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Refractory Adenovirus Infection

MedGen UID:
1684480
•Concept ID:
C4763551
•
Disease or Syndrome

Definition

An adenovirus infection that does not respond to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Adenovirus Infection

Professional guidelines

PubMed

Treatment of prostate cancer with Ad5/3Delta24hCG allows non-invasive detection of the magnitude and persistence of virus replication in vivo.
Rajecki M, Kanerva A, Stenman UH, Tenhunen M, Kangasniemi L, Särkioja M, Ala-Opas MY, Alfthan H, Sankila A, Rintala E, Desmond RA, Hakkarainen T, Hemminki A
Mol Cancer Ther 2007 Feb;6(2):742-51. doi: 10.1158/1535-7163.MCT-06-0403. PMID: 17308070
Potential of the conditionally replicative adenovirus Ad5-Delta24RGD in the treatment of malignant gliomas and its enhanced effect with radiotherapy.
Lamfers ML, Grill J, Dirven CM, Van Beusechem VW, Geoerger B, Van Den Berg J, Alemany R, Fueyo J, Curiel DT, Vassal G, Pinedo HM, Vandertop WP, Gerritsen WR
Cancer Res 2002 Oct 15;62(20):5736-42. PMID: 12384532
Advances in the management of hemophagocytic lymphohistiocytosis.
Imashuku S
Int J Hematol 2000 Jul;72(1):1-11. PMID: 10979202

Recent clinical studies

Etiology

Impact of viral coinfection and macrolide-resistant mycoplasma infection in children with refractory Mycoplasma pneumoniae pneumonia.
Zhou Y, Wang J, Chen W, Shen N, Tao Y, Zhao R, Luo L, Li B, Cao Q
BMC Infect Dis 2020 Aug 26;20(1):633. doi: 10.1186/s12879-020-05356-1. PMID: 32847534Free PMC Article
Transfer of Hexon- and Penton-selected adenovirus-specific T cells for refractory adenovirus infection after haploidentical stem cell transplantation.
Schultze-Florey RE, Tischer-Zimmermann S, Heuft HG, Priesner C, Lamottke B, Heim A, Sauer M, Sykora KW, Blasczyk R, Eiz-Vesper B, Maecker-Kolhoff B
Transpl Infect Dis 2020 Feb;22(1):e13201. Epub 2019 Nov 11 doi: 10.1111/tid.13201. PMID: 31643129
Pathogens and outcomes in pediatric septic shock patients supported by extracorporeal membrane oxygenation.
Chang TH, Wu ET, Lu CY, Huang SC, Yang TI, Wang CC, Chen JM, Lee PI, Huang LM, Chang LY
J Microbiol Immunol Infect 2018 Jun;51(3):385-391. Epub 2017 Aug 4 doi: 10.1016/j.jmii.2017.07.012. PMID: 28821378
Microbial agents associated with waterborne diseases.
Leclerc H, Schwartzbrod L, Dei-Cas E
Crit Rev Microbiol 2002;28(4):371-409. doi: 10.1080/1040-840291046768. PMID: 12546197
Advances in the management of hemophagocytic lymphohistiocytosis.
Imashuku S
Int J Hematol 2000 Jul;72(1):1-11. PMID: 10979202

