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11q23 Abnormality

MedGen UID:
1691246
•Concept ID:
C5203883
•
Cell or Molecular Dysfunction
Synonyms: 11q23 Aberration; 11q23 Alteration; 11q23 Anomaly

Definition

Any cytogenetic abnormality involving chromosome band 11q23. [from NCI]

Professional guidelines

PubMed

11q23 balanced chromosome aberrations in treatment-related myelodysplastic syndromes and acute leukemia: report from an international workshop.
Bloomfield CD, Archer KJ, Mrózek K, Lillington DM, Kaneko Y, Head DR, Dal Cin P, Raimondi SC
Genes Chromosomes Cancer 2002 Apr;33(4):362-78. doi: 10.1002/gcc.10046. PMID: 11921271
Chromosomal abnormalities in 478 children with acute myeloid leukemia: clinical characteristics and treatment outcome in a cooperative pediatric oncology group study-POG 8821.
Raimondi SC, Chang MN, Ravindranath Y, Behm FG, Gresik MV, Steuber CP, Weinstein HJ, Carroll AJ
Blood 1999 Dec 1;94(11):3707-16. PMID: 10572083
Correlation of cytogenetic results with immunophenotype, genotype, clinical features, and ras mutation in acute myeloid leukemia. A study of 235 Chinese patients in Taiwan.
Tien HF, Wang CH, Lin MT, Lee FY, Liu MC, Chuang SM, Chen YC, Shen MC, Lin KH, Lin DT
Cancer Genet Cytogenet 1995 Oct 1;84(1):60-8. doi: 10.1016/0165-4608(95)00084-4. PMID: 7497445

Recent clinical studies

Etiology

Cytogenetic abnormalities predict survival after allogeneic hematopoietic stem cell transplantation for pediatric acute myeloid leukemia: a PDWP/EBMT study.
Sharma A, Galimard JE, Pryce A, Bhoopalan SV, Dalissier A, Dalle JH, Locatelli F, Jubert C, Mirci-Danicar O, Kitra-Roussou V, Bertrand Y, Fagioli F, Rialland F, Biffi A, Wynn RF, Michel G, Tambaro FP, Al-Ahmari A, Tbakhi A, Furness CL, Diaz MA, Sedlacek P, Bodova I, Faraci M, Rao K, Kleinschmidt K, Petit A, Gibson B, Bhatt NS, Kalwak K, Corbacioglu S
Bone Marrow Transplant 2024 Apr;59(4):451-458. Epub 2024 Jan 15 doi: 10.1038/s41409-024-02197-3. PMID: 38225386
Allogeneic hematopoietic cell transplantation in adult acute myeloid leukemia with 11q23 abnormality: a retrospective study of the Adult Acute Myeloid Leukemia Working Group of the Japan Society for Hematopoietic Cell Transplantation (JSHCT).
Konuma T, Mizuno S, Kondo T, Yamaguchi H, Fukuda T, Uchida N, Najima Y, Kanamori H, Ota S, Nakamae H, Nakamae M, Mizuno I, Sugita J, Onishi Y, Yokota A, Takahashi S, Kanda Y, Ichinohe T, Atsuta Y, Yano S; Adult Acute Myeloid Leukemia Working Group of the Japan Society for Hematopoietic Cell Transplantation
Ann Hematol 2018 Nov;97(11):2173-2183. Epub 2018 Jul 6 doi: 10.1007/s00277-018-3419-1. PMID: 29978286
Therapy-related acute lymphoblastic leukemia without 11q23 abnormality: report of six cases and a literature review.
Chen W, Wang E, Lu Y, Gaal KK, Huang Q
Am J Clin Pathol 2010 Jan;133(1):75-82. doi: 10.1309/AJCPYWC6AQC7BAVJ. PMID: 20023261
Outcome of treatment in childhood acute lymphoblastic leukaemia with rearrangements of the 11q23 chromosomal region.
Pui CH, Gaynon PS, Boyett JM, Chessells JM, Baruchel A, Kamps W, Silverman LB, Biondi A, Harms DO, Vilmer E, Schrappe M, Camitta B
Lancet 2002 Jun 1;359(9321):1909-15. doi: 10.1016/S0140-6736(02)08782-2. PMID: 12057554
11q23 balanced chromosome aberrations in treatment-related myelodysplastic syndromes and acute leukemia: report from an international workshop.
Bloomfield CD, Archer KJ, Mrózek K, Lillington DM, Kaneko Y, Head DR, Dal Cin P, Raimondi SC
Genes Chromosomes Cancer 2002 Apr;33(4):362-78. doi: 10.1002/gcc.10046. PMID: 11921271

