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Abnormal circulating citrulline concentration

MedGen UID:
1684868
•Concept ID:
C5139062
•
Finding
Synonym: Abnormality of citrulline metabolism
 
HPO: HP:0011965

Definition

Any deviation from the normal concentration of citrulline in the blood circulation. [from HPO]

Recent clinical studies

Etiology

Nonalcoholic Fatty Liver Disease Severity Is Related to Plasma Pro-Oxidative Biomarkers Rather Than Liver Tissue-Measured Nitrogen Metabolism Biomarkers in Population with Obesity and Metabolic Syndrome.
Suárez-Cuenca JA, Domínguez-Pérez GA, Hernández-Muñóz RE, Hernández-Patricio A, Vera-Gómez E, Gutiérrez-Buendía JA, Salamanca-García M, Montoya-Ramírez J, Gaytán-Fuentes OF, Aranda-Rodríguez C, Rojas-Noverón AR, García S, Mondragón-Terán P
Metab Syndr Relat Disord 2023 Mar;21(2):115-121. Epub 2023 Feb 14 doi: 10.1089/met.2022.0007. PMID: 36787445
Chyme reinfusion in patients with intestinal failure due to temporary double enterostomy: A 15-year prospective cohort in a referral centre.
Picot D, Layec S, Dussaulx L, Trivin F, Thibault R
Clin Nutr 2017 Apr;36(2):593-600. Epub 2016 Apr 28 doi: 10.1016/j.clnu.2016.04.020. PMID: 27161895
Digital plethysmography and arginine metabolism in prehypertension: effect of nebivolol therapy.
Kandavar R, Fernandez C, Sander GE, Kim C, Velaga S, Sukhanov S, Delafontaine P, Egan P, Roffidal LE, Giles TD
J Clin Hypertens (Greenwich) 2015 Jan;17(1):14-9. Epub 2014 Dec 15 doi: 10.1111/jch.12451. PMID: 25495953Free PMC Article
Effect of L-arginine administration on myocardial thallium-201 perfusion during exercise in patients with angina pectoris and normal coronary angiograms.
Fujita H, Yamabe H, Yokoyama M
J Nucl Cardiol 2000 Mar-Apr;7(2):97-102. doi: 10.1016/s1071-3581(00)90028-x. PMID: 10795997

Diagnosis

Nonalcoholic Fatty Liver Disease Severity Is Related to Plasma Pro-Oxidative Biomarkers Rather Than Liver Tissue-Measured Nitrogen Metabolism Biomarkers in Population with Obesity and Metabolic Syndrome.
Suárez-Cuenca JA, Domínguez-Pérez GA, Hernández-Muñóz RE, Hernández-Patricio A, Vera-Gómez E, Gutiérrez-Buendía JA, Salamanca-García M, Montoya-Ramírez J, Gaytán-Fuentes OF, Aranda-Rodríguez C, Rojas-Noverón AR, García S, Mondragón-Terán P
Metab Syndr Relat Disord 2023 Mar;21(2):115-121. Epub 2023 Feb 14 doi: 10.1089/met.2022.0007. PMID: 36787445

Therapy

Digital plethysmography and arginine metabolism in prehypertension: effect of nebivolol therapy.
Kandavar R, Fernandez C, Sander GE, Kim C, Velaga S, Sukhanov S, Delafontaine P, Egan P, Roffidal LE, Giles TD
J Clin Hypertens (Greenwich) 2015 Jan;17(1):14-9. Epub 2014 Dec 15 doi: 10.1111/jch.12451. PMID: 25495953Free PMC Article

Prognosis

Nonalcoholic Fatty Liver Disease Severity Is Related to Plasma Pro-Oxidative Biomarkers Rather Than Liver Tissue-Measured Nitrogen Metabolism Biomarkers in Population with Obesity and Metabolic Syndrome.
Suárez-Cuenca JA, Domínguez-Pérez GA, Hernández-Muñóz RE, Hernández-Patricio A, Vera-Gómez E, Gutiérrez-Buendía JA, Salamanca-García M, Montoya-Ramírez J, Gaytán-Fuentes OF, Aranda-Rodríguez C, Rojas-Noverón AR, García S, Mondragón-Terán P
Metab Syndr Relat Disord 2023 Mar;21(2):115-121. Epub 2023 Feb 14 doi: 10.1089/met.2022.0007. PMID: 36787445
Chyme reinfusion in patients with intestinal failure due to temporary double enterostomy: A 15-year prospective cohort in a referral centre.
Picot D, Layec S, Dussaulx L, Trivin F, Thibault R
Clin Nutr 2017 Apr;36(2):593-600. Epub 2016 Apr 28 doi: 10.1016/j.clnu.2016.04.020. PMID: 27161895

Clinical prediction guides

Effect of L-arginine administration on myocardial thallium-201 perfusion during exercise in patients with angina pectoris and normal coronary angiograms.
Fujita H, Yamabe H, Yokoyama M
J Nucl Cardiol 2000 Mar-Apr;7(2):97-102. doi: 10.1016/s1071-3581(00)90028-x. PMID: 10795997

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    Curated

    • ACMG Algorithm, 2022
      American College of Medical Genetics and Genomics, Algorithm, Decreased Citrulline, 2022

    Consumer resources

    Reviews

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