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Increased blood drug concentration

MedGen UID:
1691772
•Concept ID:
C5209255
•
Finding
Synonyms: Elevated blood drug concentration; Elevated plasma drug concentration; Elevated serum drug concentrations; Increased plasma drug concentration; Increased serum drug concentration
 
HPO: HP:0020170

Definition

High plasma concentration of a drug as compared to previously measured thresholds given the expected concentration for the applied dosage regime. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased blood drug concentration

Professional guidelines

PubMed

Continuous glucose monitoring and metrics for clinical trials: an international consensus statement.
Battelino T, Alexander CM, Amiel SA, Arreaza-Rubin G, Beck RW, Bergenstal RM, Buckingham BA, Carroll J, Ceriello A, Chow E, Choudhary P, Close K, Danne T, Dutta S, Gabbay R, Garg S, Heverly J, Hirsch IB, Kader T, Kenney J, Kovatchev B, Laffel L, Maahs D, Mathieu C, Mauricio D, Nimri R, Nishimura R, Scharf M, Del Prato S, Renard E, Rosenstock J, Saboo B, Ueki K, Umpierrez GE, Weinzimer SA, Phillip M
Lancet Diabetes Endocrinol 2023 Jan;11(1):42-57. Epub 2022 Dec 6 doi: 10.1016/S2213-8587(22)00319-9. PMID: 36493795
Diagnosis and Treatment of Hyponatremia: Compilation of the Guidelines.
Hoorn EJ, Zietse R
J Am Soc Nephrol 2017 May;28(5):1340-1349. Epub 2017 Feb 7 doi: 10.1681/ASN.2016101139. PMID: 28174217Free PMC Article
Clinical practice guideline on diagnosis and treatment of hyponatraemia.
Spasovski G, Vanholder R, Allolio B, Annane D, Ball S, Bichet D, Decaux G, Fenske W, Hoorn EJ, Ichai C, Joannidis M, Soupart A, Zietse R, Haller M, van der Veer S, Van Biesen W, Nagler E; Hyponatraemia Guideline Development Group
Eur J Endocrinol 2014 Mar;170(3):G1-47. Epub 2014 Feb 25 doi: 10.1530/EJE-13-1020. PMID: 24569125

Recent clinical studies

Etiology

Roles of Four-Factor Prothrombin Complex Concentrate in the Management of Critical Bleeding.
Tanaka KA, Shettar S, Vandyck K, Shea SM, Abuelkasem E
Transfus Med Rev 2021 Oct;35(4):96-103. Epub 2021 Aug 26 doi: 10.1016/j.tmrv.2021.06.007. PMID: 34551881
Perioperative thrombocytopenia.
Lombard FW, Popescu WM, Oprea AD, Kertai MD
Curr Opin Anaesthesiol 2021 Jun 1;34(3):335-344. doi: 10.1097/ACO.0000000000000999. PMID: 33935182
Apixaban: A Clinical Pharmacokinetic and Pharmacodynamic Review.
Byon W, Garonzik S, Boyd RA, Frost CE
Clin Pharmacokinet 2019 Oct;58(10):1265-1279. doi: 10.1007/s40262-019-00775-z. PMID: 31089975Free PMC Article
Disseminated Intravascular Coagulation: An Update on Pathogenesis, Diagnosis, and Therapeutic Strategies.
Papageorgiou C, Jourdi G, Adjambri E, Walborn A, Patel P, Fareed J, Elalamy I, Hoppensteadt D, Gerotziafas GT
Clin Appl Thromb Hemost 2018 Dec;24(9_suppl):8S-28S. Epub 2018 Oct 8 doi: 10.1177/1076029618806424. PMID: 30296833Free PMC Article
Modern haemophilia care.
Berntorp E, Shapiro AD
Lancet 2012 Apr 14;379(9824):1447-56. Epub 2012 Mar 27 doi: 10.1016/S0140-6736(11)61139-2. PMID: 22456059

