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Extraprostatic Extension

MedGen UID:
1686147
•Concept ID:
C1717821
•
Finding

Definition

A finding indicating the presence of a prostatic carcinoma that has invaded the prostatic capsule and has spread to nearby tissues or distant anatomic sites. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVExtraprostatic Extension

Professional guidelines

PubMed

Expanding Active Surveillance Inclusion Criteria: A Novel Nomogram Including Preoperative Clinical Parameters and Magnetic Resonance Imaging Findings.
Lantz A, Falagario UG, Ratnani P, Jambor I, Dovey Z, Martini A, Lewis S, Lundon D, Nair S, Phillip D, Haines K, Cormio L, Carrieri G, Kryprianou N, Tewari A
Eur Urol Oncol 2022 Apr;5(2):187-194. Epub 2020 Sep 3 doi: 10.1016/j.euo.2020.08.001. PMID: 32891599
Extraprostatic Tumor Extension: Comparison of Preoperative Multiparametric MRI Criteria and Histopathologic Correlation after Radical Prostatectomy.
Park KJ, Kim MH, Kim JK
Radiology 2020 Jul;296(1):87-95. Epub 2020 May 5 doi: 10.1148/radiol.2020192133. PMID: 32368959
Adjuvant and salvage radiotherapy after prostatectomy: American Society of Clinical Oncology clinical practice guideline endorsement.
Freedland SJ, Rumble RB, Finelli A, Chen RC, Slovin S, Stein MN, Mendelson DS, Wackett C, Sandler HM; American Society of Clinical Oncology
J Clin Oncol 2014 Dec 1;32(34):3892-8. Epub 2014 Nov 3 doi: 10.1200/JCO.2014.58.8525. PMID: 25366677

Recent clinical studies

Etiology

Extraprostatic extension in prostate cancer: primer for radiologists.
Shieh AC, Guler E, Ojili V, Paspulati RM, Elliott R, Ramaiya NH, Tirumani SH
Abdom Radiol (NY) 2020 Dec;45(12):4040-4051. doi: 10.1007/s00261-020-02555-x. PMID: 32390076
Multifocal Extraprostatic Extension of Prostate Cancer.
Farchoukh L, Laframboise WA, Nelson JB, Bastacky S, Parwani AV, Dhir R
Am J Clin Pathol 2020 Mar 9;153(4):548-553. doi: 10.1093/ajcp/aqz193. PMID: 31825470
Clinical and oncologic findings of extraprostatic extension on needle biopsy in de novo metastatic prostate cancer.
Chen JR, Zhao JG, Zhu S, Zhang MN, Chen N, Liu JD, Sun GX, Shen PF, Zeng H
Asian J Androl 2020 Jul-Aug;22(4):427-431. doi: 10.4103/aja.aja_77_19. PMID: 31424026Free PMC Article
Defining clinically significant prostate cancer on the basis of pathological findings.
Matoso A, Epstein JI
Histopathology 2019 Jan;74(1):135-145. doi: 10.1111/his.13712. PMID: 30565298
Staging prostate cancer.
Hoedemaeker RF, Vis AN, Van Der Kwast TH
Microsc Res Tech 2000 Dec 1;51(5):423-9. doi: 10.1002/1097-0029(20001201)51:5<423::AID-JEMT4>3.0.CO;2-4. PMID: 11074612

Diagnosis

MRI Extraprostatic Extension Grade: Accuracy and Clinical Incremental Value in the Assessment of Extraprostatic Cancer.
Xiang JY, Huang XS, Xu JX, Huang RH, Zheng XZ, Xue LM, Liu YL
Biomed Res Int 2022;2022:3203965. Epub 2022 Aug 30 doi: 10.1155/2022/3203965. PMID: 36082151Free PMC Article
Head-to-Head Comparison of (68)Ga-PSMA-11 PET/CT and mpMRI with a Histopathology Gold Standard in the Detection, Intraprostatic Localization, and Determination of Local Extension of Primary Prostate Cancer: Results from a Prospective Single-Center Imaging Trial.
Sonni I, Felker ER, Lenis AT, Sisk AE, Bahri S, Allen-Auerbach M, Armstrong WR, Suvannarerg V, Tubtawee T, Grogan T, Elashoff D, Eiber M, Raman SS, Czernin J, Reiter RE, Calais J
J Nucl Med 2022 Jun;63(6):847-854. Epub 2021 Oct 14 doi: 10.2967/jnumed.121.262398. PMID: 34649942Free PMC Article
Extraprostatic extension in prostate cancer: primer for radiologists.
Shieh AC, Guler E, Ojili V, Paspulati RM, Elliott R, Ramaiya NH, Tirumani SH
Abdom Radiol (NY) 2020 Dec;45(12):4040-4051. doi: 10.1007/s00261-020-02555-x. PMID: 32390076
Contribution of Radiology to Staging of Prostate Cancer.
Woo S, Ghafoor S, Vargas HA
Semin Nucl Med 2019 Jul;49(4):294-301. Epub 2019 Mar 9 doi: 10.1053/j.semnuclmed.2019.02.007. PMID: 31227052Free PMC Article
Prostate Magnetic Resonance Imaging: Lesion Detection and Local Staging.
Turkbey B, Choyke PL
Annu Rev Med 2019 Jan 27;70:451-459. doi: 10.1146/annurev-med-053117-123215. PMID: 30691375

