U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Decreased pre-bronchodilator forced vital capacity

MedGen UID:
1690458
•Concept ID:
C5139289
•
Finding
Synonyms: Decreased pre bronchodilator forced vital capacity; Decreased prebronchodilator forced vital capacity
 
HPO: HP:0032356

Definition

An abnormal reduction in the amount of air a person can expel following maximal insipiration, with the test being performed before the administration of a bronchodilating medication. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased pre-bronchodilator forced vital capacity

Professional guidelines

PubMed

Assessing two spirometric criteria of pre-bronchodilator and post-bronchodilator FEV1/FVC ratio in detecting air flow obstruction.
Waheed Z, Irfan M, Haque AS, Siddiqui NH, Awan S, Syed B, Khan JA
J Pak Med Assoc 2011 Dec;61(12):1172-5. PMID: 22355960
Post-bronchodilator spirometry reference values in adults and implications for disease management.
Johannessen A, Lehmann S, Omenaas ER, Eide GE, Bakke PS, Gulsvik A
Am J Respir Crit Care Med 2006 Jun 15;173(12):1316-25. Epub 2006 Mar 23 doi: 10.1164/rccm.200601-023OC. PMID: 16556696

Recent clinical studies

Etiology

Clinical Implications of Bronchodilator Testing: Diagnosing and Differentiating COPD and Asthma-COPD Overlap.
Annangi S, Coz-Yataco AO
Respir Care 2022 Apr;67(4):440-447. doi: 10.4187/respcare.09215. PMID: 35338095
Significance of FEV(3)/FEV(6) in Recognition of Early Airway Disease in Smokers at Risk of Development of COPD: Analysis of the SPIROMICS Cohort.
Yee N, Markovic D, Buhr RG, Fortis S, Arjomandi M, Couper D, Anderson WH, Paine R 3rd, Woodruff PG, Han MK, Martinez FJ, Barr RG, Wells JM, Ortega VE, Hoffman EA, Kim V, Drummond MB, Bowler RP, Curtis JL, Cooper CB, Tashkin DP, Barjaktarevic IZ
Chest 2022 Apr;161(4):949-959. Epub 2021 Nov 10 doi: 10.1016/j.chest.2021.10.046. PMID: 34767825Free PMC Article
Factors Associated with Chronic Obstructive Pulmonary Diseases in Nepal: Evidence from a Nationally Representative Population-Based Study.
Karki KB, Poudyal A, Shrestha N, Mahato NK, Aryal KK, Sijapati MJ, Bista B, Gautam N, Subedi R, Siddiquee NKA, Gyanwali P, Kuch U, Groneberg DA, Jha AK, Dhimal M
Int J Chron Obstruct Pulmon Dis 2021;16:1109-1118. Epub 2021 Apr 20 doi: 10.2147/COPD.S295321. PMID: 33907397Free PMC Article
Pulmonary function is associated with fibrosis severity in patients with biopsy-proven nonalcoholic fatty liver disease.
Lee HW, Lee DH, Lee JK, Lee S, Koo BK, Joo SK, Heo EY, Jung YJ, Kim W, Kim DK
Liver Int 2020 Dec;40(12):3008-3017. Epub 2020 Nov 17 doi: 10.1111/liv.14626. PMID: 32737958
Physiological effects of roflumilast at rest and during exercise in COPD.
O'Donnell DE, Bredenbröker D, Brose M, Webb KA
Eur Respir J 2012 May;39(5):1104-12. Epub 2011 Sep 29 doi: 10.1183/09031936.00096511. PMID: 21965226

