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Head and Neck Small Cell Neuroendocrine Carcinoma

MedGen UID:
1689515
•Concept ID:
C5205700
•
Neoplastic Process
Synonym: Head and Neck Small Cell Carcinoma

Definition

A small cell neuroendocrine carcinoma that arises from the head and neck. [from NCI]

Professional guidelines

PubMed

DLL3 as an Emerging Target for the Treatment of Neuroendocrine Neoplasms.
Yao J, Bergsland E, Aggarwal R, Aparicio A, Beltran H, Crabtree JS, Hann CL, Ibrahim T, Byers LA, Sasano H, Umejiego J, Pavel M
Oncologist 2022 Nov 3;27(11):940-951. doi: 10.1093/oncolo/oyac161. PMID: 35983951Free PMC Article
Activation of PI3K/AKT Pathway Is a Potential Mechanism of Treatment Resistance in Small Cell Lung Cancer.
Jin Y, Chen Y, Tang H, Hu X, Hubert SM, Li Q, Su D, Xu H, Fan Y, Yu X, Chen Q, Liu J, Hong W, Xu Y, Deng H, Zhu D, Li P, Gong Y, Xia X, Gay CM, Zhang J, Chen M
Clin Cancer Res 2022 Feb 1;28(3):526-539. Epub 2021 Dec 17 doi: 10.1158/1078-0432.CCR-21-1943. PMID: 34921019
Chemistry-First Approach for Nomination of Personalized Treatment in Lung Cancer.
McMillan EA, Ryu MJ, Diep CH, Mendiratta S, Clemenceau JR, Vaden RM, Kim JH, Motoyaji T, Covington KR, Peyton M, Huffman K, Wu X, Girard L, Sung Y, Chen PH, Mallipeddi PL, Lee JY, Hanson J, Voruganti S, Yu Y, Park S, Sudderth J, DeSevo C, Muzny DM, Doddapaneni H, Gazdar A, Gibbs RA, Hwang TH, Heymach JV, Wistuba I, Coombes KR, Williams NS, Wheeler DA, MacMillan JB, Deberardinis RJ, Roth MG, Posner BA, Minna JD, Kim HS, White MA
Cell 2018 May 3;173(4):864-878.e29. Epub 2018 Apr 19 doi: 10.1016/j.cell.2018.03.028. PMID: 29681454Free PMC Article

Recent clinical studies

Etiology

DLL3 as an Emerging Target for the Treatment of Neuroendocrine Neoplasms.
Yao J, Bergsland E, Aggarwal R, Aparicio A, Beltran H, Crabtree JS, Hann CL, Ibrahim T, Byers LA, Sasano H, Umejiego J, Pavel M
Oncologist 2022 Nov 3;27(11):940-951. doi: 10.1093/oncolo/oyac161. PMID: 35983951Free PMC Article
lncRNA CYTOR promotes aberrant glycolysis and mitochondrial respiration via HNRNPC-mediated ZEB1 stabilization in oral squamous cell carcinoma.
Zhu W, Wang J, Liu X, Xu Y, Zhai R, Zhang J, Wang M, Wang M, Liu L
Cell Death Dis 2022 Aug 13;13(8):703. doi: 10.1038/s41419-022-05157-1. PMID: 35963855Free PMC Article
CD73 in small extracellular vesicles derived from HNSCC defines tumour-associated immunosuppression mediated by macrophages in the microenvironment.
Lu T, Zhang Z, Zhang J, Pan X, Zhu X, Wang X, Li Z, Ruan M, Li H, Chen W, Yan M
J Extracell Vesicles 2022 May;11(5):e12218. doi: 10.1002/jev2.12218. PMID: 35524455Free PMC Article
microRNAs deregulation in head and neck squamous cell carcinoma.
Carron J, Torricelli C, Silva JK, Queiroz GSR, Ortega MM, Lima CSP, Lourenço GJ
Head Neck 2021 Feb;43(2):645-667. Epub 2020 Nov 6 doi: 10.1002/hed.26533. PMID: 33159410
Radiomic biomarkers for head and neck squamous cell carcinoma.
Tanadini-Lang S, Balermpas P, Guckenberger M, Pavic M, Riesterer O, Vuong D, Bogowicz M
Strahlenther Onkol 2020 Oct;196(10):868-878. Epub 2020 Jun 3 doi: 10.1007/s00066-020-01638-4. PMID: 32495038

