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Abnormal circulating dicarboxylic acid concentration

MedGen UID:
1684672
•Concept ID:
C5139055
•
Finding
Synonym: Abnormality of dicarboxylic acid metabolism
 
HPO: HP:0010995

Definition

Any deviation from the normal concentration of a dicarboxylic acid in the blood circulation. [from HPO]

Recent clinical studies

Etiology

Highly specific monitoring and imaging of endogenous and exogenous cysteine in living cells.
Song X, Yang Y, Ru J, Wang Y, Qiu F, Feng Y, Zhang G, Liu W
Talanta 2019 Nov 1;204:561-568. Epub 2019 Jun 8 doi: 10.1016/j.talanta.2019.06.020. PMID: 31357334
Association of TCN2 rs1801198 c.776G>C polymorphism with markers of one-carbon metabolism and related diseases: a systematic review and meta-analysis of genetic association studies.
Oussalah A, Levy J, Filhine-Trésarrieu P, Namour F, Guéant JL
Am J Clin Nutr 2017 Oct;106(4):1142-1156. Epub 2017 Aug 16 doi: 10.3945/ajcn.117.156349. PMID: 28814397Free PMC Article
Plasma and urinary soluble adhesion molecule expression is increased during first documented acute pyelonephritis.
Gbadegesin RA, Cotton SA, Coupes BM, Awan A, Brenchley PE, Webb NJ
Arch Dis Child 2002 Mar;86(3):218-21. doi: 10.1136/adc.86.3.218. PMID: 11861252Free PMC Article

Diagnosis

Highly specific monitoring and imaging of endogenous and exogenous cysteine in living cells.
Song X, Yang Y, Ru J, Wang Y, Qiu F, Feng Y, Zhang G, Liu W
Talanta 2019 Nov 1;204:561-568. Epub 2019 Jun 8 doi: 10.1016/j.talanta.2019.06.020. PMID: 31357334
Plasma homocysteine is a sensitive marker for tissue deficiency of both cobalamines and folates in a psychogeriatric population.
Nilsson K, Gustafson L, Hultberg B
Dement Geriatr Cogn Disord 1999 Nov-Dec;10(6):476-82. doi: 10.1159/000017193. PMID: 10559563

Therapy

5-HT2A receptor antagonist increases circulating adiponectin in patients with type 2 diabetes.
Nomura S, Shouzu A, Omoto S, Nishikawa M, Iwasaka T
Blood Coagul Fibrinolysis 2005 Sep;16(6):423-8. doi: 10.1097/01.mbc.0000176197.48134.08. PMID: 16093733
Plasma homocysteine is a sensitive marker for tissue deficiency of both cobalamines and folates in a psychogeriatric population.
Nilsson K, Gustafson L, Hultberg B
Dement Geriatr Cogn Disord 1999 Nov-Dec;10(6):476-82. doi: 10.1159/000017193. PMID: 10559563
Urate metabolism and renal calcium stone disease.
Fellström B
Scand J Urol Nephrol Suppl 1981;62:1-59. PMID: 6960474

Prognosis

Plasma and urinary soluble adhesion molecule expression is increased during first documented acute pyelonephritis.
Gbadegesin RA, Cotton SA, Coupes BM, Awan A, Brenchley PE, Webb NJ
Arch Dis Child 2002 Mar;86(3):218-21. doi: 10.1136/adc.86.3.218. PMID: 11861252Free PMC Article
Urate metabolism and renal calcium stone disease.
Fellström B
Scand J Urol Nephrol Suppl 1981;62:1-59. PMID: 6960474

Clinical prediction guides

Association of TCN2 rs1801198 c.776G>C polymorphism with markers of one-carbon metabolism and related diseases: a systematic review and meta-analysis of genetic association studies.
Oussalah A, Levy J, Filhine-Trésarrieu P, Namour F, Guéant JL
Am J Clin Nutr 2017 Oct;106(4):1142-1156. Epub 2017 Aug 16 doi: 10.3945/ajcn.117.156349. PMID: 28814397Free PMC Article
Plasma and urinary soluble adhesion molecule expression is increased during first documented acute pyelonephritis.
Gbadegesin RA, Cotton SA, Coupes BM, Awan A, Brenchley PE, Webb NJ
Arch Dis Child 2002 Mar;86(3):218-21. doi: 10.1136/adc.86.3.218. PMID: 11861252Free PMC Article

Recent systematic reviews

Association of TCN2 rs1801198 c.776G>C polymorphism with markers of one-carbon metabolism and related diseases: a systematic review and meta-analysis of genetic association studies.
Oussalah A, Levy J, Filhine-Trésarrieu P, Namour F, Guéant JL
Am J Clin Nutr 2017 Oct;106(4):1142-1156. Epub 2017 Aug 16 doi: 10.3945/ajcn.117.156349. PMID: 28814397Free PMC Article

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