Diagnosis

Viral Coinfections in Kawasaki Disease: A Meta-analysis.
Neubauer HC, Lopez MA, Haq HA, Ouellette L, Ramirez AA, Wallace SS
Hosp Pediatr 2023 Jun 1;13(6):e153-e169. doi: 10.1542/hpeds.2023-007150. PMID: 37170763
Mystery eye: Human adenovirus and the enigma of epidemic keratoconjunctivitis.
Jonas RA, Ung L, Rajaiya J, Chodosh J
Prog Retin Eye Res 2020 May;76:100826. Epub 2019 Dec 28 doi: 10.1016/j.preteyeres.2019.100826. PMID: 31891773Free PMC Article
Disseminated adenovirus infection in a patient with relapsed refractory multiple myeloma undergoing autologous stem cell transplantation and pomalidomide/dexamethasone as salvage regimens.
Yasuda S, Najima Y, Konishi T, Yamada Y, Takezaki T, Kurosawa S, Sakaguchi M, Harada K, Yoshioka K, Igarashi A, Inamoto K, Toya T, Kobayashi T, Doki N, Kakihana K, Sakamaki H, Sekiya N, Ohashi K
J Infect Chemother 2019 May;25(5):371-375. Epub 2019 Jan 11 doi: 10.1016/j.jiac.2018.11.011. PMID: 30642772
Microbial agents associated with waterborne diseases.
Leclerc H, Schwartzbrod L, Dei-Cas E
Crit Rev Microbiol 2002;28(4):371-409. doi: 10.1080/1040-840291046768. PMID: 12546197
Advances in the management of hemophagocytic lymphohistiocytosis.
Imashuku S
Int J Hematol 2000 Jul;72(1):1-11. PMID: 10979202

Therapy

Viral Coinfections in Kawasaki Disease: A Meta-analysis.
Neubauer HC, Lopez MA, Haq HA, Ouellette L, Ramirez AA, Wallace SS
Hosp Pediatr 2023 Jun 1;13(6):e153-e169. doi: 10.1542/hpeds.2023-007150. PMID: 37170763
Impact of viral coinfection and macrolide-resistant mycoplasma infection in children with refractory Mycoplasma pneumoniae pneumonia.
Zhou Y, Wang J, Chen W, Shen N, Tao Y, Zhao R, Luo L, Li B, Cao Q
BMC Infect Dis 2020 Aug 26;20(1):633. doi: 10.1186/s12879-020-05356-1. PMID: 32847534Free PMC Article
Strategies of adoptive T -cell transfer to treat refractory viral infections post allogeneic stem cell transplantation.
Kaeuferle T, Krauss R, Blaeschke F, Willier S, Feuchtinger T
J Hematol Oncol 2019 Feb 6;12(1):13. doi: 10.1186/s13045-019-0701-1. PMID: 30728058Free PMC Article
Adenovirus infection in pediatric transplant recipients: are effective antiviral agents coming our way?
Lopez SMC, Michaels MG, Green M
Curr Opin Organ Transplant 2018 Aug;23(4):395-399. doi: 10.1097/MOT.0000000000000542. PMID: 29846196
Off-the-Shelf Virus-Specific T Cells to Treat BK Virus, Human Herpesvirus 6, Cytomegalovirus, Epstein-Barr Virus, and Adenovirus Infections After Allogeneic Hematopoietic Stem-Cell Transplantation.
Tzannou I, Papadopoulou A, Naik S, Leung K, Martinez CA, Ramos CA, Carrum G, Sasa G, Lulla P, Watanabe A, Kuvalekar M, Gee AP, Wu MF, Liu H, Grilley BJ, Krance RA, Gottschalk S, Brenner MK, Rooney CM, Heslop HE, Leen AM, Omer B
J Clin Oncol 2017 Nov 1;35(31):3547-3557. Epub 2017 Aug 7 doi: 10.1200/JCO.2017.73.0655. PMID: 28783452Free PMC Article

