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Virus-Associated Hemophagocytic Syndrome

MedGen UID:
1692156
•Concept ID:
C5207031
•
Disease or Syndrome

Definition

Hemophagocytic syndrome that is associated with viral infection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVirus-Associated Hemophagocytic Syndrome

Professional guidelines

PubMed

Epstein-Barr virus-associated acute renal failure: diagnosis, treatment, and follow-up.
Tsai JD, Lee HC, Lin CC, Liang DC, Chen SH, Huang FY
Pediatr Nephrol 2003 Jul;18(7):667-74. Epub 2003 May 15 doi: 10.1007/s00467-003-1152-y. PMID: 12750978
The use of cyclosporin-A in the treatment of virus-associated hemophagocytic syndrome in adults.
Tsuda H
Leuk Lymphoma 1997 Dec;28(1-2):73-82. doi: 10.3109/10428199709058333. PMID: 9498706
Prevention and treatment of Epstein-Barr virus (EBV)-associated lymphoproliferative diseases in immune deficient patients.
Purtilo DT
AIDS Res 1986 Dec;2 Suppl 1:S177-81. PMID: 2435295

Recent clinical studies

Etiology

Inherited Immunodeficiencies With High Predisposition to Epstein-Barr Virus-Driven Lymphoproliferative Diseases.
Latour S, Winter S
Front Immunol 2018;9:1103. Epub 2018 Jun 4 doi: 10.3389/fimmu.2018.01103. PMID: 29942301Free PMC Article
Analysis of prognostic risk factors in children with Epstein-Barr virus-associated hemophagocytic syndrome.
Xue H, Chen C, Li W, Lin C, Fang J, Li Y, Xu H
Minerva Pediatr 2015 Jun;67(3):251-61. PMID: 25941132
Virus-associated hemophagocytic syndrome as a major contributor to death in patients with 2009 influenza A (H1N1) infection.
Beutel G, Wiesner O, Eder M, Hafer C, Schneider AS, Kielstein JT, Kühn C, Heim A, Ganzenmüller T, Kreipe HH, Haverich A, Tecklenburg A, Ganser A, Welte T, Hoeper MM
Crit Care 2011;15(2):R80. Epub 2011 Mar 2 doi: 10.1186/cc10073. PMID: 21366922Free PMC Article
Infected-associated hemophagocytic syndrome.
Currimbhoy ZE
Indian Pediatr 1995 Mar;32(3):285-90. PMID: 8613281
Virus-associated hemophagocytic syndrome: a benign histiocytic proliferation distinct from malignant histiocytosis.
Risdall RJ, McKenna RW, Nesbit ME, Krivit W, Balfour HH Jr, Simmons RL, Brunning RD
Cancer 1979 Sep;44(3):993-1002. doi: 10.1002/1097-0142(197909)44:3<993::aid-cncr2820440329>3.0.co;2-5. PMID: 225008

Diagnosis

Early Use of Blood Purification in Severe Epstein-Barr Virus-Associated Hemophagocytic Syndrome.
Huang P, Huang C, Xu H, Lu J, Tian R, Wang Z, Chen Y
Pediatrics 2020 Jun;145(6) Epub 2020 May 19 doi: 10.1542/peds.2019-3197. PMID: 32430444
Inherited Immunodeficiencies With High Predisposition to Epstein-Barr Virus-Driven Lymphoproliferative Diseases.
Latour S, Winter S
Front Immunol 2018;9:1103. Epub 2018 Jun 4 doi: 10.3389/fimmu.2018.01103. PMID: 29942301Free PMC Article
Infected-associated hemophagocytic syndrome.
Currimbhoy ZE
Indian Pediatr 1995 Mar;32(3):285-90. PMID: 8613281
Epstein-Barr virus-associated hemophagocytic syndrome.
Kikuta H
Leuk Lymphoma 1995 Feb;16(5-6):425-9. doi: 10.3109/10428199509054429. PMID: 7787752
Cytophagic panniculitis.
March LM, Webb J, Eckstein RP
Aust N Z J Med 1986 Jun;16(3):397-401. doi: 10.1111/j.1445-5994.1986.tb01197.x. PMID: 3465317

