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Absence of Langerhans cells in affected skin

MedGen UID:
1684026
•Concept ID:
C5194136
•
Finding

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbsence of Langerhans cells in affected skin

Recent clinical studies

Etiology

Merkel cell polyomavirus DNA sequences in peripheral blood and tissues from patients with Langerhans cell histiocytosis.
Murakami I, Matsushita M, Iwasaki T, Kuwamoto S, Kato M, Horie Y, Hayashi K, Imamura T, Morimoto A, Imashuku S, Gogusev J, Jaubert F, Takata K, Oka T, Yoshino T
Hum Pathol 2014 Jan;45(1):119-26. doi: 10.1016/j.humpath.2013.05.028. PMID: 24321520
Natural killer T cell facilitated engraftment of rat skin but not islet xenografts in mice.
Gordon EJ, Kelkar V
Xenotransplantation 2009 May-Jun;16(3):135-44. doi: 10.1111/j.1399-3089.2009.00524.x. PMID: 19566653
Counts and areas of S-100-positive epidermal dendritic cells in atypical molluscum contagiosum affecting HIV+ patients.
Vera-Sempere FJ, Rubio L, Massmanian A
Histol Histopathol 2001 Jan;16(1):45-51. doi: 10.14670/HH-16.45. PMID: 11193211

Diagnosis

Juvenile xanthogranuloma.
Hernandez-Martin A, Baselga E, Drolet BA, Esterly NB
J Am Acad Dermatol 1997 Mar;36(3 Pt 1):355-67; quiz 368-9. doi: 10.1016/s0190-9622(97)80207-1. PMID: 9091465

Therapy

Immune Profiles Identification by Vaccinomics After MVA Immunization in Randomized Clinical Study.
Sanchez J, Gonçalves E, Llano A, Gonzáles P, Fernández-Maldonado M, Vogt A, Soria A, Perez S, Cedeño S, Fernández MA, Nourikyan J, de Bernard S, Ganoza C, Pedruzzi E, Bonduelle O, Mothe B, Gòmez CE, Esteban M, Garcia F, Lama JR, Brander C, Combadiere B
Front Immunol 2020;11:586124. Epub 2020 Nov 10 doi: 10.3389/fimmu.2020.586124. PMID: 33244316Free PMC Article

Prognosis

Langerhans cell histiocytosis in Chinese adults: absence of BRAF mutations and increased FOXP3(+) regulatory T cells.
Tong C, Jia X, Jia Y, He Y
Int J Clin Exp Pathol 2014;7(6):3166-73. Epub 2014 May 15 PMID: 25031736Free PMC Article
Natural killer T cell facilitated engraftment of rat skin but not islet xenografts in mice.
Gordon EJ, Kelkar V
Xenotransplantation 2009 May-Jun;16(3):135-44. doi: 10.1111/j.1399-3089.2009.00524.x. PMID: 19566653
Counts and areas of S-100-positive epidermal dendritic cells in atypical molluscum contagiosum affecting HIV+ patients.
Vera-Sempere FJ, Rubio L, Massmanian A
Histol Histopathol 2001 Jan;16(1):45-51. doi: 10.14670/HH-16.45. PMID: 11193211
Juvenile xanthogranuloma.
Hernandez-Martin A, Baselga E, Drolet BA, Esterly NB
J Am Acad Dermatol 1997 Mar;36(3 Pt 1):355-67; quiz 368-9. doi: 10.1016/s0190-9622(97)80207-1. PMID: 9091465
Disseminated superficial porokeratosis in a patient with AIDS.
Kanitakis J, Misery L, Nicolas JF, Lyonnet S, Chouvet B, Haftek M, Faure M, Claudy A, Thivolet J
Br J Dermatol 1994 Aug;131(2):284-9. doi: 10.1111/j.1365-2133.1994.tb08507.x. PMID: 7917997

Clinical prediction guides

Natural killer T cell facilitated engraftment of rat skin but not islet xenografts in mice.
Gordon EJ, Kelkar V
Xenotransplantation 2009 May-Jun;16(3):135-44. doi: 10.1111/j.1399-3089.2009.00524.x. PMID: 19566653
Counts and areas of S-100-positive epidermal dendritic cells in atypical molluscum contagiosum affecting HIV+ patients.
Vera-Sempere FJ, Rubio L, Massmanian A
Histol Histopathol 2001 Jan;16(1):45-51. doi: 10.14670/HH-16.45. PMID: 11193211
The high-affinity receptor for IgE is the predominant IgE-binding structure in lesional skin of atopic dermatitis patients.
Klubal R, Osterhoff B, Wang B, Kinet JP, Maurer D, Stingl G
J Invest Dermatol 1997 Mar;108(3):336-42. doi: 10.1111/1523-1747.ep12286482. PMID: 9036935
A comparative immunohistochemical study of cytokeratin and vimentin expression in middle ear mucosa and cholesteatoma, and in epidermis.
Broekaert D, Cornille A, Eto H, Leigh I, Ramaekers F, Van Muijen G, Coucke P, De Bersaques J, Kluyskens P, Gillis E
Virchows Arch A Pathol Anat Histopathol 1988;413(1):39-51. doi: 10.1007/BF00844280. PMID: 2453971

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