Prognosis

Long-term safety and efficacy of intramyocardial adenovirus-mediated VEGF-D(ΔNΔC) gene therapy eight-year follow-up of phase I KAT301 study.
Leikas AJ, Hassinen I, Hedman A, Kivelä A, Ylä-Herttuala S, Hartikainen JEK
Gene Ther 2022 May;29(5):289-293. Epub 2021 Oct 1 doi: 10.1038/s41434-021-00295-1. PMID: 34593990Free PMC Article
Impact of viral coinfection and macrolide-resistant mycoplasma infection in children with refractory Mycoplasma pneumoniae pneumonia.
Zhou Y, Wang J, Chen W, Shen N, Tao Y, Zhao R, Luo L, Li B, Cao Q
BMC Infect Dis 2020 Aug 26;20(1):633. doi: 10.1186/s12879-020-05356-1. PMID: 32847534Free PMC Article
Disseminated adenovirus infection in a patient with relapsed refractory multiple myeloma undergoing autologous stem cell transplantation and pomalidomide/dexamethasone as salvage regimens.
Yasuda S, Najima Y, Konishi T, Yamada Y, Takezaki T, Kurosawa S, Sakaguchi M, Harada K, Yoshioka K, Igarashi A, Inamoto K, Toya T, Kobayashi T, Doki N, Kakihana K, Sakamaki H, Sekiya N, Ohashi K
J Infect Chemother 2019 May;25(5):371-375. Epub 2019 Jan 11 doi: 10.1016/j.jiac.2018.11.011. PMID: 30642772
Malignancy and chemotherapy induced haemophagocytic lymphohistiocytosis in children and adolescents-a single centre experience of 20 years.
Strenger V, Merth G, Lackner H, Aberle SW, Kessler HH, Seidel MG, Schwinger W, Sperl D, Sovinz P, Karastaneva A, Benesch M, Urban C
Ann Hematol 2018 Jun;97(6):989-998. Epub 2018 Feb 6 doi: 10.1007/s00277-018-3254-4. PMID: 29411124Free PMC Article
Disseminated adenovirus infection causing severe ARDS.
Campbell SJ, Kynyk JA, Davis JA
BMJ Case Rep 2017 Jan 17;2017 doi: 10.1136/bcr-2016-217524. PMID: 28096226Free PMC Article

Clinical prediction guides

Viral Coinfections in Kawasaki Disease: A Meta-analysis.
Neubauer HC, Lopez MA, Haq HA, Ouellette L, Ramirez AA, Wallace SS
Hosp Pediatr 2023 Jun 1;13(6):e153-e169. doi: 10.1542/hpeds.2023-007150. PMID: 37170763
Impact of viral coinfection and macrolide-resistant mycoplasma infection in children with refractory Mycoplasma pneumoniae pneumonia.
Zhou Y, Wang J, Chen W, Shen N, Tao Y, Zhao R, Luo L, Li B, Cao Q
BMC Infect Dis 2020 Aug 26;20(1):633. doi: 10.1186/s12879-020-05356-1. PMID: 32847534Free PMC Article
Adenovirus-specific T-lymphocyte efficacy in the presence of methylprednisolone: An in vitro study.
Campidelli A, Qian C, Laroye C, Decot V, Reppel L, D'aveni M, Bensoussan D
Cytotherapy 2018 Apr;20(4):524-531. Epub 2018 Mar 1 doi: 10.1016/j.jcyt.2017.12.010. PMID: 29496461
Pathogens and outcomes in pediatric septic shock patients supported by extracorporeal membrane oxygenation.
Chang TH, Wu ET, Lu CY, Huang SC, Yang TI, Wang CC, Chen JM, Lee PI, Huang LM, Chang LY
J Microbiol Immunol Infect 2018 Jun;51(3):385-391. Epub 2017 Aug 4 doi: 10.1016/j.jmii.2017.07.012. PMID: 28821378
Off-the-Shelf Virus-Specific T Cells to Treat BK Virus, Human Herpesvirus 6, Cytomegalovirus, Epstein-Barr Virus, and Adenovirus Infections After Allogeneic Hematopoietic Stem-Cell Transplantation.
Tzannou I, Papadopoulou A, Naik S, Leung K, Martinez CA, Ramos CA, Carrum G, Sasa G, Lulla P, Watanabe A, Kuvalekar M, Gee AP, Wu MF, Liu H, Grilley BJ, Krance RA, Gottschalk S, Brenner MK, Rooney CM, Heslop HE, Leen AM, Omer B
J Clin Oncol 2017 Nov 1;35(31):3547-3557. Epub 2017 Aug 7 doi: 10.1200/JCO.2017.73.0655. PMID: 28783452Free PMC Article

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