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Locally Advanced Unresectable Colon Adenocarcinoma

MedGen UID:
1685944
•Concept ID:
C5206479
•
Neoplastic Process

Definition

A colon adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Unresectable Colon Adenocarcinoma

Professional guidelines

PubMed

Therapy with pembrolizumab in treatment-naïve patients with nonmetastatic, mismatch repair deficient colorectal cancer.
Eefsen RL, Larsen JS, Klarskov LL, Altaf R, Høgdall E, Ingeholm P, Lykke J, Nielsen DL, Pfeiffer P, Poulsen LØ, Qvortrup C, Schou JV, Mau-Sørensen M, Østerlind K, Jensen BV
Int J Cancer 2023 May 15;152(10):2145-2152. Epub 2023 Jan 18 doi: 10.1002/ijc.34420. PMID: 36594580
Residual, recurrent, or unresectable gastrointestinal cancer. Role of radiation in single or combined modality treatment.
Gunderson LL, Martin JK, O'Connell MJ, Beart RW, Kvols LK, Nagorney DM
Cancer 1985 May 1;55(9 Suppl):2250-8. doi: 10.1002/1097-0142(19850501)55:9+<2250::aid-cncr2820551431>3.0.co;2-0. PMID: 3919929

Recent clinical studies

Etiology

Tucatinib plus trastuzumab for chemotherapy-refractory, HER2-positive, RAS wild-type unresectable or metastatic colorectal cancer (MOUNTAINEER): a multicentre, open-label, phase 2 study.
Strickler JH, Cercek A, Siena S, André T, Ng K, Van Cutsem E, Wu C, Paulson AS, Hubbard JM, Coveler AL, Fountzilas C, Kardosh A, Kasi PM, Lenz HJ, Ciombor KK, Elez E, Bajor DL, Cremolini C, Sanchez F, Stecher M, Feng W, Bekaii-Saab TS; MOUNTAINEER investigators
Lancet Oncol 2023 May;24(5):496-508. doi: 10.1016/S1470-2045(23)00150-X. PMID: 37142372
Neoadjuvant Immunotherapy for MSI-H/dMMR Locally Advanced Colorectal Cancer: New Strategies and Unveiled Opportunities.
Zhang X, Wu T, Cai X, Dong J, Xia C, Zhou Y, Ding R, Yang R, Tan J, Zhang L, Zhang Y, Wang Y, Dong C, Li Y
Front Immunol 2022;13:795972. Epub 2022 Mar 17 doi: 10.3389/fimmu.2022.795972. PMID: 35371084Free PMC Article
Neoadjuvant chemoradiotherapy in patients with unresectable locally advanced sigmoid colon cancer: clinical feasibility and outcome.
Niu SQ, Li RZ, Yuan Y, Xie WH, Wang QX, Chang H, Lu ZH, Ding PR, Li LR, Wu XJ, Zeng ZF, Xiao WW, Gao YH
Radiat Oncol 2021 May 24;16(1):93. doi: 10.1186/s13014-021-01823-4. PMID: 34030722Free PMC Article
Outcomes of preoperative chemoradiotherapy followed by surgery in patients with unresectable locally advanced sigmoid colon cancer.
Qiu B, Ding PR, Cai L, Xiao WW, Zeng ZF, Chen G, Lu ZH, Li LR, Wu XJ, Mirimanoff RO, Pan ZZ, Xu RH, Gao YH
Chin J Cancer 2016 Jul 7;35(1):65. doi: 10.1186/s40880-016-0126-y. PMID: 27389519Free PMC Article
Therapy of gastrointestinal cancer.
Greig RG, Schein PS
Scand J Gastroenterol Suppl 1985;117:9-25. doi: 10.3109/00365528509092224. PMID: 3912966