Therapy

Head-to-Head Comparison of (68)Ga-PSMA-11 PET/CT and mpMRI with a Histopathology Gold Standard in the Detection, Intraprostatic Localization, and Determination of Local Extension of Primary Prostate Cancer: Results from a Prospective Single-Center Imaging Trial.
Sonni I, Felker ER, Lenis AT, Sisk AE, Bahri S, Allen-Auerbach M, Armstrong WR, Suvannarerg V, Tubtawee T, Grogan T, Elashoff D, Eiber M, Raman SS, Czernin J, Reiter RE, Calais J
J Nucl Med 2022 Jun;63(6):847-854. Epub 2021 Oct 14 doi: 10.2967/jnumed.121.262398. PMID: 34649942Free PMC Article
Adjuvant radiotherapy versus early salvage radiotherapy following radical prostatectomy (TROG 08.03/ANZUP RAVES): a randomised, controlled, phase 3, non-inferiority trial.
Kneebone A, Fraser-Browne C, Duchesne GM, Fisher R, Frydenberg M, Herschtal A, Williams SG, Brown C, Delprado W, Haworth A, Joseph DJ, Martin JM, Matthews JHL, Millar JL, Sidhom M, Spry N, Tang CI, Turner S, Wiltshire KL, Woo HH, Davis ID, Lim TS, Pearse M
Lancet Oncol 2020 Oct;21(10):1331-1340. doi: 10.1016/S1470-2045(20)30456-3. PMID: 33002437
Clinical and oncologic findings of extraprostatic extension on needle biopsy in de novo metastatic prostate cancer.
Chen JR, Zhao JG, Zhu S, Zhang MN, Chen N, Liu JD, Sun GX, Shen PF, Zeng H
Asian J Androl 2020 Jul-Aug;22(4):427-431. doi: 10.4103/aja.aja_77_19. PMID: 31424026Free PMC Article
Androgen deprivation therapy in nonmetastatic prostate cancer patients: Indications, treatment effects, and new predictive biomarkers.
Fang D, Zhou L
Asia Pac J Clin Oncol 2019 Jun;15(3):108-120. Epub 2019 Feb 6 doi: 10.1111/ajco.13108. PMID: 30729683Free PMC Article
Adjuvant and salvage radiation therapy after prostatectomy: American Society for Radiation Oncology/American Urological Association guidelines.
Valicenti RK, Thompson I Jr, Albertsen P, Davis BJ, Goldenberg SL, Wolf JS, Sartor O, Klein E, Hahn C, Michalski J, Roach M 3rd, Faraday MM; American Society for Radiation Oncology/American Urological Association
Int J Radiat Oncol Biol Phys 2013 Aug 1;86(5):822-8. doi: 10.1016/j.ijrobp.2013.05.029. PMID: 23845839

Prognosis

MRI Extraprostatic Extension Grade: Accuracy and Clinical Incremental Value in the Assessment of Extraprostatic Cancer.
Xiang JY, Huang XS, Xu JX, Huang RH, Zheng XZ, Xue LM, Liu YL
Biomed Res Int 2022;2022:3203965. Epub 2022 Aug 30 doi: 10.1155/2022/3203965. PMID: 36082151Free PMC Article
Extraprostatic extension in prostate cancer: primer for radiologists.
Shieh AC, Guler E, Ojili V, Paspulati RM, Elliott R, Ramaiya NH, Tirumani SH
Abdom Radiol (NY) 2020 Dec;45(12):4040-4051. doi: 10.1007/s00261-020-02555-x. PMID: 32390076
Multifocal Extraprostatic Extension of Prostate Cancer.
Farchoukh L, Laframboise WA, Nelson JB, Bastacky S, Parwani AV, Dhir R
Am J Clin Pathol 2020 Mar 9;153(4):548-553. doi: 10.1093/ajcp/aqz193. PMID: 31825470
Contribution of Radiology to Staging of Prostate Cancer.
Woo S, Ghafoor S, Vargas HA
Semin Nucl Med 2019 Jul;49(4):294-301. Epub 2019 Mar 9 doi: 10.1053/j.semnuclmed.2019.02.007. PMID: 31227052Free PMC Article
Staging prostate cancer.
Hoedemaeker RF, Vis AN, Van Der Kwast TH
Microsc Res Tech 2000 Dec 1;51(5):423-9. doi: 10.1002/1097-0029(20001201)51:5<423::AID-JEMT4>3.0.CO;2-4. PMID: 11074612

