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Labial hemangioma

MedGen UID:
1691308
•Concept ID:
C5139440
•
Neoplastic Process
HPO: HP:0410269

Definition

A hemangioma, a benign tumor of the vascular endothelial cells, that is located in the upper lip. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLabial hemangioma

Professional guidelines

PubMed

The treatment of facial asymmetry: Review.
Kobus K, Kobus-Zaleśna K
Adv Clin Exp Med 2017 Nov;26(8):1301-1311. doi: 10.17219/acem/68976. PMID: 29264890
2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT).
Galiè N, Humbert M, Vachiery JL, Gibbs S, Lang I, Torbicki A, Simonneau G, Peacock A, Vonk Noordegraaf A, Beghetti M, Ghofrani A, Gomez Sanchez MA, Hansmann G, Klepetko W, Lancellotti P, Matucci M, McDonagh T, Pierard LA, Trindade PT, Zompatori M, Hoeper M; ESC Scientific Document Group
Eur Heart J 2016 Jan 1;37(1):67-119. Epub 2015 Aug 29 doi: 10.1093/eurheartj/ehv317. PMID: 26320113
Diagnosis and treatment of cutaneous vascular lesions.
Wirth FA, Lowitt MH
Am Fam Physician 1998 Feb 15;57(4):765-73. PMID: 9490999

Recent clinical studies

Etiology

Examination of oral hemangiomas by intraoral ultrasonography.
Derindağ G, Sarıca İ, Çağlayan F
Oral Radiol 2021 Oct;37(4):687-692. Epub 2021 Mar 3 doi: 10.1007/s11282-021-00511-z. PMID: 33656695
Oral pyogenic granuloma: An 18-year retrospective clinicopathological and immunohistochemical study.
Ribeiro JL, Moraes RM, Carvalho BFC, Nascimento AO, Milhan NVM, Anbinder AL
J Cutan Pathol 2021 Jul;48(7):863-869. Epub 2021 Feb 15 doi: 10.1111/cup.13970. PMID: 33486806
Benign vascular lesions of the lips: Diagnostic approach.
Tobouti PL, Olegário I, de Sousa SC
J Cutan Pathol 2017 May;44(5):451-455. Epub 2017 Feb 16 doi: 10.1111/cup.12911. PMID: 28111788
2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT).
Galiè N, Humbert M, Vachiery JL, Gibbs S, Lang I, Torbicki A, Simonneau G, Peacock A, Vonk Noordegraaf A, Beghetti M, Ghofrani A, Gomez Sanchez MA, Hansmann G, Klepetko W, Lancellotti P, Matucci M, McDonagh T, Pierard LA, Trindade PT, Zompatori M, Hoeper M; ESC Scientific Document Group
Eur Heart J 2016 Jan 1;37(1):67-119. Epub 2015 Aug 29 doi: 10.1093/eurheartj/ehv317. PMID: 26320113
Rhinoplasty for cleft and hemangioma-related nasal deformities.
Lee TS, Schwartz GM, Tatum SA
Curr Opin Otolaryngol Head Neck Surg 2010 Dec;18(6):526-35. doi: 10.1097/MOO.0b013e3283402984. PMID: 20962645

Diagnosis

Examination of oral hemangiomas by intraoral ultrasonography.
Derindağ G, Sarıca İ, Çağlayan F
Oral Radiol 2021 Oct;37(4):687-692. Epub 2021 Mar 3 doi: 10.1007/s11282-021-00511-z. PMID: 33656695
Update on classification and diagnosis of vascular malformations.
McCuaig CC
Curr Opin Pediatr 2017 Aug;29(4):448-454. doi: 10.1097/MOP.0000000000000518. PMID: 28654575
Infantile hemangiomas, complications and treatments.
Cheng CE, Friedlander SF
Semin Cutan Med Surg 2016 Sep;35(3):108-16. doi: 10.12788/j.sder.2016.050. PMID: 27607318
2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT).
Galiè N, Humbert M, Vachiery JL, Gibbs S, Lang I, Torbicki A, Simonneau G, Peacock A, Vonk Noordegraaf A, Beghetti M, Ghofrani A, Gomez Sanchez MA, Hansmann G, Klepetko W, Lancellotti P, Matucci M, McDonagh T, Pierard LA, Trindade PT, Zompatori M, Hoeper M; ESC Scientific Document Group
Eur Heart J 2016 Jan 1;37(1):67-119. Epub 2015 Aug 29 doi: 10.1093/eurheartj/ehv317. PMID: 26320113
Rhinoplasty for cleft and hemangioma-related nasal deformities.
Lee TS, Schwartz GM, Tatum SA
Curr Opin Otolaryngol Head Neck Surg 2010 Dec;18(6):526-35. doi: 10.1097/MOO.0b013e3283402984. PMID: 20962645

