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Borderline Resectable Pancreatic Ductal Adenocarcinoma

MedGen UID:
1682507
Concept ID:
C4763562
Neoplastic Process
Synonyms: Borderline Resectable Pancreatic Adenocarcinoma; Borderline Resectable Pancreatic Cancer; Borderline Resectable Pancreatic Carcinoma

Definition

A pancreatic ductal adenocarcinoma term that refers to a continuum between resectable and locally advanced unresectable disease. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBorderline Resectable Pancreatic Ductal Adenocarcinoma

Professional guidelines

PubMed

Kaufmann B, Hartmann D, D'Haese JG, Stupakov P, Radenkovic D, Gloor B, Friess H
Dig Surg 2019;36(6):455-461. Epub 2018 Nov 8 doi: 10.1159/000493466. PMID: 30408790
Isaji S, Mizuno S, Windsor JA, Bassi C, Fernández-Del Castillo C, Hackert T, Hayasaki A, Katz MHG, Kim SW, Kishiwada M, Kitagawa H, Michalski CW, Wolfgang CL
Pancreatology 2018 Jan;18(1):2-11. Epub 2017 Nov 22 doi: 10.1016/j.pan.2017.11.011. PMID: 29191513
Bockhorn M, Uzunoglu FG, Adham M, Imrie C, Milicevic M, Sandberg AA, Asbun HJ, Bassi C, Büchler M, Charnley RM, Conlon K, Cruz LF, Dervenis C, Fingerhutt A, Friess H, Gouma DJ, Hartwig W, Lillemoe KD, Montorsi M, Neoptolemos JP, Shrikhande SV, Takaori K, Traverso W, Vashist YK, Vollmer C, Yeo CJ, Izbicki JR; International Study Group of Pancreatic Surgery
Surgery 2014 Jun;155(6):977-88. Epub 2014 Feb 7 doi: 10.1016/j.surg.2014.02.001. PMID: 24856119

Recent clinical studies

Etiology

Ghaneh P, Palmer D, Cicconi S, Jackson R, Halloran CM, Rawcliffe C, Sripadam R, Mukherjee S, Soonawalla Z, Wadsley J, Al-Mukhtar A, Dickson E, Graham J, Jiao L, Wasan HS, Tait IS, Prachalias A, Ross P, Valle JW, O'Reilly DA, Al-Sarireh B, Gwynne S, Ahmed I, Connolly K, Yim KL, Cunningham D, Armstrong T, Archer C, Roberts K, Ma YT, Springfeld C, Tjaden C, Hackert T, Büchler MW, Neoptolemos JP; European Study Group for Pancreatic Cancer
Lancet Gastroenterol Hepatol 2023 Feb;8(2):157-168. Epub 2022 Dec 12 doi: 10.1016/S2468-1253(22)00348-X. PMID: 36521500
Katz MHG, Shi Q, Meyers J, Herman JM, Chuong M, Wolpin BM, Ahmad S, Marsh R, Schwartz L, Behr S, Frankel WL, Collisson E, Leenstra J, Williams TM, Vaccaro G, Venook A, Meyerhardt JA, O'Reilly EM
JAMA Oncol 2022 Sep 1;8(9):1263-1270. doi: 10.1001/jamaoncol.2022.2319. PMID: 35834226Free PMC Article
Murphy JE, Wo JY, Ryan DP, Jiang W, Yeap BY, Drapek LC, Blaszkowsky LS, Kwak EL, Allen JN, Clark JW, Faris JE, Zhu AX, Goyal L, Lillemoe KD, DeLaney TF, Fernández-Del Castillo C, Ferrone CR, Hong TS
JAMA Oncol 2018 Jul 1;4(7):963-969. doi: 10.1001/jamaoncol.2018.0329. PMID: 29800971Free PMC Article
Isaji S, Mizuno S, Windsor JA, Bassi C, Fernández-Del Castillo C, Hackert T, Hayasaki A, Katz MHG, Kim SW, Kishiwada M, Kitagawa H, Michalski CW, Wolfgang CL
Pancreatology 2018 Jan;18(1):2-11. Epub 2017 Nov 22 doi: 10.1016/j.pan.2017.11.011. PMID: 29191513
Bockhorn M, Uzunoglu FG, Adham M, Imrie C, Milicevic M, Sandberg AA, Asbun HJ, Bassi C, Büchler M, Charnley RM, Conlon K, Cruz LF, Dervenis C, Fingerhutt A, Friess H, Gouma DJ, Hartwig W, Lillemoe KD, Montorsi M, Neoptolemos JP, Shrikhande SV, Takaori K, Traverso W, Vashist YK, Vollmer C, Yeo CJ, Izbicki JR; International Study Group of Pancreatic Surgery
Surgery 2014 Jun;155(6):977-88. Epub 2014 Feb 7 doi: 10.1016/j.surg.2014.02.001. PMID: 24856119

