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Abnormal dendritic cell count

MedGen UID:
1685417
•Concept ID:
C5209261
•
Finding
HPO: HP:0020178

Definition

A deviation from the normal count of dendritic cells in the peripheral blood circulation. Dendritic cells are of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. These cells are lineage negative (CD3-negative, CD19-negative, CD34-negative, and CD56-negative). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal dendritic cell count

Professional guidelines

PubMed

Epidermal Langerhans cells in erythrokeratodermia variabilis. Histochemical and ultrastructural investigations before and after treatment with etretinate (RO 10-9359).
van der Schroeff JG, Ruiter DJ, Bots GT
Arch Dermatol Res 1982;274(3-4):339-48. doi: 10.1007/BF00403739. PMID: 6187301

Recent clinical studies

Etiology

Immune restoration with ibrutinib plus venetoclax in first-line chronic lymphocytic leukemia: the phase 2 CAPTIVATE study.
Moreno C, Solman IG, Tam CS, Grigg A, Scarfò L, Kipps TJ, Srinivasan S, Mali RS, Zhou C, Dean JP, Szafer-Glusman E, Choi M
Blood Adv 2023 Sep 26;7(18):5294-5303. doi: 10.1182/bloodadvances.2023010236. PMID: 37315225Free PMC Article
How should we diagnose and treat blastic plasmacytoid dendritic cell neoplasm patients?
Garnache-Ottou F, Vidal C, Biichlé S, Renosi F, Poret E, Pagadoy M, Desmarets M, Roggy A, Seilles E, Soret L, Schillinger F, Puyraimond S, Petrella T, Preudhomme C, Roumier C, MacIntyre EA, Harrivel V, Desbrosses Y, Gruson B, Geneviève F, Thepot S, Drebit Y, Leguay T, Gros FX, Lechevalier N, Saussoy P, Salaun V, Cornet E, Benseddik Z, Veyrat-Masson R, Wagner-Ballon O, Salanoubat C, Maynadié M, Guy J, Caillot D, Jacob MC, Cahn JY, Gressin R, Rose J, Quesnel B, Guerin E, Trimoreau F, Feuillard J, Gourin MP, Plesa A, Baseggio L, Arnoux I, Vey N, Blaise D, Lacroix R, Arnoulet C, Benet B, Dorvaux V, Bret C, Drenou B, Debliquis A, Latger-Cannard V, Bonmati C, Bene MC, Peterlin P, Ticchioni M, Rohrlich PS, Arnaud A, Wickenhauser S, Bardet V, Brechignac S, Papoular B, Raggueneau V, Vargaftig J, Letestu R, Lusina D, Braun T, Foissaud V, Tamburini J, Bennani H, Freynet N, Cordonnier C, Le Garff-Tavernier M, Jacques N, Maloum K, Roos-Weil D, Bouscary D, Asnafi V, Lhermitte L, Suarez F, Lengline E, Féger F, Battipaglia G, Mohty M, Bouyer S, Ghoual O, Dindinaud E, Basle C, Puyade M, Lafon C, Fest T, Roussel M, Cahu X, Bera E, Daliphard S, Jardin F, Campos L, Solly F, Guyotat D, Galoisy AC, Eischen A, Mayeur-Rousse C, Guffroy B, Recher C, Loosveld M, Garnier A, Barlogis V, Rosenthal MA, Brun S, Contentin N, Maury S, Callanan M, Lefebvre C, Maillard N, Okamba P, Ferrand C, Adotevi O, Saas P, Angelot-Delettre F, Binda D, Deconinck E
Blood Adv 2019 Dec 23;3(24):4238-4251. doi: 10.1182/bloodadvances.2019000647. PMID: 31869411Free PMC Article
The impact of several phenotypic features at diagnosis on survival of patients with myelodysplastic syndromes.
Reis-Alves SC, Traina F, Saad ST, Metze K, Lorand-Metze I
Neoplasma 2010;57(6):530-6. doi: 10.4149/neo_2010_06_530. PMID: 20845991
Anatomical abnormalities of the anterior cingulate cortex in schizophrenia: bridging the gap between neuroimaging and neuropathology.
Fornito A, Yücel M, Dean B, Wood SJ, Pantelis C
Schizophr Bull 2009 Sep;35(5):973-93. Epub 2008 Apr 23 doi: 10.1093/schbul/sbn025. PMID: 18436528Free PMC Article
Langerhans cells in human papillomaviruses types 6/11 associated laryngeal papillomas.
Ferluga D, Luzar B, Vodovnik A, Poljak M, Cör A, Gale N, Kambic V
Acta Otolaryngol Suppl 1997;527:87-91. doi: 10.3109/00016489709124043. PMID: 9197490

