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Abnormal circulating carnitine concentration

MedGen UID:
1684845
•Concept ID:
C5139053
•
Finding
Synonym: Abnormality of carnitine metabolism
 
HPO: HP:0010967

Definition

Any deviation from the normal concentration of carnitine in the blood circulation. [from HPO]

Recent clinical studies

Diagnosis

Genistein stimulates insulin sensitivity through gut microbiota reshaping and skeletal muscle AMPK activation in obese subjects.
Guevara-Cruz M, Godinez-Salas ET, Sanchez-Tapia M, Torres-Villalobos G, Pichardo-Ontiveros E, Guizar-Heredia R, Arteaga-Sanchez L, Gamba G, Mojica-Espinosa R, Schcolnik-Cabrera A, Granados O, López-Barradas A, Vargas-Castillo A, Torre-Villalvazo I, Noriega LG, Torres N, Tovar AR
BMJ Open Diabetes Res Care 2020 Mar;8(1) doi: 10.1136/bmjdrc-2019-000948. PMID: 32152146Free PMC Article
Are the beta-cell signaling molecules malonyl-CoA and cystolic long-chain acyl-CoA implicated in multiple tissue defects of obesity and NIDDM?
Prentki M, Corkey BE
Diabetes 1996 Mar;45(3):273-83. doi: 10.2337/diab.45.3.273. PMID: 8593930

Therapy

Genistein stimulates insulin sensitivity through gut microbiota reshaping and skeletal muscle AMPK activation in obese subjects.
Guevara-Cruz M, Godinez-Salas ET, Sanchez-Tapia M, Torres-Villalobos G, Pichardo-Ontiveros E, Guizar-Heredia R, Arteaga-Sanchez L, Gamba G, Mojica-Espinosa R, Schcolnik-Cabrera A, Granados O, López-Barradas A, Vargas-Castillo A, Torre-Villalvazo I, Noriega LG, Torres N, Tovar AR
BMJ Open Diabetes Res Care 2020 Mar;8(1) doi: 10.1136/bmjdrc-2019-000948. PMID: 32152146Free PMC Article
Evaluation of atorvastatin efficacy and toxicity on spermatozoa, accessory glands and gonadal hormones of healthy men: a pilot prospective clinical trial.
Pons-Rejraji H, Brugnon F, Sion B, Maqdasy S, Gouby G, Pereira B, Marceau G, Gremeau AS, Drevet J, Grizard G, Janny L, Tauveron I
Reprod Biol Endocrinol 2014 Jul 12;12:65. doi: 10.1186/1477-7827-12-65. PMID: 25016482Free PMC Article
Micronutrient profiles in HIV-1-infected heterosexual adults.
Skurnick JH, Bogden JD, Baker H, Kemp FW, Sheffet A, Quattrone G, Louria DB
J Acquir Immune Defic Syndr Hum Retrovirol 1996 May 1;12(1):75-83. doi: 10.1097/00042560-199605010-00011. PMID: 8624765
Plasma carnitine and lipid-lowering drugs.
Nestruck AC, Pande SV, Davignon J
Atherosclerosis 1985 Jun;55(3):353-6. doi: 10.1016/0021-9150(85)90112-1. PMID: 4015753

Prognosis

Trimethylamine oxide: a potential target for heart failure therapy.
Lv S, Wang Y, Zhang W, Shang H
Heart 2022 May 25;108(12):917-922. doi: 10.1136/heartjnl-2021-320054. PMID: 34611047

Clinical prediction guides

Carnitine function and requirements during the life cycle.
Rebouche CJ
FASEB J 1992 Dec;6(15):3379-86. PMID: 1464372

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