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Monoclonal elevation of IgG

MedGen UID:
1685918
Concept ID:
C5139247
Finding
HPO: HP:0032290

Definition

An increase in circulating immunoglobulins characterized by a single band in serum electrophoresis but not the broad diffuse band that characterizes a polyclonal increase in circulating immunoglobulins. [from HPO]

Professional guidelines

PubMed

Varghese JL, Fung AWS, Mattman A, Quach TTT, Gauiran DTV, Carruthers MN, Chen LYC
Clin Chim Acta 2020 Jul;506:228-235. Epub 2020 Apr 6 doi: 10.1016/j.cca.2020.04.001. PMID: 32272158
Isabwe GAC, de Las Vecillas Sanchez L, Castells M
Allergy Asthma Proc 2017 Nov 1;38(6):409-418. doi: 10.2500/aap.2017.38.4085. PMID: 29046192
Simon A, Asli B, Braun-Falco M, De Koning H, Fermand JP, Grattan C, Krause K, Lachmann H, Lenormand C, Martinez-Taboada V, Maurer M, Peters M, Rizzi R, Rongioletti F, Ruzicka T, Schnitzler L, Schubert B, Sibilia J, Lipsker D
Allergy 2013;68(5):562-8. Epub 2013 Mar 9 doi: 10.1111/all.12129. PMID: 23480774

Recent clinical studies

Etiology

Weinshenker BG, Wingerchuk DM, Green AJ, Bennett JL, Kim HJ, Pittock SJ, Fujihara K, Paul F, Cutter G, Marignier R, Aktas O, Hartung HP, She D, Smith M, Rees W, Patterson K, Cimbora D, Katz E, Cree BA
Mult Scler 2023 Jul;29(8):945-955. Epub 2023 Jun 6 doi: 10.1177/13524585231172145. PMID: 37282545Free PMC Article
Kelsen SG, Agache IO, Soong W, Israel E, Chupp GL, Cheung DS, Theess W, Yang X, Staton TL, Choy DF, Fong A, Dash A, Dolton M, Pappu R, Brightling CE
J Allergy Clin Immunol 2021 Sep;148(3):790-798. Epub 2021 Apr 16 doi: 10.1016/j.jaci.2021.03.044. PMID: 33872652
Didona D, Maglie R, Eming R, Hertl M
Front Immunol 2019;10:1418. Epub 2019 Jun 25 doi: 10.3389/fimmu.2019.01418. PMID: 31293582Free PMC Article
Engelhart S, Glynn RJ, Schur PH
Semin Arthritis Rheum 2017 Oct;47(2):276-280. Epub 2017 Mar 30 doi: 10.1016/j.semarthrit.2017.03.021. PMID: 28457528
Simon A, Asli B, Braun-Falco M, De Koning H, Fermand JP, Grattan C, Krause K, Lachmann H, Lenormand C, Martinez-Taboada V, Maurer M, Peters M, Rizzi R, Rongioletti F, Ruzicka T, Schnitzler L, Schubert B, Sibilia J, Lipsker D
Allergy 2013;68(5):562-8. Epub 2013 Mar 9 doi: 10.1111/all.12129. PMID: 23480774

Diagnosis

Zhang W, Shao T, Leung PSC, Tsuneyama K, Heuer L, Young HA, Ridgway WM, Gershwin ME
J Autoimmun 2022 Oct;132:102897. Epub 2022 Aug 24 doi: 10.1016/j.jaut.2022.102897. PMID: 36029718Free PMC Article
Miller P, Xiao AY, Kung VL, Sibley RK, Higgins JP, Kambham N, Charu V, Lenihan C, Uber AM, Talley EM, Arora N, Walavalkar V, Laszik ZG, Nast CC, Troxell ML
Pediatr Nephrol 2021 Apr;36(4):927-937. Epub 2020 Oct 12 doi: 10.1007/s00467-020-04763-5. PMID: 33044675
Varghese JL, Fung AWS, Mattman A, Quach TTT, Gauiran DTV, Carruthers MN, Chen LYC
Clin Chim Acta 2020 Jul;506:228-235. Epub 2020 Apr 6 doi: 10.1016/j.cca.2020.04.001. PMID: 32272158
Engelhart S, Glynn RJ, Schur PH
Semin Arthritis Rheum 2017 Oct;47(2):276-280. Epub 2017 Mar 30 doi: 10.1016/j.semarthrit.2017.03.021. PMID: 28457528
Simon A, Asli B, Braun-Falco M, De Koning H, Fermand JP, Grattan C, Krause K, Lachmann H, Lenormand C, Martinez-Taboada V, Maurer M, Peters M, Rizzi R, Rongioletti F, Ruzicka T, Schnitzler L, Schubert B, Sibilia J, Lipsker D
Allergy 2013;68(5):562-8. Epub 2013 Mar 9 doi: 10.1111/all.12129. PMID: 23480774