Diagnosis

Clinical insights into small cell lung cancer: Tumor heterogeneity, diagnosis, therapy, and future directions.
Megyesfalvi Z, Gay CM, Popper H, Pirker R, Ostoros G, Heeke S, Lang C, Hoetzenecker K, Schwendenwein A, Boettiger K, Bunn PA Jr, Renyi-Vamos F, Schelch K, Prosch H, Byers LA, Hirsch FR, Dome B
CA Cancer J Clin 2023 Nov-Dec;73(6):620-652. Epub 2023 Jun 17 doi: 10.3322/caac.21785. PMID: 37329269
Non-squamous Laryngeal Cancer.
MacNeil SD
Otolaryngol Clin North Am 2023 Apr;56(2):345-359. doi: 10.1016/j.otc.2023.01.003. PMID: 37030947
Immunologically active phenotype by gene expression profiling is associated with clinical benefit from PD-1/PD-L1 inhibitors in real-world head and neck and lung cancer patients.
Foy JP, Karabajakian A, Ortiz-Cuaran S, Boussageon M, Michon L, Bouaoud J, Fekiri D, Robert M, Baffert KA, Hervé G, Quilhot P, Attignon V, Girod A, Chaine A, Benassarou M, Zrounba P, Caux C, Ghiringhelli F, Lantuejoul S, Crozes C, Brochériou I, Pérol M, Fayette J, Bertolus C, Saintigny P
Eur J Cancer 2022 Oct;174:287-298. Epub 2022 Aug 26 doi: 10.1016/j.ejca.2022.06.034. PMID: 36038492
Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Overview of the 2022 WHO Classification of Head and Neck Neuroendocrine Neoplasms.
Mete O, Wenig BM
Head Neck Pathol 2022 Mar;16(1):123-142. Epub 2022 Mar 21 doi: 10.1007/s12105-022-01435-8. PMID: 35312985Free PMC Article
Identification of Potential Biomarkers and Survival Analysis for Head and Neck Squamous Cell Carcinoma Using Bioinformatics Strategy: A Study Based on TCGA and GEO Datasets.
Shen Y, Liu J, Zhang L, Dong S, Zhang J, Liu Y, Zhou H, Dong W
Biomed Res Int 2019;2019:7376034. Epub 2019 Aug 7 doi: 10.1155/2019/7376034. PMID: 31485443Free PMC Article

Therapy

Design and Rationale for a Phase III, Double-Blind, Placebo-Controlled Study of Neoadjuvant Durvalumab + Chemotherapy Followed by Adjuvant Durvalumab for the Treatment of Patients With Resectable Stages II and III non-small-cell Lung Cancer: The AEGEAN Trial.
Heymach JV, Mitsudomi T, Harpole D, Aperghis M, Jones S, Mann H, Fouad TM, Reck M
Clin Lung Cancer 2022 May;23(3):e247-e251. Epub 2021 Oct 10 doi: 10.1016/j.cllc.2021.09.010. PMID: 34819266
Neoadjuvant nivolumab or nivolumab plus ipilimumab in operable non-small cell lung cancer: the phase 2 randomized NEOSTAR trial.
Cascone T, William WN Jr, Weissferdt A, Leung CH, Lin HY, Pataer A, Godoy MCB, Carter BW, Federico L, Reuben A, Khan MAW, Dejima H, Francisco-Cruz A, Parra ER, Solis LM, Fujimoto J, Tran HT, Kalhor N, Fossella FV, Mott FE, Tsao AS, Blumenschein G Jr, Le X, Zhang J, Skoulidis F, Kurie JM, Altan M, Lu C, Glisson BS, Byers LA, Elamin YY, Mehran RJ, Rice DC, Walsh GL, Hofstetter WL, Roth JA, Antonoff MB, Kadara H, Haymaker C, Bernatchez C, Ajami NJ, Jenq RR, Sharma P, Allison JP, Futreal A, Wargo JA, Wistuba II, Swisher SG, Lee JJ, Gibbons DL, Vaporciyan AA, Heymach JV, Sepesi B
Nat Med 2021 Mar;27(3):504-514. Epub 2021 Feb 18 doi: 10.1038/s41591-020-01224-2. PMID: 33603241Free PMC Article
Clinical Development of BRAF plus MEK Inhibitor Combinations.
Subbiah V, Baik C, Kirkwood JM
Trends Cancer 2020 Sep;6(9):797-810. Epub 2020 Jun 13 doi: 10.1016/j.trecan.2020.05.009. PMID: 32540454
Targeting DNA Damage Response Promotes Antitumor Immunity through STING-Mediated T-cell Activation in Small Cell Lung Cancer.
Sen T, Rodriguez BL, Chen L, Corte CMD, Morikawa N, Fujimoto J, Cristea S, Nguyen T, Diao L, Li L, Fan Y, Yang Y, Wang J, Glisson BS, Wistuba II, Sage J, Heymach JV, Gibbons DL, Byers LA
Cancer Discov 2019 May;9(5):646-661. Epub 2019 Feb 18 doi: 10.1158/2159-8290.CD-18-1020. PMID: 30777870Free PMC Article
Cetuximab for treating non-small cell lung cancer.
Mazzarella L, Guida A, Curigliano G
Expert Opin Biol Ther 2018 Apr;18(4):483-493. doi: 10.1080/14712598.2018.1452906. PMID: 29534625

