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Refractory Rectal Adenocarcinoma

MedGen UID:
1691064
Concept ID:
C5206377
Neoplastic Process

Definition

Rectal adenocarcinoma that is resistant to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Rectal Adenocarcinoma

Professional guidelines

PubMed

Petrelli NJ, Rodriguez-Bigas M, Rustum Y, Herrera L, Creaven P
Cancer 1993 Sep 1;72(5):1543-6. doi: 10.1002/1097-0142(19930901)72:5<1543::aid-cncr2820720509>3.0.co;2-z. PMID: 8348489
Hines JD, Zakem MH, Adelstein DJ, Rustum YM
J Clin Oncol 1988 Jan;6(1):142-6. doi: 10.1200/JCO.1988.6.1.142. PMID: 3257256
Wile A, Smolin M
Arch Surg 1987 Nov;122(11):1321-5. doi: 10.1001/archsurg.1987.01400230107019. PMID: 3675195

Recent clinical studies

Etiology

Dasari A, Lonardi S, Garcia-Carbonero R, Elez E, Yoshino T, Sobrero A, Yao J, García-Alfonso P, Kocsis J, Cubillo Gracian A, Sartore-Bianchi A, Satoh T, Randrian V, Tomasek J, Chong G, Paulson AS, Masuishi T, Jones J, Csőszi T, Cremolini C, Ghiringhelli F, Shergill A, Hochster HS, Krauss J, Bassam A, Ducreux M, Elme A, Faugeras L, Kasper S, Van Cutsem E, Arnold D, Nanda S, Yang Z, Schelman WR, Kania M, Tabernero J, Eng C; FRESCO-2 Study Investigators
Lancet 2023 Jul 1;402(10395):41-53. Epub 2023 Jun 15 doi: 10.1016/S0140-6736(23)00772-9. PMID: 37331369
Bancheno WM, Adidam SR, Melaku MA
Medicine (Baltimore) 2022 Jul 22;101(29):e29616. doi: 10.1097/MD.0000000000029616. PMID: 35866784Free PMC Article
Piha-Paul SA, Geva R, Tan TJ, Lim DW, Hierro C, Doi T, Rahma O, Lesokhin A, Luke JJ, Otero J, Nardi L, Singh A, Xyrafas A, Chen X, Mataraza J, Bedard PL
J Immunother Cancer 2021 Aug;9(8) doi: 10.1136/jitc-2021-002863. PMID: 34389618Free PMC Article
Haas S, Møller Faaborg P, Brock C, Krogh K, Gram M, Lundby L, Mohr Drewes A, Laurberg S, Christensen P
Dis Colon Rectum 2020 Sep;63(9):1234-1241. doi: 10.1097/DCR.0000000000001610. PMID: 33216494
Sclafani F, Roy A, Cunningham D, Wotherspoon A, Peckitt C, Gonzalez de Castro D, Tabernero J, Glimelius B, Cervantes A, Eltahir Z, Oates J, Chau I
Ann Oncol 2013 Dec;24(12):3123-8. Epub 2013 Oct 20 doi: 10.1093/annonc/mdt408. PMID: 24146218

Diagnosis

Bancheno WM, Adidam SR, Melaku MA
Medicine (Baltimore) 2022 Jul 22;101(29):e29616. doi: 10.1097/MD.0000000000029616. PMID: 35866784Free PMC Article
Parker NA, McBride C, Forge J, Lalich D
World J Surg Oncol 2019 Apr 8;17(1):63. doi: 10.1186/s12957-019-1611-y. PMID: 30961608Free PMC Article
Boustani J, Kim S, Lescut N, Lakkis Z, de Billy M, Arbez-Gindre F, Jary M, Borg C, Bosset JF
Am J Case Rep 2015 Aug 31;16:581-5. doi: 10.12659/AJCR.893830. PMID: 26322720Free PMC Article
Nomiya T, Akamatsu H, Harada M, Ota I, Hagiwara Y, Ichikawa M, Miwa M, Kawashiro S, Hagiwara M, Chin M, Hashizume E, Nemoto K
World J Gastroenterol 2014 Dec 28;20(48):18480-6. doi: 10.3748/wjg.v20.i48.18480. PMID: 25561820Free PMC Article
Hung CF, Lee CH, Hung SW, Chiu KY, Cheng CL, Yang CR, Chen CJ, Li JR
J Chin Med Assoc 2010 Feb;73(2):101-3. doi: 10.1016/S1726-4901(10)70010-1. PMID: 20171591

