intraocular lymphoma: a multicenter prospective 'proof of concept' phase II study of the French Oculo-Cerebral lymphoma (LOC) Network and the Lymphoma Study Association (LYSA)†.
Ghesquieres H, Chevrier M, Laadhari M, Chinot O, Choquet S, Moluçon-Chabrot C, Beauchesne P, Gressin R, Morschhauser F, Schmitt A, Gyan E, Hoang-Xuan K, Nicolas-Virelizier E, Cassoux N, Touitou V, Le Garff-Tavernier M, Savignoni A, Turbiez I, Soumelis V, Houillier C, Soussain C
Ann Oncol 2019 Apr 1;30(4):621-628. doi: 10.1093/annonc/mdz032. PMID: 30698644
Optical coherence tomography manifestations of primary vitreoretinal lymphoma.
Saito T, Ohguro N, Iwahashi C, Hashida N
Graefes Arch Clin Exp Ophthalmol 2016 Dec;254(12):2319-2326. Epub 2016 Jun 1 doi: 10.1007/s00417-016-3395-x. PMID: 27251192

Diagnosis

Vitreoretinal lymphoma: a diagnostic challenge.
Sáenz Decker E, García Fernández M, Gómez De la Torre R, Coto Hernández R, Santana García LI
Arch Soc Esp Oftalmol (Engl Ed) 2023 Dec;98(12):718-722. Epub 2023 Oct 7 doi: 10.1016/j.oftale.2023.10.002. PMID: 37813184
Evidence-based expert consensus on the management of primary central nervous system lymphoma in China.
Chen T, Liu Y, Wang Y, Chang Q, Wu J, Wang Z, Geng D, Yu JT, Li Y, Li XQ, Chen H, Zhuang D, Li J, Wang B, Jiang T, Lyu L, Song Y, Qiu X, Li W, Lin S, Zhang X, Lu D, Lei J, Chen Y, Mao Y
J Hematol Oncol 2022 Sep 29;15(1):136. doi: 10.1186/s13045-022-01356-7. PMID: 36176002Free PMC Article
Primary central nervous system lymphoma.
Schaff LR, Grommes C
Blood 2022 Sep 1;140(9):971-979. doi: 10.1182/blood.2020008377. PMID: 34699590Free PMC Article
CYSTOID MACULAR EDEMA IN THE SETTING OF PRIMARY VITREORETINAL LYMPHOMA.
Deák GG, Sneed SR, Jampol LM
Retin Cases Brief Rep 2021 Mar 1;15(2):104-106. doi: 10.1097/ICB.0000000000000797. PMID: 30015778
How we diagnose and treat vitreoretinal lymphoma.
Fend F, Ferreri AJ, Coupland SE
Br J Haematol 2016 Jun;173(5):680-92. Epub 2016 May 2 doi: 10.1111/bjh.14025. PMID: 27133587

Therapy

Long-term outcomes of combined intravitreal methotrexate and systemic high-dose methotrexate therapy in vitreoretinal lymphoma.
Cheng CL, Yeh PT, Fang WQ, Ma WL, Hou HA, Tsai CH, Lin CP, Tien HF
Cancer Med 2023 Apr;12(7):8102-8111. Epub 2023 Jan 5 doi: 10.1002/cam4.5609. PMID: 36602288Free PMC Article
Evidence-based expert consensus on the management of primary central nervous system lymphoma in China.
Chen T, Liu Y, Wang Y, Chang Q, Wu J, Wang Z, Geng D, Yu JT, Li Y, Li XQ, Chen H, Zhuang D, Li J, Wang B, Jiang T, Lyu L, Song Y, Qiu X, Li W, Lin S, Zhang X, Lu D, Lei J, Chen Y, Mao Y
J Hematol Oncol 2022 Sep 29;15(1):136. doi: 10.1186/s13045-022-01356-7. PMID: 36176002Free PMC Article
Primary central nervous system lymphoma.
Schaff LR, Grommes C
Blood 2022 Sep 1;140(9):971-979. doi: 10.1182/blood.2020008377. PMID: 34699590Free PMC Article
Lenalidomide in combination with intravenous rituximab (REVRI) in relapsed/refractory primary CNS lymphoma or primary intraocular lymphoma: a multicenter prospective 'proof of concept' phase II study of the French Oculo-Cerebral lymphoma (LOC) Network and the Lymphoma Study Association (LYSA)†.
Ghesquieres H, Chevrier M, Laadhari M, Chinot O, Choquet S, Moluçon-Chabrot C, Beauchesne P, Gressin R, Morschhauser F, Schmitt A, Gyan E, Hoang-Xuan K, Nicolas-Virelizier E, Cassoux N, Touitou V, Le Garff-Tavernier M, Savignoni A, Turbiez I, Soumelis V, Houillier C, Soussain C
Ann Oncol 2019 Apr 1;30(4):621-628. doi: 10.1093/annonc/mdz032. PMID: 30698644
Primary vitreoretinal natural killer/T-cell lymphoma with breast involvement: A case report and review of the literature.
Gao S, Zhou Y, Jin X, Lin Z, Zhong Y, Shen X
Surv Ophthalmol 2019 Mar-Apr;64(2):225-232. Epub 2018 Oct 13 doi: 10.1016/j.survophthal.2018.10.003. PMID: 30321569