Diagnosis

Predictive value for increased activated factor XI activity in acute venous thromboembolism.
Nagy M, Robles AP, Visser M, Koeck T, Ten Cate V, Ten Cate-Hoek AJ, Schwers S, Heitmeier S, Ten Cate H, Wild PS, Spronk HMH
J Thromb Haemost 2023 Jun;21(6):1610-1622. Epub 2023 Mar 30 doi: 10.1016/j.jtha.2023.02.031. PMID: 37003466
Disseminated Intravascular Coagulation: An Update on Pathogenesis, Diagnosis, and Therapeutic Strategies.
Papageorgiou C, Jourdi G, Adjambri E, Walborn A, Patel P, Fareed J, Elalamy I, Hoppensteadt D, Gerotziafas GT
Clin Appl Thromb Hemost 2018 Dec;24(9_suppl):8S-28S. Epub 2018 Oct 8 doi: 10.1177/1076029618806424. PMID: 30296833Free PMC Article
Rivaroxaban - Metabolism, Pharmacologic Properties and Drug Interactions.
Kvasnicka T, Malikova I, Zenahlikova Z, Kettnerova K, Brzezkova R, Zima T, Ulrych J, Briza J, Netuka I, Kvasnicka J
Curr Drug Metab 2017;18(7):636-642. doi: 10.2174/1389200218666170518165443. PMID: 28524005
International Normalized Ratio Is Significantly Elevated With Rivaroxaban and Apixaban Drug Therapies: A Retrospective Study.
Ofek F, Bar Chaim S, Kronenfeld N, Ziv-Baran T, Berkovitch M
Clin Ther 2017 May;39(5):1003-1010. Epub 2017 May 2 doi: 10.1016/j.clinthera.2017.04.007. PMID: 28476405
Guidelines on the diagnosis and treatment of iron deficiency across indications: a systematic review.
Peyrin-Biroulet L, Williet N, Cacoub P
Am J Clin Nutr 2015 Dec;102(6):1585-94. Epub 2015 Nov 11 doi: 10.3945/ajcn.114.103366. PMID: 26561626

Therapy

Direct oral anticoagulants for use in paediatrics.
Jaffray J, Young G
Lancet Child Adolesc Health 2022 Mar;6(3):207-214. Epub 2022 Jan 13 doi: 10.1016/S2352-4642(21)00343-6. PMID: 35033222
Roles of Four-Factor Prothrombin Complex Concentrate in the Management of Critical Bleeding.
Tanaka KA, Shettar S, Vandyck K, Shea SM, Abuelkasem E
Transfus Med Rev 2021 Oct;35(4):96-103. Epub 2021 Aug 26 doi: 10.1016/j.tmrv.2021.06.007. PMID: 34551881
Disseminated Intravascular Coagulation: An Update on Pathogenesis, Diagnosis, and Therapeutic Strategies.
Papageorgiou C, Jourdi G, Adjambri E, Walborn A, Patel P, Fareed J, Elalamy I, Hoppensteadt D, Gerotziafas GT
Clin Appl Thromb Hemost 2018 Dec;24(9_suppl):8S-28S. Epub 2018 Oct 8 doi: 10.1177/1076029618806424. PMID: 30296833Free PMC Article
Antifactor Xa levels versus activated partial thromboplastin time for monitoring unfractionated heparin.
Vandiver JW, Vondracek TG
Pharmacotherapy 2012 Jun;32(6):546-58. Epub 2012 Apr 24 doi: 10.1002/j.1875-9114.2011.01049.x. PMID: 22531940
Ferric carboxymaltose: a review of its use in iron-deficiency anaemia.
Lyseng-Williamson KA, Keating GM
Drugs 2009;69(6):739-56. doi: 10.2165/00003495-200969060-00007. PMID: 19405553

Prognosis

Exploring the complex relationship between vitamin K, gut microbiota, and warfarin variability in cardiac surgery patients.
Xue L, Singla RK, Qin Q, Ding Y, Liu L, Ding X, Qu W, Huang C, Shen Z, Shen B, Miao L
Int J Surg 2023 Dec 1;109(12):3861-3871. doi: 10.1097/JS9.0000000000000673. PMID: 37598356Free PMC Article
Predictive value for increased activated factor XI activity in acute venous thromboembolism.
Nagy M, Robles AP, Visser M, Koeck T, Ten Cate V, Ten Cate-Hoek AJ, Schwers S, Heitmeier S, Ten Cate H, Wild PS, Spronk HMH
J Thromb Haemost 2023 Jun;21(6):1610-1622. Epub 2023 Mar 30 doi: 10.1016/j.jtha.2023.02.031. PMID: 37003466
Pleiotropic Effects of PCSK-9 Inhibitors.
Basiak M, Kosowski M, Cyrnek M, Bułdak Ł, Maligłówka M, Machnik G, Okopień B
Int J Mol Sci 2021 Mar 19;22(6) doi: 10.3390/ijms22063144. PMID: 33808697Free PMC Article
Modern haemophilia care.
Berntorp E, Shapiro AD
Lancet 2012 Apr 14;379(9824):1447-56. Epub 2012 Mar 27 doi: 10.1016/S0140-6736(11)61139-2. PMID: 22456059
Reversing anticoagulant therapy.
Ghanny S, Warkentin TE, Crowther MA
Curr Drug Discov Technol 2012 Jun 1;9(2):143-9. doi: 10.2174/1570163811209020143. PMID: 22023256