Therapy

Weinshenker BG, Wingerchuk DM, Green AJ, Bennett JL, Kim HJ, Pittock SJ, Fujihara K, Paul F, Cutter G, Marignier R, Aktas O, Hartung HP, She D, Smith M, Rees W, Patterson K, Cimbora D, Katz E, Cree BA
Mult Scler 2023 Jul;29(8):945-955. Epub 2023 Jun 6 doi: 10.1177/13524585231172145. PMID: 37282545Free PMC Article
Kelsen SG, Agache IO, Soong W, Israel E, Chupp GL, Cheung DS, Theess W, Yang X, Staton TL, Choy DF, Fong A, Dash A, Dolton M, Pappu R, Brightling CE
J Allergy Clin Immunol 2021 Sep;148(3):790-798. Epub 2021 Apr 16 doi: 10.1016/j.jaci.2021.03.044. PMID: 33872652
Didona D, Maglie R, Eming R, Hertl M
Front Immunol 2019;10:1418. Epub 2019 Jun 25 doi: 10.3389/fimmu.2019.01418. PMID: 31293582Free PMC Article
Isabwe GAC, de Las Vecillas Sanchez L, Castells M
Allergy Asthma Proc 2017 Nov 1;38(6):409-418. doi: 10.2500/aap.2017.38.4085. PMID: 29046192
Samy E, Wax S, Huard B, Hess H, Schneider P
Int Rev Immunol 2017 Jan 2;36(1):3-19. doi: 10.1080/08830185.2016.1276903. PMID: 28215100

Prognosis

Ramsey N, Berin MC
Pediatr Allergy Immunol 2021 Oct;32(7):1416-1425. Epub 2021 Jun 17 doi: 10.1111/pai.13501. PMID: 33715245Free PMC Article
Miller P, Xiao AY, Kung VL, Sibley RK, Higgins JP, Kambham N, Charu V, Lenihan C, Uber AM, Talley EM, Arora N, Walavalkar V, Laszik ZG, Nast CC, Troxell ML
Pediatr Nephrol 2021 Apr;36(4):927-937. Epub 2020 Oct 12 doi: 10.1007/s00467-020-04763-5. PMID: 33044675
Didona D, Maglie R, Eming R, Hertl M
Front Immunol 2019;10:1418. Epub 2019 Jun 25 doi: 10.3389/fimmu.2019.01418. PMID: 31293582Free PMC Article
Isabwe GAC, de Las Vecillas Sanchez L, Castells M
Allergy Asthma Proc 2017 Nov 1;38(6):409-418. doi: 10.2500/aap.2017.38.4085. PMID: 29046192
Samy E, Wax S, Huard B, Hess H, Schneider P
Int Rev Immunol 2017 Jan 2;36(1):3-19. doi: 10.1080/08830185.2016.1276903. PMID: 28215100

Clinical prediction guides

Wingert S, Reusch U, Knackmuss S, Kluge M, Damrat M, Pahl J, Schniegler-Mattox U, Mueller T, Fucek I, Ellwanger K, Tesar M, Haneke T, Koch J, Treder M, Fischer W, Rajkovic E
MAbs 2021 Jan-Dec;13(1):1950264. doi: 10.1080/19420862.2021.1950264. PMID: 34325617Free PMC Article
Ramsey N, Berin MC
Pediatr Allergy Immunol 2021 Oct;32(7):1416-1425. Epub 2021 Jun 17 doi: 10.1111/pai.13501. PMID: 33715245Free PMC Article
Didona D, Maglie R, Eming R, Hertl M
Front Immunol 2019;10:1418. Epub 2019 Jun 25 doi: 10.3389/fimmu.2019.01418. PMID: 31293582Free PMC Article
Isabwe GAC, de Las Vecillas Sanchez L, Castells M
Allergy Asthma Proc 2017 Nov 1;38(6):409-418. doi: 10.2500/aap.2017.38.4085. PMID: 29046192
Samy E, Wax S, Huard B, Hess H, Schneider P
Int Rev Immunol 2017 Jan 2;36(1):3-19. doi: 10.1080/08830185.2016.1276903. PMID: 28215100

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