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Abnormal oocyte morphology

MedGen UID:
1686256
•Concept ID:
C5209248
•
Finding
HPO: HP:0020155

Definition

An abnormal structure of the female germ cell (egg cell). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal oocyte morphology

Professional guidelines

PubMed

Ovarian Aging: Molecular Mechanisms and Medical Management.
Tesarik J, Galán-Lázaro M, Mendoza-Tesarik R
Int J Mol Sci 2021 Jan 29;22(3) doi: 10.3390/ijms22031371. PMID: 33573050Free PMC Article
Preimplantation genetic testing for aneuploidies (abnormal number of chromosomes) in in vitro fertilisation.
Cornelisse S, Zagers M, Kostova E, Fleischer K, van Wely M, Mastenbroek S
Cochrane Database Syst Rev 2020 Sep 8;9(9):CD005291. doi: 10.1002/14651858.CD005291.pub3. PMID: 32898291Free PMC Article
Preimplantation diagnosis and other modern methods for prenatal diagnosis.
Simpson JL, Rechitsky S
J Steroid Biochem Mol Biol 2017 Jan;165(Pt A):124-130. Epub 2016 Apr 21 doi: 10.1016/j.jsbmb.2016.03.022. PMID: 27108943

Recent clinical studies

Etiology

Effects of Oocyte Cytoplasmic Central Granulation on Embryonic Development, Blastocyst Formation, and Pregnancy Outcome in Assisted Reproductive Technology and Its Mechanism.
Zhang L, Zeng L, Liu H, Jia H, Wu Y, He C
Cell Mol Biol (Noisy-le-grand) 2022 May 31;68(5):161-169. doi: 10.14715/cmb/2022.68.5.22. PMID: 36029502
Detrimental effects of endometriosis on oocyte morphology in intracytoplasmic sperm injection cycles: a retrospective cohort study.
Kasapoglu I, Kuspinar G, Saribal S, Turk P, Avcı B, Uncu G
Gynecol Endocrinol 2018 Mar;34(3):206-211. Epub 2017 Oct 23 doi: 10.1080/09513590.2017.1391203. PMID: 29057690
Oocyte morphology does not affect fertilization rate, embryo quality and implantation rate after intracytoplasmic sperm injection.
Balaban B, Urman B, Sertac A, Alatas C, Aksoy S, Mercan R
Hum Reprod 1998 Dec;13(12):3431-3. doi: 10.1093/humrep/13.12.3431. PMID: 9886529

Diagnosis

Biallelic variants in MOS cause large polar body in oocyte and human female infertility.
Zhang YL, Zheng W, Ren P, Jin J, Hu Z, Liu Q, Fan HY, Gong F, Lu GX, Lin G, Zhang S, Tong X
Hum Reprod 2022 Jul 30;37(8):1932-1944. doi: 10.1093/humrep/deac120. PMID: 35670744
Detrimental effects of endometriosis on oocyte morphology in intracytoplasmic sperm injection cycles: a retrospective cohort study.
Kasapoglu I, Kuspinar G, Saribal S, Turk P, Avcı B, Uncu G
Gynecol Endocrinol 2018 Mar;34(3):206-211. Epub 2017 Oct 23 doi: 10.1080/09513590.2017.1391203. PMID: 29057690
Oocyte morphology does not affect fertilization rate, embryo quality and implantation rate after intracytoplasmic sperm injection.
Balaban B, Urman B, Sertac A, Alatas C, Aksoy S, Mercan R
Hum Reprod 1998 Dec;13(12):3431-3. doi: 10.1093/humrep/13.12.3431. PMID: 9886529

Therapy

Effects of Oocyte Cytoplasmic Central Granulation on Embryonic Development, Blastocyst Formation, and Pregnancy Outcome in Assisted Reproductive Technology and Its Mechanism.
Zhang L, Zeng L, Liu H, Jia H, Wu Y, He C
Cell Mol Biol (Noisy-le-grand) 2022 May 31;68(5):161-169. doi: 10.14715/cmb/2022.68.5.22. PMID: 36029502

Prognosis

Oocyte morphology does not affect fertilization rate, embryo quality and implantation rate after intracytoplasmic sperm injection.
Balaban B, Urman B, Sertac A, Alatas C, Aksoy S, Mercan R
Hum Reprod 1998 Dec;13(12):3431-3. doi: 10.1093/humrep/13.12.3431. PMID: 9886529

Clinical prediction guides

Genetic and physiological study of morphologically abnormal human zona pellucida.
Margalit M, Paz G, Yavetz H, Yogev L, Amit A, Hevlin-Schwartz T, Gupta SK, Kleiman SE
Eur J Obstet Gynecol Reprod Biol 2012 Nov;165(1):70-6. Epub 2012 Aug 11 doi: 10.1016/j.ejogrb.2012.07.022. PMID: 22889493
Oocyte morphology does not affect fertilization rate, embryo quality and implantation rate after intracytoplasmic sperm injection.
Balaban B, Urman B, Sertac A, Alatas C, Aksoy S, Mercan R
Hum Reprod 1998 Dec;13(12):3431-3. doi: 10.1093/humrep/13.12.3431. PMID: 9886529

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