Prognosis

Non-squamous Laryngeal Cancer.
MacNeil SD
Otolaryngol Clin North Am 2023 Apr;56(2):345-359. doi: 10.1016/j.otc.2023.01.003. PMID: 37030947
DLL3 as an Emerging Target for the Treatment of Neuroendocrine Neoplasms.
Yao J, Bergsland E, Aggarwal R, Aparicio A, Beltran H, Crabtree JS, Hann CL, Ibrahim T, Byers LA, Sasano H, Umejiego J, Pavel M
Oncologist 2022 Nov 3;27(11):940-951. doi: 10.1093/oncolo/oyac161. PMID: 35983951Free PMC Article
Poziotinib in Non-Small-Cell Lung Cancer Harboring HER2 Exon 20 Insertion Mutations After Prior Therapies: ZENITH20-2 Trial.
Le X, Cornelissen R, Garassino M, Clarke JM, Tchekmedyian N, Goldman JW, Leu SY, Bhat G, Lebel F, Heymach JV, Socinski MA
J Clin Oncol 2022 Mar 1;40(7):710-718. Epub 2021 Nov 29 doi: 10.1200/JCO.21.01323. PMID: 34843401Free PMC Article
Long-Term Results of NRG Oncology RTOG 0617: Standard- Versus High-Dose Chemoradiotherapy With or Without Cetuximab for Unresectable Stage III Non-Small-Cell Lung Cancer.
Bradley JD, Hu C, Komaki RR, Masters GA, Blumenschein GR, Schild SE, Bogart JA, Forster KM, Magliocco AM, Kavadi VS, Narayan S, Iyengar P, Robinson CG, Wynn RB, Koprowski CD, Olson MR, Meng J, Paulus R, Curran WJ Jr, Choy H
J Clin Oncol 2020 Mar 1;38(7):706-714. Epub 2019 Dec 16 doi: 10.1200/JCO.19.01162. PMID: 31841363Free PMC Article
Outcomes to first-line pembrolizumab in patients with non-small-cell lung cancer and very high PD-L1 expression.
Aguilar EJ, Ricciuti B, Gainor JF, Kehl KL, Kravets S, Dahlberg S, Nishino M, Sholl LM, Adeni A, Subegdjo S, Khosrowjerdi S, Peterson RM, Digumarthy S, Liu C, Sauter J, Rizvi H, Arbour KC, Carter BW, Heymach JV, Altan M, Hellmann MD, Awad MM
Ann Oncol 2019 Oct 1;30(10):1653-1659. doi: 10.1093/annonc/mdz288. PMID: 31435660

