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Abnormal circulating long-chain fatty-acid concentration

MedGen UID:
1684802
•Concept ID:
C5139650
•
Finding
Synonym: Abnormality of long-chain fatty-acid metabolism
 
HPO: HP:0010964

Definition

Any deviation from the normal concentration of a long-chain fatty acid in the blood circulation. [from HPO]

Recent clinical studies

Etiology

Plasma phospholipid dysregulation in patients with cystathionine-β synthase deficiency.
Di Minno A, Anesi A, Chiesa M, Cirillo F, Colombo GI, Orsini RC, Capasso F, Morisco F, Fiorelli S, Eligini S, Cavalca V, Tremoli E, Porro B, Di Minno MND
Nutr Metab Cardiovasc Dis 2020 Nov 27;30(12):2286-2295. Epub 2020 Jul 23 doi: 10.1016/j.numecd.2020.07.019. PMID: 32912785
Rationale for a metabolic approach in diabetic coronary patients.
Stanley WC
Coron Artery Dis 2005 Nov;16 Suppl 1:S11-5. doi: 10.1097/00019501-200511001-00003. PMID: 16340398
Membrane proteins implicated in long-chain fatty acid uptake by mammalian cells: CD36, FATP and FABPm.
Abumrad N, Coburn C, Ibrahimi A
Biochim Biophys Acta 1999 Oct 18;1441(1):4-13. doi: 10.1016/s1388-1981(99)00137-7. PMID: 10526223

Diagnosis

Plasma phospholipid dysregulation in patients with cystathionine-β synthase deficiency.
Di Minno A, Anesi A, Chiesa M, Cirillo F, Colombo GI, Orsini RC, Capasso F, Morisco F, Fiorelli S, Eligini S, Cavalca V, Tremoli E, Porro B, Di Minno MND
Nutr Metab Cardiovasc Dis 2020 Nov 27;30(12):2286-2295. Epub 2020 Jul 23 doi: 10.1016/j.numecd.2020.07.019. PMID: 32912785
Evidence for Intramyocardial Disruption of Lipid Metabolism and Increased Myocardial Ketone Utilization in Advanced Human Heart Failure.
Bedi KC Jr, Snyder NW, Brandimarto J, Aziz M, Mesaros C, Worth AJ, Wang LL, Javaheri A, Blair IA, Margulies KB, Rame JE
Circulation 2016 Feb 23;133(8):706-16. Epub 2016 Jan 27 doi: 10.1161/CIRCULATIONAHA.115.017545. PMID: 26819374Free PMC Article
The effects of partial chronic denervation on forearm metabolism.
Karpati G, Klassen G, Tanser P
Can J Neurol Sci 1979 May;6(2):105-12. doi: 10.1017/s0317167100119481. PMID: 487296

Therapy

Rationale for a metabolic approach in diabetic coronary patients.
Stanley WC
Coron Artery Dis 2005 Nov;16 Suppl 1:S11-5. doi: 10.1097/00019501-200511001-00003. PMID: 16340398

Clinical prediction guides

Evidence for Intramyocardial Disruption of Lipid Metabolism and Increased Myocardial Ketone Utilization in Advanced Human Heart Failure.
Bedi KC Jr, Snyder NW, Brandimarto J, Aziz M, Mesaros C, Worth AJ, Wang LL, Javaheri A, Blair IA, Margulies KB, Rame JE
Circulation 2016 Feb 23;133(8):706-16. Epub 2016 Jan 27 doi: 10.1161/CIRCULATIONAHA.115.017545. PMID: 26819374Free PMC Article

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