Diagnosis

Cytogenetic abnormalities predict survival after allogeneic hematopoietic stem cell transplantation for pediatric acute myeloid leukemia: a PDWP/EBMT study.
Sharma A, Galimard JE, Pryce A, Bhoopalan SV, Dalissier A, Dalle JH, Locatelli F, Jubert C, Mirci-Danicar O, Kitra-Roussou V, Bertrand Y, Fagioli F, Rialland F, Biffi A, Wynn RF, Michel G, Tambaro FP, Al-Ahmari A, Tbakhi A, Furness CL, Diaz MA, Sedlacek P, Bodova I, Faraci M, Rao K, Kleinschmidt K, Petit A, Gibson B, Bhatt NS, Kalwak K, Corbacioglu S
Bone Marrow Transplant 2024 Apr;59(4):451-458. Epub 2024 Jan 15 doi: 10.1038/s41409-024-02197-3. PMID: 38225386
Prevalence and clinical characteristics of acute myeloid leukemia associated with disseminated intravascular coagulation.
Uchiumi H, Matsushima T, Yamane A, Doki N, Irisawa H, Saitoh T, Sakura T, Jimbo T, Handa H, Tsukamoto N, Karasawa M, Miyawaki S, Murakami H, Nojima Y
Int J Hematol 2007 Aug;86(2):137-42. doi: 10.1532/IJH97.06173. PMID: 17875527
11q23 balanced chromosome aberrations in treatment-related myelodysplastic syndromes and acute leukemia: report from an international workshop.
Bloomfield CD, Archer KJ, Mrózek K, Lillington DM, Kaneko Y, Head DR, Dal Cin P, Raimondi SC
Genes Chromosomes Cancer 2002 Apr;33(4):362-78. doi: 10.1002/gcc.10046. PMID: 11921271
Refractory thrombocytopenia with chromosome 11q23 abnormality.
Imoto S, Hayashi Y, Matsui T, Murayama T, Iwata N, Matsuoka H, Nagata A, Itoh H, Chihara K
Ann Hematol 1996 Aug;73(2):99-102. doi: 10.1007/s002770050209. PMID: 8774620
Expression of CD56/NCAM on hematopoietic malignant cells. A useful marker for acute monocytic and megakaryocytic leukemias.
Ikushima S, Yoshihara T, Matsumura T, Misawa S, Morioka Y, Hibi S, Imashuku S
Int J Hematol 1991 Oct;54(5):395-403. PMID: 1721853

Therapy

Allogeneic hematopoietic cell transplantation in adult acute myeloid leukemia with 11q23 abnormality: a retrospective study of the Adult Acute Myeloid Leukemia Working Group of the Japan Society for Hematopoietic Cell Transplantation (JSHCT).
Konuma T, Mizuno S, Kondo T, Yamaguchi H, Fukuda T, Uchida N, Najima Y, Kanamori H, Ota S, Nakamae H, Nakamae M, Mizuno I, Sugita J, Onishi Y, Yokota A, Takahashi S, Kanda Y, Ichinohe T, Atsuta Y, Yano S; Adult Acute Myeloid Leukemia Working Group of the Japan Society for Hematopoietic Cell Transplantation
Ann Hematol 2018 Nov;97(11):2173-2183. Epub 2018 Jul 6 doi: 10.1007/s00277-018-3419-1. PMID: 29978286
Therapy-related acute lymphoblastic leukemia without 11q23 abnormality: report of six cases and a literature review.
Chen W, Wang E, Lu Y, Gaal KK, Huang Q
Am J Clin Pathol 2010 Jan;133(1):75-82. doi: 10.1309/AJCPYWC6AQC7BAVJ. PMID: 20023261
Therapy-related acute myeloid leukemia with 11q23 abnormality coexisting with refractory metastatic Ewing sarcoma: report of a case and review of the literature.
Worcester HD, Vasef MA
Pediatr Dev Pathol 2010 Jan-Feb;13(1):50-4. doi: 10.2350/09-03-621-CR.1. PMID: 19925255
Outcome of treatment in childhood acute lymphoblastic leukaemia with rearrangements of the 11q23 chromosomal region.
Pui CH, Gaynon PS, Boyett JM, Chessells JM, Baruchel A, Kamps W, Silverman LB, Biondi A, Harms DO, Vilmer E, Schrappe M, Camitta B
Lancet 2002 Jun 1;359(9321):1909-15. doi: 10.1016/S0140-6736(02)08782-2. PMID: 12057554
Myeloid neoplasia in children treated for solid tumours.
Pui CH, Hancock ML, Raimondi SC, Head DR, Thompson E, Wilimas J, Kun LE, Bowman LC, Crist WM, Pratt CB
Lancet 1990 Aug 18;336(8712):417-21. doi: 10.1016/0140-6736(90)91956-b. PMID: 1974952

