U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

11q23 Abnormality

MedGen UID:
1691246
•Concept ID:
C5203883
•
Cell or Molecular Dysfunction
Synonyms: 11q23 Aberration; 11q23 Alteration; 11q23 Anomaly

Definition

Any cytogenetic abnormality involving chromosome band 11q23. [from NCI]

Professional guidelines

PubMed

11q23 balanced chromosome aberrations in treatment-related myelodysplastic syndromes and acute leukemia: report from an international workshop.
Bloomfield CD, Archer KJ, Mrózek K, Lillington DM, Kaneko Y, Head DR, Dal Cin P, Raimondi SC
Genes Chromosomes Cancer 2002 Apr;33(4):362-78. doi: 10.1002/gcc.10046. PMID: 11921271
Chromosomal abnormalities in 478 children with acute myeloid leukemia: clinical characteristics and treatment outcome in a cooperative pediatric oncology group study-POG 8821.
Raimondi SC, Chang MN, Ravindranath Y, Behm FG, Gresik MV, Steuber CP, Weinstein HJ, Carroll AJ
Blood 1999 Dec 1;94(11):3707-16. PMID: 10572083
Correlation of cytogenetic results with immunophenotype, genotype, clinical features, and ras mutation in acute myeloid leukemia. A study of 235 Chinese patients in Taiwan.
Tien HF, Wang CH, Lin MT, Lee FY, Liu MC, Chuang SM, Chen YC, Shen MC, Lin KH, Lin DT
Cancer Genet Cytogenet 1995 Oct 1;84(1):60-8. doi: 10.1016/0165-4608(95)00084-4. PMID: 7497445

Recent clinical studies

Etiology

Allogeneic hematopoietic cell transplantation in adult acute myeloid leukemia with 11q23 abnormality: a retrospective study of the Adult Acute Myeloid Leukemia Working Group of the Japan Society for Hematopoietic Cell Transplantation (JSHCT).
Konuma T, Mizuno S, Kondo T, Yamaguchi H, Fukuda T, Uchida N, Najima Y, Kanamori H, Ota S, Nakamae H, Nakamae M, Mizuno I, Sugita J, Onishi Y, Yokota A, Takahashi S, Kanda Y, Ichinohe T, Atsuta Y, Yano S; Adult Acute Myeloid Leukemia Working Group of the Japan Society for Hematopoietic Cell Transplantation
Ann Hematol 2018 Nov;97(11):2173-2183. Epub 2018 Jul 6 doi: 10.1007/s00277-018-3419-1. PMID: 29978286
Therapy-related acute lymphoblastic leukemia without 11q23 abnormality: report of six cases and a literature review.
Chen W, Wang E, Lu Y, Gaal KK, Huang Q
Am J Clin Pathol 2010 Jan;133(1):75-82. doi: 10.1309/AJCPYWC6AQC7BAVJ. PMID: 20023261
Prevalence and clinical characteristics of acute myeloid leukemia associated with disseminated intravascular coagulation.
Uchiumi H, Matsushima T, Yamane A, Doki N, Irisawa H, Saitoh T, Sakura T, Jimbo T, Handa H, Tsukamoto N, Karasawa M, Miyawaki S, Murakami H, Nojima Y
Int J Hematol 2007 Aug;86(2):137-42. doi: 10.1532/IJH97.06173. PMID: 17875527
Outcome of treatment in childhood acute lymphoblastic leukaemia with rearrangements of the 11q23 chromosomal region.
Pui CH, Gaynon PS, Boyett JM, Chessells JM, Baruchel A, Kamps W, Silverman LB, Biondi A, Harms DO, Vilmer E, Schrappe M, Camitta B
Lancet 2002 Jun 1;359(9321):1909-15. doi: 10.1016/S0140-6736(02)08782-2. PMID: 12057554
Cytogenetic findings in acute leukaemias of infants.
Lampert F, Harbott J, Ritterbach J
Br J Cancer Suppl 1992 Aug;18:S20-2. PMID: 1503922Free PMC Article

