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Increased circulating globulin level

MedGen UID:
1686812
•Concept ID:
C5139265
•
Finding
HPO: HP:0032311

Definition

An abnormally elevated concentration of globulins in the blood. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased circulating globulin level

Professional guidelines

PubMed

Placental growth factor promotes tumour desmoplasia and treatment resistance in intrahepatic cholangiocarcinoma.
Aoki S, Inoue K, Klein S, Halvorsen S, Chen J, Matsui A, Nikmaneshi MR, Kitahara S, Hato T, Chen X, Kawakubo K, Nia HT, Chen I, Schanne DH, Mamessier E, Shigeta K, Kikuchi H, Ramjiawan RR, Schmidt TC, Iwasaki M, Yau T, Hong TS, Quaas A, Plum PS, Dima S, Popescu I, Bardeesy N, Munn LL, Borad MJ, Sassi S, Jain RK, Zhu AX, Duda DG
Gut 2022 Jan;71(1):185-193. Epub 2021 Jan 11 doi: 10.1136/gutjnl-2020-322493. PMID: 33431577Free PMC Article
Diagnosis and Management of Pediatric Autoimmune Liver Disease: ESPGHAN Hepatology Committee Position Statement.
Mieli-Vergani G, Vergani D, Baumann U, Czubkowski P, Debray D, Dezsofi A, Fischler B, Gupte G, Hierro L, Indolfi G, Jahnel J, Smets F, Verkade HJ, Hadžić N
J Pediatr Gastroenterol Nutr 2018 Feb;66(2):345-360. doi: 10.1097/MPG.0000000000001801. PMID: 29356770
Diagnosis and follow-up of monoclonal gammopathies of undetermined significance; information for referring physicians.
Caers J, Vekemans MC, Bries G, Beel K, Delrieu V, Deweweire A, Demuynck H, De Prijck B, De Samblanx H, Kentos A, Meuleman N, Mineur P, Offner F, Vande Broek I, Van Droogenbroeck J, Vande Velde A, Wu KL, Delforge M, Schots R, Doyen C; Multiple Myeloma Study Group of the Belgian Hematological Society
Ann Med 2013 Sep;45(5-6):413-22. Epub 2013 Jun 14 doi: 10.3109/07853890.2013.801562. PMID: 23767978

Recent clinical studies

Etiology

Sex Hormone-Binding Globulin and Risk of Coronary Heart Disease in Men and Women.
Li J, Zheng L, Chan KHK, Zou X, Zhang J, Liu J, Zhong Q, Madsen TE, Wu WC, Manson JE, Yu X, Liu S
Clin Chem 2023 Apr 3;69(4):374-385. doi: 10.1093/clinchem/hvac209. PMID: 36702572
Aerobic exercise increases irisin serum levels and improves depression and fatigue in patients with relapsing remitting multiple sclerosis: A randomized controlled trial.
Bilek F, Cetisli-Korkmaz N, Ercan Z, Deniz G, Demir CF
Mult Scler Relat Disord 2022 May;61:103742. Epub 2022 Mar 15 doi: 10.1016/j.msard.2022.103742. PMID: 35349884
Increased Circulating Cell-Free DNA in Eosinophilic Granulomatosis With Polyangiitis: Implications for Eosinophil Extracellular Traps and Immunothrombosis.
Hashimoto T, Ueki S, Kamide Y, Miyabe Y, Fukuchi M, Yokoyama Y, Furukawa T, Azuma N, Oka N, Takeuchi H, Kanno K, Ishida-Yamamoto A, Taniguchi M, Hashiramoto A, Matsui K
Front Immunol 2021;12:801897. Epub 2022 Jan 12 doi: 10.3389/fimmu.2021.801897. PMID: 35095884Free PMC Article
The roles of free iron, heme, haemoglobin, and the scavenger proteins haemopexin and alpha-1-microglobulin in preeclampsia and fetal growth restriction.
Erlandsson L, Masoumi Z, Hansson LR, Hansson SR
J Intern Med 2021 Nov;290(5):952-968. Epub 2021 Jul 6 doi: 10.1111/joim.13349. PMID: 34146434
Natural Antibodies Against Sialoglycans.
Shilova N, Huflejt ME, Vuskovic M, Obukhova P, Navakouski M, Khasbiullina N, Pazynina G, Galanina O, Bazhenov A, Bovin N
Top Curr Chem 2015;366:169-81. doi: 10.1007/128_2013_469. PMID: 24037491

