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Advanced Colorectal Carcinoma

MedGen UID:
1690161
•Concept ID:
C5206582
•
Neoplastic Process

Definition

Colorectal carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Professional guidelines

PubMed

The role of capecitabine in the treatment of colorectal cancer in the elderly.
Pasetto LM, Monfardini S
Anticancer Res 2006 May-Jun;26(3B):2381-6. PMID: 16821620
Systemic treatment of advanced colorectal carcinoma.
van Laarhoven HW, Punt CJ
Eur J Gastroenterol Hepatol 2004 Mar;16(3):283-9. doi: 10.1097/00042737-200403000-00006. PMID: 15195891
New systemic frontline treatment for metastatic colorectal carcinoma.
Braun AH, Achterrath W, Wilke H, Vanhoefer U, Harstrick A, Preusser P
Cancer 2004 Apr 15;100(8):1558-77. doi: 10.1002/cncr.20154. PMID: 15073842

Recent clinical studies

Etiology

Mucinous histology is associated with poor prognosis in locally advanced colorectal adenocarcinoma treated with postoperative first-line adjuvant chemotherapy: A systematic review and meta-analysis.
Zhang Y, Chen Y, Huang J, Wu X, Tang R, Huang Q, Xu Y, Peng X, Fu K, Xiao S
Eur J Surg Oncol 2022 Oct;48(10):2075-2081. Epub 2022 Jun 23 doi: 10.1016/j.ejso.2022.06.024. PMID: 35768312
Simultaneous colorectal and parenchymal-sparing liver resection for advanced colorectal carcinoma with synchronous liver metastases: Between conventional and mini-invasive approaches.
De Raffele E, Mirarchi M, Cuicchi D, Lecce F, Casadei R, Ricci C, Selva S, Minni F
World J Gastroenterol 2020 Nov 14;26(42):6529-6555. doi: 10.3748/wjg.v26.i42.6529. PMID: 33268945Free PMC Article
New systemic frontline treatment for metastatic colorectal carcinoma.
Braun AH, Achterrath W, Wilke H, Vanhoefer U, Harstrick A, Preusser P
Cancer 2004 Apr 15;100(8):1558-77. doi: 10.1002/cncr.20154. PMID: 15073842
Regional and systemic therapies for advanced colorectal carcinoma: randomized clinical trial results.
Benson AB 3rd
Oncology (Williston Park) 1998 Oct;12(10 Suppl 7):28-34. PMID: 9830622
Biochemical modulation of fluorouracil: evidence of significant improvement of survival and quality of life in patients with advanced colorectal carcinoma.
Poon MA, O'Connell MJ, Moertel CG, Wieand HS, Cullinan SA, Everson LK, Krook JE, Mailliard JA, Laurie JA, Tschetter LK
J Clin Oncol 1989 Oct;7(10):1407-18. doi: 10.1200/JCO.1989.7.10.1407. PMID: 2476530

Diagnosis

N-glycosylation Regulates Intrinsic IFN-γ Resistance in Colorectal Cancer: Implications for Immunotherapy.
Krug J, Rodrian G, Petter K, Yang H, Khoziainova S, Guo W, Bénard A, Merkel S, Gellert S, Maschauer S, Spermann M, Waldner M, Bailey P, Pilarsky C, Liebl A, Tripal P, Christoph J, Naschberger E, Croner R, Schellerer VS, Becker C, Hartmann A, Tüting T, Prante O, Grützmann R, Grivennikov SI, Stürzl M, Britzen-Laurent N
Gastroenterology 2023 Mar;164(3):392-406.e5. Epub 2022 Nov 17 doi: 10.1053/j.gastro.2022.11.018. PMID: 36402190Free PMC Article
Advanced colorectal carcinoma with testicular metastasis in an adolescent: a case report.
Pratap Singh A, Kumar A, Dhar A, Agarwal S, Bhimaniya S
J Med Case Rep 2018 Oct 11;12(1):304. doi: 10.1186/s13256-018-1831-8. PMID: 30305152Free PMC Article
Nutritional status, cachexia and survival in patients with advanced colorectal carcinoma. Different assessment criteria for nutritional status provide unequal results.
Thoresen L, Frykholm G, Lydersen S, Ulveland H, Baracos V, Prado CM, Birdsell L, Falkmer U
Clin Nutr 2013 Feb;32(1):65-72. Epub 2012 Jun 12 doi: 10.1016/j.clnu.2012.05.009. PMID: 22695408
Critical update and emerging trends in epidermal growth factor receptor targeting in cancer.
Baselga J, Arteaga CL
J Clin Oncol 2005 Apr 10;23(11):2445-59. Epub 2005 Mar 7 doi: 10.1200/JCO.2005.11.890. PMID: 15753456
Prognostic factors in advanced colorectal carcinoma. Importance of lactic dehydrogenase level, performance status, and white blood cell count.
Kemeny N, Braun DW Jr
Am J Med 1983 May;74(5):786-94. doi: 10.1016/0002-9343(83)91066-5. PMID: 6837602