Diagnosis

Bohan RP, Riner AN, Herremans KM, George TJ, Hughes SJ, Solberg LB
JCO Oncol Pract 2023 Oct;19(10):882-887. Epub 2023 Aug 30 doi: 10.1200/OP.23.00044. PMID: 37647578Free PMC Article
Kaufmann B, Hartmann D, D'Haese JG, Stupakov P, Radenkovic D, Gloor B, Friess H
Dig Surg 2019;36(6):455-461. Epub 2018 Nov 8 doi: 10.1159/000493466. PMID: 30408790
Murphy JE, Wo JY, Ryan DP, Jiang W, Yeap BY, Drapek LC, Blaszkowsky LS, Kwak EL, Allen JN, Clark JW, Faris JE, Zhu AX, Goyal L, Lillemoe KD, DeLaney TF, Fernández-Del Castillo C, Ferrone CR, Hong TS
JAMA Oncol 2018 Jul 1;4(7):963-969. doi: 10.1001/jamaoncol.2018.0329. PMID: 29800971Free PMC Article
Isaji S, Mizuno S, Windsor JA, Bassi C, Fernández-Del Castillo C, Hackert T, Hayasaki A, Katz MHG, Kim SW, Kishiwada M, Kitagawa H, Michalski CW, Wolfgang CL
Pancreatology 2018 Jan;18(1):2-11. Epub 2017 Nov 22 doi: 10.1016/j.pan.2017.11.011. PMID: 29191513
Hackert T, Ulrich A, Büchler MW
Cancer Lett 2016 Jun 1;375(2):231-237. Epub 2016 Mar 9 doi: 10.1016/j.canlet.2016.02.039. PMID: 26970276

Therapy

Ghaneh P, Palmer D, Cicconi S, Jackson R, Halloran CM, Rawcliffe C, Sripadam R, Mukherjee S, Soonawalla Z, Wadsley J, Al-Mukhtar A, Dickson E, Graham J, Jiao L, Wasan HS, Tait IS, Prachalias A, Ross P, Valle JW, O'Reilly DA, Al-Sarireh B, Gwynne S, Ahmed I, Connolly K, Yim KL, Cunningham D, Armstrong T, Archer C, Roberts K, Ma YT, Springfeld C, Tjaden C, Hackert T, Büchler MW, Neoptolemos JP; European Study Group for Pancreatic Cancer
Lancet Gastroenterol Hepatol 2023 Feb;8(2):157-168. Epub 2022 Dec 12 doi: 10.1016/S2468-1253(22)00348-X. PMID: 36521500
Dias Costa A, Väyrynen SA, Chawla A, Zhang J, Väyrynen JP, Lau MC, Williams HL, Yuan C, Morales-Oyarvide V, Elganainy D, Singh H, Cleary JM, Perez K, Ng K, Freed-Pastor W, Mancias JD, Dougan SK, Wang J, Rubinson DA, Dunne RF, Kozak MM, Brais L, Reilly E, Clancy T, Linehan DC, Chang DT, Hezel AF, Koong AC, Aguirre AJ, Wolpin BM, Nowak JA
Clin Cancer Res 2022 Dec 1;28(23):5167-5179. doi: 10.1158/1078-0432.CCR-22-1125. PMID: 36129461Free PMC Article
Katz MHG, Shi Q, Meyers J, Herman JM, Chuong M, Wolpin BM, Ahmad S, Marsh R, Schwartz L, Behr S, Frankel WL, Collisson E, Leenstra J, Williams TM, Vaccaro G, Venook A, Meyerhardt JA, O'Reilly EM
JAMA Oncol 2022 Sep 1;8(9):1263-1270. doi: 10.1001/jamaoncol.2022.2319. PMID: 35834226Free PMC Article
Murphy JE, Wo JY, Ryan DP, Jiang W, Yeap BY, Drapek LC, Blaszkowsky LS, Kwak EL, Allen JN, Clark JW, Faris JE, Zhu AX, Goyal L, Lillemoe KD, DeLaney TF, Fernández-Del Castillo C, Ferrone CR, Hong TS
JAMA Oncol 2018 Jul 1;4(7):963-969. doi: 10.1001/jamaoncol.2018.0329. PMID: 29800971Free PMC Article
Hackert T, Ulrich A, Büchler MW
Cancer Lett 2016 Jun 1;375(2):231-237. Epub 2016 Mar 9 doi: 10.1016/j.canlet.2016.02.039. PMID: 26970276