Therapy

Fulminant Epstein-Barr virus-associated hemophagocytic syndrome in a renal transplant patient and review of the literature.
Romiopoulos I, Pyrpasopoulou A, Onoufriadis I, Massa E, Mouloudi E, Kydona C, Giasnetsova T, Gerogianni N, Myserlis G, Solonaki F, Nikodimopoulou M, Mandala E, Antachopoulos C, Roilides E
Transpl Infect Dis 2016 Oct;18(5):795-800. Epub 2016 Sep 16 doi: 10.1111/tid.12586. PMID: 27496079
Hemophagocytic syndrome associated with hepatitis A: case report and literature review.
Tuon FF, Gomes VS, Amato VS, Graf ME, Fonseca GH, Lazari C, Nicodemo AC
Rev Inst Med Trop Sao Paulo 2008 Mar-Apr;50(2):123-7. doi: 10.1590/s0036-46652008000200012. PMID: 18488094
Hemophagocytic syndrome.
Al-Talag AH, Mohamed AE, Dafulla MM, Ghandour Z, Al-Karawi MA, Haleem A
Saudi Med J 2000 Oct;21(10):979-82. PMID: 11369969
The use of cyclosporin-A in the treatment of virus-associated hemophagocytic syndrome in adults.
Tsuda H
Leuk Lymphoma 1997 Dec;28(1-2):73-82. doi: 10.3109/10428199709058333. PMID: 9498706
Virus associated hemophagocytic syndrome.
McKenna RW, Risdall RJ, Brunning RD
Hum Pathol 1981 May;12(5):395-8. doi: 10.1016/s0046-8177(81)80019-6. PMID: 7250953

Prognosis

Fulminant Epstein-Barr virus-associated hemophagocytic syndrome in a renal transplant patient and review of the literature.
Romiopoulos I, Pyrpasopoulou A, Onoufriadis I, Massa E, Mouloudi E, Kydona C, Giasnetsova T, Gerogianni N, Myserlis G, Solonaki F, Nikodimopoulou M, Mandala E, Antachopoulos C, Roilides E
Transpl Infect Dis 2016 Oct;18(5):795-800. Epub 2016 Sep 16 doi: 10.1111/tid.12586. PMID: 27496079
Analysis of prognostic risk factors in children with Epstein-Barr virus-associated hemophagocytic syndrome.
Xue H, Chen C, Li W, Lin C, Fang J, Li Y, Xu H
Minerva Pediatr 2015 Jun;67(3):251-61. PMID: 25941132
Virus-associated hemophagocytic syndrome as a major contributor to death in patients with 2009 influenza A (H1N1) infection.
Beutel G, Wiesner O, Eder M, Hafer C, Schneider AS, Kielstein JT, Kühn C, Heim A, Ganzenmüller T, Kreipe HH, Haverich A, Tecklenburg A, Ganser A, Welte T, Hoeper MM
Crit Care 2011;15(2):R80. Epub 2011 Mar 2 doi: 10.1186/cc10073. PMID: 21366922Free PMC Article
Infected-associated hemophagocytic syndrome.
Currimbhoy ZE
Indian Pediatr 1995 Mar;32(3):285-90. PMID: 8613281
Prognosis of children with virus-associated hemophagocytic syndrome and malignant histiocytosis: correlation with levels of serum interleukin-1 and tumor necrosis factor.
Ishii E, Ohga S, Aoki T, Yamada S, Sako M, Tasaka H, Kuwano A, Sasaki M, Tsunematsu Y, Ueda K
Acta Haematol 1991;85(2):93-9. doi: 10.1159/000204864. PMID: 1850944

Clinical prediction guides

Early Use of Blood Purification in Severe Epstein-Barr Virus-Associated Hemophagocytic Syndrome.
Huang P, Huang C, Xu H, Lu J, Tian R, Wang Z, Chen Y
Pediatrics 2020 Jun;145(6) Epub 2020 May 19 doi: 10.1542/peds.2019-3197. PMID: 32430444
Virus-associated hemophagocytic syndrome as a major contributor to death in patients with 2009 influenza A (H1N1) infection.
Beutel G, Wiesner O, Eder M, Hafer C, Schneider AS, Kielstein JT, Kühn C, Heim A, Ganzenmüller T, Kreipe HH, Haverich A, Tecklenburg A, Ganser A, Welte T, Hoeper MM
Crit Care 2011;15(2):R80. Epub 2011 Mar 2 doi: 10.1186/cc10073. PMID: 21366922Free PMC Article
Hemophagocytic syndrome associated with hepatitis A: case report and literature review.
Tuon FF, Gomes VS, Amato VS, Graf ME, Fonseca GH, Lazari C, Nicodemo AC
Rev Inst Med Trop Sao Paulo 2008 Mar-Apr;50(2):123-7. doi: 10.1590/s0036-46652008000200012. PMID: 18488094
Prognosis of children with virus-associated hemophagocytic syndrome and malignant histiocytosis: correlation with levels of serum interleukin-1 and tumor necrosis factor.
Ishii E, Ohga S, Aoki T, Yamada S, Sako M, Tasaka H, Kuwano A, Sasaki M, Tsunematsu Y, Ueda K
Acta Haematol 1991;85(2):93-9. doi: 10.1159/000204864. PMID: 1850944
Epstein-Barr virus-associated hemophagocytic syndrome: virological and immunopathological studies.
Sullivan JL, Woda BA, Herrod HG, Koh G, Rivara FP, Mulder C
Blood 1985 May;65(5):1097-104. PMID: 2986741

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