Prognosis

Primary central nervous system lymphoma.
Schaff LR, Grommes C
Blood 2022 Sep 1;140(9):971-979. doi: 10.1182/blood.2020008377. PMID: 34699590Free PMC Article
CYSTOID MACULAR EDEMA IN THE SETTING OF PRIMARY VITREORETINAL LYMPHOMA.
Deák GG, Sneed SR, Jampol LM
Retin Cases Brief Rep 2021 Mar 1;15(2):104-106. doi: 10.1097/ICB.0000000000000797. PMID: 30015778
Lenalidomide in combination with intravenous rituximab (REVRI) in relapsed/refractory primary CNS lymphoma or primary intraocular lymphoma: a multicenter prospective 'proof of concept' phase II study of the French Oculo-Cerebral lymphoma (LOC) Network and the Lymphoma Study Association (LYSA)†.
Ghesquieres H, Chevrier M, Laadhari M, Chinot O, Choquet S, Moluçon-Chabrot C, Beauchesne P, Gressin R, Morschhauser F, Schmitt A, Gyan E, Hoang-Xuan K, Nicolas-Virelizier E, Cassoux N, Touitou V, Le Garff-Tavernier M, Savignoni A, Turbiez I, Soumelis V, Houillier C, Soussain C
Ann Oncol 2019 Apr 1;30(4):621-628. doi: 10.1093/annonc/mdz032. PMID: 30698644
Optical coherence tomography manifestations of primary vitreoretinal lymphoma.
Saito T, Ohguro N, Iwahashi C, Hashida N
Graefes Arch Clin Exp Ophthalmol 2016 Dec;254(12):2319-2326. Epub 2016 Jun 1 doi: 10.1007/s00417-016-3395-x. PMID: 27251192
How we diagnose and treat vitreoretinal lymphoma.
Fend F, Ferreri AJ, Coupland SE
Br J Haematol 2016 Jun;173(5):680-92. Epub 2016 May 2 doi: 10.1111/bjh.14025. PMID: 27133587

Clinical prediction guides

Comparative Molecular Analysis of Primary Central Nervous System Lymphomas and Matched Vitreoretinal Lymphomas by Vitreous Liquid Biopsy.
Balikov DA, Hu K, Liu CJ, Betz BL, Chinnaiyan AM, Devisetty LV, Venneti S, Tomlins SA, Cani AK, Rao RC
Int J Mol Sci 2021 Sep 16;22(18) doi: 10.3390/ijms22189992. PMID: 34576156Free PMC Article
Lenalidomide in combination with intravenous rituximab (REVRI) in relapsed/refractory primary CNS lymphoma or primary intraocular lymphoma: a multicenter prospective 'proof of concept' phase II study of the French Oculo-Cerebral lymphoma (LOC) Network and the Lymphoma Study Association (LYSA)†.
Ghesquieres H, Chevrier M, Laadhari M, Chinot O, Choquet S, Moluçon-Chabrot C, Beauchesne P, Gressin R, Morschhauser F, Schmitt A, Gyan E, Hoang-Xuan K, Nicolas-Virelizier E, Cassoux N, Touitou V, Le Garff-Tavernier M, Savignoni A, Turbiez I, Soumelis V, Houillier C, Soussain C
Ann Oncol 2019 Apr 1;30(4):621-628. doi: 10.1093/annonc/mdz032. PMID: 30698644
How we diagnose and treat vitreoretinal lymphoma.
Fend F, Ferreri AJ, Coupland SE
Br J Haematol 2016 Jun;173(5):680-92. Epub 2016 May 2 doi: 10.1111/bjh.14025. PMID: 27133587

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