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Decreased circulating mannose-binding protein concentration

MedGen UID:
1691135
•Concept ID:
C5139261
•
Finding
Synonym: Decreased mannose-binding protein level
 
HPO: HP:0032305

Definition

Concentration of mannose-binding protein in the blood circulation below the lower limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased circulating mannose-binding protein concentration

Recent clinical studies

Etiology

Hemodialysis leads to plasma depletion of lectin complement pathway initiator molecule ficolin-2.
Nielsen TL, Pilely K, Lund KP, Warming PE, Plesner LL, Iversen KK, Garred P
Hemodial Int 2021 Oct;25(4):479-488. Epub 2021 Jun 16 doi: 10.1111/hdi.12948. PMID: 34132045
Mannan-binding lectin at supraphysiological concentrations inhibits differentiation of dendritic cells from human CD14+ monocytes.
Xu XY, Li HJ, Zhang LY, Lu X, Zuo DM, Shan GQ, Xu TY, Chen ZL
Microbiol Immunol 2015 Dec;59(12):724-34. doi: 10.1111/1348-0421.12337. PMID: 26564804
Heparin-coated cardiopulmonary bypass circuits selectively deplete the pattern recognition molecule ficolin-2 of the lectin complement pathway in vivo.
Hein E, Munthe-Fog L, Thiara AS, Fiane AE, Mollnes TE, Garred P
Clin Exp Immunol 2015 Feb;179(2):294-9. doi: 10.1111/cei.12446. PMID: 25174443Free PMC Article
Mannose binding lectin and soluble Toll-like receptor 2 in heart failure following acute myocardial infarction.
Ueland T, Espevik T, Kjekshus J, Gullestad L, Omland T, Squire IB, Frøland SS, Mollnes TE, Dickstein K, Aukrust P
J Card Fail 2006 Oct;12(8):659-63. doi: 10.1016/j.cardfail.2006.07.002. PMID: 17045187
Protection from inflammatory disease in insulin resistance: the role of mannan-binding lectin.
Fernández-Real JM, Straczkowski M, Vendrell J, Soriguer F, Pérez Del Pulgar S, Gallart L, López-Bermejo A, Kowalska I, Manco M, Cardona F, García-Gil MM, Mingrone G, Richart C, Ricart W, Zorzano A
Diabetologia 2006 Oct;49(10):2402-11. Epub 2006 Aug 29 doi: 10.1007/s00125-006-0381-6. PMID: 16955210

Diagnosis

Development of a Quantitative Assay for the Characterization of Human Collectin-11 (CL-11, CL-K1).
Bayarri-Olmos R, Kirketerp-Moller N, Pérez-Alós L, Skjodt K, Skjoedt MO, Garred P
Front Immunol 2018;9:2238. Epub 2018 Sep 28 doi: 10.3389/fimmu.2018.02238. PMID: 30323815Free PMC Article
Protection from inflammatory disease in insulin resistance: the role of mannan-binding lectin.
Fernández-Real JM, Straczkowski M, Vendrell J, Soriguer F, Pérez Del Pulgar S, Gallart L, López-Bermejo A, Kowalska I, Manco M, Cardona F, García-Gil MM, Mingrone G, Richart C, Ricart W, Zorzano A
Diabetologia 2006 Oct;49(10):2402-11. Epub 2006 Aug 29 doi: 10.1007/s00125-006-0381-6. PMID: 16955210

Therapy

Hemodialysis leads to plasma depletion of lectin complement pathway initiator molecule ficolin-2.
Nielsen TL, Pilely K, Lund KP, Warming PE, Plesner LL, Iversen KK, Garred P
Hemodial Int 2021 Oct;25(4):479-488. Epub 2021 Jun 16 doi: 10.1111/hdi.12948. PMID: 34132045
Heparin-coated cardiopulmonary bypass circuits selectively deplete the pattern recognition molecule ficolin-2 of the lectin complement pathway in vivo.
Hein E, Munthe-Fog L, Thiara AS, Fiane AE, Mollnes TE, Garred P
Clin Exp Immunol 2015 Feb;179(2):294-9. doi: 10.1111/cei.12446. PMID: 25174443Free PMC Article
Mannose binding lectin and soluble Toll-like receptor 2 in heart failure following acute myocardial infarction.
Ueland T, Espevik T, Kjekshus J, Gullestad L, Omland T, Squire IB, Frøland SS, Mollnes TE, Dickstein K, Aukrust P
J Card Fail 2006 Oct;12(8):659-63. doi: 10.1016/j.cardfail.2006.07.002. PMID: 17045187

Prognosis

Mannose-binding lectin levels and variation during invasive candidiasis.
Damiens S, Poissy J, François N, Salleron J, Jawhara S, Jouault T, Poulain D, Sendid B
J Clin Immunol 2012 Dec;32(6):1317-23. Epub 2012 Jul 26 doi: 10.1007/s10875-012-9748-2. PMID: 22833166

Clinical prediction guides

Development of a Quantitative Assay for the Characterization of Human Collectin-11 (CL-11, CL-K1).
Bayarri-Olmos R, Kirketerp-Moller N, Pérez-Alós L, Skjodt K, Skjoedt MO, Garred P
Front Immunol 2018;9:2238. Epub 2018 Sep 28 doi: 10.3389/fimmu.2018.02238. PMID: 30323815Free PMC Article
Mannan-binding lectin at supraphysiological concentrations inhibits differentiation of dendritic cells from human CD14+ monocytes.
Xu XY, Li HJ, Zhang LY, Lu X, Zuo DM, Shan GQ, Xu TY, Chen ZL
Microbiol Immunol 2015 Dec;59(12):724-34. doi: 10.1111/1348-0421.12337. PMID: 26564804
Mannose-binding lectin levels and variation during invasive candidiasis.
Damiens S, Poissy J, François N, Salleron J, Jawhara S, Jouault T, Poulain D, Sendid B
J Clin Immunol 2012 Dec;32(6):1317-23. Epub 2012 Jul 26 doi: 10.1007/s10875-012-9748-2. PMID: 22833166

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