Diagnosis

Increased Circulating Cell-Free DNA in Eosinophilic Granulomatosis With Polyangiitis: Implications for Eosinophil Extracellular Traps and Immunothrombosis.
Hashimoto T, Ueki S, Kamide Y, Miyabe Y, Fukuchi M, Yokoyama Y, Furukawa T, Azuma N, Oka N, Takeuchi H, Kanno K, Ishida-Yamamoto A, Taniguchi M, Hashiramoto A, Matsui K
Front Immunol 2021;12:801897. Epub 2022 Jan 12 doi: 10.3389/fimmu.2021.801897. PMID: 35095884Free PMC Article
Circulating C1q levels in health and disease, more than just a biomarker.
van de Bovenkamp FS, Dijkstra DJ, van Kooten C, Gelderman KA, Trouw LA
Mol Immunol 2021 Dec;140:206-216. Epub 2021 Nov 2 doi: 10.1016/j.molimm.2021.10.010. PMID: 34735869
Sex Hormone-Binding Globulin (SHBG) as an Early Biomarker and Therapeutic Target in Polycystic Ovary Syndrome.
Qu X, Donnelly R
Int J Mol Sci 2020 Nov 1;21(21) doi: 10.3390/ijms21218191. PMID: 33139661Free PMC Article
B Cell-Mediated Autoimmune Diseases.
Lin X, Lu L
Adv Exp Med Biol 2020;1254:145-160. doi: 10.1007/978-981-15-3532-1_11. PMID: 32323275
Glucose-Sensitive Myokine/Cardiokine MG53 Regulates Systemic Insulin Response and Metabolic Homeostasis.
Wu HK, Zhang Y, Cao CM, Hu X, Fang M, Yao Y, Jin L, Chen G, Jiang P, Zhang S, Song R, Peng W, Liu F, Guo J, Tang L, He Y, Shan D, Huang J, Zhou Z, Wang DW, Lv F, Xiao RP
Circulation 2019 Feb 12;139(7):901-914. doi: 10.1161/CIRCULATIONAHA.118.037216. PMID: 30586741

Therapy

Sex Hormone-Binding Globulin and Risk of Coronary Heart Disease in Men and Women.
Li J, Zheng L, Chan KHK, Zou X, Zhang J, Liu J, Zhong Q, Madsen TE, Wu WC, Manson JE, Yu X, Liu S
Clin Chem 2023 Apr 3;69(4):374-385. doi: 10.1093/clinchem/hvac209. PMID: 36702572
Circulating Spike Protein Detected in Post-COVID-19 mRNA Vaccine Myocarditis.
Yonker LM, Swank Z, Bartsch YC, Burns MD, Kane A, Boribong BP, Davis JP, Loiselle M, Novak T, Senussi Y, Cheng CA, Burgess E, Edlow AG, Chou J, Dionne A, Balaguru D, Lahoud-Rahme M, Arditi M, Julg B, Randolph AG, Alter G, Fasano A, Walt DR
Circulation 2023 Mar 14;147(11):867-876. Epub 2023 Jan 4 doi: 10.1161/CIRCULATIONAHA.122.061025. PMID: 36597886Free PMC Article
Increased Circulating Cell-Free DNA in Eosinophilic Granulomatosis With Polyangiitis: Implications for Eosinophil Extracellular Traps and Immunothrombosis.
Hashimoto T, Ueki S, Kamide Y, Miyabe Y, Fukuchi M, Yokoyama Y, Furukawa T, Azuma N, Oka N, Takeuchi H, Kanno K, Ishida-Yamamoto A, Taniguchi M, Hashiramoto A, Matsui K
Front Immunol 2021;12:801897. Epub 2022 Jan 12 doi: 10.3389/fimmu.2021.801897. PMID: 35095884Free PMC Article
Effect of Alirocumab on Stroke in ODYSSEY OUTCOMES.
Jukema JW, Zijlstra LE, Bhatt DL, Bittner VA, Diaz R, Drexel H, Goodman SG, Kim YU, Pordy R, Reiner Ž, Roe MT, Tse HF, Montenegro Valdovinos PC, White HD, Zeiher AM, Szarek M, Schwartz GG, Steg PG; ODYSSEY OUTCOMES Investigators
Circulation 2019 Dec 17;140(25):2054-2062. Epub 2019 Nov 11 doi: 10.1161/CIRCULATIONAHA.119.043826. PMID: 31707788Free PMC Article
PCSK9 inhibitors.
Gencer B, Lambert G, Mach F
Swiss Med Wkly 2015;145:w14094. Epub 2015 Apr 9 doi: 10.4414/smw.2015.14094. PMID: 25856746