Diagnosis

Dic (17;20) (p11;q11) preceded MLL gene amplification in a patient with de novo mixed-lineage leukemia.
Amakawa R, Hiramoto N, Kawano S, Hyo A, Nakamichi N, Tajima K, Ito T, Mori S, Kishimoto Y, Fukuhara S
J Clin Exp Hematop 2010;50(1):51-8. doi: 10.3960/jslrt.50.51. PMID: 20505276
Infant acute lymphoblastic leukemia: a 20-year children's hospital experience.
Murray RA, Thom G, Gardner RV, Craver RD
Fetal Pediatr Pathol 2008;27(4-5):197-205. doi: 10.1080/15513810802319392. PMID: 18800262
Prevalence and clinical characteristics of acute myeloid leukemia associated with disseminated intravascular coagulation.
Uchiumi H, Matsushima T, Yamane A, Doki N, Irisawa H, Saitoh T, Sakura T, Jimbo T, Handa H, Tsukamoto N, Karasawa M, Miyawaki S, Murakami H, Nojima Y
Int J Hematol 2007 Aug;86(2):137-42. doi: 10.1532/IJH97.06173. PMID: 17875527
11q23 balanced chromosome aberrations in treatment-related myelodysplastic syndromes and acute leukemia: report from an international workshop.
Bloomfield CD, Archer KJ, Mrózek K, Lillington DM, Kaneko Y, Head DR, Dal Cin P, Raimondi SC
Genes Chromosomes Cancer 2002 Apr;33(4):362-78. doi: 10.1002/gcc.10046. PMID: 11921271
Expression of CD56/NCAM on hematopoietic malignant cells. A useful marker for acute monocytic and megakaryocytic leukemias.
Ikushima S, Yoshihara T, Matsumura T, Misawa S, Morioka Y, Hibi S, Imashuku S
Int J Hematol 1991 Oct;54(5):395-403. PMID: 1721853

Therapy

Allogeneic hematopoietic cell transplantation in adult acute myeloid leukemia with 11q23 abnormality: a retrospective study of the Adult Acute Myeloid Leukemia Working Group of the Japan Society for Hematopoietic Cell Transplantation (JSHCT).
Konuma T, Mizuno S, Kondo T, Yamaguchi H, Fukuda T, Uchida N, Najima Y, Kanamori H, Ota S, Nakamae H, Nakamae M, Mizuno I, Sugita J, Onishi Y, Yokota A, Takahashi S, Kanda Y, Ichinohe T, Atsuta Y, Yano S; Adult Acute Myeloid Leukemia Working Group of the Japan Society for Hematopoietic Cell Transplantation
Ann Hematol 2018 Nov;97(11):2173-2183. Epub 2018 Jul 6 doi: 10.1007/s00277-018-3419-1. PMID: 29978286
Therapy-related acute lymphoblastic leukemia without 11q23 abnormality: report of six cases and a literature review.
Chen W, Wang E, Lu Y, Gaal KK, Huang Q
Am J Clin Pathol 2010 Jan;133(1):75-82. doi: 10.1309/AJCPYWC6AQC7BAVJ. PMID: 20023261
Therapy-related acute myeloid leukemia with 11q23 abnormality coexisting with refractory metastatic Ewing sarcoma: report of a case and review of the literature.
Worcester HD, Vasef MA
Pediatr Dev Pathol 2010 Jan-Feb;13(1):50-4. doi: 10.2350/09-03-621-CR.1. PMID: 19925255
Outcome of treatment in childhood acute lymphoblastic leukaemia with rearrangements of the 11q23 chromosomal region.
Pui CH, Gaynon PS, Boyett JM, Chessells JM, Baruchel A, Kamps W, Silverman LB, Biondi A, Harms DO, Vilmer E, Schrappe M, Camitta B
Lancet 2002 Jun 1;359(9321):1909-15. doi: 10.1016/S0140-6736(02)08782-2. PMID: 12057554
Abnormalities in the long arm of chromosome 11 (11q) in patients with de novo and secondary acute myelogenous leukemias and myelodysplastic syndromes.
Cortes J, O'Brien S, Kantarjian H, Cork A, Stass S, Freireich EJ, Keating M, Pierce S, Estey E
Leukemia 1994 Dec;8(12):2174-8. PMID: 7808007

