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Advanced Clear Cell Renal Cell Carcinoma

MedGen UID:
1688790
Concept ID:
C5204529
Neoplastic Process

Definition

A clear cell renal cell carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Clear Cell Renal Cell Carcinoma

Professional guidelines

PubMed

Plimack ER, Powles T, Stus V, Gafanov R, Nosov D, Waddell T, Alekseev B, Pouliot F, Melichar B, Soulières D, Borchiellini D, McDermott RS, Vynnychenko I, Chang YH, Tamada S, Atkins MB, Li C, Perini R, Molife LR, Bedke J, Rini BI
Eur Urol 2023 Nov;84(5):449-454. Epub 2023 Jul 25 doi: 10.1016/j.eururo.2023.06.006. PMID: 37500340
Zhang G, Chen X, Fang J, Tai P, Chen A, Cao K
Front Immunol 2022;13:954440. Epub 2022 Aug 19 doi: 10.3389/fimmu.2022.954440. PMID: 36059510Free PMC Article
Tannir NM, Pal SK, Atkins MB
Oncologist 2018 May;23(5):540-555. Epub 2018 Feb 27 doi: 10.1634/theoncologist.2017-0534. PMID: 29487224Free PMC Article

Recent clinical studies

Etiology

Xu Y, Li L, Yang W, Zhang K, Zhang Z, Yu C, Qiu J, Cai L, Gong Y, Zhang Z, Zhou J, Gong K
J Exp Clin Cancer Res 2023 Jul 6;42(1):159. doi: 10.1186/s13046-023-02742-w. PMID: 37415241Free PMC Article
Choueiri TK, Powles T, Albiges L, Burotto M, Szczylik C, Zurawski B, Yanez Ruiz E, Maruzzo M, Suarez Zaizar A, Fein LE, Schutz FA, Heng DYC, Wang F, Mataveli F, Chang YL, van Kooten Losio M, Suarez C, Motzer RJ; COSMIC-313 Investigators
N Engl J Med 2023 May 11;388(19):1767-1778. doi: 10.1056/NEJMoa2212851. PMID: 37163623Free PMC Article
Choueiri TK, McDermott DF, Merchan J, Bauer TM, Figlin R, Heath EI, Michaelson MD, Arrowsmith E, D'Souza A, Zhao S, Roy A, Perini R, Vickery D, Tykodi SS
Lancet Oncol 2023 May;24(5):553-562. Epub 2023 Mar 31 doi: 10.1016/S1470-2045(23)00097-9. PMID: 37011650
Motzer R, Porta C, Alekseev B, Rha SY, Choueiri TK, Mendez-Vidal MJ, Hong SH, Kapoor A, Goh JC, Eto M, Bennett L, Wang J, Pan JJ, Saretsky TL, Perini RF, He CS, Mody K, Cella D
Lancet Oncol 2022 Jun;23(6):768-780. Epub 2022 Apr 27 doi: 10.1016/S1470-2045(22)00212-1. PMID: 35489363Free PMC Article
Rini BI, Plimack ER, Stus V, Gafanov R, Hawkins R, Nosov D, Pouliot F, Alekseev B, Soulières D, Melichar B, Vynnychenko I, Kryzhanivska A, Bondarenko I, Azevedo SJ, Borchiellini D, Szczylik C, Markus M, McDermott RS, Bedke J, Tartas S, Chang YH, Tamada S, Shou Q, Perini RF, Chen M, Atkins MB, Powles T; KEYNOTE-426 Investigators
N Engl J Med 2019 Mar 21;380(12):1116-1127. Epub 2019 Feb 16 doi: 10.1056/NEJMoa1816714. PMID: 30779529

Diagnosis

Kotecha RR, Gedvilaite E, Ptashkin R, Knezevic A, Murray S, Johnson I, Shapnik N, Feldman DR, Carlo MI, Shah NJ, Dunigan M, Huberman K, Benayed R, Zehir A, Berger MF, Ladanyi M, Tsui DWY, Motzer RJ, Lee CH, Voss MH
JCO Precis Oncol 2022 Jul;6:e2200012. doi: 10.1200/PO.22.00012. PMID: 35797508Free PMC Article
Liu XL, Zhang GM, Huang SS, Shi WH, Ye LX, Ren ZL, Zhang JJ, Liu SW, Yu L, Li YL
Acta Pharmacol Sin 2022 Sep;43(9):2397-2409. Epub 2022 Feb 14 doi: 10.1038/s41401-022-00862-1. PMID: 35165399Free PMC Article
Goebell PJ, Ivanyi P, Bedke J, Bergmann L, Berthold D, Boegemann M, Busch J, Doehn C, Krege S, Retz M, Amsberg GV, Grimm MO, Gruenwald V
Future Oncol 2020 Oct;16(29):2307-2328. Epub 2020 Sep 23 doi: 10.2217/fon-2020-0403. PMID: 32964728
Verbiest A, Renders I, Caruso S, Couchy G, Job S, Laenen A, Verkarre V, Rioux-Leclercq N, Schöffski P, Vano Y, Elaidi RT, Lerut E, Albersen M, Oudard S, Fridman WH, Sautès-Fridman C, Albigès L, Wozniak A, Zucman-Rossi J, Beuselinck B
Clin Genitourin Cancer 2019 Oct;17(5):e981-e994. Epub 2019 May 25 doi: 10.1016/j.clgc.2019.05.009. PMID: 31229459
Abdel-Rahman O, Fouad M
Crit Rev Oncol Hematol 2015 May;94(2):238-50. Epub 2015 Jan 19 doi: 10.1016/j.critrevonc.2015.01.006. PMID: 25638704