Diagnosis

Preserved ratio impaired spirometry is associated with small airway dysfunction and reduced total lung capacity.
Zhao N, Wu F, Peng J, Zheng Y, Tian H, Yang H, Deng Z, Wang Z, Li H, Wen X, Xiao S, Huang P, Dai C, Lu L, Zhou K, Chen S, Zhou Y, Ran P
Respir Res 2022 Oct 31;23(1):298. doi: 10.1186/s12931-022-02216-1. PMID: 36316732Free PMC Article
Clinical Implications of Bronchodilator Testing: Diagnosing and Differentiating COPD and Asthma-COPD Overlap.
Annangi S, Coz-Yataco AO
Respir Care 2022 Apr;67(4):440-447. doi: 10.4187/respcare.09215. PMID: 35338095
Pulmonary function is associated with fibrosis severity in patients with biopsy-proven nonalcoholic fatty liver disease.
Lee HW, Lee DH, Lee JK, Lee S, Koo BK, Joo SK, Heo EY, Jung YJ, Kim W, Kim DK
Liver Int 2020 Dec;40(12):3008-3017. Epub 2020 Nov 17 doi: 10.1111/liv.14626. PMID: 32737958
Forced Oscillation Technique and Small Airway Involvement in Chronic Hypersensitivity Pneumonitis.
Dias OM, Baldi BG, Chate RC, Ribeiro de Carvalho CR, Dellacà RL, Milesi I, Pereira de Albuquerque AL
Arch Bronconeumol (Engl Ed) 2019 Oct;55(10):519-525. Epub 2019 Apr 8 doi: 10.1016/j.arbres.2019.01.022. PMID: 30975515
Assessing two spirometric criteria of pre-bronchodilator and post-bronchodilator FEV1/FVC ratio in detecting air flow obstruction.
Waheed Z, Irfan M, Haque AS, Siddiqui NH, Awan S, Syed B, Khan JA
J Pak Med Assoc 2011 Dec;61(12):1172-5. PMID: 22355960

Therapy

Clinical Implications of Bronchodilator Testing: Diagnosing and Differentiating COPD and Asthma-COPD Overlap.
Annangi S, Coz-Yataco AO
Respir Care 2022 Apr;67(4):440-447. doi: 10.4187/respcare.09215. PMID: 35338095
Significance of FEV(3)/FEV(6) in Recognition of Early Airway Disease in Smokers at Risk of Development of COPD: Analysis of the SPIROMICS Cohort.
Yee N, Markovic D, Buhr RG, Fortis S, Arjomandi M, Couper D, Anderson WH, Paine R 3rd, Woodruff PG, Han MK, Martinez FJ, Barr RG, Wells JM, Ortega VE, Hoffman EA, Kim V, Drummond MB, Bowler RP, Curtis JL, Cooper CB, Tashkin DP, Barjaktarevic IZ
Chest 2022 Apr;161(4):949-959. Epub 2021 Nov 10 doi: 10.1016/j.chest.2021.10.046. PMID: 34767825Free PMC Article
Effects of Indoor and Ambient Black Carbon and [Formula: see text] on Pulmonary Function among Individuals with COPD.
Hart JE, Grady ST, Laden F, Coull BA, Koutrakis P, Schwartz JD, Moy ML, Garshick E
Environ Health Perspect 2018 Dec;126(12):127008. doi: 10.1289/EHP3668. PMID: 30570336Free PMC Article
Longitudinal inspiratory capacity changes in chronic obstructive pulmonary disease.
Celli BR, Decramer M, Lystig T, Kesten S, Tashkin DP
Respir Res 2012 Aug 6;13(1):66. doi: 10.1186/1465-9921-13-66. PMID: 22866681Free PMC Article
Physiological effects of roflumilast at rest and during exercise in COPD.
O'Donnell DE, Bredenbröker D, Brose M, Webb KA
Eur Respir J 2012 May;39(5):1104-12. Epub 2011 Sep 29 doi: 10.1183/09031936.00096511. PMID: 21965226