Diagnosis

Diagnosing and Treating Blastic Plasmacytoid Dendritic Cell Neoplasm in a Resource-Limited Setting.
Khan F, Hashmi F, Ghahramanyan N, Baloyan E, Tamamyan G, Konopleva M, Pemmaraju N, Voskanyan A
Oncology (Williston Park) 2024 Mar 1;38(3):104-106. doi: 10.46883/2024.25921014. PMID: 38517410
How should we diagnose and treat blastic plasmacytoid dendritic cell neoplasm patients?
Garnache-Ottou F, Vidal C, Biichlé S, Renosi F, Poret E, Pagadoy M, Desmarets M, Roggy A, Seilles E, Soret L, Schillinger F, Puyraimond S, Petrella T, Preudhomme C, Roumier C, MacIntyre EA, Harrivel V, Desbrosses Y, Gruson B, Geneviève F, Thepot S, Drebit Y, Leguay T, Gros FX, Lechevalier N, Saussoy P, Salaun V, Cornet E, Benseddik Z, Veyrat-Masson R, Wagner-Ballon O, Salanoubat C, Maynadié M, Guy J, Caillot D, Jacob MC, Cahn JY, Gressin R, Rose J, Quesnel B, Guerin E, Trimoreau F, Feuillard J, Gourin MP, Plesa A, Baseggio L, Arnoux I, Vey N, Blaise D, Lacroix R, Arnoulet C, Benet B, Dorvaux V, Bret C, Drenou B, Debliquis A, Latger-Cannard V, Bonmati C, Bene MC, Peterlin P, Ticchioni M, Rohrlich PS, Arnaud A, Wickenhauser S, Bardet V, Brechignac S, Papoular B, Raggueneau V, Vargaftig J, Letestu R, Lusina D, Braun T, Foissaud V, Tamburini J, Bennani H, Freynet N, Cordonnier C, Le Garff-Tavernier M, Jacques N, Maloum K, Roos-Weil D, Bouscary D, Asnafi V, Lhermitte L, Suarez F, Lengline E, Féger F, Battipaglia G, Mohty M, Bouyer S, Ghoual O, Dindinaud E, Basle C, Puyade M, Lafon C, Fest T, Roussel M, Cahu X, Bera E, Daliphard S, Jardin F, Campos L, Solly F, Guyotat D, Galoisy AC, Eischen A, Mayeur-Rousse C, Guffroy B, Recher C, Loosveld M, Garnier A, Barlogis V, Rosenthal MA, Brun S, Contentin N, Maury S, Callanan M, Lefebvre C, Maillard N, Okamba P, Ferrand C, Adotevi O, Saas P, Angelot-Delettre F, Binda D, Deconinck E
Blood Adv 2019 Dec 23;3(24):4238-4251. doi: 10.1182/bloodadvances.2019000647. PMID: 31869411Free PMC Article
Extended immunophenotyping reference values in a healthy pediatric population.
Garcia-Prat M, Álvarez-Sierra D, Aguiló-Cucurull A, Salgado-Perandrés S, Briongos-Sebastian S, Franco-Jarava C, Martin-Nalda A, Colobran R, Montserrat I, Hernández-González M, Pujol-Borrell R, Soler-Palacin P, Martínez-Gallo M
Cytometry B Clin Cytom 2019 May;96(3):223-233. Epub 2018 Oct 17 doi: 10.1002/cyto.b.21728. PMID: 30334372
Anatomical abnormalities of the anterior cingulate cortex in schizophrenia: bridging the gap between neuroimaging and neuropathology.
Fornito A, Yücel M, Dean B, Wood SJ, Pantelis C
Schizophr Bull 2009 Sep;35(5):973-93. Epub 2008 Apr 23 doi: 10.1093/schbul/sbn025. PMID: 18436528Free PMC Article
OKT6+ epidermal Langerhans' cell numbers in DNCB reactions among leprosy patients.
Narayanan RB, Girdhar BK, Desikan KV
Int J Lepr Other Mycobact Dis 1986 Sep;54(3):423-6. PMID: 3755743