Therapy

Choueiri TK, Powles T, Albiges L, Burotto M, Szczylik C, Zurawski B, Yanez Ruiz E, Maruzzo M, Suarez Zaizar A, Fein LE, Schutz FA, Heng DYC, Wang F, Mataveli F, Chang YL, van Kooten Losio M, Suarez C, Motzer RJ; COSMIC-313 Investigators
N Engl J Med 2023 May 11;388(19):1767-1778. doi: 10.1056/NEJMoa2212851. PMID: 37163623Free PMC Article
Motzer R, Porta C, Alekseev B, Rha SY, Choueiri TK, Mendez-Vidal MJ, Hong SH, Kapoor A, Goh JC, Eto M, Bennett L, Wang J, Pan JJ, Saretsky TL, Perini RF, He CS, Mody K, Cella D
Lancet Oncol 2022 Jun;23(6):768-780. Epub 2022 Apr 27 doi: 10.1016/S1470-2045(22)00212-1. PMID: 35489363Free PMC Article
Braun DA, Hou Y, Bakouny Z, Ficial M, Sant' Angelo M, Forman J, Ross-Macdonald P, Berger AC, Jegede OA, Elagina L, Steinharter J, Sun M, Wind-Rotolo M, Pignon JC, Cherniack AD, Lichtenstein L, Neuberg D, Catalano P, Freeman GJ, Sharpe AH, McDermott DF, Van Allen EM, Signoretti S, Wu CJ, Shukla SA, Choueiri TK
Nat Med 2020 Jun;26(6):909-918. Epub 2020 May 29 doi: 10.1038/s41591-020-0839-y. PMID: 32472114Free PMC Article
Rini BI, Plimack ER, Stus V, Gafanov R, Hawkins R, Nosov D, Pouliot F, Alekseev B, Soulières D, Melichar B, Vynnychenko I, Kryzhanivska A, Bondarenko I, Azevedo SJ, Borchiellini D, Szczylik C, Markus M, McDermott RS, Bedke J, Tartas S, Chang YH, Tamada S, Shou Q, Perini RF, Chen M, Atkins MB, Powles T; KEYNOTE-426 Investigators
N Engl J Med 2019 Mar 21;380(12):1116-1127. Epub 2019 Feb 16 doi: 10.1056/NEJMoa1816714. PMID: 30779529
Motzer RJ, Escudier B, McDermott DF, George S, Hammers HJ, Srinivas S, Tykodi SS, Sosman JA, Procopio G, Plimack ER, Castellano D, Choueiri TK, Gurney H, Donskov F, Bono P, Wagstaff J, Gauler TC, Ueda T, Tomita Y, Schutz FA, Kollmannsberger C, Larkin J, Ravaud A, Simon JS, Xu LA, Waxman IM, Sharma P; CheckMate 025 Investigators
N Engl J Med 2015 Nov 5;373(19):1803-13. Epub 2015 Sep 25 doi: 10.1056/NEJMoa1510665. PMID: 26406148Free PMC Article