Clinical prediction guides

MRI Extraprostatic Extension Grade: Accuracy and Clinical Incremental Value in the Assessment of Extraprostatic Cancer.
Xiang JY, Huang XS, Xu JX, Huang RH, Zheng XZ, Xue LM, Liu YL
Biomed Res Int 2022;2022:3203965. Epub 2022 Aug 30 doi: 10.1155/2022/3203965. PMID: 36082151Free PMC Article
Extraprostatic extension in prostate cancer: primer for radiologists.
Shieh AC, Guler E, Ojili V, Paspulati RM, Elliott R, Ramaiya NH, Tirumani SH
Abdom Radiol (NY) 2020 Dec;45(12):4040-4051. doi: 10.1007/s00261-020-02555-x. PMID: 32390076
Clinical and oncologic findings of extraprostatic extension on needle biopsy in de novo metastatic prostate cancer.
Chen JR, Zhao JG, Zhu S, Zhang MN, Chen N, Liu JD, Sun GX, Shen PF, Zeng H
Asian J Androl 2020 Jul-Aug;22(4):427-431. doi: 10.4103/aja.aja_77_19. PMID: 31424026Free PMC Article
Adjuvant and salvage radiotherapy after prostatectomy: American Society of Clinical Oncology clinical practice guideline endorsement.
Freedland SJ, Rumble RB, Finelli A, Chen RC, Slovin S, Stein MN, Mendelson DS, Wackett C, Sandler HM; American Society of Clinical Oncology
J Clin Oncol 2014 Dec 1;32(34):3892-8. Epub 2014 Nov 3 doi: 10.1200/JCO.2014.58.8525. PMID: 25366677
Staging prostate cancer.
Hoedemaeker RF, Vis AN, Van Der Kwast TH
Microsc Res Tech 2000 Dec 1;51(5):423-9. doi: 10.1002/1097-0029(20001201)51:5<423::AID-JEMT4>3.0.CO;2-4. PMID: 11074612

Recent systematic reviews

MRI-based nomograms and radiomics in presurgical prediction of extraprostatic extension in prostate cancer: a systematic review.
Calimano-Ramirez LF, Virarkar MK, Hernandez M, Ozdemir S, Kumar S, Gopireddy DR, Lall C, Balaji KC, Mete M, Gumus KZ
Abdom Radiol (NY) 2023 Jul;48(7):2379-2400. Epub 2023 May 4 doi: 10.1007/s00261-023-03924-y. PMID: 37142824
Adjuvant versus early Salvage radiation therapy for prostate cancer with adverse pathological features on radical prostatectomy-Do we finally have an answer?
Jain S, Mallick I, Tamhankar AS, Gautam G
Indian J Cancer 2022 Apr-Jun;59(2):170-177. doi: 10.4103/ijc.IJC_516_20. PMID: 35946183
The Role of Magnetic Resonance Imaging and Positron Emission Tomography/Computed Tomography in the Primary Staging of Newly Diagnosed Prostate Cancer: A Systematic Review of the Literature.
Abrams-Pompe RS, Fanti S, Schoots IG, Moore CM, Turkbey B, Vickers AJ, Walz J, Steuber T, Eastham JA
Eur Urol Oncol 2021 Jun;4(3):370-395. Epub 2020 Dec 4 doi: 10.1016/j.euo.2020.11.002. PMID: 33272865Free PMC Article
The Diagnostic Performance of the Length of Tumor Capsular Contact on MRI for Detecting Prostate Cancer Extraprostatic Extension: A Systematic Review and Meta-Analysis.
Kim TH, Woo S, Han S, Suh CH, Ghafoor S, Hricak H, Vargas HA
Korean J Radiol 2020 Jun;21(6):684-694. doi: 10.3348/kjr.2019.0842. PMID: 32410407Free PMC Article
Perineural invasion as a predictor of extraprostatic extension of prostate cancer: a systematic review and meta-analysis.
Cozzi G, Rocco BM, Grasso A, Rosso M, Abed El Rahman D, Oliva I, Talso M, Costa B, Tafa A, Palumbo C, Gadda F, Rocco F
Scand J Urol 2013 Dec;47(6):443-8. Epub 2013 Mar 15 doi: 10.3109/21681805.2013.776106. PMID: 23495828

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