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Abnormal HDL3c concentration

MedGen UID:
1689641
•Concept ID:
C5139339
•
Finding
HPO: HP:0032427

Definition

Any deviation from the normal concentration of the HDL3c subfraction in the blood circulation. An HDL3c particle is defined as an HDL particle with a size of 7.20-7.79 nm. [from HPO]

Recent clinical studies

Etiology

Pathophysiology of Diabetic Dyslipidemia.
Hirano T
J Atheroscler Thromb 2018 Sep 1;25(9):771-782. Epub 2018 Jul 12 doi: 10.5551/jat.RV17023. PMID: 29998913Free PMC Article
Shift of high-density lipoprotein size distribution toward large particles in patients with proteinuria.
Soto-Miranda E, Carreón-Torres E, Lorenzo K, Bazán-Salinas B, García-Sánchez C, Franco M, Posadas-Romero C, Fragoso JM, López-Olmos V, Madero M, Rodriguez-Pérez JM, Vargas-Alarcón G, Pérez-Méndez O
Clin Chim Acta 2012 Dec 24;414:241-5. Epub 2012 Oct 2 doi: 10.1016/j.cca.2012.09.028. PMID: 23041214
High-density lipoprotein subclasses distribution and composition in Mexican adolescents with low HDL cholesterol and/or high triglyceride concentrations, and its association with insulin and C-reactive protein.
Medina-Urrutia A, Juarez-Rojas JG, Martínez-Alvarado R, Jorge-Galarza E, Posadas-Sánchez R, Cardoso-Saldaña G, Caracas-Portilla N, Mendoza-Perez E, Posadas-Romero C
Atherosclerosis 2008 Dec;201(2):392-7. Epub 2008 Mar 18 doi: 10.1016/j.atherosclerosis.2008.02.029. PMID: 18420210
Metabolic syndrome features small, apolipoprotein A-I-poor, triglyceride-rich HDL3 particles with defective anti-apoptotic activity.
de Souza JA, Vindis C, Hansel B, Nègre-Salvayre A, Therond P, Serrano CV Jr, Chantepie S, Salvayre R, Bruckert E, Chapman MJ, Kontush A
Atherosclerosis 2008 Mar;197(1):84-94. Epub 2007 Sep 14 doi: 10.1016/j.atherosclerosis.2007.08.009. PMID: 17868679
Hyperinsulinemia and insulin resistance are associated with multiple abnormalities of lipoprotein subclasses in glucose-tolerant relatives of NIDDM patients. Botnia Study Group.
Tilly-Kiesi M, Knudsen P, Groop L, Taskinen MR
J Lipid Res 1996 Jul;37(7):1569-78. PMID: 8827527

Diagnosis

Hyperinsulinemia and insulin resistance are associated with multiple abnormalities of lipoprotein subclasses in glucose-tolerant relatives of NIDDM patients. Botnia Study Group.
Tilly-Kiesi M, Knudsen P, Groop L, Taskinen MR
J Lipid Res 1996 Jul;37(7):1569-78. PMID: 8827527

Therapy

Production of small high-density lipoprotein particles after stimulation of in vivo lipolysis in hypertriglyceridemic individuals: studies before and after triglyceride-lowering therapy.
Lewis GF, Uffelman KD, Lamarche B, Cabana VG, Getz GS
Metabolism 1998 Feb;47(2):234-42. doi: 10.1016/s0026-0495(98)90227-x. PMID: 9472977

Prognosis

Pathophysiology of Diabetic Dyslipidemia.
Hirano T
J Atheroscler Thromb 2018 Sep 1;25(9):771-782. Epub 2018 Jul 12 doi: 10.5551/jat.RV17023. PMID: 29998913Free PMC Article

Clinical prediction guides

Pathophysiology of Diabetic Dyslipidemia.
Hirano T
J Atheroscler Thromb 2018 Sep 1;25(9):771-782. Epub 2018 Jul 12 doi: 10.5551/jat.RV17023. PMID: 29998913Free PMC Article
Shift of high-density lipoprotein size distribution toward large particles in patients with proteinuria.
Soto-Miranda E, Carreón-Torres E, Lorenzo K, Bazán-Salinas B, García-Sánchez C, Franco M, Posadas-Romero C, Fragoso JM, López-Olmos V, Madero M, Rodriguez-Pérez JM, Vargas-Alarcón G, Pérez-Méndez O
Clin Chim Acta 2012 Dec 24;414:241-5. Epub 2012 Oct 2 doi: 10.1016/j.cca.2012.09.028. PMID: 23041214
High-density lipoproteins are abnormal in young women with uncomplicated systemic lupus erythematosus.
Juárez-Rojas J, Medina-Urrutia A, Posadas-Sánchez R, Jorge-Galarza E, Mendoza-Pérez E, Caracas-Portilla N, Cardoso-Saldaña G, Muñoz-Gallegos G, Posadas-Romero C
Lupus 2008 Nov;17(11):981-7. doi: 10.1177/0961203308093072. PMID: 18852221
High-density lipoprotein subclasses distribution and composition in Mexican adolescents with low HDL cholesterol and/or high triglyceride concentrations, and its association with insulin and C-reactive protein.
Medina-Urrutia A, Juarez-Rojas JG, Martínez-Alvarado R, Jorge-Galarza E, Posadas-Sánchez R, Cardoso-Saldaña G, Caracas-Portilla N, Mendoza-Perez E, Posadas-Romero C
Atherosclerosis 2008 Dec;201(2):392-7. Epub 2008 Mar 18 doi: 10.1016/j.atherosclerosis.2008.02.029. PMID: 18420210
Hyperinsulinemia and insulin resistance are associated with multiple abnormalities of lipoprotein subclasses in glucose-tolerant relatives of NIDDM patients. Botnia Study Group.
Tilly-Kiesi M, Knudsen P, Groop L, Taskinen MR
J Lipid Res 1996 Jul;37(7):1569-78. PMID: 8827527

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