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Immunotactoid glomerulopathy

MedGen UID:
1684714
•Concept ID:
C5202806
•
Disease or Syndrome
Synonyms: FGN; fibrillary glomerulonephritis; Glomerulonephritis with Organized Monoclonal Microtubular Immunoglobulin Deposits; Immunotactoid glomerulonephritis; Immunotactoid Glomerulopathy; immunotactoid glomerulopathy
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0019991
Orphanet: ORPHA97567

Definition

Immunotactoid glomerulopathy (ITG) is a very rare condition characterized by glomerular accumulation of microtubules in the mesangium and the glomerular basement membrane, that mainly presents with proteinuria, micro-hematuria, nephrotic syndrome, renal insufficiency and hematologic malignancy. ITG and non-amyloid fibrillary glomerulopathy (non-amyloid FGP, see this term) are often grouped together as pathogenetically related diseases. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVImmunotactoid glomerulopathy

Professional guidelines

PubMed

Nonamyloidotic fibrillary glomerulopathy, immunotactoid glomerulopathy, and the differential diagnosis of filamentous glomerulopathies.
Devaney K, Sabnis SG, Antonovych TT
Mod Pathol 1991 Jan;4(1):36-45. PMID: 2020659

Recent clinical studies

Etiology

Paraprotein-Mediated Glomerular Diseases.
Miao J, Herrmann SM, Obaidi Z, Caza T, Bonilla M
Adv Kidney Dis Health 2024 Jul;31(4):358-373. doi: 10.1053/j.akdh.2024.02.005. PMID: 39084761
Immunotactoid Glomerulopathy.
Abramson M, Shaikh A
Adv Kidney Dis Health 2024 Jul;31(4):326-333. doi: 10.1053/j.akdh.2024.03.003. PMID: 39084758
Dysproteinemias and Glomerular Disease.
Leung N, Drosou ME, Nasr SH
Clin J Am Soc Nephrol 2018 Jan 6;13(1):128-139. Epub 2017 Nov 7 doi: 10.2215/CJN.00560117. PMID: 29114004Free PMC Article
Hepatitis C virus associated glomerulopathies.
Ozkok A, Yildiz A
World J Gastroenterol 2014 Jun 28;20(24):7544-54. doi: 10.3748/wjg.v20.i24.7544. PMID: 24976695Free PMC Article
Immunotactoid glomerulopathy.
Korbet SM, Schwartz MM, Rosenberg BF, Sibley RK, Lewis EJ
Medicine (Baltimore) 1985 Jul;64(4):228-43. doi: 10.1097/00005792-198507000-00004. PMID: 4010500

Diagnosis

Paraprotein-Mediated Glomerular Diseases.
Miao J, Herrmann SM, Obaidi Z, Caza T, Bonilla M
Adv Kidney Dis Health 2024 Jul;31(4):358-373. doi: 10.1053/j.akdh.2024.02.005. PMID: 39084761
Immunotactoid Glomerulopathy.
Abramson M, Shaikh A
Adv Kidney Dis Health 2024 Jul;31(4):326-333. doi: 10.1053/j.akdh.2024.03.003. PMID: 39084758
The Complexity and Heterogeneity of Monoclonal Immunoglobulin-Associated Renal Diseases.
Sethi S, Rajkumar SV, D'Agati VD
J Am Soc Nephrol 2018 Jul;29(7):1810-1823. Epub 2018 Apr 27 doi: 10.1681/ASN.2017121319. PMID: 29703839Free PMC Article
Dysproteinemias and Glomerular Disease.
Leung N, Drosou ME, Nasr SH
Clin J Am Soc Nephrol 2018 Jan 6;13(1):128-139. Epub 2017 Nov 7 doi: 10.2215/CJN.00560117. PMID: 29114004Free PMC Article
Immunotactoid glomerulopathy.
Schwartz MM, Korbet SM, Lewis EJ
J Am Soc Nephrol 2002 May;13(5):1390-7. doi: 10.1097/01.asn.0000013397.06964.19. PMID: 11961029