Prognosis

Cytogenetic abnormalities predict survival after allogeneic hematopoietic stem cell transplantation for pediatric acute myeloid leukemia: a PDWP/EBMT study.
Sharma A, Galimard JE, Pryce A, Bhoopalan SV, Dalissier A, Dalle JH, Locatelli F, Jubert C, Mirci-Danicar O, Kitra-Roussou V, Bertrand Y, Fagioli F, Rialland F, Biffi A, Wynn RF, Michel G, Tambaro FP, Al-Ahmari A, Tbakhi A, Furness CL, Diaz MA, Sedlacek P, Bodova I, Faraci M, Rao K, Kleinschmidt K, Petit A, Gibson B, Bhatt NS, Kalwak K, Corbacioglu S
Bone Marrow Transplant 2024 Apr;59(4):451-458. Epub 2024 Jan 15 doi: 10.1038/s41409-024-02197-3. PMID: 38225386
Allogeneic hematopoietic cell transplantation in adult acute myeloid leukemia with 11q23 abnormality: a retrospective study of the Adult Acute Myeloid Leukemia Working Group of the Japan Society for Hematopoietic Cell Transplantation (JSHCT).
Konuma T, Mizuno S, Kondo T, Yamaguchi H, Fukuda T, Uchida N, Najima Y, Kanamori H, Ota S, Nakamae H, Nakamae M, Mizuno I, Sugita J, Onishi Y, Yokota A, Takahashi S, Kanda Y, Ichinohe T, Atsuta Y, Yano S; Adult Acute Myeloid Leukemia Working Group of the Japan Society for Hematopoietic Cell Transplantation
Ann Hematol 2018 Nov;97(11):2173-2183. Epub 2018 Jul 6 doi: 10.1007/s00277-018-3419-1. PMID: 29978286
Outcome of treatment in childhood acute lymphoblastic leukaemia with rearrangements of the 11q23 chromosomal region.
Pui CH, Gaynon PS, Boyett JM, Chessells JM, Baruchel A, Kamps W, Silverman LB, Biondi A, Harms DO, Vilmer E, Schrappe M, Camitta B
Lancet 2002 Jun 1;359(9321):1909-15. doi: 10.1016/S0140-6736(02)08782-2. PMID: 12057554
Myelodysplastic syndromes associated with 11q23 abnormalities. European 11q23 Workshop participants.
Bain BJ, Moorman AV, Johansson B, Mehta AB, Secker-Walker LM
Leukemia 1998 May;12(5):834-9. doi: 10.1038/sj.leu.2401020. PMID: 9593289
Abnormalities in the long arm of chromosome 11 (11q) in patients with de novo and secondary acute myelogenous leukemias and myelodysplastic syndromes.
Cortes J, O'Brien S, Kantarjian H, Cork A, Stass S, Freireich EJ, Keating M, Pierce S, Estey E
Leukemia 1994 Dec;8(12):2174-8. PMID: 7808007

Clinical prediction guides

Cytogenetic abnormalities predict survival after allogeneic hematopoietic stem cell transplantation for pediatric acute myeloid leukemia: a PDWP/EBMT study.
Sharma A, Galimard JE, Pryce A, Bhoopalan SV, Dalissier A, Dalle JH, Locatelli F, Jubert C, Mirci-Danicar O, Kitra-Roussou V, Bertrand Y, Fagioli F, Rialland F, Biffi A, Wynn RF, Michel G, Tambaro FP, Al-Ahmari A, Tbakhi A, Furness CL, Diaz MA, Sedlacek P, Bodova I, Faraci M, Rao K, Kleinschmidt K, Petit A, Gibson B, Bhatt NS, Kalwak K, Corbacioglu S
Bone Marrow Transplant 2024 Apr;59(4):451-458. Epub 2024 Jan 15 doi: 10.1038/s41409-024-02197-3. PMID: 38225386
Therapy-related acute lymphoblastic leukemia without 11q23 abnormality: report of six cases and a literature review.
Chen W, Wang E, Lu Y, Gaal KK, Huang Q
Am J Clin Pathol 2010 Jan;133(1):75-82. doi: 10.1309/AJCPYWC6AQC7BAVJ. PMID: 20023261
Chromosome 8 tetrasomies and pentasomies--a clonal abnormality closely associated with acute monocytic leukaemia.
Lessard M, Herry A, Berthou C, Léglise MC, Abgrall JF, Luquet I, Dastugue N, Duchayne E, Rigal-Huguet F, Lafage M, Sainty D, Reiffers J, Bernard P
Leuk Lymphoma 1997 Sep;27(1-2):127-35. doi: 10.3109/10428199709068279. PMID: 9373204
Refractory thrombocytopenia with chromosome 11q23 abnormality.
Imoto S, Hayashi Y, Matsui T, Murayama T, Iwata N, Matsuoka H, Nagata A, Itoh H, Chihara K
Ann Hematol 1996 Aug;73(2):99-102. doi: 10.1007/s002770050209. PMID: 8774620
Expression of CD56/NCAM on hematopoietic malignant cells. A useful marker for acute monocytic and megakaryocytic leukemias.
Ikushima S, Yoshihara T, Matsumura T, Misawa S, Morioka Y, Hibi S, Imashuku S
Int J Hematol 1991 Oct;54(5):395-403. PMID: 1721853

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