Therapy

Ramucirumab Clinical Development: an Emerging Role in Gastrointestinal Tumors.
Sanchez-Gastaldo A, Gonzalez-Exposito R, Garcia-Carbonero R
Target Oncol 2016 Aug;11(4):479-87. doi: 10.1007/s11523-016-0419-8. PMID: 26887374
Targeting BRAF aberrations in advanced colorectal carcinoma: from bench to bedside.
Abdel-Rahman O
Future Oncol 2016 Jan;12(1):25-30. Epub 2015 Nov 30 doi: 10.2217/fon.15.226. PMID: 26616508
Systemic treatment of advanced colorectal carcinoma.
van Laarhoven HW, Punt CJ
Eur J Gastroenterol Hepatol 2004 Mar;16(3):283-9. doi: 10.1097/00042737-200403000-00006. PMID: 15195891
Regional and systemic therapies for advanced colorectal carcinoma: randomized clinical trial results.
Benson AB 3rd
Oncology (Williston Park) 1998 Oct;12(10 Suppl 7):28-34. PMID: 9830622
Biochemical modulation of fluorouracil: evidence of significant improvement of survival and quality of life in patients with advanced colorectal carcinoma.
Poon MA, O'Connell MJ, Moertel CG, Wieand HS, Cullinan SA, Everson LK, Krook JE, Mailliard JA, Laurie JA, Tschetter LK
J Clin Oncol 1989 Oct;7(10):1407-18. doi: 10.1200/JCO.1989.7.10.1407. PMID: 2476530

Prognosis

N-glycosylation Regulates Intrinsic IFN-γ Resistance in Colorectal Cancer: Implications for Immunotherapy.
Krug J, Rodrian G, Petter K, Yang H, Khoziainova S, Guo W, Bénard A, Merkel S, Gellert S, Maschauer S, Spermann M, Waldner M, Bailey P, Pilarsky C, Liebl A, Tripal P, Christoph J, Naschberger E, Croner R, Schellerer VS, Becker C, Hartmann A, Tüting T, Prante O, Grützmann R, Grivennikov SI, Stürzl M, Britzen-Laurent N
Gastroenterology 2023 Mar;164(3):392-406.e5. Epub 2022 Nov 17 doi: 10.1053/j.gastro.2022.11.018. PMID: 36402190Free PMC Article
Mucinous histology is associated with poor prognosis in locally advanced colorectal adenocarcinoma treated with postoperative first-line adjuvant chemotherapy: A systematic review and meta-analysis.
Zhang Y, Chen Y, Huang J, Wu X, Tang R, Huang Q, Xu Y, Peng X, Fu K, Xiao S
Eur J Surg Oncol 2022 Oct;48(10):2075-2081. Epub 2022 Jun 23 doi: 10.1016/j.ejso.2022.06.024. PMID: 35768312
Tumour-associated angiogenesis in human colorectal cancer.
Rmali KA, Puntis MC, Jiang WG
Colorectal Dis 2007 Jan;9(1):3-14. doi: 10.1111/j.1463-1318.2006.01089.x. PMID: 17181841
Systemic treatment of advanced colorectal carcinoma.
van Laarhoven HW, Punt CJ
Eur J Gastroenterol Hepatol 2004 Mar;16(3):283-9. doi: 10.1097/00042737-200403000-00006. PMID: 15195891
Biochemical modulation of fluorouracil: evidence of significant improvement of survival and quality of life in patients with advanced colorectal carcinoma.
Poon MA, O'Connell MJ, Moertel CG, Wieand HS, Cullinan SA, Everson LK, Krook JE, Mailliard JA, Laurie JA, Tschetter LK
J Clin Oncol 1989 Oct;7(10):1407-18. doi: 10.1200/JCO.1989.7.10.1407. PMID: 2476530

Clinical prediction guides

N-glycosylation Regulates Intrinsic IFN-γ Resistance in Colorectal Cancer: Implications for Immunotherapy.
Krug J, Rodrian G, Petter K, Yang H, Khoziainova S, Guo W, Bénard A, Merkel S, Gellert S, Maschauer S, Spermann M, Waldner M, Bailey P, Pilarsky C, Liebl A, Tripal P, Christoph J, Naschberger E, Croner R, Schellerer VS, Becker C, Hartmann A, Tüting T, Prante O, Grützmann R, Grivennikov SI, Stürzl M, Britzen-Laurent N
Gastroenterology 2023 Mar;164(3):392-406.e5. Epub 2022 Nov 17 doi: 10.1053/j.gastro.2022.11.018. PMID: 36402190Free PMC Article
Mucinous histology is associated with poor prognosis in locally advanced colorectal adenocarcinoma treated with postoperative first-line adjuvant chemotherapy: A systematic review and meta-analysis.
Zhang Y, Chen Y, Huang J, Wu X, Tang R, Huang Q, Xu Y, Peng X, Fu K, Xiao S
Eur J Surg Oncol 2022 Oct;48(10):2075-2081. Epub 2022 Jun 23 doi: 10.1016/j.ejso.2022.06.024. PMID: 35768312
Prediction of metastasis in advanced colorectal carcinomas using CGH data.
Saghapour E, Sehhati M
J Theor Biol 2017 Sep 21;429:116-123. Epub 2017 Jun 21 doi: 10.1016/j.jtbi.2017.06.024. PMID: 28647497
Epidermal growth factor receptor targeting in cancer.
Mendelsohn J, Baselga J
Semin Oncol 2006 Aug;33(4):369-85. doi: 10.1053/j.seminoncol.2006.04.003. PMID: 16890793
Clinical and pharmacological studies of interferon and chemotherapy in gastrointestinal and breast cancer.
Sparano JA, Wadler S, Schwartz EL, Diasio R
Int J Clin Pharmacol Res 1993;13(1):1-9. PMID: 8509231

Recent systematic reviews

Mucinous histology is associated with poor prognosis in locally advanced colorectal adenocarcinoma treated with postoperative first-line adjuvant chemotherapy: A systematic review and meta-analysis.
Zhang Y, Chen Y, Huang J, Wu X, Tang R, Huang Q, Xu Y, Peng X, Fu K, Xiao S
Eur J Surg Oncol 2022 Oct;48(10):2075-2081. Epub 2022 Jun 23 doi: 10.1016/j.ejso.2022.06.024. PMID: 35768312

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