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Increased circulating globulin level

MedGen UID:
1686812
•Concept ID:
C5139265
•
Finding
HPO: HP:0032311

Definition

An abnormally elevated concentration of globulins in the blood. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased circulating globulin level

Professional guidelines

PubMed

Current Understanding of Complement Proteins as Therapeutic Targets for the Treatment of Immunoglobulin A Nephropathy.
Rajasekaran A, Green TJ, Renfrow MB, Julian BA, Novak J, Rizk DV
Drugs 2023 Nov;83(16):1475-1499. Epub 2023 Sep 25 doi: 10.1007/s40265-023-01940-2. PMID: 37747686Free PMC Article
Diagnosis and Management of Pediatric Autoimmune Liver Disease: ESPGHAN Hepatology Committee Position Statement.
Mieli-Vergani G, Vergani D, Baumann U, Czubkowski P, Debray D, Dezsofi A, Fischler B, Gupte G, Hierro L, Indolfi G, Jahnel J, Smets F, Verkade HJ, Hadžić N
J Pediatr Gastroenterol Nutr 2018 Feb;66(2):345-360. doi: 10.1097/MPG.0000000000001801. PMID: 29356770
Staphylococcal scalded skin syndrome: diagnosis and management in children and adults.
Handler MZ, Schwartz RA
J Eur Acad Dermatol Venereol 2014 Nov;28(11):1418-23. Epub 2014 May 20 doi: 10.1111/jdv.12541. PMID: 24841497

Recent clinical studies

Etiology

Association between genetically proxied HMGCR inhibition and male reproductive health: A Mendelian randomization study.
Yan Z, Xu Y, Li K, Liu L
Medicine (Baltimore) 2023 Sep 29;102(39):e34690. doi: 10.1097/MD.0000000000034690. PMID: 37773823Free PMC Article
Circulating Sex Hormone Levels and Risk of Gastrointestinal Cancer: Systematic Review and Meta-Analysis of Prospective Studies.
Liu Z, Zhang Y, Lagergren J, Li S, Li J, Zhou Z, Hu Z, Xie SH
Cancer Epidemiol Biomarkers Prev 2023 Jul 5;32(7):936-946. doi: 10.1158/1055-9965.EPI-23-0039. PMID: 37104672
Sex Hormone-Binding Globulin and Risk of Coronary Heart Disease in Men and Women.
Li J, Zheng L, Chan KHK, Zou X, Zhang J, Liu J, Zhong Q, Madsen TE, Wu WC, Manson JE, Yu X, Liu S
Clin Chem 2023 Apr 3;69(4):374-385. doi: 10.1093/clinchem/hvac209. PMID: 36702572
Increased Circulating Cell-Free DNA in Eosinophilic Granulomatosis With Polyangiitis: Implications for Eosinophil Extracellular Traps and Immunothrombosis.
Hashimoto T, Ueki S, Kamide Y, Miyabe Y, Fukuchi M, Yokoyama Y, Furukawa T, Azuma N, Oka N, Takeuchi H, Kanno K, Ishida-Yamamoto A, Taniguchi M, Hashiramoto A, Matsui K
Front Immunol 2021;12:801897. Epub 2022 Jan 12 doi: 10.3389/fimmu.2021.801897. PMID: 35095884Free PMC Article
Natural Antibodies Against Sialoglycans.
Shilova N, Huflejt ME, Vuskovic M, Obukhova P, Navakouski M, Khasbiullina N, Pazynina G, Galanina O, Bazhenov A, Bovin N
Top Curr Chem 2015;366:169-81. doi: 10.1007/128_2013_469. PMID: 24037491