Prognosis

Choueiri TK, Powles T, Albiges L, Burotto M, Szczylik C, Zurawski B, Yanez Ruiz E, Maruzzo M, Suarez Zaizar A, Fein LE, Schutz FA, Heng DYC, Wang F, Mataveli F, Chang YL, van Kooten Losio M, Suarez C, Motzer RJ; COSMIC-313 Investigators
N Engl J Med 2023 May 11;388(19):1767-1778. doi: 10.1056/NEJMoa2212851. PMID: 37163623Free PMC Article
Motzer R, Porta C, Alekseev B, Rha SY, Choueiri TK, Mendez-Vidal MJ, Hong SH, Kapoor A, Goh JC, Eto M, Bennett L, Wang J, Pan JJ, Saretsky TL, Perini RF, He CS, Mody K, Cella D
Lancet Oncol 2022 Jun;23(6):768-780. Epub 2022 Apr 27 doi: 10.1016/S1470-2045(22)00212-1. PMID: 35489363Free PMC Article
Motzer RJ, Choueiri TK, McDermott DF, Powles T, Vano YA, Gupta S, Yao J, Han C, Ammar R, Papillon-Cavanagh S, Saggi SS, McHenry MB, Ross-Macdonald P, Wind-Rotolo M
J Immunother Cancer 2022 Mar;10(3) doi: 10.1136/jitc-2021-004316. PMID: 35304405Free PMC Article
Braun DA, Hou Y, Bakouny Z, Ficial M, Sant' Angelo M, Forman J, Ross-Macdonald P, Berger AC, Jegede OA, Elagina L, Steinharter J, Sun M, Wind-Rotolo M, Pignon JC, Cherniack AD, Lichtenstein L, Neuberg D, Catalano P, Freeman GJ, Sharpe AH, McDermott DF, Van Allen EM, Signoretti S, Wu CJ, Shukla SA, Choueiri TK
Nat Med 2020 Jun;26(6):909-918. Epub 2020 May 29 doi: 10.1038/s41591-020-0839-y. PMID: 32472114Free PMC Article
Rini BI, Plimack ER, Stus V, Gafanov R, Hawkins R, Nosov D, Pouliot F, Alekseev B, Soulières D, Melichar B, Vynnychenko I, Kryzhanivska A, Bondarenko I, Azevedo SJ, Borchiellini D, Szczylik C, Markus M, McDermott RS, Bedke J, Tartas S, Chang YH, Tamada S, Shou Q, Perini RF, Chen M, Atkins MB, Powles T; KEYNOTE-426 Investigators
N Engl J Med 2019 Mar 21;380(12):1116-1127. Epub 2019 Feb 16 doi: 10.1056/NEJMoa1816714. PMID: 30779529

Clinical prediction guides

Xu Y, Li L, Yang W, Zhang K, Zhang Z, Yu C, Qiu J, Cai L, Gong Y, Zhang Z, Zhou J, Gong K
J Exp Clin Cancer Res 2023 Jul 6;42(1):159. doi: 10.1186/s13046-023-02742-w. PMID: 37415241Free PMC Article
Choueiri TK, McDermott DF, Merchan J, Bauer TM, Figlin R, Heath EI, Michaelson MD, Arrowsmith E, D'Souza A, Zhao S, Roy A, Perini R, Vickery D, Tykodi SS
Lancet Oncol 2023 May;24(5):553-562. Epub 2023 Mar 31 doi: 10.1016/S1470-2045(23)00097-9. PMID: 37011650
Motzer R, Porta C, Alekseev B, Rha SY, Choueiri TK, Mendez-Vidal MJ, Hong SH, Kapoor A, Goh JC, Eto M, Bennett L, Wang J, Pan JJ, Saretsky TL, Perini RF, He CS, Mody K, Cella D
Lancet Oncol 2022 Jun;23(6):768-780. Epub 2022 Apr 27 doi: 10.1016/S1470-2045(22)00212-1. PMID: 35489363Free PMC Article
Motzer RJ, Choueiri TK, McDermott DF, Powles T, Vano YA, Gupta S, Yao J, Han C, Ammar R, Papillon-Cavanagh S, Saggi SS, McHenry MB, Ross-Macdonald P, Wind-Rotolo M
J Immunother Cancer 2022 Mar;10(3) doi: 10.1136/jitc-2021-004316. PMID: 35304405Free PMC Article
Rini BI, Plimack ER, Stus V, Gafanov R, Hawkins R, Nosov D, Pouliot F, Alekseev B, Soulières D, Melichar B, Vynnychenko I, Kryzhanivska A, Bondarenko I, Azevedo SJ, Borchiellini D, Szczylik C, Markus M, McDermott RS, Bedke J, Tartas S, Chang YH, Tamada S, Shou Q, Perini RF, Chen M, Atkins MB, Powles T; KEYNOTE-426 Investigators
N Engl J Med 2019 Mar 21;380(12):1116-1127. Epub 2019 Feb 16 doi: 10.1056/NEJMoa1816714. PMID: 30779529

Recent systematic reviews

Abdel-Rahman O, Fouad M
Crit Rev Oncol Hematol 2015 May;94(2):238-50. Epub 2015 Jan 19 doi: 10.1016/j.critrevonc.2015.01.006. PMID: 25638704
Minardi D, Quaresima L, Santoni M, Bianconi M, Scartozzi M, Cascinu S, Muzzonigro G
Curr Urol Rep 2015 Feb;16(2):3. doi: 10.1007/s11934-014-0478-2. PMID: 25627021

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