Clinical prediction guides

Andexanet Alfa or Prothrombin Complex Concentrate for Factor Xa Inhibitor Reversal in Acute Major Bleeding: A Systematic Review and Meta-Analysis.
Nederpelt CJ, Naar L, Krijnen P, le Cessie S, Kaafarani HMA, Huisman MV, Velmahos GC, Schipper IB
Crit Care Med 2021 Oct 1;49(10):e1025-e1036. doi: 10.1097/CCM.0000000000005059. PMID: 33967205
Drug-Drug Interactions with Direct Oral Anticoagulants.
Foerster KI, Hermann S, Mikus G, Haefeli WE
Clin Pharmacokinet 2020 Aug;59(8):967-980. doi: 10.1007/s40262-020-00879-x. PMID: 32157630Free PMC Article
AGA Clinical Practice Update: Coagulation in Cirrhosis.
O'Leary JG, Greenberg CS, Patton HM, Caldwell SH
Gastroenterology 2019 Jul;157(1):34-43.e1. Epub 2019 Apr 12 doi: 10.1053/j.gastro.2019.03.070. PMID: 30986390
Apixaban Pharmacokinetics at Steady State in Hemodialysis Patients.
Mavrakanas TA, Samer CF, Nessim SJ, Frisch G, Lipman ML
J Am Soc Nephrol 2017 Jul;28(7):2241-2248. Epub 2017 Mar 16 doi: 10.1681/ASN.2016090980. PMID: 28302754Free PMC Article
Reversing anticoagulant therapy.
Ghanny S, Warkentin TE, Crowther MA
Curr Drug Discov Technol 2012 Jun 1;9(2):143-9. doi: 10.2174/1570163811209020143. PMID: 22023256

Recent systematic reviews

The effects of oral ferrous bisglycinate supplementation on hemoglobin and ferritin concentrations in adults and children: a systematic review and meta-analysis of randomized controlled trials.
Fischer JAJ, Cherian AM, Bone JN, Karakochuk CD
Nutr Rev 2023 Jul 10;81(8):904-920. doi: 10.1093/nutrit/nuac106. PMID: 36728680Free PMC Article
Interventions for the long-term prevention of hereditary angioedema attacks.
Beard N, Frese M, Smertina E, Mere P, Katelaris C, Mills K
Cochrane Database Syst Rev 2022 Nov 3;11(11):CD013403. doi: 10.1002/14651858.CD013403.pub2. PMID: 36326435Free PMC Article
Systematic review of drug-drug interactions between rifamycins and anticoagulant and antiplatelet agents and considerations for management.
MacDougall C, Canonica T, Keh C, P Phan BA, Louie J
Pharmacotherapy 2022 Apr;42(4):343-361. Epub 2022 Feb 28 doi: 10.1002/phar.2672. PMID: 35152432
Vitamin D and Calcium for the Prevention of Fracture: A Systematic Review and Meta-analysis.
Yao P, Bennett D, Mafham M, Lin X, Chen Z, Armitage J, Clarke R
JAMA Netw Open 2019 Dec 2;2(12):e1917789. doi: 10.1001/jamanetworkopen.2019.17789. PMID: 31860103Free PMC Article
Lithium toxicity profile: a systematic review and meta-analysis.
McKnight RF, Adida M, Budge K, Stockton S, Goodwin GM, Geddes JR
Lancet 2012 Feb 25;379(9817):721-8. Epub 2012 Jan 20 doi: 10.1016/S0140-6736(11)61516-X. PMID: 22265699

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