Diagnosis

Selection and Interpretation of Molecular Diagnostics in Heart Transplantation.
Goldberg JF, Truby LK, Agbor-Enoh S, Jackson AM, deFilippi CR, Khush KK, Shah P
Circulation 2023 Aug 22;148(8):679-694. Epub 2023 Aug 21 doi: 10.1161/CIRCULATIONAHA.123.062847. PMID: 37603604Free PMC Article
Alpha-1 antitrypsin deficiency: current therapy and emerging targets.
McElvaney OF, Fraughen DD, McElvaney OJ, Carroll TP, McElvaney NG
Expert Rev Respir Med 2023 Mar;17(3):191-202. Epub 2023 Mar 15 doi: 10.1080/17476348.2023.2174973. PMID: 36896570
IgG memory B cells expressing IL4R and FCER2 are associated with atopic diseases.
Aranda CJ, Gonzalez-Kozlova E, Saunders SP, Fernandes-Braga W, Ota M, Narayanan S, He JS, Del Duca E, Swaroop B, Gnjatic S, Shattner G, Reibman J, Soter NA, Guttman-Yassky E, Curotto de Lafaille MA
Allergy 2023 Mar;78(3):752-766. Epub 2022 Dec 19 doi: 10.1111/all.15601. PMID: 36445014Free PMC Article
Sex Hormone-Binding Globulin (SHBG) as an Early Biomarker and Therapeutic Target in Polycystic Ovary Syndrome.
Qu X, Donnelly R
Int J Mol Sci 2020 Nov 1;21(21) doi: 10.3390/ijms21218191. PMID: 33139661Free PMC Article
B Cell-Mediated Autoimmune Diseases.
Lin X, Lu L
Adv Exp Med Biol 2020;1254:145-160. doi: 10.1007/978-981-15-3532-1_11. PMID: 32323275

Therapy

Sex Hormone-Binding Globulin and Risk of Coronary Heart Disease in Men and Women.
Li J, Zheng L, Chan KHK, Zou X, Zhang J, Liu J, Zhong Q, Madsen TE, Wu WC, Manson JE, Yu X, Liu S
Clin Chem 2023 Apr 3;69(4):374-385. doi: 10.1093/clinchem/hvac209. PMID: 36702572
Circulating Spike Protein Detected in Post-COVID-19 mRNA Vaccine Myocarditis.
Yonker LM, Swank Z, Bartsch YC, Burns MD, Kane A, Boribong BP, Davis JP, Loiselle M, Novak T, Senussi Y, Cheng CA, Burgess E, Edlow AG, Chou J, Dionne A, Balaguru D, Lahoud-Rahme M, Arditi M, Julg B, Randolph AG, Alter G, Fasano A, Walt DR
Circulation 2023 Mar 14;147(11):867-876. Epub 2023 Jan 4 doi: 10.1161/CIRCULATIONAHA.122.061025. PMID: 36597886Free PMC Article
Anti-IgE treatment in allergic rhinitis.
Bayar Muluk N, Bafaqeeh SA, Cingi C
Int J Pediatr Otorhinolaryngol 2019 Dec;127:109674. Epub 2019 Sep 10 doi: 10.1016/j.ijporl.2019.109674. PMID: 31526939
Dyslipidemia in systemic lupus erythematosus.
Szabó MZ, Szodoray P, Kiss E
Immunol Res 2017 Apr;65(2):543-550. doi: 10.1007/s12026-016-8892-9. PMID: 28168401
PCSK9 inhibitors.
Gencer B, Lambert G, Mach F
Swiss Med Wkly 2015;145:w14094. Epub 2015 Apr 9 doi: 10.4414/smw.2015.14094. PMID: 25856746

Prognosis

Selection and Interpretation of Molecular Diagnostics in Heart Transplantation.
Goldberg JF, Truby LK, Agbor-Enoh S, Jackson AM, deFilippi CR, Khush KK, Shah P
Circulation 2023 Aug 22;148(8):679-694. Epub 2023 Aug 21 doi: 10.1161/CIRCULATIONAHA.123.062847. PMID: 37603604Free PMC Article
Sex Hormone-Binding Globulin and Risk of Coronary Heart Disease in Men and Women.
Li J, Zheng L, Chan KHK, Zou X, Zhang J, Liu J, Zhong Q, Madsen TE, Wu WC, Manson JE, Yu X, Liu S
Clin Chem 2023 Apr 3;69(4):374-385. doi: 10.1093/clinchem/hvac209. PMID: 36702572
Biomarkers of disease activity in dermatomyositis.
Lu X, Peng Q, Wang G
Curr Opin Rheumatol 2022 Nov 1;34(6):289-294. Epub 2022 Aug 30 doi: 10.1097/BOR.0000000000000905. PMID: 36082751
Staphylococcal scalded skin syndrome: diagnosis and management in children and adults.
Handler MZ, Schwartz RA
J Eur Acad Dermatol Venereol 2014 Nov;28(11):1418-23. Epub 2014 May 20 doi: 10.1111/jdv.12541. PMID: 24841497
Acquired inhibitors.
Cohen AJ, Kessler CM
Baillieres Clin Haematol 1996 Jun;9(2):331-54. doi: 10.1016/s0950-3536(96)80067-9. PMID: 8800509