Prognosis

Ghaneh P, Palmer D, Cicconi S, Jackson R, Halloran CM, Rawcliffe C, Sripadam R, Mukherjee S, Soonawalla Z, Wadsley J, Al-Mukhtar A, Dickson E, Graham J, Jiao L, Wasan HS, Tait IS, Prachalias A, Ross P, Valle JW, O'Reilly DA, Al-Sarireh B, Gwynne S, Ahmed I, Connolly K, Yim KL, Cunningham D, Armstrong T, Archer C, Roberts K, Ma YT, Springfeld C, Tjaden C, Hackert T, Büchler MW, Neoptolemos JP; European Study Group for Pancreatic Cancer
Lancet Gastroenterol Hepatol 2023 Feb;8(2):157-168. Epub 2022 Dec 12 doi: 10.1016/S2468-1253(22)00348-X. PMID: 36521500
Maggino L, Malleo G, Crippa S, Belfiori G, Nobile S, Gasparini G, Lionetto G, Luchini C, Mattiolo P, Schiavo-Lena M, Doglioni C, Scarpa A, Bassi C, Falconi M, Salvia R
Ann Surg Oncol 2023 Jan;30(1):207-219. Epub 2022 Oct 13 doi: 10.1245/s10434-022-12622-w. PMID: 36227391Free PMC Article
Murphy JE, Wo JY, Ryan DP, Jiang W, Yeap BY, Drapek LC, Blaszkowsky LS, Kwak EL, Allen JN, Clark JW, Faris JE, Zhu AX, Goyal L, Lillemoe KD, DeLaney TF, Fernández-Del Castillo C, Ferrone CR, Hong TS
JAMA Oncol 2018 Jul 1;4(7):963-969. doi: 10.1001/jamaoncol.2018.0329. PMID: 29800971Free PMC Article
Hackert T, Ulrich A, Büchler MW
Cancer Lett 2016 Jun 1;375(2):231-237. Epub 2016 Mar 9 doi: 10.1016/j.canlet.2016.02.039. PMID: 26970276
Bockhorn M, Uzunoglu FG, Adham M, Imrie C, Milicevic M, Sandberg AA, Asbun HJ, Bassi C, Büchler M, Charnley RM, Conlon K, Cruz LF, Dervenis C, Fingerhutt A, Friess H, Gouma DJ, Hartwig W, Lillemoe KD, Montorsi M, Neoptolemos JP, Shrikhande SV, Takaori K, Traverso W, Vashist YK, Vollmer C, Yeo CJ, Izbicki JR; International Study Group of Pancreatic Surgery
Surgery 2014 Jun;155(6):977-88. Epub 2014 Feb 7 doi: 10.1016/j.surg.2014.02.001. PMID: 24856119

Clinical prediction guides

Lee B, Yoon YS, Kang M, Park Y, Lee E, Jo Y, Lee JS, Lee HW, Cho JY, Han HS
Ann Surg Oncol 2023 Jun;30(6):3444-3454. Epub 2023 Jan 25 doi: 10.1245/s10434-022-13043-5. PMID: 36695994
Ghaneh P, Palmer D, Cicconi S, Jackson R, Halloran CM, Rawcliffe C, Sripadam R, Mukherjee S, Soonawalla Z, Wadsley J, Al-Mukhtar A, Dickson E, Graham J, Jiao L, Wasan HS, Tait IS, Prachalias A, Ross P, Valle JW, O'Reilly DA, Al-Sarireh B, Gwynne S, Ahmed I, Connolly K, Yim KL, Cunningham D, Armstrong T, Archer C, Roberts K, Ma YT, Springfeld C, Tjaden C, Hackert T, Büchler MW, Neoptolemos JP; European Study Group for Pancreatic Cancer
Lancet Gastroenterol Hepatol 2023 Feb;8(2):157-168. Epub 2022 Dec 12 doi: 10.1016/S2468-1253(22)00348-X. PMID: 36521500
Maggino L, Malleo G, Crippa S, Belfiori G, Nobile S, Gasparini G, Lionetto G, Luchini C, Mattiolo P, Schiavo-Lena M, Doglioni C, Scarpa A, Bassi C, Falconi M, Salvia R
Ann Surg Oncol 2023 Jan;30(1):207-219. Epub 2022 Oct 13 doi: 10.1245/s10434-022-12622-w. PMID: 36227391Free PMC Article
Kaufmann B, Hartmann D, D'Haese JG, Stupakov P, Radenkovic D, Gloor B, Friess H
Dig Surg 2019;36(6):455-461. Epub 2018 Nov 8 doi: 10.1159/000493466. PMID: 30408790
Bockhorn M, Uzunoglu FG, Adham M, Imrie C, Milicevic M, Sandberg AA, Asbun HJ, Bassi C, Büchler M, Charnley RM, Conlon K, Cruz LF, Dervenis C, Fingerhutt A, Friess H, Gouma DJ, Hartwig W, Lillemoe KD, Montorsi M, Neoptolemos JP, Shrikhande SV, Takaori K, Traverso W, Vashist YK, Vollmer C, Yeo CJ, Izbicki JR; International Study Group of Pancreatic Surgery
Surgery 2014 Jun;155(6):977-88. Epub 2014 Feb 7 doi: 10.1016/j.surg.2014.02.001. PMID: 24856119

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