Clinical prediction guides

Immunologically active phenotype by gene expression profiling is associated with clinical benefit from PD-1/PD-L1 inhibitors in real-world head and neck and lung cancer patients.
Foy JP, Karabajakian A, Ortiz-Cuaran S, Boussageon M, Michon L, Bouaoud J, Fekiri D, Robert M, Baffert KA, Hervé G, Quilhot P, Attignon V, Girod A, Chaine A, Benassarou M, Zrounba P, Caux C, Ghiringhelli F, Lantuejoul S, Crozes C, Brochériou I, Pérol M, Fayette J, Bertolus C, Saintigny P
Eur J Cancer 2022 Oct;174:287-298. Epub 2022 Aug 26 doi: 10.1016/j.ejca.2022.06.034. PMID: 36038492
CD73 in small extracellular vesicles derived from HNSCC defines tumour-associated immunosuppression mediated by macrophages in the microenvironment.
Lu T, Zhang Z, Zhang J, Pan X, Zhu X, Wang X, Li Z, Ruan M, Li H, Chen W, Yan M
J Extracell Vesicles 2022 May;11(5):e12218. doi: 10.1002/jev2.12218. PMID: 35524455Free PMC Article
Pembrolizumab Alone or With Chemotherapy for Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma in KEYNOTE-048: Subgroup Analysis by Programmed Death Ligand-1 Combined Positive Score.
Burtness B, Rischin D, Greil R, Soulières D, Tahara M, de Castro G Jr, Psyrri A, Brana I, Basté N, Neupane P, Bratland Å, Fuereder T, Hughes BGM, Mesia R, Ngamphaiboon N, Rordorf T, Wan Ishak WZ, Ge J, Swaby RF, Gumuscu B, Harrington K
J Clin Oncol 2022 Jul 20;40(21):2321-2332. Epub 2022 Mar 25 doi: 10.1200/JCO.21.02198. PMID: 35333599Free PMC Article
Programmed death ligand-1 (PD-L1) as a predictive marker for immunotherapy in solid tumours: a guide to immunohistochemistry implementation and interpretation.
Paver EC, Cooper WA, Colebatch AJ, Ferguson PM, Hill SK, Lum T, Shin JS, O'Toole S, Anderson L, Scolyer RA, Gupta R
Pathology 2021 Feb;53(2):141-156. Epub 2020 Dec 30 doi: 10.1016/j.pathol.2020.10.007. PMID: 33388161
Assessing Tumor-Infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method from the International Immuno-Oncology Biomarkers Working Group: Part 2: TILs in Melanoma, Gastrointestinal Tract Carcinomas, Non-Small Cell Lung Carcinoma and Mesothelioma, Endometrial and Ovarian Carcinomas, Squamous Cell Carcinoma of the Head and Neck, Genitourinary Carcinomas, and Primary Brain Tumors.
Hendry S, Salgado R, Gevaert T, Russell PA, John T, Thapa B, Christie M, van de Vijver K, Estrada MV, Gonzalez-Ericsson PI, Sanders M, Solomon B, Solinas C, Van den Eynden GGGM, Allory Y, Preusser M, Hainfellner J, Pruneri G, Vingiani A, Demaria S, Symmans F, Nuciforo P, Comerma L, Thompson EA, Lakhani S, Kim SR, Schnitt S, Colpaert C, Sotiriou C, Scherer SJ, Ignatiadis M, Badve S, Pierce RH, Viale G, Sirtaine N, Penault-Llorca F, Sugie T, Fineberg S, Paik S, Srinivasan A, Richardson A, Wang Y, Chmielik E, Brock J, Johnson DB, Balko J, Wienert S, Bossuyt V, Michiels S, Ternes N, Burchardi N, Luen SJ, Savas P, Klauschen F, Watson PH, Nelson BH, Criscitiello C, O'Toole S, Larsimont D, de Wind R, Curigliano G, André F, Lacroix-Triki M, van de Vijver M, Rojo F, Floris G, Bedri S, Sparano J, Rimm D, Nielsen T, Kos Z, Hewitt S, Singh B, Farshid G, Loibl S, Allison KH, Tung N, Adams S, Willard-Gallo K, Horlings HM, Gandhi L, Moreira A, Hirsch F, Dieci MV, Urbanowicz M, Brcic I, Korski K, Gaire F, Koeppen H, Lo A, Giltnane J, Rebelatto MC, Steele KE, Zha J, Emancipator K, Juco JW, Denkert C, Reis-Filho J, Loi S, Fox SB
Adv Anat Pathol 2017 Nov;24(6):311-335. doi: 10.1097/PAP.0000000000000161. PMID: 28777143Free PMC Article

Recent systematic reviews

Cannabis-based medicines and medical cannabis for adults with cancer pain.
Häuser W, Welsch P, Radbruch L, Fisher E, Bell RF, Moore RA
Cochrane Database Syst Rev 2023 Jun 5;6(6):CD014915. doi: 10.1002/14651858.CD014915.pub2. PMID: 37283486Free PMC Article
What is the malignant transformation potential of oral lichen planus?
Offen E, Allison JR
Evid Based Dent 2022 Mar;23(1):36-37. Epub 2022 Mar 25 doi: 10.1038/s41432-022-0240-4. PMID: 35338329
Association between immune-related side effects and efficacy and benefit of immune checkpoint inhibitors - A systematic review and meta-analysis.
Hussaini S, Chehade R, Boldt RG, Raphael J, Blanchette P, Maleki Vareki S, Fernandes R
Cancer Treat Rev 2021 Jan;92:102134. Epub 2020 Dec 3 doi: 10.1016/j.ctrv.2020.102134. PMID: 33302134
Evidence for different molecular parameters in head and neck squamous cell carcinoma of nonsmokers and nondrinkers: Systematic review and meta-analysis on HPV, p16, and TP53.
Mulder FJ, Pierssens DDCG, Baijens LWJ, Kremer B, Speel EM
Head Neck 2021 Jan;43(1):303-322. Epub 2020 Oct 23 doi: 10.1002/hed.26513. PMID: 33098216Free PMC Article
Tumour budding in head and neck squamous cell carcinoma - a systematic review.
Almangush A, Salo T, Hagström J, Leivo I
Histopathology 2014 Nov;65(5):587-94. Epub 2014 Oct 6 doi: 10.1111/his.12471. PMID: 24897954

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