Clinical prediction guides

Sex Hormone-Binding Globulin and Risk of Coronary Heart Disease in Men and Women.
Li J, Zheng L, Chan KHK, Zou X, Zhang J, Liu J, Zhong Q, Madsen TE, Wu WC, Manson JE, Yu X, Liu S
Clin Chem 2023 Apr 3;69(4):374-385. doi: 10.1093/clinchem/hvac209. PMID: 36702572
Anti-IgE treatment in allergic rhinitis.
Bayar Muluk N, Bafaqeeh SA, Cingi C
Int J Pediatr Otorhinolaryngol 2019 Dec;127:109674. Epub 2019 Sep 10 doi: 10.1016/j.ijporl.2019.109674. PMID: 31526939
Natural Antibodies Against Sialoglycans.
Shilova N, Huflejt ME, Vuskovic M, Obukhova P, Navakouski M, Khasbiullina N, Pazynina G, Galanina O, Bazhenov A, Bovin N
Top Curr Chem 2015;366:169-81. doi: 10.1007/128_2013_469. PMID: 24037491
Immunological responses to exogenous insulin.
Fineberg SE, Kawabata TT, Finco-Kent D, Fountaine RJ, Finch GL, Krasner AS
Endocr Rev 2007 Oct;28(6):625-52. Epub 2007 Sep 4 doi: 10.1210/er.2007-0002. PMID: 17785428
Inhibitors of the hyaluronidases.
Mio K, Stern R
Matrix Biol 2002 Jan;21(1):31-7. doi: 10.1016/s0945-053x(01)00185-8. PMID: 11827790

Recent systematic reviews

Circulating Sex Hormone Levels and Risk of Gastrointestinal Cancer: Systematic Review and Meta-Analysis of Prospective Studies.
Liu Z, Zhang Y, Lagergren J, Li S, Li J, Zhou Z, Hu Z, Xie SH
Cancer Epidemiol Biomarkers Prev 2023 Jul 5;32(7):936-946. doi: 10.1158/1055-9965.EPI-23-0039. PMID: 37104672
Systematic Review and Meta-Analysis of Circulating Irisin Levels Following Endurance Training: Results of Continuous and Interval Training.
Cosio PL, Pelaez M, Cadefau JA, Farran-Codina A
Biol Res Nurs 2023 Jul;25(3):367-381. Epub 2022 Nov 25 doi: 10.1177/10998004221142580. PMID: 36426821
A Systematic Review and Meta-Analysis of Smoking and Circulating Sex Hormone Levels Among Premenopausal Women.
Ihenacho U, Sriprasert I, Mack WJ, Hamilton AS, Unger JB, Press MF, Wu AH
Nicotine Tob Res 2022 Oct 26;24(11):1705-1713. doi: 10.1093/ntr/ntac066. PMID: 35291014
Dupilumab ocular side effects in patients with atopic dermatitis: a systematic review.
Neagu N, Dianzani C, Avallone G, Dell'Aquila C, Morariu SH, Zalaudek I, Conforti C
J Eur Acad Dermatol Venereol 2022 Jun;36(6):820-835. Epub 2022 Feb 17 doi: 10.1111/jdv.17981. PMID: 35122335
Diagnosis and Management of Pediatric Autoimmune Liver Disease: ESPGHAN Hepatology Committee Position Statement.
Mieli-Vergani G, Vergani D, Baumann U, Czubkowski P, Debray D, Dezsofi A, Fischler B, Gupte G, Hierro L, Indolfi G, Jahnel J, Smets F, Verkade HJ, Hadžić N
J Pediatr Gastroenterol Nutr 2018 Feb;66(2):345-360. doi: 10.1097/MPG.0000000000001801. PMID: 29356770

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