Diagnosis

A Case Report of Primary Unresectable Hilar Cholangiocarcinoma Causing Colonic Obstruction Due to Peritoneal Dissemination.
Toyofuku A, Kuroda H, Ito K, Sakurai A, Yoshida K, Higure A, Yamaguchi S, Yotsumoto S, Sakita KI, Nagata N
J UOEH 2022;44(3):277-286. doi: 10.7888/juoeh.44.277. PMID: 36089346
Neoadjuvant Immunotherapy for MSI-H/dMMR Locally Advanced Colorectal Cancer: New Strategies and Unveiled Opportunities.
Zhang X, Wu T, Cai X, Dong J, Xia C, Zhou Y, Ding R, Yang R, Tan J, Zhang L, Zhang Y, Wang Y, Dong C, Li Y
Front Immunol 2022;13:795972. Epub 2022 Mar 17 doi: 10.3389/fimmu.2022.795972. PMID: 35371084Free PMC Article
Neoadjuvant chemoradiotherapy for patients with unresectable radically locally advanced colon cancer: a potential improvement to overall survival and decrease to multivisceral resection.
Yuan Y, Xiao WW, Xie WH, Cai PQ, Wang QX, Chang H, Chen BQ, Zhou WH, Zeng ZF, Wu XJ, Liu Q, Li LR, Zhang R, Gao YH
BMC Cancer 2021 Feb 19;21(1):179. doi: 10.1186/s12885-021-07894-6. PMID: 33607964Free PMC Article
Colorectal cancer in young and elderly patients.
Berut M, Mik M, Kędzia-Berut R, Kujawski R, Trzciński R, Dziki Ł, Dziki A
Pol Przegl Chir 2013 Aug;85(8):446-51. doi: 10.2478/pjs-2013-0068. PMID: 24009055
Therapy of gastrointestinal cancer.
Greig RG, Schein PS
Scand J Gastroenterol Suppl 1985;117:9-25. doi: 10.3109/00365528509092224. PMID: 3912966

Therapy

Tucatinib plus trastuzumab for chemotherapy-refractory, HER2-positive, RAS wild-type unresectable or metastatic colorectal cancer (MOUNTAINEER): a multicentre, open-label, phase 2 study.
Strickler JH, Cercek A, Siena S, André T, Ng K, Van Cutsem E, Wu C, Paulson AS, Hubbard JM, Coveler AL, Fountzilas C, Kardosh A, Kasi PM, Lenz HJ, Ciombor KK, Elez E, Bajor DL, Cremolini C, Sanchez F, Stecher M, Feng W, Bekaii-Saab TS; MOUNTAINEER investigators
Lancet Oncol 2023 May;24(5):496-508. doi: 10.1016/S1470-2045(23)00150-X. PMID: 37142372
Neoadjuvant Immunotherapy for MSI-H/dMMR Locally Advanced Colorectal Cancer: New Strategies and Unveiled Opportunities.
Zhang X, Wu T, Cai X, Dong J, Xia C, Zhou Y, Ding R, Yang R, Tan J, Zhang L, Zhang Y, Wang Y, Dong C, Li Y
Front Immunol 2022;13:795972. Epub 2022 Mar 17 doi: 10.3389/fimmu.2022.795972. PMID: 35371084Free PMC Article
Neoadjuvant chemoradiotherapy in patients with unresectable locally advanced sigmoid colon cancer: clinical feasibility and outcome.
Niu SQ, Li RZ, Yuan Y, Xie WH, Wang QX, Chang H, Lu ZH, Ding PR, Li LR, Wu XJ, Zeng ZF, Xiao WW, Gao YH
Radiat Oncol 2021 May 24;16(1):93. doi: 10.1186/s13014-021-01823-4. PMID: 34030722Free PMC Article
Can unresectable colorectal cancer be cured?
Mathis KL, Nelson H, Pemberton JH
Adv Surg 2009;43:211-9. doi: 10.1016/j.yasu.2009.02.006. PMID: 19845180
Therapy of gastrointestinal cancer.
Greig RG, Schein PS
Scand J Gastroenterol Suppl 1985;117:9-25. doi: 10.3109/00365528509092224. PMID: 3912966