Therapy

Immune restoration with ibrutinib plus venetoclax in first-line chronic lymphocytic leukemia: the phase 2 CAPTIVATE study.
Moreno C, Solman IG, Tam CS, Grigg A, Scarfò L, Kipps TJ, Srinivasan S, Mali RS, Zhou C, Dean JP, Szafer-Glusman E, Choi M
Blood Adv 2023 Sep 26;7(18):5294-5303. doi: 10.1182/bloodadvances.2023010236. PMID: 37315225Free PMC Article
Antiretroviral therapy partially improves the abnormalities of dendritic cells and lymphoid and myeloid regulatory populations in recently infected HIV patients.
Márquez-Coello M, Montes de Oca Arjona M, Martín-Aspas A, Guerrero Sánchez F, Fernández-Gutiérrez Del Álamo C, Girón-González JA
Sci Rep 2019 Aug 12;9(1):11654. doi: 10.1038/s41598-019-48185-2. PMID: 31406185Free PMC Article
The T Cell in Myeloma.
Joshua D, Suen H, Brown R, Bryant C, Ho PJ, Hart D, Gibson J
Clin Lymphoma Myeloma Leuk 2016 Oct;16(10):537-542. Epub 2016 Aug 10 doi: 10.1016/j.clml.2016.08.003. PMID: 27601001
Langerhans cells in human papillomaviruses types 6/11 associated laryngeal papillomas.
Ferluga D, Luzar B, Vodovnik A, Poljak M, Cör A, Gale N, Kambic V
Acta Otolaryngol Suppl 1997;527:87-91. doi: 10.3109/00016489709124043. PMID: 9197490
Epidermal Langerhans cells in erythrokeratodermia variabilis. Histochemical and ultrastructural investigations before and after treatment with etretinate (RO 10-9359).
van der Schroeff JG, Ruiter DJ, Bots GT
Arch Dermatol Res 1982;274(3-4):339-48. doi: 10.1007/BF00403739. PMID: 6187301

