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Persistent viremia

MedGen UID:
1692312
Concept ID:
C5139222
Finding
HPO: HP:0032248

Definition

Persistence of virus in the blood circulation longer than would be normal in an immunocompetent host. [from HPO]

Term Hierarchy

Conditions with this feature

Severe combined immunodeficiency due to CTPS1 deficiency
MedGen UID:
863054
Concept ID:
C4014617
Disease or Syndrome
IMD24 is an autosomal recessive immunodeficiency characterized by the impaired capacity of activated T and B cells to proliferate in response to antigen receptor-mediated activation. Patients have early onset of severe chronic viral infections, mostly caused by herpesviruses, including Epstein-Barr virus (EBV) and varicella zoster virus (VZV); they also suffer from recurrent encapsulated bacterial infections, a spectrum typical of a combined deficiency of adaptive immunity (CID) (summary by Martin et al., 2014).

Professional guidelines

PubMed

Subramaniam S, Fares-Gusmao R, Sato S, Cullen JM, Takeda K, Farci P, McGivern DR
PLoS Pathog 2023 Sep;19(9):e1011664. Epub 2023 Sep 13 doi: 10.1371/journal.ppat.1011664. PMID: 37703304Free PMC Article
Santeusanio AD, Lukens BE, Eun J
Am J Health Syst Pharm 2017 Dec 15;74(24):2037-2045. doi: 10.2146/ajhp160585. PMID: 29222360
Varella RB, Almeida JR, Lopes Pde F, Matos JP, Menezes P, Lugon JR
J Bras Nefrol 2014 Oct-Dec;36(4):529-34. doi: 10.5935/0101-2800.20140075. PMID: 25517283

Recent clinical studies

Etiology

Mineeva-Sangwo O, Van Loon E, Andrei G, Kuypers D, Naesens M, Snoeck R
Sci Rep 2023 Aug 19;13(1):13534. doi: 10.1038/s41598-023-40714-4. PMID: 37598256Free PMC Article
Roulot D, Brichler S, Layese R, BenAbdesselam Z, Zoulim F, Thibault V, Scholtes C, Roche B, Castelnau C, Poynard T, Chazouillères O, Ganne N, Fontaine H, Gournay J, Guyader D, Le Gal F, Nahon P, Roudot-Thoraval F, Gordien E; Deltavir study group
J Hepatol 2020 Nov;73(5):1046-1062. Epub 2020 Jul 4 doi: 10.1016/j.jhep.2020.06.038. PMID: 32634548
Widera M, Dirks M, Bleekmann B, Jablonka R, Däumer M, Walter H, Ehret R, Verheyen J, Esser S
Med Microbiol Immunol 2017 Jun;206(3):203-215. Epub 2017 Feb 20 doi: 10.1007/s00430-017-0494-1. PMID: 28220254Free PMC Article
Lok AS, McMahon BJ, Brown RS Jr, Wong JB, Ahmed AT, Farah W, Almasri J, Alahdab F, Benkhadra K, Mouchli MA, Singh S, Mohamed EA, Abu Dabrh AM, Prokop LJ, Wang Z, Murad MH, Mohammed K
Hepatology 2016 Jan;63(1):284-306. Epub 2015 Nov 13 doi: 10.1002/hep.28280. PMID: 26566246
Seeff LB
Hepatology 1997 Sep;26(3 Suppl 1):21S-28S. doi: 10.1002/hep.510260704. PMID: 9305659

Diagnosis

Roulot D, Brichler S, Layese R, BenAbdesselam Z, Zoulim F, Thibault V, Scholtes C, Roche B, Castelnau C, Poynard T, Chazouillères O, Ganne N, Fontaine H, Gournay J, Guyader D, Le Gal F, Nahon P, Roudot-Thoraval F, Gordien E; Deltavir study group
J Hepatol 2020 Nov;73(5):1046-1062. Epub 2020 Jul 4 doi: 10.1016/j.jhep.2020.06.038. PMID: 32634548
Lok AS, McMahon BJ, Brown RS Jr, Wong JB, Ahmed AT, Farah W, Almasri J, Alahdab F, Benkhadra K, Mouchli MA, Singh S, Mohamed EA, Abu Dabrh AM, Prokop LJ, Wang Z, Murad MH, Mohammed K
Hepatology 2016 Jan;63(1):284-306. Epub 2015 Nov 13 doi: 10.1002/hep.28280. PMID: 26566246
Waldman M, Kopp JB
Nat Clin Pract Nephrol 2007 Oct;3(10):540-50. doi: 10.1038/ncpneph0609. PMID: 17895931
Waldman M, Kopp JB
Clin J Am Soc Nephrol 2007 Jul;2 Suppl 1:S47-56. doi: 10.2215/CJN.01060307. PMID: 17699510
Seeff LB
Hepatology 1997 Sep;26(3 Suppl 1):21S-28S. doi: 10.1002/hep.510260704. PMID: 9305659