Therapy

Sandwich therapy in the management of propranolol resistant infantile hemangioma of the lip.
Tiwari P, Pandey V, Bera RN, Tiwary N, Mishra A, Sharma SP
J Stomatol Oral Maxillofac Surg 2022 Oct;123(5):e499-e505. Epub 2022 Feb 22 doi: 10.1016/j.jormas.2022.02.010. PMID: 35217221
Benign vascular lesions of the lips: Diagnostic approach.
Tobouti PL, Olegário I, de Sousa SC
J Cutan Pathol 2017 May;44(5):451-455. Epub 2017 Feb 16 doi: 10.1111/cup.12911. PMID: 28111788
Infantile hemangiomas, complications and treatments.
Cheng CE, Friedlander SF
Semin Cutan Med Surg 2016 Sep;35(3):108-16. doi: 10.12788/j.sder.2016.050. PMID: 27607318
2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT).
Galiè N, Humbert M, Vachiery JL, Gibbs S, Lang I, Torbicki A, Simonneau G, Peacock A, Vonk Noordegraaf A, Beghetti M, Ghofrani A, Gomez Sanchez MA, Hansmann G, Klepetko W, Lancellotti P, Matucci M, McDonagh T, Pierard LA, Trindade PT, Zompatori M, Hoeper M; ESC Scientific Document Group
Eur Heart J 2016 Jan 1;37(1):67-119. Epub 2015 Aug 29 doi: 10.1093/eurheartj/ehv317. PMID: 26320113
Diffuse neonatal hemangiomatosis.
Holden KR, Alexander F
Pediatrics 1970 Sep;46(3):411-21. PMID: 5465931

Prognosis

Infantile Hemangiomas of the Lip: Patterns, Outcomes, and Implications.
Yanes DA, Pearson GD, Witman PM
Pediatr Dermatol 2016 Sep;33(5):511-7. Epub 2016 Jul 11 doi: 10.1111/pde.12928. PMID: 27397475
Clinical Features of Neonates with Hydrops Fetalis.
An X, Wang J, Zhuang X, Dai J, Lu C, Li X, Yan Y
Am J Perinatol 2015 Nov;32(13):1231-9. Epub 2015 Jun 12 doi: 10.1055/s-0035-1552934. PMID: 26070120
Rhinoplasty for cleft and hemangioma-related nasal deformities.
Lee TS, Schwartz GM, Tatum SA
Curr Opin Otolaryngol Head Neck Surg 2010 Dec;18(6):526-35. doi: 10.1097/MOO.0b013e3283402984. PMID: 20962645
Oral tumors in children: a review.
Maaita JK
J Clin Pediatr Dent 2000 Winter;24(2):133-5. PMID: 11314322
Congenital brain tumors.
Raisanen JM, Davis RL
Pathology (Phila) 1993;2(1):103-16. PMID: 9420933

Clinical prediction guides

Examination of oral hemangiomas by intraoral ultrasonography.
Derindağ G, Sarıca İ, Çağlayan F
Oral Radiol 2021 Oct;37(4):687-692. Epub 2021 Mar 3 doi: 10.1007/s11282-021-00511-z. PMID: 33656695
Distribution, clinical characteristics, and surgical treatment of lip infantile hemangiomas.
O TM, Scheuermann-Poley C, Tan M, Waner M
JAMA Facial Plast Surg 2013 Jul-Aug;15(4):292-304. doi: 10.1001/jamafacial.2013.883. PMID: 23752875
Clinical spectrum and risk of PHACE syndrome in cutaneous and airway hemangiomas.
Haggstrom AN, Skillman S, Garzon MC, Drolet BA, Holland K, Matt B, McCuaig C, Metry DW, Morel K, Powell J, Frieden IJ
Arch Otolaryngol Head Neck Surg 2011 Jul;137(7):680-7. doi: 10.1001/archoto.2011.113. PMID: 21768412
Transiently arterialized hemangiomas: relevant clinical and cardiac issues.
Blei F, Rutkowski M
Lymphat Res Biol 2003;1(4):317-20. doi: 10.1089/153968503322758139. PMID: 15624561
Congenital brain tumors.
Raisanen JM, Davis RL
Pathology (Phila) 1993;2(1):103-16. PMID: 9420933

Recent systematic reviews

Recurrent Intramuscular Hemangioma (Infiltrating Angiolipoma) of the Lower Lip: A Case Report and Review of the Literature.
DeGiovanni JC, Simmonds J, Lang-Orsini M, Lee A
Ear Nose Throat J 2022 Jun;101(5):306-311. Epub 2020 Sep 14 doi: 10.1177/0145561320957759. PMID: 32921186
Intravascular papillary endothelial hyperplasia in the oral mucosa and jawbones: A collaborative study of 20 cases and a systematic review.
Vieira CC, Gomes APN, Galdino Dos Santos L, de Almeida DS, Hildebrand LC, Flores IL, Dos Santos JN, Schuch LF, Vasconcelos ACU
J Oral Pathol Med 2021 Jan;50(1):103-113. Epub 2020 Dec 7 doi: 10.1111/jop.13127. PMID: 33188642

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