U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Chromosome 5 Abnormality

MedGen UID:
1686438
•Concept ID:
C5204447
•
Cell or Molecular Dysfunction
Synonyms: Aberrant Chromosome 5; Chromosome 5 Aberration

Definition

A cytogenic abnormality that refers to any structural irregularity in chromosome 5. [from NCI]

Professional guidelines

PubMed

Application of SNP array for rapid prenatal diagnosis: implementation, genetic counselling and diagnostic flow.
Srebniak M, Boter M, Oudesluijs G, Joosten M, Govaerts L, Van Opstal D, Galjaard RJ
Eur J Hum Genet 2011 Dec;19(12):1230-7. Epub 2011 Jun 22 doi: 10.1038/ejhg.2011.119. PMID: 21694736Free PMC Article

Recent clinical studies

Etiology

A phase II study of lenalidomide alone in relapsed/refractory acute myeloid leukemia or high-risk myelodysplastic syndromes with chromosome 5 abnormalities.
Chen Y, Kantarjian H, Estrov Z, Faderl S, Ravandi F, Rey K, Cortes J, Borthakur G
Clin Lymphoma Myeloma Leuk 2012 Oct;12(5):341-4. Epub 2012 May 10 doi: 10.1016/j.clml.2012.04.001. PMID: 22579233Free PMC Article
The heterogeneous prognosis of patients with myelodysplastic syndrome and chromosome 5 abnormalities: how does it relate to the original lenalidomide experience in MDS?
Kantarjian H, O'Brien S, Ravandi F, Borthakur G, Faderl S, Bueso-Ramos C, Abruzzo L, Pierce S, Shan J, Issa JP, Garcia-Manero G
Cancer 2009 Nov 15;115(22):5202-9. doi: 10.1002/cncr.24575. PMID: 19691096Free PMC Article

Diagnosis

Amelioration of the typical cognitive phenotype in a patient with the 5pter deletion associated with Cri-du-chat syndrome in addition to a partial duplication of CTNND2.
Sardina JM, Walters AR, Singh KE, Owen RX, Kimonis VE
Am J Med Genet A 2014 Jul;164A(7):1761-4. Epub 2014 Mar 26 doi: 10.1002/ajmg.a.36494. PMID: 24677774
T-cell lineage acute lymphoblastic leukemia with chromosome 5 abnormality in a patient with Crohn's disease and lipoid nephrosis.
Pérard L, Thomas X, Jaumain H, Theuil G, Bret M, Coronel B, Charrin C, Boulétreau P
Ann Hematol 2000 Apr;79(4):222-5. doi: 10.1007/s002770050583. PMID: 10834511
Hematologic and clinical features of patients with chromosome 5 monosomy or deletion (5q).
Brusamolino E, Orlandi E, Morra E, Bernasconi P, Pagnucco G, Colombo A, Lazzarino M, Bernasconi C
Med Pediatr Oncol 1988;16(2):88-94. doi: 10.1002/mpo.2950160204. PMID: 3352540

Therapy

A phase II study of lenalidomide alone in relapsed/refractory acute myeloid leukemia or high-risk myelodysplastic syndromes with chromosome 5 abnormalities.
Chen Y, Kantarjian H, Estrov Z, Faderl S, Ravandi F, Rey K, Cortes J, Borthakur G
Clin Lymphoma Myeloma Leuk 2012 Oct;12(5):341-4. Epub 2012 May 10 doi: 10.1016/j.clml.2012.04.001. PMID: 22579233Free PMC Article
The heterogeneous prognosis of patients with myelodysplastic syndrome and chromosome 5 abnormalities: how does it relate to the original lenalidomide experience in MDS?
Kantarjian H, O'Brien S, Ravandi F, Borthakur G, Faderl S, Bueso-Ramos C, Abruzzo L, Pierce S, Shan J, Issa JP, Garcia-Manero G
Cancer 2009 Nov 15;115(22):5202-9. doi: 10.1002/cncr.24575. PMID: 19691096Free PMC Article

Prognosis

The heterogeneous prognosis of patients with myelodysplastic syndrome and chromosome 5 abnormalities: how does it relate to the original lenalidomide experience in MDS?
Kantarjian H, O'Brien S, Ravandi F, Borthakur G, Faderl S, Bueso-Ramos C, Abruzzo L, Pierce S, Shan J, Issa JP, Garcia-Manero G
Cancer 2009 Nov 15;115(22):5202-9. doi: 10.1002/cncr.24575. PMID: 19691096Free PMC Article

Clinical prediction guides

The heterogeneous prognosis of patients with myelodysplastic syndrome and chromosome 5 abnormalities: how does it relate to the original lenalidomide experience in MDS?
Kantarjian H, O'Brien S, Ravandi F, Borthakur G, Faderl S, Bueso-Ramos C, Abruzzo L, Pierce S, Shan J, Issa JP, Garcia-Manero G
Cancer 2009 Nov 15;115(22):5202-9. doi: 10.1002/cncr.24575. PMID: 19691096Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...