Prognosis

Preserved ratio impaired spirometry is associated with small airway dysfunction and reduced total lung capacity.
Zhao N, Wu F, Peng J, Zheng Y, Tian H, Yang H, Deng Z, Wang Z, Li H, Wen X, Xiao S, Huang P, Dai C, Lu L, Zhou K, Chen S, Zhou Y, Ran P
Respir Res 2022 Oct 31;23(1):298. doi: 10.1186/s12931-022-02216-1. PMID: 36316732Free PMC Article
Significance of FEV(3)/FEV(6) in Recognition of Early Airway Disease in Smokers at Risk of Development of COPD: Analysis of the SPIROMICS Cohort.
Yee N, Markovic D, Buhr RG, Fortis S, Arjomandi M, Couper D, Anderson WH, Paine R 3rd, Woodruff PG, Han MK, Martinez FJ, Barr RG, Wells JM, Ortega VE, Hoffman EA, Kim V, Drummond MB, Bowler RP, Curtis JL, Cooper CB, Tashkin DP, Barjaktarevic IZ
Chest 2022 Apr;161(4):949-959. Epub 2021 Nov 10 doi: 10.1016/j.chest.2021.10.046. PMID: 34767825Free PMC Article
Pulmonary function is associated with fibrosis severity in patients with biopsy-proven nonalcoholic fatty liver disease.
Lee HW, Lee DH, Lee JK, Lee S, Koo BK, Joo SK, Heo EY, Jung YJ, Kim W, Kim DK
Liver Int 2020 Dec;40(12):3008-3017. Epub 2020 Nov 17 doi: 10.1111/liv.14626. PMID: 32737958
Forced Oscillation Technique and Small Airway Involvement in Chronic Hypersensitivity Pneumonitis.
Dias OM, Baldi BG, Chate RC, Ribeiro de Carvalho CR, Dellacà RL, Milesi I, Pereira de Albuquerque AL
Arch Bronconeumol (Engl Ed) 2019 Oct;55(10):519-525. Epub 2019 Apr 8 doi: 10.1016/j.arbres.2019.01.022. PMID: 30975515
Physiological effects of roflumilast at rest and during exercise in COPD.
O'Donnell DE, Bredenbröker D, Brose M, Webb KA
Eur Respir J 2012 May;39(5):1104-12. Epub 2011 Sep 29 doi: 10.1183/09031936.00096511. PMID: 21965226

Clinical prediction guides

Preserved ratio impaired spirometry is associated with small airway dysfunction and reduced total lung capacity.
Zhao N, Wu F, Peng J, Zheng Y, Tian H, Yang H, Deng Z, Wang Z, Li H, Wen X, Xiao S, Huang P, Dai C, Lu L, Zhou K, Chen S, Zhou Y, Ran P
Respir Res 2022 Oct 31;23(1):298. doi: 10.1186/s12931-022-02216-1. PMID: 36316732Free PMC Article
Significance of FEV(3)/FEV(6) in Recognition of Early Airway Disease in Smokers at Risk of Development of COPD: Analysis of the SPIROMICS Cohort.
Yee N, Markovic D, Buhr RG, Fortis S, Arjomandi M, Couper D, Anderson WH, Paine R 3rd, Woodruff PG, Han MK, Martinez FJ, Barr RG, Wells JM, Ortega VE, Hoffman EA, Kim V, Drummond MB, Bowler RP, Curtis JL, Cooper CB, Tashkin DP, Barjaktarevic IZ
Chest 2022 Apr;161(4):949-959. Epub 2021 Nov 10 doi: 10.1016/j.chest.2021.10.046. PMID: 34767825Free PMC Article
Forced Oscillation Technique and Small Airway Involvement in Chronic Hypersensitivity Pneumonitis.
Dias OM, Baldi BG, Chate RC, Ribeiro de Carvalho CR, Dellacà RL, Milesi I, Pereira de Albuquerque AL
Arch Bronconeumol (Engl Ed) 2019 Oct;55(10):519-525. Epub 2019 Apr 8 doi: 10.1016/j.arbres.2019.01.022. PMID: 30975515
Physiological effects of roflumilast at rest and during exercise in COPD.
O'Donnell DE, Bredenbröker D, Brose M, Webb KA
Eur Respir J 2012 May;39(5):1104-12. Epub 2011 Sep 29 doi: 10.1183/09031936.00096511. PMID: 21965226
Assessing two spirometric criteria of pre-bronchodilator and post-bronchodilator FEV1/FVC ratio in detecting air flow obstruction.
Waheed Z, Irfan M, Haque AS, Siddiqui NH, Awan S, Syed B, Khan JA
J Pak Med Assoc 2011 Dec;61(12):1172-5. PMID: 22355960

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...