Prognosis

Diagnosing and Treating Blastic Plasmacytoid Dendritic Cell Neoplasm in a Resource-Limited Setting.
Khan F, Hashmi F, Ghahramanyan N, Baloyan E, Tamamyan G, Konopleva M, Pemmaraju N, Voskanyan A
Oncology (Williston Park) 2024 Mar 1;38(3):104-106. doi: 10.46883/2024.25921014. PMID: 38517410
Signatures of Multi-Omics Reveal Distinct Tumor Immune Microenvironment Contributing to Immunotherapy in Lung Adenocarcinoma.
Huang Z, Li B, Guo Y, Wu L, Kou F, Yang L
Front Immunol 2021;12:723172. Epub 2021 Sep 3 doi: 10.3389/fimmu.2021.723172. PMID: 34539658Free PMC Article
How should we diagnose and treat blastic plasmacytoid dendritic cell neoplasm patients?
Garnache-Ottou F, Vidal C, Biichlé S, Renosi F, Poret E, Pagadoy M, Desmarets M, Roggy A, Seilles E, Soret L, Schillinger F, Puyraimond S, Petrella T, Preudhomme C, Roumier C, MacIntyre EA, Harrivel V, Desbrosses Y, Gruson B, Geneviève F, Thepot S, Drebit Y, Leguay T, Gros FX, Lechevalier N, Saussoy P, Salaun V, Cornet E, Benseddik Z, Veyrat-Masson R, Wagner-Ballon O, Salanoubat C, Maynadié M, Guy J, Caillot D, Jacob MC, Cahn JY, Gressin R, Rose J, Quesnel B, Guerin E, Trimoreau F, Feuillard J, Gourin MP, Plesa A, Baseggio L, Arnoux I, Vey N, Blaise D, Lacroix R, Arnoulet C, Benet B, Dorvaux V, Bret C, Drenou B, Debliquis A, Latger-Cannard V, Bonmati C, Bene MC, Peterlin P, Ticchioni M, Rohrlich PS, Arnaud A, Wickenhauser S, Bardet V, Brechignac S, Papoular B, Raggueneau V, Vargaftig J, Letestu R, Lusina D, Braun T, Foissaud V, Tamburini J, Bennani H, Freynet N, Cordonnier C, Le Garff-Tavernier M, Jacques N, Maloum K, Roos-Weil D, Bouscary D, Asnafi V, Lhermitte L, Suarez F, Lengline E, Féger F, Battipaglia G, Mohty M, Bouyer S, Ghoual O, Dindinaud E, Basle C, Puyade M, Lafon C, Fest T, Roussel M, Cahu X, Bera E, Daliphard S, Jardin F, Campos L, Solly F, Guyotat D, Galoisy AC, Eischen A, Mayeur-Rousse C, Guffroy B, Recher C, Loosveld M, Garnier A, Barlogis V, Rosenthal MA, Brun S, Contentin N, Maury S, Callanan M, Lefebvre C, Maillard N, Okamba P, Ferrand C, Adotevi O, Saas P, Angelot-Delettre F, Binda D, Deconinck E
Blood Adv 2019 Dec 23;3(24):4238-4251. doi: 10.1182/bloodadvances.2019000647. PMID: 31869411Free PMC Article
The impact of several phenotypic features at diagnosis on survival of patients with myelodysplastic syndromes.
Reis-Alves SC, Traina F, Saad ST, Metze K, Lorand-Metze I
Neoplasma 2010;57(6):530-6. doi: 10.4149/neo_2010_06_530. PMID: 20845991
Dendritic cell immunotherapy for cancer: application to low-grade lymphoma and multiple myeloma.
Hart DN, Hill GR
Immunol Cell Biol 1999 Oct;77(5):451-9. doi: 10.1046/j.1440-1711.1999.00859.x. PMID: 10540212

Clinical prediction guides

Circulating myeloid and lymphoid precursor dendritic cells are clonally involved in myelodysplastic syndromes.
Ma L, Delforge M, van Duppen V, Verhoef G, Emanuel B, Boogaerts M, Hagemeijer A, Vandenberghe P
Leukemia 2004 Sep;18(9):1451-6. doi: 10.1038/sj.leu.2403430. PMID: 15284864
Development of the superior temporal neocortex is anomalous in trisomy 21.
Golden JA, Hyman BT
J Neuropathol Exp Neurol 1994 Sep;53(5):513-20. doi: 10.1097/00005072-199409000-00011. PMID: 8083693
Epidermal Langerhans cells are not principal reservoirs of virus in HIV disease.
Kalter DC, Greenhouse JJ, Orenstein JM, Schnittman SM, Gendelman HE, Meltzer MS
J Immunol 1991 May 15;146(10):3396-404. PMID: 2026871
Dendritic spine anomalies in fetal alcohol syndrome.
Ferrer I, Galofré E
Neuropediatrics 1987 Aug;18(3):161-3. doi: 10.1055/s-2008-1052472. PMID: 3683757
Unusual numbers and distribution of Langerhans cells in skin with unique immunologic properties.
Bergstresser PR, Toews GB, Gilliam JN, Streilein JW
J Invest Dermatol 1980 May;74(5):312-4. doi: 10.1111/1523-1747.ep12543542. PMID: 6993573

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