Prognosis

Sex Hormone-Binding Globulin and Risk of Coronary Heart Disease in Men and Women.
Li J, Zheng L, Chan KHK, Zou X, Zhang J, Liu J, Zhong Q, Madsen TE, Wu WC, Manson JE, Yu X, Liu S
Clin Chem 2023 Apr 3;69(4):374-385. doi: 10.1093/clinchem/hvac209. PMID: 36702572
Biomarkers of disease activity in dermatomyositis.
Lu X, Peng Q, Wang G
Curr Opin Rheumatol 2022 Nov 1;34(6):289-294. Epub 2022 Aug 30 doi: 10.1097/BOR.0000000000000905. PMID: 36082751
Effect of Alirocumab on Stroke in ODYSSEY OUTCOMES.
Jukema JW, Zijlstra LE, Bhatt DL, Bittner VA, Diaz R, Drexel H, Goodman SG, Kim YU, Pordy R, Reiner Ž, Roe MT, Tse HF, Montenegro Valdovinos PC, White HD, Zeiher AM, Szarek M, Schwartz GG, Steg PG; ODYSSEY OUTCOMES Investigators
Circulation 2019 Dec 17;140(25):2054-2062. Epub 2019 Nov 11 doi: 10.1161/CIRCULATIONAHA.119.043826. PMID: 31707788Free PMC Article
Inhibition of complement C1s improves severe hemolytic anemia in cold agglutinin disease: a first-in-human trial.
Jäger U, D'Sa S, Schörgenhofer C, Bartko J, Derhaschnig U, Sillaber C, Jilma-Stohlawetz P, Fillitz M, Schenk T, Patou G, Panicker S, Parry GC, Gilbert JC, Jilma B
Blood 2019 Feb 28;133(9):893-901. Epub 2018 Dec 17 doi: 10.1182/blood-2018-06-856930. PMID: 30559259Free PMC Article
Acquired inhibitors.
Cohen AJ, Kessler CM
Baillieres Clin Haematol 1996 Jun;9(2):331-54. doi: 10.1016/s0950-3536(96)80067-9. PMID: 8800509

Clinical prediction guides

Sex Hormone-Binding Globulin and Risk of Coronary Heart Disease in Men and Women.
Li J, Zheng L, Chan KHK, Zou X, Zhang J, Liu J, Zhong Q, Madsen TE, Wu WC, Manson JE, Yu X, Liu S
Clin Chem 2023 Apr 3;69(4):374-385. doi: 10.1093/clinchem/hvac209. PMID: 36702572
Aerobic exercise increases irisin serum levels and improves depression and fatigue in patients with relapsing remitting multiple sclerosis: A randomized controlled trial.
Bilek F, Cetisli-Korkmaz N, Ercan Z, Deniz G, Demir CF
Mult Scler Relat Disord 2022 May;61:103742. Epub 2022 Mar 15 doi: 10.1016/j.msard.2022.103742. PMID: 35349884
Sex Hormone-Binding Globulin (SHBG) as an Early Biomarker and Therapeutic Target in Polycystic Ovary Syndrome.
Qu X, Donnelly R
Int J Mol Sci 2020 Nov 1;21(21) doi: 10.3390/ijms21218191. PMID: 33139661Free PMC Article
Anti-IgE treatment in allergic rhinitis.
Bayar Muluk N, Bafaqeeh SA, Cingi C
Int J Pediatr Otorhinolaryngol 2019 Dec;127:109674. Epub 2019 Sep 10 doi: 10.1016/j.ijporl.2019.109674. PMID: 31526939
Natural Antibodies Against Sialoglycans.
Shilova N, Huflejt ME, Vuskovic M, Obukhova P, Navakouski M, Khasbiullina N, Pazynina G, Galanina O, Bazhenov A, Bovin N
Top Curr Chem 2015;366:169-81. doi: 10.1007/128_2013_469. PMID: 24037491

Recent systematic reviews

A Systematic Review and Meta-Analysis of Smoking and Circulating Sex Hormone Levels Among Premenopausal Women.
Ihenacho U, Sriprasert I, Mack WJ, Hamilton AS, Unger JB, Press MF, Wu AH
Nicotine Tob Res 2022 Oct 26;24(11):1705-1713. doi: 10.1093/ntr/ntac066. PMID: 35291014
Dupilumab ocular side effects in patients with atopic dermatitis: a systematic review.
Neagu N, Dianzani C, Avallone G, Dell'Aquila C, Morariu SH, Zalaudek I, Conforti C
J Eur Acad Dermatol Venereol 2022 Jun;36(6):820-835. Epub 2022 Feb 17 doi: 10.1111/jdv.17981. PMID: 35122335
Effect of Chronic Resistance Training on Circulating Irisin: Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Cosio PL, Crespo-Posadas M, Velarde-Sotres Á, Pelaez M
Int J Environ Res Public Health 2021 Mar 3;18(5) doi: 10.3390/ijerph18052476. PMID: 33802329Free PMC Article
Diagnosis and Management of Pediatric Autoimmune Liver Disease: ESPGHAN Hepatology Committee Position Statement.
Mieli-Vergani G, Vergani D, Baumann U, Czubkowski P, Debray D, Dezsofi A, Fischler B, Gupte G, Hierro L, Indolfi G, Jahnel J, Smets F, Verkade HJ, Hadžić N
J Pediatr Gastroenterol Nutr 2018 Feb;66(2):345-360. doi: 10.1097/MPG.0000000000001801. PMID: 29356770
Fetuin-A levels and risk of type 2 diabetes mellitus: a systematic review and meta-analysis.
Guo VY, Cao B, Cai C, Cheng KK, Cheung BMY
Acta Diabetol 2018 Jan;55(1):87-98. Epub 2017 Nov 11 doi: 10.1007/s00592-017-1068-9. PMID: 29127490

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