Prognosis

Neoadjuvant Immunotherapy for MSI-H/dMMR Locally Advanced Colorectal Cancer: New Strategies and Unveiled Opportunities.
Zhang X, Wu T, Cai X, Dong J, Xia C, Zhou Y, Ding R, Yang R, Tan J, Zhang L, Zhang Y, Wang Y, Dong C, Li Y
Front Immunol 2022;13:795972. Epub 2022 Mar 17 doi: 10.3389/fimmu.2022.795972. PMID: 35371084Free PMC Article
Neoadjuvant chemoradiotherapy in patients with unresectable locally advanced sigmoid colon cancer: clinical feasibility and outcome.
Niu SQ, Li RZ, Yuan Y, Xie WH, Wang QX, Chang H, Lu ZH, Ding PR, Li LR, Wu XJ, Zeng ZF, Xiao WW, Gao YH
Radiat Oncol 2021 May 24;16(1):93. doi: 10.1186/s13014-021-01823-4. PMID: 34030722Free PMC Article
Neoadjuvant chemoradiotherapy for patients with unresectable radically locally advanced colon cancer: a potential improvement to overall survival and decrease to multivisceral resection.
Yuan Y, Xiao WW, Xie WH, Cai PQ, Wang QX, Chang H, Chen BQ, Zhou WH, Zeng ZF, Wu XJ, Liu Q, Li LR, Zhang R, Gao YH
BMC Cancer 2021 Feb 19;21(1):179. doi: 10.1186/s12885-021-07894-6. PMID: 33607964Free PMC Article
Outcomes of preoperative chemoradiotherapy followed by surgery in patients with unresectable locally advanced sigmoid colon cancer.
Qiu B, Ding PR, Cai L, Xiao WW, Zeng ZF, Chen G, Lu ZH, Li LR, Wu XJ, Mirimanoff RO, Pan ZZ, Xu RH, Gao YH
Chin J Cancer 2016 Jul 7;35(1):65. doi: 10.1186/s40880-016-0126-y. PMID: 27389519Free PMC Article
A Phase I trial of preoperative eniluracil plus 5-fluorouracil and radiation for locally advanced or unresectable adenocarcinoma of the rectum and colon.
Czito BG, Hong TJ, Cohen DP, Tyler DS, Lee CG, Anscher MS, Ludwig KA, Seigler HF, Mantyh C, Morse MA, Lockhart AC, Petros WP, Honeycutt W, Spector NL, Ertel PJ, Mangum SG, Hurwitz HI
Int J Radiat Oncol Biol Phys 2004 Mar 1;58(3):779-85. doi: 10.1016/S0360-3016(03)01567-0. PMID: 14967434

Clinical prediction guides

Clinical impact of primary tumor sidedness and sex on unresectable post-recurrence survival in resected pathological stage II-III colorectal cancers: a nationwide multicenter retrospective study.
Abe S, Kawai K, Nozawa H, Sasaki K, Murono K, Emoto S, Ozawa T, Yokoyama Y, Nagai Y, Anzai H, Sonoda H, Yamauchi S, Sugihara K, Ishihara S
BMC Cancer 2022 May 2;22(1):486. doi: 10.1186/s12885-022-09615-z. PMID: 35501727Free PMC Article
Neoadjuvant chemoradiotherapy in patients with unresectable locally advanced sigmoid colon cancer: clinical feasibility and outcome.
Niu SQ, Li RZ, Yuan Y, Xie WH, Wang QX, Chang H, Lu ZH, Ding PR, Li LR, Wu XJ, Zeng ZF, Xiao WW, Gao YH
Radiat Oncol 2021 May 24;16(1):93. doi: 10.1186/s13014-021-01823-4. PMID: 34030722Free PMC Article
Neoadjuvant chemoradiotherapy for patients with unresectable radically locally advanced colon cancer: a potential improvement to overall survival and decrease to multivisceral resection.
Yuan Y, Xiao WW, Xie WH, Cai PQ, Wang QX, Chang H, Chen BQ, Zhou WH, Zeng ZF, Wu XJ, Liu Q, Li LR, Zhang R, Gao YH
BMC Cancer 2021 Feb 19;21(1):179. doi: 10.1186/s12885-021-07894-6. PMID: 33607964Free PMC Article
Outcomes of preoperative chemoradiotherapy followed by surgery in patients with unresectable locally advanced sigmoid colon cancer.
Qiu B, Ding PR, Cai L, Xiao WW, Zeng ZF, Chen G, Lu ZH, Li LR, Wu XJ, Mirimanoff RO, Pan ZZ, Xu RH, Gao YH
Chin J Cancer 2016 Jul 7;35(1):65. doi: 10.1186/s40880-016-0126-y. PMID: 27389519Free PMC Article
Gemcitabine plus irinotecan as first-line weekly therapy in locally advanced and/or metastatic pancreatic cancer.
Neri B, Cipriani G, Grifoni R, Molinara E, Pantaleo P, Rangan S, Vannini A, Tonelli P, Valeri A, Pantalone D, Taddei A, Bechi P
Oncol Res 2009;17(11-12):559-64. doi: 10.3727/096504009789745610. PMID: 19806786

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