Prognosis

Allogeneic hematopoietic cell transplantation in adult acute myeloid leukemia with 11q23 abnormality: a retrospective study of the Adult Acute Myeloid Leukemia Working Group of the Japan Society for Hematopoietic Cell Transplantation (JSHCT).
Konuma T, Mizuno S, Kondo T, Yamaguchi H, Fukuda T, Uchida N, Najima Y, Kanamori H, Ota S, Nakamae H, Nakamae M, Mizuno I, Sugita J, Onishi Y, Yokota A, Takahashi S, Kanda Y, Ichinohe T, Atsuta Y, Yano S; Adult Acute Myeloid Leukemia Working Group of the Japan Society for Hematopoietic Cell Transplantation
Ann Hematol 2018 Nov;97(11):2173-2183. Epub 2018 Jul 6 doi: 10.1007/s00277-018-3419-1. PMID: 29978286
Infant acute lymphoblastic leukemia: a 20-year children's hospital experience.
Murray RA, Thom G, Gardner RV, Craver RD
Fetal Pediatr Pathol 2008;27(4-5):197-205. doi: 10.1080/15513810802319392. PMID: 18800262
Outcome of treatment in childhood acute lymphoblastic leukaemia with rearrangements of the 11q23 chromosomal region.
Pui CH, Gaynon PS, Boyett JM, Chessells JM, Baruchel A, Kamps W, Silverman LB, Biondi A, Harms DO, Vilmer E, Schrappe M, Camitta B
Lancet 2002 Jun 1;359(9321):1909-15. doi: 10.1016/S0140-6736(02)08782-2. PMID: 12057554
Myelodysplastic syndromes associated with 11q23 abnormalities. European 11q23 Workshop participants.
Bain BJ, Moorman AV, Johansson B, Mehta AB, Secker-Walker LM
Leukemia 1998 May;12(5):834-9. doi: 10.1038/sj.leu.2401020. PMID: 9593289
Abnormalities in the long arm of chromosome 11 (11q) in patients with de novo and secondary acute myelogenous leukemias and myelodysplastic syndromes.
Cortes J, O'Brien S, Kantarjian H, Cork A, Stass S, Freireich EJ, Keating M, Pierce S, Estey E
Leukemia 1994 Dec;8(12):2174-8. PMID: 7808007

Clinical prediction guides

Therapy-related acute lymphoblastic leukemia without 11q23 abnormality: report of six cases and a literature review.
Chen W, Wang E, Lu Y, Gaal KK, Huang Q
Am J Clin Pathol 2010 Jan;133(1):75-82. doi: 10.1309/AJCPYWC6AQC7BAVJ. PMID: 20023261
Chromosome 8 tetrasomies and pentasomies--a clonal abnormality closely associated with acute monocytic leukaemia.
Lessard M, Herry A, Berthou C, Léglise MC, Abgrall JF, Luquet I, Dastugue N, Duchayne E, Rigal-Huguet F, Lafage M, Sainty D, Reiffers J, Bernard P
Leuk Lymphoma 1997 Sep;27(1-2):127-35. doi: 10.3109/10428199709068279. PMID: 9373204
Acute myelomonocytic leukaemia with 11q23 abnormality during multiple myeloma: is this related to anthracycline?
Matano S, Nakamura S, Kobayashi K, Matsuda T, Sugimoto T
Acta Haematol 1996;95(2):144-7. doi: 10.1159/000203864. PMID: 8638445
MLLT3 gene on 9p22 involved in t(9;11) leukemia encodes a serine/proline rich protein homologous to MLLT1 on 19p13.
Iida S, Seto M, Yamamoto K, Komatsu H, Tojo A, Asano S, Kamada N, Ariyoshi Y, Takahashi T, Ueda R
Oncogene 1993 Nov;8(11):3085-92. PMID: 8414510
Expression of CD56/NCAM on hematopoietic malignant cells. A useful marker for acute monocytic and megakaryocytic leukemias.
Ikushima S, Yoshihara T, Matsumura T, Misawa S, Morioka Y, Hibi S, Imashuku S
Int J Hematol 1991 Oct;54(5):395-403. PMID: 1721853

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...