Therapy

Glomerulopathies with Fibrillary Deposits.
Dzekova-Vidimliski P, Karanfilovski V, Nikolov IG, Rambabova-Bushljetik I, Ristovska V, Petrushevska G, Selim G
Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2023 Jul 1;44(2):99-106. Epub 2023 Jul 15 doi: 10.2478/prilozi-2023-0030. PMID: 37453107
Immunotactoid glomerulopathy associated with monoclonal gammopathy.
Inotani S, Horino T, Ishihara M, Ichii O, Matsumori A
Lancet 2021 May 29;397(10289):2081. doi: 10.1016/S0140-6736(21)00477-3. PMID: 34062142
Hepatitis C virus associated glomerulopathies.
Ozkok A, Yildiz A
World J Gastroenterol 2014 Jun 28;20(24):7544-54. doi: 10.3748/wjg.v20.i24.7544. PMID: 24976695Free PMC Article
Clinical features, predictors of disease progression and results of renal transplantation in fibrillary/immunotactoid glomerulopathy.
Pronovost PH, Brady HR, Gunning ME, Espinoza O, Rennke HG
Nephrol Dial Transplant 1996 May;11(5):837-42. doi: 10.1093/oxfordjournals.ndt.a027409. PMID: 8671905
Immunotactoid glomerulopathy.
Korbet SM, Schwartz MM, Rosenberg BF, Sibley RK, Lewis EJ
Medicine (Baltimore) 1985 Jul;64(4):228-43. doi: 10.1097/00005792-198507000-00004. PMID: 4010500

Prognosis

The Complexity and Heterogeneity of Monoclonal Immunoglobulin-Associated Renal Diseases.
Sethi S, Rajkumar SV, D'Agati VD
J Am Soc Nephrol 2018 Jul;29(7):1810-1823. Epub 2018 Apr 27 doi: 10.1681/ASN.2017121319. PMID: 29703839Free PMC Article
Dysproteinemias and Glomerular Disease.
Leung N, Drosou ME, Nasr SH
Clin J Am Soc Nephrol 2018 Jan 6;13(1):128-139. Epub 2017 Nov 7 doi: 10.2215/CJN.00560117. PMID: 29114004Free PMC Article
The fibrillary glomerulopathies.
Korbet SM, Schwartz MM, Lewis EJ
Am J Kidney Dis 1994 May;23(5):751-65. doi: 10.1016/s0272-6386(12)70290-1. PMID: 8172222
Immunotactoid glomerulopathy.
Korbet SM, Schwartz MM, Lewis EJ
Am J Kidney Dis 1991 Mar;17(3):247-57. doi: 10.1016/s0272-6386(12)80469-0. PMID: 1996564
Immunotactoid glomerulopathy.
Korbet SM, Schwartz MM, Rosenberg BF, Sibley RK, Lewis EJ
Medicine (Baltimore) 1985 Jul;64(4):228-43. doi: 10.1097/00005792-198507000-00004. PMID: 4010500

Clinical prediction guides

First case report of monoclonal IgG3-heavy-chain glomerulonephritis with microtubular structures.
Matsuura Y, Goto T, Tamayama Y, Nakamura Y, Oyama J, Ishioka H, Yoshikawa K, Nakaya I, Soma J
CEN Case Rep 2021 May;10(2):236-240. Epub 2020 Nov 6 doi: 10.1007/s13730-020-00550-1. PMID: 33156494Free PMC Article
Results of a nation-wide cohort study suggest favorable long-term outcomes of clone-targeted chemotherapy in immunotactoid glomerulopathy.
Javaugue V, Dufour-Nourigat L, Desport E, Sibille A, Moulin B, Bataille P, Bindi P, Garrouste C, Mariat C, Karlin L, Nouvier M, Goujon JM, Gnemmi V, Fermand JP, Touchard G, Bridoux F
Kidney Int 2021 Feb;99(2):421-430. Epub 2020 Jul 30 doi: 10.1016/j.kint.2020.06.039. PMID: 32739419
Fibrillary glomerulonephritis in siblings.
Chan TM, Chan KW
Am J Kidney Dis 1998 May;31(5):E4. doi: 10.1016/s0272-6386(98)70066-6. PMID: 10074581
Clinical features, predictors of disease progression and results of renal transplantation in fibrillary/immunotactoid glomerulopathy.
Pronovost PH, Brady HR, Gunning ME, Espinoza O, Rennke HG
Nephrol Dial Transplant 1996 May;11(5):837-42. doi: 10.1093/oxfordjournals.ndt.a027409. PMID: 8671905
Immunotactoid glomerulopathy and cutaneous vasculitis.
Orfila C, Meeus F, Bernadet P, Lepert JC, Suc JM
Am J Nephrol 1991;11(1):67-72. doi: 10.1159/000168276. PMID: 1904680

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