Therapy

Hong F, Jacobs JL, Aga E, Cillo AR, Fyne E, Koontz DL, Zheng L, Mellors JW
Virology 2018 Aug;521:51-57. Epub 2018 Jun 4 doi: 10.1016/j.virol.2018.05.018. PMID: 29879542Free PMC Article
Santeusanio AD, Lukens BE, Eun J
Am J Health Syst Pharm 2017 Dec 15;74(24):2037-2045. doi: 10.2146/ajhp160585. PMID: 29222360
Lok AS, McMahon BJ, Brown RS Jr, Wong JB, Ahmed AT, Farah W, Almasri J, Alahdab F, Benkhadra K, Mouchli MA, Singh S, Mohamed EA, Abu Dabrh AM, Prokop LJ, Wang Z, Murad MH, Mohammed K
Hepatology 2016 Jan;63(1):284-306. Epub 2015 Nov 13 doi: 10.1002/hep.28280. PMID: 26566246
Palmer S, Josefsson L, Coffin JM
J Intern Med 2011 Dec;270(6):550-60. Epub 2011 Oct 27 doi: 10.1111/j.1365-2796.2011.02457.x. PMID: 21929712
Josefsson L, Dahl V, Palmer S
Curr Opin Infect Dis 2010 Dec;23(6):628-32. doi: 10.1097/QCO.0b013e32833ff1d0. PMID: 20847693

Prognosis

Grabowski MK, Patel EU, Nakigozi G, Ssempijja V, Ssekubugu R, Ssekasanvu J, Ndyanabo A, Kigozi G, Nalugoda F, Gray RH, Kalibbala S, Serwadda DM, Laeyendecker O, Wawer MJ, Chang LW, Quinn TC, Kagaayi J, Tobian AAR, Reynolds SJ
J Infect Dis 2021 Apr 8;223(7):1150-1160. doi: 10.1093/infdis/jiab021. PMID: 33471100Free PMC Article
Roulot D, Brichler S, Layese R, BenAbdesselam Z, Zoulim F, Thibault V, Scholtes C, Roche B, Castelnau C, Poynard T, Chazouillères O, Ganne N, Fontaine H, Gournay J, Guyader D, Le Gal F, Nahon P, Roudot-Thoraval F, Gordien E; Deltavir study group
J Hepatol 2020 Nov;73(5):1046-1062. Epub 2020 Jul 4 doi: 10.1016/j.jhep.2020.06.038. PMID: 32634548
Kim E, Asmar BI, Thomas R, Abdel-Haq N
Pediatr Hematol Oncol 2020 Mar;37(2):119-128. Epub 2019 Dec 12 doi: 10.1080/08880018.2019.1695031. PMID: 31826701
Fiedler M, Roggendorf M
Curr Top Microbiol Immunol 2006;307:187-209. doi: 10.1007/3-540-29802-9_10. PMID: 16903227
Seeff LB
Hepatology 1997 Sep;26(3 Suppl 1):21S-28S. doi: 10.1002/hep.510260704. PMID: 9305659

Clinical prediction guides

Subramaniam S, Fares-Gusmao R, Sato S, Cullen JM, Takeda K, Farci P, McGivern DR
PLoS Pathog 2023 Sep;19(9):e1011664. Epub 2023 Sep 13 doi: 10.1371/journal.ppat.1011664. PMID: 37703304Free PMC Article
Mineeva-Sangwo O, Van Loon E, Andrei G, Kuypers D, Naesens M, Snoeck R
Sci Rep 2023 Aug 19;13(1):13534. doi: 10.1038/s41598-023-40714-4. PMID: 37598256Free PMC Article
Widera M, Dirks M, Bleekmann B, Jablonka R, Däumer M, Walter H, Ehret R, Verheyen J, Esser S
Med Microbiol Immunol 2017 Jun;206(3):203-215. Epub 2017 Feb 20 doi: 10.1007/s00430-017-0494-1. PMID: 28220254Free PMC Article
Lok AS, McMahon BJ, Brown RS Jr, Wong JB, Ahmed AT, Farah W, Almasri J, Alahdab F, Benkhadra K, Mouchli MA, Singh S, Mohamed EA, Abu Dabrh AM, Prokop LJ, Wang Z, Murad MH, Mohammed K
Hepatology 2016 Jan;63(1):284-306. Epub 2015 Nov 13 doi: 10.1002/hep.28280. PMID: 26566246
Moir S, Fauci AS
Curr Opin HIV AIDS 2014 Sep;9(5):472-7. doi: 10.1097/COH.0000000000000092. PMID: 25023621

Recent systematic reviews

Lok AS, McMahon BJ, Brown RS Jr, Wong JB, Ahmed AT, Farah W, Almasri J, Alahdab F, Benkhadra K, Mouchli MA, Singh S, Mohamed EA, Abu Dabrh AM, Prokop LJ, Wang Z, Murad MH, Mohammed K
Hepatology 2016 Jan;63(1):284-306. Epub 2015 Nov 13 doi: 10.1002/hep.28280. PMID: 26566246
Pai NP, Lawrence J, Reingold AL, Tulsky JP
Cochrane Database Syst Rev 2006 Jul 19;2006(3):CD006148. doi: 10.1002/14651858.CD006148. PMID: 16856117Free PMC Article

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