Therapy

Dasari A, Lonardi S, Garcia-Carbonero R, Elez E, Yoshino T, Sobrero A, Yao J, García-Alfonso P, Kocsis J, Cubillo Gracian A, Sartore-Bianchi A, Satoh T, Randrian V, Tomasek J, Chong G, Paulson AS, Masuishi T, Jones J, Csőszi T, Cremolini C, Ghiringhelli F, Shergill A, Hochster HS, Krauss J, Bassam A, Ducreux M, Elme A, Faugeras L, Kasper S, Van Cutsem E, Arnold D, Nanda S, Yang Z, Schelman WR, Kania M, Tabernero J, Eng C; FRESCO-2 Study Investigators
Lancet 2023 Jul 1;402(10395):41-53. Epub 2023 Jun 15 doi: 10.1016/S0140-6736(23)00772-9. PMID: 37331369
Tonelli F, Di Martino C, Amorosi A, Mini E, Nesi G
Updates Surg 2022 Apr;74(2):637-647. Epub 2022 Feb 25 doi: 10.1007/s13304-022-01250-4. PMID: 35217982Free PMC Article
Piha-Paul SA, Geva R, Tan TJ, Lim DW, Hierro C, Doi T, Rahma O, Lesokhin A, Luke JJ, Otero J, Nardi L, Singh A, Xyrafas A, Chen X, Mataraza J, Bedard PL
J Immunother Cancer 2021 Aug;9(8) doi: 10.1136/jitc-2021-002863. PMID: 34389618Free PMC Article
Tsimberidou AM, Beer PA, Cartwright CA, Haymaker C, Vo HH, Kiany S, Cecil ARL, Dow J, Haque K, Silva FA, Coe L, Berryman H, Bone EA, Nogueras-Gonzalez GM, Vining D, McElwaine-Johnn H, Wistuba II
Clin Cancer Res 2021 Jul 1;27(13):3584-3594. Epub 2021 May 4 doi: 10.1158/1078-0432.CCR-21-0238. PMID: 33947698
Haas S, Møller Faaborg P, Brock C, Krogh K, Gram M, Lundby L, Mohr Drewes A, Laurberg S, Christensen P
Dis Colon Rectum 2020 Sep;63(9):1234-1241. doi: 10.1097/DCR.0000000000001610. PMID: 33216494

Prognosis

Bancheno WM, Adidam SR, Melaku MA
Medicine (Baltimore) 2022 Jul 22;101(29):e29616. doi: 10.1097/MD.0000000000029616. PMID: 35866784Free PMC Article
Tsimberidou AM, Beer PA, Cartwright CA, Haymaker C, Vo HH, Kiany S, Cecil ARL, Dow J, Haque K, Silva FA, Coe L, Berryman H, Bone EA, Nogueras-Gonzalez GM, Vining D, McElwaine-Johnn H, Wistuba II
Clin Cancer Res 2021 Jul 1;27(13):3584-3594. Epub 2021 May 4 doi: 10.1158/1078-0432.CCR-21-0238. PMID: 33947698
Parker NA, McBride C, Forge J, Lalich D
World J Surg Oncol 2019 Apr 8;17(1):63. doi: 10.1186/s12957-019-1611-y. PMID: 30961608Free PMC Article
Cardin DB, Thota R, Goff LW, Berlin JD, Jones CM, Ayers GD, Whisenant JG, Chan E
Am J Clin Oncol 2018 Aug;41(8):772-776. doi: 10.1097/COC.0000000000000377. PMID: 28301350Free PMC Article
Sclafani F, Roy A, Cunningham D, Wotherspoon A, Peckitt C, Gonzalez de Castro D, Tabernero J, Glimelius B, Cervantes A, Eltahir Z, Oates J, Chau I
Ann Oncol 2013 Dec;24(12):3123-8. Epub 2013 Oct 20 doi: 10.1093/annonc/mdt408. PMID: 24146218

Clinical prediction guides

Tonelli F, Di Martino C, Amorosi A, Mini E, Nesi G
Updates Surg 2022 Apr;74(2):637-647. Epub 2022 Feb 25 doi: 10.1007/s13304-022-01250-4. PMID: 35217982Free PMC Article
Piha-Paul SA, Geva R, Tan TJ, Lim DW, Hierro C, Doi T, Rahma O, Lesokhin A, Luke JJ, Otero J, Nardi L, Singh A, Xyrafas A, Chen X, Mataraza J, Bedard PL
J Immunother Cancer 2021 Aug;9(8) doi: 10.1136/jitc-2021-002863. PMID: 34389618Free PMC Article
Tsimberidou AM, Beer PA, Cartwright CA, Haymaker C, Vo HH, Kiany S, Cecil ARL, Dow J, Haque K, Silva FA, Coe L, Berryman H, Bone EA, Nogueras-Gonzalez GM, Vining D, McElwaine-Johnn H, Wistuba II
Clin Cancer Res 2021 Jul 1;27(13):3584-3594. Epub 2021 May 4 doi: 10.1158/1078-0432.CCR-21-0238. PMID: 33947698
Sclafani F, Roy A, Cunningham D, Wotherspoon A, Peckitt C, Gonzalez de Castro D, Tabernero J, Glimelius B, Cervantes A, Eltahir Z, Oates J, Chau I
Ann Oncol 2013 Dec;24(12):3123-8. Epub 2013 Oct 20 doi: 10.1093/annonc/mdt408. PMID: 24146218
Hung CF, Lee CH, Hung SW, Chiu KY, Cheng CL, Yang CR, Chen CJ, Li JR
J Chin Med Assoc 2010 Feb;73(2):101-3. doi: 10.1016/S1726-4901(10)70010-1. PMID: 20171591

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